LeishMANIAdb
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Calmegin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Calmegin
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HDY8_LEIBR
TriTrypDb:
LbrM.25.0410 , LBRM2903_250010100
Length:
132

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4HDY8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDY8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 6 8 PF00675 0.513
CLV_PCSK_KEX2_1 109 111 PF00082 0.662
CLV_PCSK_KEX2_1 123 125 PF00082 0.731
CLV_PCSK_KEX2_1 6 8 PF00082 0.513
CLV_PCSK_KEX2_1 70 72 PF00082 0.442
CLV_PCSK_PC1ET2_1 109 111 PF00082 0.662
CLV_PCSK_PC1ET2_1 123 125 PF00082 0.731
CLV_PCSK_PC1ET2_1 6 8 PF00082 0.513
CLV_PCSK_PC1ET2_1 70 72 PF00082 0.442
CLV_PCSK_SKI1_1 79 83 PF00082 0.411
DEG_APCC_DBOX_1 78 86 PF00400 0.546
DOC_MAPK_gen_1 6 14 PF00069 0.714
DOC_MAPK_HePTP_8 4 16 PF00069 0.712
DOC_MAPK_MEF2A_6 7 16 PF00069 0.714
DOC_MAPK_MEF2A_6 79 87 PF00069 0.367
DOC_USP7_UBL2_3 119 123 PF12436 0.418
DOC_WW_Pin1_4 53 58 PF00397 0.731
LIG_14-3-3_CanoR_1 128 132 PF00244 0.611
LIG_FHA_1 109 115 PF00498 0.465
LIG_FHA_1 86 92 PF00498 0.513
LIG_FHA_2 37 43 PF00498 0.673
LIG_FHA_2 99 105 PF00498 0.430
LIG_LIR_Gen_1 78 87 PF02991 0.546
LIG_NRBOX 86 92 PF00104 0.455
LIG_SH2_CRK 72 76 PF00017 0.658
LIG_SH2_STAT5 80 83 PF00017 0.411
LIG_SH3_1 51 57 PF00018 0.613
LIG_SH3_3 51 57 PF00018 0.727
LIG_SUMO_SIM_par_1 83 88 PF11976 0.365
LIG_TRAF2_1 39 42 PF00917 0.687
MOD_CDK_SPxxK_3 55 62 PF00069 0.626
MOD_CK1_1 52 58 PF00069 0.795
MOD_CK2_1 36 42 PF00069 0.709
MOD_CK2_1 98 104 PF00069 0.428
MOD_DYRK1A_RPxSP_1 53 57 PF00069 0.730
MOD_GSK3_1 49 56 PF00069 0.722
MOD_NEK2_1 49 54 PF00069 0.755
MOD_NEK2_1 85 90 PF00069 0.369
MOD_NEK2_1 92 97 PF00069 0.349
MOD_PKA_2 52 58 PF00069 0.795
MOD_Plk_2-3 100 106 PF00069 0.458
MOD_Plk_4 85 91 PF00069 0.424
MOD_ProDKin_1 53 59 PF00069 0.733
MOD_SUMO_rev_2 104 111 PF00179 0.354
MOD_SUMO_rev_2 95 103 PF00179 0.640
TRG_DiLeu_BaEn_1 78 83 PF01217 0.619
TRG_ENDOCYTIC_2 72 75 PF00928 0.661
TRG_ENDOCYTIC_2 80 83 PF00928 0.411
TRG_ER_diArg_1 51 54 PF00400 0.725

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0C5 Leptomonas seymouri 48% 100%
A0A3S7WYV4 Leishmania donovani 70% 99%
A4I189 Leishmania infantum 70% 99%
E9AXC3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 99%
Q4QA49 Leishmania major 69% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS