Putative transcription factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription factor IIIb, putative

Species:

Leishmania braziliensis

UniProt:

A4HDY6_LEIBR

TriTrypDb:

LbrM.25.0390 , LBRM2903_250009800

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097550	transcription preinitiation complex	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDY6

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0065004	protein-DNA complex assembly	6	10
GO:0070897	transcription preinitiation complex assembly	7	10
GO:0071824	protein-DNA complex subunit organization	5	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006352	DNA-templated transcription initiation	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008134	transcription factor binding	3	10
GO:0017025	TBP-class protein binding	5	10
GO:0140296	general transcription initiation factor binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.448
CLV_C14_Caspase3-7	461	465	PF00656	0.506
CLV_NRD_NRD_1	137	139	PF00675	0.247
CLV_NRD_NRD_1	219	221	PF00675	0.247
CLV_NRD_NRD_1	292	294	PF00675	0.612
CLV_NRD_NRD_1	333	335	PF00675	0.449
CLV_NRD_NRD_1	572	574	PF00675	0.527
CLV_NRD_NRD_1	607	609	PF00675	0.510
CLV_NRD_NRD_1	644	646	PF00675	0.592
CLV_NRD_NRD_1	87	89	PF00675	0.247
CLV_PCSK_FUR_1	570	574	PF00082	0.565
CLV_PCSK_FUR_1	605	609	PF00082	0.491
CLV_PCSK_FUR_1	642	646	PF00082	0.545
CLV_PCSK_KEX2_1	137	139	PF00082	0.247
CLV_PCSK_KEX2_1	219	221	PF00082	0.247
CLV_PCSK_KEX2_1	258	260	PF00082	0.247
CLV_PCSK_KEX2_1	333	335	PF00082	0.449
CLV_PCSK_KEX2_1	393	395	PF00082	0.502
CLV_PCSK_KEX2_1	572	574	PF00082	0.527
CLV_PCSK_KEX2_1	607	609	PF00082	0.509
CLV_PCSK_KEX2_1	621	623	PF00082	0.578
CLV_PCSK_KEX2_1	641	643	PF00082	0.488
CLV_PCSK_KEX2_1	644	646	PF00082	0.572
CLV_PCSK_KEX2_1	87	89	PF00082	0.247
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.290
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.566
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.629
CLV_PCSK_PC1ET2_1	641	643	PF00082	0.488
CLV_PCSK_PC7_1	389	395	PF00082	0.580
CLV_PCSK_PC7_1	638	644	PF00082	0.548
CLV_PCSK_SKI1_1	112	116	PF00082	0.330
CLV_PCSK_SKI1_1	258	262	PF00082	0.302
CLV_PCSK_SKI1_1	381	385	PF00082	0.506
CLV_PCSK_SKI1_1	408	412	PF00082	0.508
CLV_PCSK_SKI1_1	55	59	PF00082	0.668
CLV_PCSK_SKI1_1	560	564	PF00082	0.618
CLV_PCSK_SKI1_1	573	577	PF00082	0.518
CLV_PCSK_SKI1_1	62	66	PF00082	0.656
CLV_PCSK_SKI1_1	88	92	PF00082	0.290
DEG_APCC_DBOX_1	559	567	PF00400	0.624
DEG_SCF_FBW7_2	345	350	PF00400	0.618
DEG_SCF_FBW7_2	539	546	PF00400	0.599
DOC_CKS1_1	323	328	PF01111	0.474
DOC_CKS1_1	540	545	PF01111	0.670
DOC_CYCLIN_RxL_1	361	371	PF00134	0.364
DOC_MAPK_gen_1	605	615	PF00069	0.585
DOC_MAPK_gen_1	664	673	PF00069	0.495
DOC_MAPK_gen_1	85	93	PF00069	0.469
DOC_MAPK_MEF2A_6	112	119	PF00069	0.389
DOC_MAPK_MEF2A_6	442	449	PF00069	0.497
DOC_MAPK_MEF2A_6	607	615	PF00069	0.594
DOC_MAPK_NFAT4_5	112	120	PF00069	0.389
DOC_PP2B_LxvP_1	366	369	PF13499	0.439
DOC_PP2B_LxvP_1	581	584	PF13499	0.602
DOC_USP7_MATH_1	318	322	PF00917	0.466
DOC_USP7_MATH_1	404	408	PF00917	0.693
DOC_USP7_MATH_1	419	423	PF00917	0.644
DOC_USP7_MATH_1	432	436	PF00917	0.485
DOC_USP7_MATH_1	458	462	PF00917	0.600
DOC_USP7_MATH_1	515	519	PF00917	0.681
DOC_USP7_MATH_1	584	588	PF00917	0.449
DOC_USP7_MATH_1	63	67	PF00917	0.697
DOC_USP7_MATH_1	637	641	PF00917	0.580
DOC_WW_Pin1_4	238	243	PF00397	0.447
DOC_WW_Pin1_4	263	268	PF00397	0.609
DOC_WW_Pin1_4	322	327	PF00397	0.484
DOC_WW_Pin1_4	343	348	PF00397	0.518
DOC_WW_Pin1_4	355	360	PF00397	0.422
DOC_WW_Pin1_4	467	472	PF00397	0.614
DOC_WW_Pin1_4	511	516	PF00397	0.557
DOC_WW_Pin1_4	534	539	PF00397	0.712
LIG_14-3-3_CanoR_1	140	148	PF00244	0.447
LIG_14-3-3_CanoR_1	250	256	PF00244	0.447
LIG_14-3-3_CanoR_1	259	267	PF00244	0.447
LIG_14-3-3_CanoR_1	293	300	PF00244	0.574
LIG_14-3-3_CanoR_1	408	416	PF00244	0.653
LIG_14-3-3_CanoR_1	45	54	PF00244	0.517
LIG_14-3-3_CanoR_1	610	616	PF00244	0.687
LIG_14-3-3_CanoR_1	62	68	PF00244	0.553
LIG_14-3-3_CanoR_1	624	631	PF00244	0.493
LIG_14-3-3_CanoR_1	642	648	PF00244	0.736
LIG_Actin_WH2_2	361	379	PF00022	0.370
LIG_APCC_ABBA_1	613	618	PF00400	0.604
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BRCT_BRCA1_1	307	311	PF00533	0.510
LIG_BRCT_BRCA1_1	8	12	PF00533	0.513
LIG_deltaCOP1_diTrp_1	330	335	PF00928	0.417
LIG_EH1_1	673	681	PF00400	0.370
LIG_eIF4E_1	674	680	PF01652	0.362
LIG_FHA_1	139	145	PF00498	0.530
LIG_FHA_1	19	25	PF00498	0.356
LIG_FHA_1	194	200	PF00498	0.447
LIG_FHA_1	266	272	PF00498	0.433
LIG_FHA_1	369	375	PF00498	0.516
LIG_FHA_1	411	417	PF00498	0.507
LIG_FHA_1	480	486	PF00498	0.562
LIG_FHA_1	590	596	PF00498	0.594
LIG_FHA_1	6	12	PF00498	0.510
LIG_FHA_1	70	76	PF00498	0.677
LIG_FHA_2	149	155	PF00498	0.623
LIG_FHA_2	168	174	PF00498	0.357
LIG_FHA_2	294	300	PF00498	0.564
LIG_FHA_2	344	350	PF00498	0.525
LIG_FHA_2	398	404	PF00498	0.438
LIG_FHA_2	540	546	PF00498	0.809
LIG_FHA_2	625	631	PF00498	0.512
LIG_Integrin_isoDGR_2	17	19	PF01839	0.421
LIG_IRF3_LxIS_1	93	100	PF10401	0.465
LIG_LIR_Gen_1	480	489	PF02991	0.516
LIG_LIR_Gen_1	579	586	PF02991	0.525
LIG_LIR_Nem_3	308	314	PF02991	0.406
LIG_LIR_Nem_3	330	335	PF02991	0.417
LIG_LIR_Nem_3	480	484	PF02991	0.447
LIG_LIR_Nem_3	579	583	PF02991	0.532
LIG_OCRL_FandH_1	334	346	PF00620	0.467
LIG_SH2_CRK	370	374	PF00017	0.379
LIG_SH2_CRK	481	485	PF00017	0.443
LIG_SH2_SRC	277	280	PF00017	0.565
LIG_SH2_STAP1	481	485	PF00017	0.559
LIG_SH2_STAT5	165	168	PF00017	0.567
LIG_SH2_STAT5	182	185	PF00017	0.420
LIG_SH2_STAT5	234	237	PF00017	0.530
LIG_SH2_STAT5	370	373	PF00017	0.382
LIG_SH2_STAT5	481	484	PF00017	0.567
LIG_SH2_STAT5	597	600	PF00017	0.496
LIG_SH3_2	323	328	PF14604	0.470
LIG_SH3_3	173	179	PF00018	0.447
LIG_SH3_3	320	326	PF00018	0.477
LIG_SH3_3	537	543	PF00018	0.708
LIG_SH3_3	650	656	PF00018	0.547
LIG_TRAF2_1	295	298	PF00917	0.637
LIG_TRAF2_1	347	350	PF00917	0.568
LIG_TRAF2_1	543	546	PF00917	0.692
LIG_TRAF2_1	627	630	PF00917	0.530
LIG_TRFH_1	34	38	PF08558	0.543
LIG_TYR_ITIM	310	315	PF00017	0.514
LIG_TYR_ITIM	595	600	PF00017	0.617
LIG_UBA3_1	159	164	PF00899	0.473
LIG_UBA3_1	310	319	PF00899	0.524
LIG_UBA3_1	365	372	PF00899	0.456
MOD_CDK_SPxK_1	322	328	PF00069	0.470
MOD_CDK_SPxxK_3	263	270	PF00069	0.588
MOD_CK1_1	100	106	PF00069	0.530
MOD_CK1_1	280	286	PF00069	0.528
MOD_CK1_1	292	298	PF00069	0.530
MOD_CK1_1	397	403	PF00069	0.449
MOD_CK1_1	435	441	PF00069	0.743
MOD_CK1_1	518	524	PF00069	0.694
MOD_CK1_1	79	85	PF00069	0.585
MOD_CK2_1	148	154	PF00069	0.423
MOD_CK2_1	167	173	PF00069	0.395
MOD_CK2_1	292	298	PF00069	0.611
MOD_CK2_1	300	306	PF00069	0.467
MOD_CK2_1	343	349	PF00069	0.553
MOD_CK2_1	379	385	PF00069	0.394
MOD_CK2_1	539	545	PF00069	0.801
MOD_CK2_1	624	630	PF00069	0.508
MOD_CK2_1	654	660	PF00069	0.612
MOD_Cter_Amidation	217	220	PF01082	0.247
MOD_Cter_Amidation	256	259	PF01082	0.302
MOD_GlcNHglycan	120	123	PF01048	0.247
MOD_GlcNHglycan	306	310	PF01048	0.428
MOD_GlcNHglycan	456	459	PF01048	0.804
MOD_GlcNHglycan	460	463	PF01048	0.746
MOD_GlcNHglycan	48	51	PF01048	0.602
MOD_GlcNHglycan	656	659	PF01048	0.440
MOD_GlcNHglycan	8	11	PF01048	0.471
MOD_GSK3_1	288	295	PF00069	0.565
MOD_GSK3_1	313	320	PF00069	0.439
MOD_GSK3_1	399	406	PF00069	0.488
MOD_GSK3_1	432	439	PF00069	0.726
MOD_GSK3_1	454	461	PF00069	0.642
MOD_GSK3_1	511	518	PF00069	0.632
MOD_GSK3_1	53	60	PF00069	0.592
MOD_GSK3_1	63	70	PF00069	0.601
MOD_N-GLC_1	280	285	PF02516	0.475
MOD_N-GLC_1	288	293	PF02516	0.611
MOD_N-GLC_1	419	424	PF02516	0.490
MOD_N-GLC_1	522	527	PF02516	0.726
MOD_N-GLC_1	70	75	PF02516	0.570
MOD_N-GLC_1	91	96	PF02516	0.302
MOD_NEK2_1	148	153	PF00069	0.389
MOD_NEK2_1	236	241	PF00069	0.502
MOD_NEK2_1	288	293	PF00069	0.537
MOD_NEK2_1	410	415	PF00069	0.543
MOD_NEK2_1	436	441	PF00069	0.719
MOD_NEK2_1	57	62	PF00069	0.681
MOD_NEK2_1	74	79	PF00069	0.549
MOD_NEK2_1	91	96	PF00069	0.414
MOD_PIKK_1	158	164	PF00454	0.475
MOD_PIKK_1	318	324	PF00454	0.572
MOD_PIKK_1	518	524	PF00454	0.730
MOD_PIKK_1	528	534	PF00454	0.706
MOD_PK_1	643	649	PF00069	0.652
MOD_PKA_1	258	264	PF00069	0.502
MOD_PKA_1	293	299	PF00069	0.591
MOD_PKA_1	643	649	PF00069	0.652
MOD_PKA_2	123	129	PF00069	0.504
MOD_PKA_2	139	145	PF00069	0.387
MOD_PKA_2	18	24	PF00069	0.457
MOD_PKA_2	249	255	PF00069	0.447
MOD_PKA_2	258	264	PF00069	0.447
MOD_PKA_2	292	298	PF00069	0.627
MOD_PKA_2	637	643	PF00069	0.539
MOD_PKA_2	79	85	PF00069	0.520
MOD_PKB_1	622	630	PF00069	0.630
MOD_Plk_1	100	106	PF00069	0.530
MOD_Plk_1	280	286	PF00069	0.358
MOD_Plk_1	305	311	PF00069	0.523
MOD_Plk_1	394	400	PF00069	0.676
MOD_Plk_1	432	438	PF00069	0.628
MOD_Plk_1	479	485	PF00069	0.559
MOD_Plk_1	522	528	PF00069	0.627
MOD_Plk_1	70	76	PF00069	0.571
MOD_Plk_4	123	129	PF00069	0.530
MOD_Plk_4	155	161	PF00069	0.407
MOD_Plk_4	611	617	PF00069	0.674
MOD_Plk_4	70	76	PF00069	0.498
MOD_ProDKin_1	238	244	PF00069	0.447
MOD_ProDKin_1	263	269	PF00069	0.611
MOD_ProDKin_1	322	328	PF00069	0.473
MOD_ProDKin_1	343	349	PF00069	0.524
MOD_ProDKin_1	355	361	PF00069	0.421
MOD_ProDKin_1	467	473	PF00069	0.608
MOD_ProDKin_1	511	517	PF00069	0.556
MOD_ProDKin_1	534	540	PF00069	0.712
MOD_SUMO_for_1	383	386	PF00179	0.473
MOD_SUMO_for_1	392	395	PF00179	0.450
MOD_SUMO_rev_2	313	321	PF00179	0.420
TRG_DiLeu_BaEn_1	386	391	PF01217	0.486
TRG_DiLeu_BaEn_1	480	485	PF01217	0.555
TRG_DiLeu_BaEn_4	349	355	PF01217	0.555
TRG_DiLeu_BaEn_4	629	635	PF01217	0.521
TRG_DiLeu_LyEn_5	386	391	PF01217	0.535
TRG_DiLeu_LyEn_5	480	485	PF01217	0.555
TRG_ENDOCYTIC_2	312	315	PF00928	0.410
TRG_ENDOCYTIC_2	481	484	PF00928	0.452
TRG_ENDOCYTIC_2	597	600	PF00928	0.496
TRG_ER_diArg_1	219	221	PF00400	0.447
TRG_ER_diArg_1	332	334	PF00400	0.445
TRG_ER_diArg_1	605	608	PF00400	0.492
TRG_ER_diArg_1	642	645	PF00400	0.587
TRG_ER_diArg_1	663	666	PF00400	0.496
TRG_NES_CRM1_1	89	102	PF08389	0.530
TRG_NLS_Bipartite_1	607	625	PF00514	0.569
TRG_NLS_MonoCore_2	640	645	PF00514	0.532
TRG_NLS_MonoExtC_3	640	645	PF00514	0.532
TRG_NLS_MonoExtN_4	619	625	PF00514	0.629
TRG_NLS_MonoExtN_4	638	645	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.247

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM92	Leptomonas seymouri	70%	99%
A0A3R7L9Y8	Trypanosoma rangeli	48%	100%
A0A3S7WYT5	Leishmania donovani	86%	99%
A4I187	Leishmania infantum	86%	99%
D0A5H2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AXC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QA51	Leishmania major	85%	100%
V5DPA1	Trypanosoma cruzi	49%	100%