Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat/Utp13 specific WD40 associated domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDY5_LEIBR

TriTrypDb:

LbrM.25.0380 , LBRM2903_250009700

Length:

968

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0005840	ribosome	5	12
GO:0030684	preribosome	3	12
GO:0032040	small-subunit processome	4	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0030686	90S preribosome	4	1

Expansion

Sequence features

A4HDY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDY5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	1
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000966	RNA 5'-end processing	7	1
GO:0000967	rRNA 5'-end processing	9	1
GO:0034471	ncRNA 5'-end processing	8	1
GO:0036260	RNA capping	7	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0030515	snoRNA binding	5	1
GO:0034511	U3 snoRNA binding	6	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.297
CLV_NRD_NRD_1	318	320	PF00675	0.376
CLV_NRD_NRD_1	383	385	PF00675	0.428
CLV_NRD_NRD_1	663	665	PF00675	0.302
CLV_NRD_NRD_1	75	77	PF00675	0.572
CLV_NRD_NRD_1	807	809	PF00675	0.324
CLV_NRD_NRD_1	913	915	PF00675	0.372
CLV_NRD_NRD_1	925	927	PF00675	0.252
CLV_PCSK_FUR_1	316	320	PF00082	0.495
CLV_PCSK_KEX2_1	100	102	PF00082	0.753
CLV_PCSK_KEX2_1	286	288	PF00082	0.561
CLV_PCSK_KEX2_1	318	320	PF00082	0.493
CLV_PCSK_KEX2_1	383	385	PF00082	0.410
CLV_PCSK_KEX2_1	663	665	PF00082	0.304
CLV_PCSK_KEX2_1	925	927	PF00082	0.320
CLV_PCSK_KEX2_1	963	965	PF00082	0.612
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.753
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.561
CLV_PCSK_PC1ET2_1	963	965	PF00082	0.658
CLV_PCSK_SKI1_1	319	323	PF00082	0.462
CLV_PCSK_SKI1_1	403	407	PF00082	0.443
CLV_PCSK_SKI1_1	758	762	PF00082	0.340
CLV_PCSK_SKI1_1	829	833	PF00082	0.373
CLV_PCSK_SKI1_1	83	87	PF00082	0.710
DEG_APCC_DBOX_1	318	326	PF00400	0.535
DOC_ANK_TNKS_1	286	293	PF00023	0.290
DOC_CYCLIN_yCln2_LP_2	851	857	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	905	911	PF00134	0.425
DOC_MAPK_gen_1	506	516	PF00069	0.551
DOC_MAPK_gen_1	600	608	PF00069	0.384
DOC_MAPK_gen_1	663	671	PF00069	0.304
DOC_MAPK_MEF2A_6	584	592	PF00069	0.504
DOC_MAPK_MEF2A_6	705	713	PF00069	0.320
DOC_PP2B_LxvP_1	123	126	PF13499	0.598
DOC_PP4_FxxP_1	447	450	PF00568	0.266
DOC_USP7_MATH_1	103	107	PF00917	0.759
DOC_USP7_MATH_1	114	118	PF00917	0.623
DOC_USP7_MATH_1	252	256	PF00917	0.469
DOC_USP7_MATH_1	270	274	PF00917	0.467
DOC_USP7_MATH_1	298	302	PF00917	0.397
DOC_USP7_MATH_1	393	397	PF00917	0.494
DOC_USP7_MATH_1	453	457	PF00917	0.588
DOC_USP7_MATH_1	519	523	PF00917	0.504
DOC_USP7_MATH_1	65	69	PF00917	0.768
DOC_USP7_MATH_1	679	683	PF00917	0.327
DOC_USP7_MATH_1	733	737	PF00917	0.507
DOC_USP7_MATH_1	900	904	PF00917	0.199
DOC_WW_Pin1_4	151	156	PF00397	0.743
DOC_WW_Pin1_4	478	483	PF00397	0.507
DOC_WW_Pin1_4	669	674	PF00397	0.304
DOC_WW_Pin1_4	956	961	PF00397	0.490
LIG_14-3-3_CanoR_1	20	24	PF00244	0.509
LIG_14-3-3_CanoR_1	205	214	PF00244	0.415
LIG_14-3-3_CanoR_1	372	379	PF00244	0.507
LIG_14-3-3_CanoR_1	495	503	PF00244	0.438
LIG_14-3-3_CanoR_1	509	516	PF00244	0.477
LIG_14-3-3_CanoR_1	537	547	PF00244	0.529
LIG_14-3-3_CanoR_1	566	574	PF00244	0.450
LIG_14-3-3_CanoR_1	663	673	PF00244	0.303
LIG_14-3-3_CanoR_1	67	75	PF00244	0.762
LIG_14-3-3_CanoR_1	688	693	PF00244	0.296
LIG_14-3-3_CanoR_1	705	709	PF00244	0.252
LIG_14-3-3_CanoR_1	821	825	PF00244	0.397
LIG_14-3-3_CanoR_1	914	923	PF00244	0.319
LIG_14-3-3_CanoR_1	925	929	PF00244	0.278
LIG_Actin_WH2_2	813	831	PF00022	0.304
LIG_APCC_ABBA_1	28	33	PF00400	0.544
LIG_APCC_ABBA_1	474	479	PF00400	0.494
LIG_BIR_II_1	1	5	PF00653	0.331
LIG_BRCT_BRCA1_1	300	304	PF00533	0.493
LIG_BRCT_BRCA1_1	349	353	PF00533	0.426
LIG_BRCT_BRCA1_1	559	563	PF00533	0.432
LIG_BRCT_BRCA1_1	667	671	PF00533	0.361
LIG_BRCT_BRCA1_1	71	75	PF00533	0.519
LIG_BRCT_BRCA1_1	812	816	PF00533	0.425
LIG_BRCT_BRCA1_1	889	893	PF00533	0.389
LIG_BRCT_BRCA1_2	71	77	PF00533	0.518
LIG_DLG_GKlike_1	688	695	PF00625	0.320
LIG_EH1_1	931	939	PF00400	0.414
LIG_eIF4E_1	932	938	PF01652	0.334
LIG_FHA_1	133	139	PF00498	0.422
LIG_FHA_1	191	197	PF00498	0.608
LIG_FHA_1	20	26	PF00498	0.364
LIG_FHA_1	232	238	PF00498	0.470
LIG_FHA_1	244	250	PF00498	0.368
LIG_FHA_1	368	374	PF00498	0.370
LIG_FHA_1	4	10	PF00498	0.432
LIG_FHA_1	431	437	PF00498	0.546
LIG_FHA_1	568	574	PF00498	0.478
LIG_FHA_1	617	623	PF00498	0.471
LIG_FHA_1	704	710	PF00498	0.335
LIG_FHA_1	716	722	PF00498	0.350
LIG_FHA_1	745	751	PF00498	0.469
LIG_FHA_1	82	88	PF00498	0.549
LIG_FHA_1	859	865	PF00498	0.451
LIG_FHA_1	879	885	PF00498	0.121
LIG_FHA_1	925	931	PF00498	0.312
LIG_FHA_2	114	120	PF00498	0.675
LIG_FHA_2	189	195	PF00498	0.450
LIG_FHA_2	277	283	PF00498	0.435
LIG_FHA_2	301	307	PF00498	0.288
LIG_FHA_2	34	40	PF00498	0.629
LIG_FHA_2	68	74	PF00498	0.691
LIG_FHA_2	780	786	PF00498	0.433
LIG_GBD_Chelix_1	464	472	PF00786	0.373
LIG_Integrin_isoDGR_2	564	566	PF01839	0.451
LIG_LIR_Gen_1	129	138	PF02991	0.399
LIG_LIR_Gen_1	265	274	PF02991	0.374
LIG_LIR_Gen_1	279	289	PF02991	0.347
LIG_LIR_Gen_1	456	465	PF02991	0.519
LIG_LIR_Gen_1	52	62	PF02991	0.507
LIG_LIR_Gen_1	568	577	PF02991	0.391
LIG_LIR_Gen_1	890	900	PF02991	0.339
LIG_LIR_Nem_3	129	133	PF02991	0.382
LIG_LIR_Nem_3	265	271	PF02991	0.377
LIG_LIR_Nem_3	279	284	PF02991	0.326
LIG_LIR_Nem_3	456	461	PF02991	0.534
LIG_LIR_Nem_3	52	58	PF02991	0.507
LIG_LIR_Nem_3	568	574	PF02991	0.409
LIG_LIR_Nem_3	668	674	PF02991	0.425
LIG_LIR_Nem_3	890	896	PF02991	0.339
LIG_LIR_Nem_3	927	932	PF02991	0.320
LIG_NRBOX	467	473	PF00104	0.516
LIG_PCNA_yPIPBox_3	305	319	PF02747	0.428
LIG_Pex14_1	418	422	PF04695	0.420
LIG_Pex14_2	443	447	PF04695	0.412
LIG_Pex14_2	812	816	PF04695	0.425
LIG_SH2_CRK	21	25	PF00017	0.446
LIG_SH2_CRK	571	575	PF00017	0.278
LIG_SH2_CRK	885	889	PF00017	0.326
LIG_SH2_NCK_1	885	889	PF00017	0.379
LIG_SH2_PTP2	130	133	PF00017	0.403
LIG_SH2_SRC	225	228	PF00017	0.376
LIG_SH2_STAP1	199	203	PF00017	0.487
LIG_SH2_STAP1	623	627	PF00017	0.456
LIG_SH2_STAP1	866	870	PF00017	0.406
LIG_SH2_STAT5	130	133	PF00017	0.365
LIG_SH2_STAT5	141	144	PF00017	0.361
LIG_SH2_STAT5	21	24	PF00017	0.511
LIG_SH2_STAT5	225	228	PF00017	0.513
LIG_SH2_STAT5	268	271	PF00017	0.387
LIG_SH2_STAT5	437	440	PF00017	0.420
LIG_SH2_STAT5	623	626	PF00017	0.407
LIG_SH2_STAT5	633	636	PF00017	0.260
LIG_SH2_STAT5	781	784	PF00017	0.452
LIG_SH2_STAT5	866	869	PF00017	0.406
LIG_SH2_STAT5	885	888	PF00017	0.245
LIG_SH2_STAT5	929	932	PF00017	0.243
LIG_SH3_1	383	389	PF00018	0.580
LIG_SH3_3	146	152	PF00018	0.617
LIG_SH3_3	383	389	PF00018	0.548
LIG_SH3_3	585	591	PF00018	0.443
LIG_SUMO_SIM_par_1	691	696	PF11976	0.320
LIG_SUMO_SIM_par_1	880	886	PF11976	0.334
LIG_TRAF2_1	170	173	PF00917	0.722
LIG_TRAF2_1	396	399	PF00917	0.638
LIG_TRAF2_1	754	757	PF00917	0.509
LIG_TRAF2_1	782	785	PF00917	0.457
LIG_TYR_ITIM	883	888	PF00017	0.425
LIG_WRC_WIRS_1	271	276	PF05994	0.369
MOD_CDK_SPxxK_3	478	485	PF00069	0.494
MOD_CDK_SPxxK_3	669	676	PF00069	0.304
MOD_CDK_SPxxK_3	956	963	PF00069	0.494
MOD_CK1_1	228	234	PF00069	0.463
MOD_CK1_1	349	355	PF00069	0.365
MOD_CK1_1	431	437	PF00069	0.461
MOD_CK1_1	504	510	PF00069	0.308
MOD_CK1_1	576	582	PF00069	0.401
MOD_CK1_1	68	74	PF00069	0.699
MOD_CK1_1	691	697	PF00069	0.293
MOD_CK1_1	736	742	PF00069	0.440
MOD_CK1_1	901	907	PF00069	0.401
MOD_CK2_1	114	120	PF00069	0.529
MOD_CK2_1	144	150	PF00069	0.522
MOD_CK2_1	172	178	PF00069	0.542
MOD_CK2_1	188	194	PF00069	0.624
MOD_CK2_1	33	39	PF00069	0.605
MOD_CK2_1	371	377	PF00069	0.412
MOD_CK2_1	393	399	PF00069	0.540
MOD_CK2_1	453	459	PF00069	0.509
MOD_CK2_1	575	581	PF00069	0.434
MOD_CK2_1	67	73	PF00069	0.752
MOD_CK2_1	779	785	PF00069	0.434
MOD_CK2_1	901	907	PF00069	0.329
MOD_CK2_1	951	957	PF00069	0.690
MOD_Cter_Amidation	649	652	PF01082	0.304
MOD_GlcNHglycan	105	108	PF01048	0.636
MOD_GlcNHglycan	13	16	PF01048	0.599
MOD_GlcNHglycan	159	162	PF01048	0.711
MOD_GlcNHglycan	172	177	PF01048	0.739
MOD_GlcNHglycan	221	224	PF01048	0.264
MOD_GlcNHglycan	227	230	PF01048	0.250
MOD_GlcNHglycan	349	352	PF01048	0.407
MOD_GlcNHglycan	354	357	PF01048	0.442
MOD_GlcNHglycan	39	43	PF01048	0.672
MOD_GlcNHglycan	394	398	PF01048	0.646
MOD_GlcNHglycan	611	614	PF01048	0.420
MOD_GlcNHglycan	679	682	PF01048	0.316
MOD_GlcNHglycan	741	744	PF01048	0.302
MOD_GlcNHglycan	767	770	PF01048	0.302
MOD_GSK3_1	151	158	PF00069	0.733
MOD_GSK3_1	168	175	PF00069	0.501
MOD_GSK3_1	252	259	PF00069	0.434
MOD_GSK3_1	306	313	PF00069	0.468
MOD_GSK3_1	33	40	PF00069	0.452
MOD_GSK3_1	367	374	PF00069	0.370
MOD_GSK3_1	424	431	PF00069	0.605
MOD_GSK3_1	449	456	PF00069	0.588
MOD_GSK3_1	65	72	PF00069	0.684
MOD_GSK3_1	665	672	PF00069	0.329
MOD_GSK3_1	679	686	PF00069	0.239
MOD_GSK3_1	715	722	PF00069	0.378
MOD_GSK3_1	761	768	PF00069	0.429
MOD_GSK3_1	775	782	PF00069	0.278
MOD_GSK3_1	883	890	PF00069	0.270
MOD_GSK3_1	910	917	PF00069	0.368
MOD_LATS_1	662	668	PF00433	0.304
MOD_LATS_1	912	918	PF00433	0.199
MOD_N-GLC_1	205	210	PF02516	0.531
MOD_N-GLC_1	646	651	PF02516	0.389
MOD_N-GLC_1	65	70	PF02516	0.775
MOD_N-GLC_1	715	720	PF02516	0.507
MOD_NEK2_1	219	224	PF00069	0.456
MOD_NEK2_1	256	261	PF00069	0.382
MOD_NEK2_1	401	406	PF00069	0.534
MOD_NEK2_1	573	578	PF00069	0.398
MOD_NEK2_1	709	714	PF00069	0.375
MOD_NEK2_1	761	766	PF00069	0.381
MOD_NEK2_1	820	825	PF00069	0.359
MOD_NEK2_1	878	883	PF00069	0.382
MOD_NEK2_1	887	892	PF00069	0.354
MOD_NEK2_1	910	915	PF00069	0.375
MOD_NEK2_1	924	929	PF00069	0.249
MOD_NEK2_2	276	281	PF00069	0.452
MOD_PIKK_1	217	223	PF00454	0.538
MOD_PIKK_1	453	459	PF00454	0.475
MOD_PIKK_1	715	721	PF00454	0.366
MOD_PIKK_1	914	920	PF00454	0.324
MOD_PIKK_1	951	957	PF00454	0.661
MOD_PK_1	639	645	PF00069	0.425
MOD_PKA_1	914	920	PF00069	0.425
MOD_PKA_2	19	25	PF00069	0.508
MOD_PKA_2	371	377	PF00069	0.474
MOD_PKA_2	565	571	PF00069	0.473
MOD_PKA_2	66	72	PF00069	0.644
MOD_PKA_2	704	710	PF00069	0.397
MOD_PKA_2	820	826	PF00069	0.383
MOD_PKA_2	924	930	PF00069	0.361
MOD_Plk_1	431	437	PF00069	0.470
MOD_Plk_1	453	459	PF00069	0.477
MOD_Plk_1	556	562	PF00069	0.392
MOD_Plk_1	639	645	PF00069	0.389
MOD_Plk_1	655	661	PF00069	0.192
MOD_Plk_1	703	709	PF00069	0.421
MOD_Plk_1	784	790	PF00069	0.338
MOD_Plk_2-3	168	174	PF00069	0.674
MOD_Plk_2-3	300	306	PF00069	0.281
MOD_Plk_2-3	33	39	PF00069	0.591
MOD_Plk_4	126	132	PF00069	0.441
MOD_Plk_4	252	258	PF00069	0.431
MOD_Plk_4	276	282	PF00069	0.404
MOD_Plk_4	432	438	PF00069	0.416
MOD_Plk_4	543	549	PF00069	0.515
MOD_Plk_4	567	573	PF00069	0.428
MOD_Plk_4	704	710	PF00069	0.391
MOD_Plk_4	736	742	PF00069	0.494
MOD_Plk_4	761	767	PF00069	0.441
MOD_Plk_4	878	884	PF00069	0.304
MOD_Plk_4	901	907	PF00069	0.396
MOD_ProDKin_1	151	157	PF00069	0.745
MOD_ProDKin_1	478	484	PF00069	0.501
MOD_ProDKin_1	669	675	PF00069	0.304
MOD_ProDKin_1	956	962	PF00069	0.493
MOD_SUMO_for_1	201	204	PF00179	0.298
MOD_SUMO_for_1	85	88	PF00179	0.617
MOD_SUMO_rev_2	329	339	PF00179	0.574
MOD_SUMO_rev_2	469	477	PF00179	0.371
TRG_DiLeu_BaEn_4	756	762	PF01217	0.321
TRG_DiLeu_BaLyEn_6	859	864	PF01217	0.304
TRG_DiLeu_BaLyEn_6	905	910	PF01217	0.425
TRG_ENDOCYTIC_2	130	133	PF00928	0.371
TRG_ENDOCYTIC_2	268	271	PF00928	0.401
TRG_ENDOCYTIC_2	458	461	PF00928	0.434
TRG_ENDOCYTIC_2	571	574	PF00928	0.368
TRG_ENDOCYTIC_2	885	888	PF00928	0.386
TRG_ER_diArg_1	318	320	PF00400	0.493
TRG_ER_diArg_1	382	384	PF00400	0.430
TRG_ER_diArg_1	601	604	PF00400	0.647
TRG_ER_diArg_1	924	926	PF00400	0.320
TRG_NES_CRM1_1	27	39	PF08389	0.460
TRG_NLS_MonoExtC_3	75	80	PF00514	0.681
TRG_NLS_MonoExtC_3	962	968	PF00514	0.689
TRG_NLS_MonoExtN_4	76	81	PF00514	0.685
TRG_NLS_MonoExtN_4	960	967	PF00514	0.685
TRG_Pf-PMV_PEXEL_1	595	599	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	826	830	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7W8	Leptomonas seymouri	70%	96%
A0A0S4IPM0	Bodo saltans	42%	100%
A0A1X0P4G2	Trypanosomatidae	52%	97%
A0A3Q8IN66	Leishmania donovani	84%	95%
A0A3S5IS62	Trypanosoma rangeli	50%	100%
A4I186	Leishmania infantum	84%	95%
D0A5H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AXC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	95%
Q05946	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q12788	Homo sapiens	26%	100%
Q2KJJ5	Bos taurus	26%	100%
Q4QA52	Leishmania major	84%	100%
Q5U2W5	Rattus norvegicus	25%	100%
Q8C4J7	Mus musculus	26%	100%
Q9LFE2	Arabidopsis thaliana	27%	100%
Q9USN3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
V5BSU7	Trypanosoma cruzi	49%	97%