SUI1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor SUI1, putative

Species:

Leishmania braziliensis

UniProt:

A4HDY3_LEIBR

TriTrypDb:

LbrM.25.0360 , LBRM2903_250009400

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDY3

Function

Biological processes
Term	Name	Level	Count
GO:0001731	formation of translation preinitiation complex	7	1
GO:0002183	cytoplasmic translational initiation	4	1
GO:0002188	translation reinitiation	5	1
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.500
CLV_C14_Caspase3-7	71	75	PF00656	0.609
CLV_NRD_NRD_1	179	181	PF00675	0.479
CLV_NRD_NRD_1	215	217	PF00675	0.269
CLV_NRD_NRD_1	238	240	PF00675	0.336
CLV_PCSK_FUR_1	175	179	PF00082	0.467
CLV_PCSK_KEX2_1	177	179	PF00082	0.480
CLV_PCSK_KEX2_1	211	213	PF00082	0.346
CLV_PCSK_KEX2_1	215	217	PF00082	0.325
CLV_PCSK_KEX2_1	240	242	PF00082	0.336
CLV_PCSK_KEX2_1	292	294	PF00082	0.459
CLV_PCSK_KEX2_1	6	8	PF00082	0.694
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.346
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.336
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.459
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.694
CLV_PCSK_PC7_1	175	181	PF00082	0.466
CLV_PCSK_SKI1_1	179	183	PF00082	0.475
CLV_PCSK_SKI1_1	195	199	PF00082	0.473
CLV_PCSK_SKI1_1	215	219	PF00082	0.279
DEG_SPOP_SBC_1	28	32	PF00917	0.600
DOC_CKS1_1	53	58	PF01111	0.721
DOC_MAPK_gen_1	198	206	PF00069	0.456
DOC_USP7_MATH_1	281	285	PF00917	0.489
DOC_USP7_MATH_1	38	42	PF00917	0.650
DOC_USP7_UBL2_3	232	236	PF12436	0.384
DOC_USP7_UBL2_3	5	9	PF12436	0.542
DOC_USP7_UBL2_3	78	82	PF12436	0.643
DOC_USP7_UBL2_3	98	102	PF12436	0.598
DOC_WW_Pin1_4	52	57	PF00397	0.718
LIG_14-3-3_CanoR_1	179	188	PF00244	0.465
LIG_14-3-3_CanoR_1	215	224	PF00244	0.456
LIG_14-3-3_CanoR_1	239	248	PF00244	0.555
LIG_Actin_RPEL_3	188	207	PF02755	0.488
LIG_Actin_WH2_2	217	234	PF00022	0.496
LIG_deltaCOP1_diTrp_1	237	242	PF00928	0.442
LIG_FHA_1	216	222	PF00498	0.386
LIG_FHA_2	181	187	PF00498	0.461
LIG_GBD_Chelix_1	266	274	PF00786	0.242
LIG_LIR_Apic_2	276	281	PF02991	0.455
LIG_LIR_Nem_3	135	141	PF02991	0.404
LIG_NRBOX	187	193	PF00104	0.472
LIG_Pex14_1	238	242	PF04695	0.442
LIG_SH2_CRK	138	142	PF00017	0.385
LIG_SH2_CRK	278	282	PF00017	0.442
LIG_SH2_SRC	37	40	PF00017	0.517
LIG_SH2_STAT5	138	141	PF00017	0.375
LIG_SH3_3	291	297	PF00018	0.579
LIG_SH3_3	50	56	PF00018	0.625
LIG_SUMO_SIM_anti_2	202	208	PF11976	0.279
LIG_SUMO_SIM_par_1	122	129	PF11976	0.585
LIG_SUMO_SIM_par_1	202	208	PF11976	0.297
LIG_TRAF2_1	18	21	PF00917	0.599
LIG_TRAF2_1	250	253	PF00917	0.442
LIG_TYR_ITIM	136	141	PF00017	0.399
MOD_CK2_1	15	21	PF00069	0.662
MOD_Cter_Amidation	175	178	PF01082	0.459
MOD_Cter_Amidation	213	216	PF01082	0.255
MOD_Cter_Amidation	289	292	PF01082	0.556
MOD_GlcNHglycan	150	154	PF01048	0.427
MOD_GlcNHglycan	61	64	PF01048	0.687
MOD_GlcNHglycan	74	77	PF01048	0.765
MOD_GSK3_1	28	35	PF00069	0.676
MOD_GSK3_1	55	62	PF00069	0.694
MOD_GSK3_1	63	70	PF00069	0.725
MOD_N-GLC_1	102	107	PF02516	0.699
MOD_NEK2_1	126	131	PF00069	0.559
MOD_NEK2_1	217	222	PF00069	0.463
MOD_NEK2_1	273	278	PF00069	0.531
MOD_NEK2_2	281	286	PF00069	0.486
MOD_PK_1	102	108	PF00069	0.516
MOD_PKA_1	215	221	PF00069	0.386
MOD_PKA_1	240	246	PF00069	0.536
MOD_PKA_1	5	11	PF00069	0.542
MOD_PKA_2	215	221	PF00069	0.384
MOD_PKA_2	240	246	PF00069	0.554
MOD_PKA_2	67	73	PF00069	0.645
MOD_PKB_1	178	186	PF00069	0.388
MOD_Plk_1	102	108	PF00069	0.516
MOD_Plk_4	217	223	PF00069	0.536
MOD_Plk_4	281	287	PF00069	0.481
MOD_ProDKin_1	52	58	PF00069	0.718
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.516
TRG_ENDOCYTIC_2	138	141	PF00928	0.402
TRG_ER_diArg_1	175	178	PF00400	0.461
TRG_ER_diArg_1	179	181	PF00400	0.473
TRG_ER_diArg_1	215	217	PF00400	0.496
TRG_ER_diArg_1	238	241	PF00400	0.536
TRG_NLS_MonoExtC_3	290	295	PF00514	0.544
TRG_NLS_MonoExtC_3	4	9	PF00514	0.543
TRG_NLS_MonoExtN_4	236	243	PF00514	0.536
TRG_NLS_MonoExtN_4	3	10	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAD2	Leptomonas seymouri	58%	100%
A0A1X0P4H3	Trypanosomatidae	54%	100%
A0A3Q8ICD2	Leishmania donovani	80%	100%
A0A3R7KWX6	Trypanosoma rangeli	56%	100%
A4I184	Leishmania infantum	79%	100%
D0A5G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AXB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QA54	Leishmania major	79%	98%
V5BN78	Trypanosoma cruzi	47%	100%