B30.2/SPRY domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDY0_LEIBR

TriTrypDb:

LbrM.25.0330 , LBRM2903_250008600

Length:

702

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HDY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDY0

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	2
GO:0006518	peptide metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043043	peptide biosynthetic process	5	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043603	amide metabolic process	3	2
GO:0043604	amide biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	2
GO:0005198	structural molecule activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.629
CLV_C14_Caspase3-7	481	485	PF00656	0.576
CLV_C14_Caspase3-7	519	523	PF00656	0.626
CLV_NRD_NRD_1	228	230	PF00675	0.619
CLV_NRD_NRD_1	295	297	PF00675	0.616
CLV_NRD_NRD_1	423	425	PF00675	0.795
CLV_NRD_NRD_1	474	476	PF00675	0.813
CLV_NRD_NRD_1	579	581	PF00675	0.707
CLV_PCSK_FUR_1	577	581	PF00082	0.812
CLV_PCSK_KEX2_1	228	230	PF00082	0.619
CLV_PCSK_KEX2_1	249	251	PF00082	0.862
CLV_PCSK_KEX2_1	295	297	PF00082	0.616
CLV_PCSK_KEX2_1	334	336	PF00082	0.813
CLV_PCSK_KEX2_1	342	344	PF00082	0.779
CLV_PCSK_KEX2_1	423	425	PF00082	0.795
CLV_PCSK_KEX2_1	474	476	PF00082	0.813
CLV_PCSK_KEX2_1	579	581	PF00082	0.716
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.862
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.749
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.668
CLV_PCSK_PC7_1	419	425	PF00082	0.786
CLV_PCSK_SKI1_1	129	133	PF00082	0.548
CLV_PCSK_SKI1_1	307	311	PF00082	0.578
CLV_PCSK_SKI1_1	556	560	PF00082	0.357
CLV_PCSK_SKI1_1	602	606	PF00082	0.611
DEG_APCC_DBOX_1	389	397	PF00400	0.494
DEG_Nend_Nbox_1	1	3	PF02207	0.732
DEG_SCF_FBW7_1	453	460	PF00400	0.545
DEG_SPOP_SBC_1	402	406	PF00917	0.551
DEG_SPOP_SBC_1	626	630	PF00917	0.491
DOC_CKS1_1	209	214	PF01111	0.604
DOC_CKS1_1	427	432	PF01111	0.833
DOC_CYCLIN_yCln2_LP_2	459	465	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	542	548	PF00134	0.602
DOC_MAPK_DCC_7	678	688	PF00069	0.530
DOC_MAPK_gen_1	127	134	PF00069	0.699
DOC_MAPK_gen_1	143	152	PF00069	0.474
DOC_MAPK_RevD_3	282	296	PF00069	0.602
DOC_PP1_RVXF_1	493	500	PF00149	0.664
DOC_PP2B_LxvP_1	542	545	PF13499	0.628
DOC_USP7_MATH_1	103	107	PF00917	0.756
DOC_USP7_MATH_1	110	114	PF00917	0.652
DOC_USP7_MATH_1	262	266	PF00917	0.696
DOC_USP7_MATH_1	280	284	PF00917	0.713
DOC_USP7_MATH_1	286	290	PF00917	0.803
DOC_USP7_MATH_1	326	330	PF00917	0.671
DOC_USP7_MATH_1	35	39	PF00917	0.636
DOC_USP7_MATH_1	77	81	PF00917	0.789
DOC_WW_Pin1_4	187	192	PF00397	0.667
DOC_WW_Pin1_4	208	213	PF00397	0.780
DOC_WW_Pin1_4	214	219	PF00397	0.840
DOC_WW_Pin1_4	258	263	PF00397	0.678
DOC_WW_Pin1_4	29	34	PF00397	0.783
DOC_WW_Pin1_4	290	295	PF00397	0.758
DOC_WW_Pin1_4	300	305	PF00397	0.627
DOC_WW_Pin1_4	327	332	PF00397	0.771
DOC_WW_Pin1_4	342	347	PF00397	0.617
DOC_WW_Pin1_4	349	354	PF00397	0.776
DOC_WW_Pin1_4	426	431	PF00397	0.827
DOC_WW_Pin1_4	453	458	PF00397	0.539
DOC_WW_Pin1_4	47	52	PF00397	0.481
DOC_WW_Pin1_4	564	569	PF00397	0.629
DOC_WW_Pin1_4	589	594	PF00397	0.465
LIG_14-3-3_CanoR_1	149	153	PF00244	0.496
LIG_14-3-3_CanoR_1	160	166	PF00244	0.815
LIG_14-3-3_CanoR_1	182	191	PF00244	0.580
LIG_14-3-3_CanoR_1	19	27	PF00244	0.575
LIG_14-3-3_CanoR_1	205	210	PF00244	0.854
LIG_14-3-3_CanoR_1	325	331	PF00244	0.825
LIG_14-3-3_CanoR_1	360	366	PF00244	0.711
LIG_14-3-3_CanoR_1	37	45	PF00244	0.483
LIG_14-3-3_CanoR_1	401	409	PF00244	0.549
LIG_14-3-3_CanoR_1	411	416	PF00244	0.588
LIG_14-3-3_CanoR_1	424	430	PF00244	0.764
LIG_14-3-3_CanoR_1	556	562	PF00244	0.562
LIG_BRCT_BRCA1_1	39	43	PF00533	0.595
LIG_BRCT_BRCA1_1	445	449	PF00533	0.582
LIG_CtBP_PxDLS_1	645	651	PF00389	0.277
LIG_CtBP_PxDLS_1	84	88	PF00389	0.545
LIG_EVH1_2	457	461	PF00568	0.545
LIG_FHA_1	403	409	PF00498	0.732
LIG_FHA_1	410	416	PF00498	0.755
LIG_FHA_1	427	433	PF00498	0.625
LIG_FHA_1	454	460	PF00498	0.658
LIG_FHA_1	465	471	PF00498	0.760
LIG_FHA_1	519	525	PF00498	0.578
LIG_FHA_1	590	596	PF00498	0.414
LIG_FHA_1	617	623	PF00498	0.544
LIG_FHA_1	64	70	PF00498	0.552
LIG_FHA_2	181	187	PF00498	0.584
LIG_FHA_2	194	200	PF00498	0.525
LIG_FHA_2	234	240	PF00498	0.600
LIG_FHA_2	303	309	PF00498	0.576
LIG_FHA_2	523	529	PF00498	0.436
LIG_HCF-1_HBM_1	383	386	PF13415	0.479
LIG_IBAR_NPY_1	90	92	PF08397	0.806
LIG_KLC1_Yacidic_2	660	664	PF13176	0.530
LIG_LIR_Apic_2	635	641	PF02991	0.530
LIG_LIR_Apic_2	96	100	PF02991	0.812
LIG_LIR_Gen_1	194	204	PF02991	0.615
LIG_LIR_Gen_1	52	62	PF02991	0.623
LIG_LIR_Nem_3	194	200	PF02991	0.614
LIG_LIR_Nem_3	273	279	PF02991	0.586
LIG_LIR_Nem_3	383	389	PF02991	0.470
LIG_LIR_Nem_3	460	464	PF02991	0.559
LIG_LIR_Nem_3	52	57	PF02991	0.674
LIG_LIR_Nem_3	601	607	PF02991	0.606
LIG_LIR_Nem_3	86	92	PF02991	0.657
LIG_MYND_1	430	434	PF01753	0.628
LIG_PDZ_Class_2	697	702	PF00595	0.576
LIG_Pex14_2	561	565	PF04695	0.571
LIG_PTAP_UEV_1	433	438	PF05743	0.586
LIG_SH2_CRK	54	58	PF00017	0.797
LIG_SH2_CRK	638	642	PF00017	0.530
LIG_SH2_NCK_1	197	201	PF00017	0.614
LIG_SH2_NCK_1	45	49	PF00017	0.534
LIG_SH2_SRC	197	200	PF00017	0.614
LIG_SH2_SRC	482	485	PF00017	0.735
LIG_SH2_SRC	642	645	PF00017	0.530
LIG_SH2_SRC	662	665	PF00017	0.199
LIG_SH2_STAP1	45	49	PF00017	0.748
LIG_SH2_STAP1	482	486	PF00017	0.579
LIG_SH2_STAP1	514	518	PF00017	0.353
LIG_SH2_STAP1	72	76	PF00017	0.548
LIG_SH2_STAT5	447	450	PF00017	0.571
LIG_SH2_STAT5	45	48	PF00017	0.751
LIG_SH2_STAT5	616	619	PF00017	0.586
LIG_SH2_STAT5	662	665	PF00017	0.530
LIG_SH2_STAT5	72	75	PF00017	0.748
LIG_SH3_1	343	349	PF00018	0.833
LIG_SH3_1	638	644	PF00018	0.530
LIG_SH3_3	174	180	PF00018	0.656
LIG_SH3_3	186	192	PF00018	0.721
LIG_SH3_3	209	215	PF00018	0.710
LIG_SH3_3	343	349	PF00018	0.833
LIG_SH3_3	431	437	PF00018	0.748
LIG_SH3_3	638	644	PF00018	0.389
LIG_SH3_3	679	685	PF00018	0.530
LIG_SH3_3	97	103	PF00018	0.814
LIG_SUMO_SIM_anti_2	521	528	PF11976	0.647
LIG_SUMO_SIM_par_1	190	196	PF11976	0.569
LIG_SUMO_SIM_par_1	65	75	PF11976	0.540
LIG_SUMO_SIM_par_1	684	690	PF11976	0.530
LIG_SxIP_EBH_1	19	33	PF03271	0.823
LIG_TYR_ITIM	195	200	PF00017	0.573
LIG_WW_3	438	442	PF00397	0.564
MOD_CDC14_SPxK_1	293	296	PF00782	0.860
MOD_CDC14_SPxK_1	298	301	PF00782	0.765
MOD_CDC14_SPxK_1	332	335	PF00782	0.858
MOD_CDC14_SPxK_1	34	37	PF00782	0.794
MOD_CDK_SPK_2	290	295	PF00069	0.676
MOD_CDK_SPK_2	329	334	PF00069	0.739
MOD_CDK_SPxK_1	290	296	PF00069	0.859
MOD_CDK_SPxK_1	31	37	PF00069	0.799
MOD_CDK_SPxK_1	329	335	PF00069	0.859
MOD_CDK_SPxK_1	342	348	PF00069	0.650
MOD_CDK_SPxxK_3	300	307	PF00069	0.652
MOD_CDK_SPxxK_3	327	334	PF00069	0.743
MOD_CK1_1	113	119	PF00069	0.491
MOD_CK1_1	151	157	PF00069	0.629
MOD_CK1_1	168	174	PF00069	0.616
MOD_CK1_1	185	191	PF00069	0.763
MOD_CK1_1	208	214	PF00069	0.716
MOD_CK1_1	21	27	PF00069	0.661
MOD_CK1_1	216	222	PF00069	0.705
MOD_CK1_1	329	335	PF00069	0.666
MOD_CK1_1	361	367	PF00069	0.737
MOD_CK1_1	403	409	PF00069	0.689
MOD_CK1_1	452	458	PF00069	0.628
MOD_CK1_1	478	484	PF00069	0.823
MOD_CK1_1	55	61	PF00069	0.791
MOD_CK1_1	627	633	PF00069	0.433
MOD_CK1_1	75	81	PF00069	0.477
MOD_CK2_1	11	17	PF00069	0.553
MOD_CK2_1	168	174	PF00069	0.570
MOD_CK2_1	180	186	PF00069	0.555
MOD_CK2_1	193	199	PF00069	0.528
MOD_CK2_1	302	308	PF00069	0.696
MOD_CK2_1	41	47	PF00069	0.797
MOD_CK2_1	522	528	PF00069	0.433
MOD_GlcNHglycan	105	108	PF01048	0.834
MOD_GlcNHglycan	13	16	PF01048	0.698
MOD_GlcNHglycan	156	159	PF01048	0.777
MOD_GlcNHglycan	161	164	PF01048	0.489
MOD_GlcNHglycan	221	224	PF01048	0.737
MOD_GlcNHglycan	239	243	PF01048	0.550
MOD_GlcNHglycan	24	27	PF01048	0.596
MOD_GlcNHglycan	319	322	PF01048	0.786
MOD_GlcNHglycan	369	372	PF01048	0.656
MOD_GlcNHglycan	37	40	PF01048	0.641
MOD_GlcNHglycan	405	408	PF01048	0.751
MOD_GlcNHglycan	434	437	PF01048	0.584
MOD_GlcNHglycan	503	506	PF01048	0.540
MOD_GlcNHglycan	54	57	PF01048	0.573
MOD_GlcNHglycan	584	587	PF01048	0.614
MOD_GlcNHglycan	59	62	PF01048	0.741
MOD_GlcNHglycan	630	633	PF01048	0.379
MOD_GlcNHglycan	689	692	PF01048	0.530
MOD_GlcNHglycan	74	77	PF01048	0.472
MOD_GSK3_1	148	155	PF00069	0.625
MOD_GSK3_1	161	168	PF00069	0.597
MOD_GSK3_1	18	25	PF00069	0.705
MOD_GSK3_1	258	265	PF00069	0.674
MOD_GSK3_1	286	293	PF00069	0.746
MOD_GSK3_1	31	38	PF00069	0.599
MOD_GSK3_1	311	318	PF00069	0.744
MOD_GSK3_1	349	356	PF00069	0.810
MOD_GSK3_1	43	50	PF00069	0.559
MOD_GSK3_1	449	456	PF00069	0.666
MOD_GSK3_1	478	485	PF00069	0.588
MOD_GSK3_1	518	525	PF00069	0.495
MOD_GSK3_1	564	571	PF00069	0.424
MOD_GSK3_1	598	605	PF00069	0.591
MOD_GSK3_1	624	631	PF00069	0.623
MOD_GSK3_1	71	78	PF00069	0.657
MOD_NEK2_1	150	155	PF00069	0.549
MOD_NEK2_1	161	166	PF00069	0.645
MOD_NEK2_1	409	414	PF00069	0.649
MOD_NEK2_1	501	506	PF00069	0.380
MOD_NEK2_1	552	557	PF00069	0.456
MOD_NEK2_1	57	62	PF00069	0.747
MOD_NEK2_1	615	620	PF00069	0.578
MOD_NEK2_1	71	76	PF00069	0.551
MOD_PIKK_1	18	24	PF00454	0.569
MOD_PIKK_1	286	292	PF00454	0.731
MOD_PK_1	169	175	PF00069	0.580
MOD_PKA_2	148	154	PF00069	0.493
MOD_PKA_2	159	165	PF00069	0.813
MOD_PKA_2	18	24	PF00069	0.569
MOD_PKA_2	400	406	PF00069	0.643
MOD_PKA_2	425	431	PF00069	0.823
MOD_PKB_1	580	588	PF00069	0.554
MOD_Plk_1	185	191	PF00069	0.688
MOD_Plk_1	193	199	PF00069	0.752
MOD_Plk_2-3	522	528	PF00069	0.433
MOD_Plk_4	443	449	PF00069	0.588
MOD_Plk_4	49	55	PF00069	0.649
MOD_Plk_4	522	528	PF00069	0.433
MOD_ProDKin_1	187	193	PF00069	0.671
MOD_ProDKin_1	208	214	PF00069	0.780
MOD_ProDKin_1	216	222	PF00069	0.813
MOD_ProDKin_1	258	264	PF00069	0.673
MOD_ProDKin_1	29	35	PF00069	0.777
MOD_ProDKin_1	290	296	PF00069	0.759
MOD_ProDKin_1	300	306	PF00069	0.625
MOD_ProDKin_1	327	333	PF00069	0.764
MOD_ProDKin_1	342	348	PF00069	0.617
MOD_ProDKin_1	349	355	PF00069	0.772
MOD_ProDKin_1	426	432	PF00069	0.831
MOD_ProDKin_1	453	459	PF00069	0.542
MOD_ProDKin_1	47	53	PF00069	0.483
MOD_ProDKin_1	564	570	PF00069	0.643
MOD_ProDKin_1	589	595	PF00069	0.443
TRG_DiLeu_BaEn_2	609	615	PF01217	0.607
TRG_DiLeu_BaLyEn_6	459	464	PF01217	0.539
TRG_ENDOCYTIC_2	197	200	PF00928	0.614
TRG_ENDOCYTIC_2	54	57	PF00928	0.796
TRG_ER_diArg_1	143	146	PF00400	0.713
TRG_ER_diArg_1	294	296	PF00400	0.611
TRG_ER_diArg_1	423	426	PF00400	0.801
TRG_ER_diArg_1	473	475	PF00400	0.807
TRG_ER_diArg_1	490	493	PF00400	0.496
TRG_ER_diArg_1	576	579	PF00400	0.691
TRG_NES_CRM1_1	198	210	PF08389	0.685
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	495	500	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYR3	Leishmania donovani	71%	100%
A4I176	Leishmania infantum	71%	100%
E9AXB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QA62	Leishmania major	69%	97%