Neprosin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania braziliensis

UniProt:

A4HDX9_LEIBR

TriTrypDb:

Length:

123

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4HDX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDX9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0030030	cell projection organization	4	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.402
CLV_PCSK_KEX2_1	108	110	PF00082	0.410
CLV_PCSK_SKI1_1	110	114	PF00082	0.401
CLV_PCSK_SKI1_1	83	87	PF00082	0.419
DEG_APCC_DBOX_1	82	90	PF00400	0.424
DEG_Nend_UBRbox_1	1	4	PF02207	0.436
DOC_CYCLIN_RxL_1	80	90	PF00134	0.422
DOC_PP2B_LxvP_1	52	55	PF13499	0.400
DOC_PP2B_PxIxI_1	26	32	PF00149	0.400
DOC_USP7_MATH_1	115	119	PF00917	0.408
DOC_WW_Pin1_4	87	92	PF00397	0.441
LIG_FHA_1	47	53	PF00498	0.400
LIG_FHA_1	62	68	PF00498	0.387
LIG_FHA_1	80	86	PF00498	0.411
LIG_LIR_Gen_1	73	84	PF02991	0.409
LIG_LIR_Nem_3	73	79	PF02991	0.410
LIG_PDZ_Class_2	118	123	PF00595	0.433
LIG_RPA_C_Fungi	104	116	PF08784	0.411
LIG_SH2_STAP1	12	16	PF00017	0.199
LIG_SH2_STAT3	39	42	PF00017	0.199
LIG_SH2_STAT5	18	21	PF00017	0.199
LIG_SH2_STAT5	51	54	PF00017	0.199
LIG_SH3_3	95	101	PF00018	0.437
MOD_GlcNHglycan	2	5	PF01048	0.414
MOD_GSK3_1	62	69	PF00069	0.390
MOD_N-GLC_1	10	15	PF02516	0.199
MOD_NEK2_1	79	84	PF00069	0.406
MOD_NEK2_2	10	15	PF00069	0.199
MOD_Plk_1	10	16	PF00069	0.199
MOD_ProDKin_1	87	93	PF00069	0.441
TRG_AP2beta_CARGO_1	73	83	PF09066	0.408
TRG_ENDOCYTIC_2	51	54	PF00928	0.199
TRG_ER_diArg_1	108	110	PF00400	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q6DGZ1	DANRE	41%	70%