RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDX6_LEIBR

TriTrypDb:

LbrM.25.0290 , LBRM2903_250008200

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDX6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	316	320	PF00656	0.500
CLV_NRD_NRD_1	234	236	PF00675	0.622
CLV_NRD_NRD_1	375	377	PF00675	0.555
CLV_NRD_NRD_1	500	502	PF00675	0.662
CLV_NRD_NRD_1	588	590	PF00675	0.521
CLV_PCSK_KEX2_1	234	236	PF00082	0.622
CLV_PCSK_KEX2_1	375	377	PF00082	0.555
CLV_PCSK_KEX2_1	500	502	PF00082	0.662
CLV_PCSK_SKI1_1	370	374	PF00082	0.528
CLV_PCSK_SKI1_1	376	380	PF00082	0.551
DEG_APCC_DBOX_1	175	183	PF00400	0.453
DEG_SPOP_SBC_1	56	60	PF00917	0.448
DOC_CYCLIN_yCln2_LP_2	492	498	PF00134	0.616
DOC_MAPK_MEF2A_6	346	354	PF00069	0.273
DOC_PP1_RVXF_1	153	160	PF00149	0.394
DOC_PP2B_LxvP_1	151	154	PF13499	0.398
DOC_PP2B_LxvP_1	188	191	PF13499	0.643
DOC_PP2B_LxvP_1	255	258	PF13499	0.607
DOC_PP2B_LxvP_1	466	469	PF13499	0.558
DOC_PP2B_LxvP_1	492	495	PF13499	0.610
DOC_PP2B_LxvP_1	538	541	PF13499	0.683
DOC_PP4_FxxP_1	183	186	PF00568	0.500
DOC_PP4_FxxP_1	355	358	PF00568	0.324
DOC_PP4_FxxP_1	81	84	PF00568	0.429
DOC_USP7_MATH_1	226	230	PF00917	0.649
DOC_USP7_MATH_1	278	282	PF00917	0.671
DOC_USP7_MATH_1	393	397	PF00917	0.423
DOC_USP7_MATH_1	504	508	PF00917	0.839
DOC_USP7_MATH_1	555	559	PF00917	0.689
DOC_WW_Pin1_4	106	111	PF00397	0.478
DOC_WW_Pin1_4	239	244	PF00397	0.637
DOC_WW_Pin1_4	249	254	PF00397	0.643
DOC_WW_Pin1_4	354	359	PF00397	0.400
DOC_WW_Pin1_4	435	440	PF00397	0.681
DOC_WW_Pin1_4	527	532	PF00397	0.653
DOC_WW_Pin1_4	576	581	PF00397	0.803
LIG_14-3-3_CanoR_1	227	231	PF00244	0.570
LIG_14-3-3_CanoR_1	23	27	PF00244	0.436
LIG_14-3-3_CanoR_1	457	463	PF00244	0.708
LIG_APCC_ABBAyCdc20_2	162	168	PF00400	0.420
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_BIR_III_2	206	210	PF00653	0.528
LIG_BIR_III_4	344	348	PF00653	0.339
LIG_deltaCOP1_diTrp_1	326	335	PF00928	0.494
LIG_EVH1_1	188	192	PF00568	0.646
LIG_EVH1_1	466	470	PF00568	0.504
LIG_EVH1_2	358	362	PF00568	0.449
LIG_FHA_1	12	18	PF00498	0.405
LIG_FHA_1	84	90	PF00498	0.476
LIG_FHA_1	92	98	PF00498	0.421
LIG_FHA_2	106	112	PF00498	0.399
LIG_FHA_2	314	320	PF00498	0.525
LIG_FHA_2	57	63	PF00498	0.466
LIG_Integrin_isoDGR_2	137	139	PF01839	0.409
LIG_LIR_Apic_2	249	253	PF02991	0.612
LIG_LIR_Apic_2	28	33	PF02991	0.403
LIG_LIR_Apic_2	326	331	PF02991	0.413
LIG_LIR_Gen_1	118	128	PF02991	0.401
LIG_LIR_Gen_1	14	24	PF02991	0.373
LIG_LIR_Gen_1	177	188	PF02991	0.637
LIG_LIR_Gen_1	94	104	PF02991	0.375
LIG_LIR_Nem_3	118	123	PF02991	0.410
LIG_LIR_Nem_3	14	19	PF02991	0.368
LIG_LIR_Nem_3	177	183	PF02991	0.621
LIG_LIR_Nem_3	310	314	PF02991	0.376
LIG_LIR_Nem_3	434	440	PF02991	0.531
LIG_LIR_Nem_3	94	99	PF02991	0.376
LIG_MYND_1	186	190	PF01753	0.656
LIG_MYND_1	69	73	PF01753	0.395
LIG_PROFILIN_1	189	195	PF00235	0.503
LIG_PROFILIN_1	208	214	PF00235	0.596
LIG_PTB_Apo_2	71	78	PF02174	0.476
LIG_PTB_Phospho_1	71	77	PF10480	0.475
LIG_REV1ctd_RIR_1	78	83	PF16727	0.395
LIG_SH2_CRK	250	254	PF00017	0.684
LIG_SH2_CRK	30	34	PF00017	0.363
LIG_SH2_GRB2like	18	21	PF00017	0.399
LIG_SH2_NCK_1	90	94	PF00017	0.404
LIG_SH2_PTP2	96	99	PF00017	0.357
LIG_SH2_SRC	18	21	PF00017	0.399
LIG_SH2_STAT3	160	163	PF00017	0.526
LIG_SH2_STAT5	100	103	PF00017	0.418
LIG_SH2_STAT5	116	119	PF00017	0.402
LIG_SH2_STAT5	166	169	PF00017	0.388
LIG_SH2_STAT5	18	21	PF00017	0.399
LIG_SH2_STAT5	314	317	PF00017	0.415
LIG_SH2_STAT5	328	331	PF00017	0.401
LIG_SH2_STAT5	37	40	PF00017	0.522
LIG_SH2_STAT5	429	432	PF00017	0.452
LIG_SH2_STAT5	96	99	PF00017	0.394
LIG_SH3_1	250	256	PF00018	0.606
LIG_SH3_1	464	470	PF00018	0.673
LIG_SH3_2	192	197	PF14604	0.653
LIG_SH3_3	183	189	PF00018	0.579
LIG_SH3_3	190	196	PF00018	0.581
LIG_SH3_3	205	211	PF00018	0.701
LIG_SH3_3	218	224	PF00018	0.588
LIG_SH3_3	250	256	PF00018	0.606
LIG_SH3_3	438	444	PF00018	0.676
LIG_SH3_3	459	465	PF00018	0.664
LIG_SH3_3	533	539	PF00018	0.558
LIG_SH3_3	577	583	PF00018	0.713
LIG_SH3_3	63	69	PF00018	0.397
LIG_SH3_CIN85_PxpxPR_1	192	197	PF14604	0.561
LIG_SUMO_SIM_anti_2	148	154	PF11976	0.395
LIG_SUMO_SIM_anti_2	22	29	PF11976	0.447
LIG_TYR_ITIM	164	169	PF00017	0.329
LIG_WW_3	194	198	PF00397	0.631
LIG_WW_3	50	54	PF00397	0.458
MOD_CK1_1	11	17	PF00069	0.525
MOD_CK1_1	271	277	PF00069	0.674
MOD_CK1_1	281	287	PF00069	0.550
MOD_CK1_1	357	363	PF00069	0.488
MOD_CK1_1	507	513	PF00069	0.803
MOD_CK1_1	523	529	PF00069	0.610
MOD_CK1_1	576	582	PF00069	0.634
MOD_CK1_1	588	594	PF00069	0.635
MOD_CK2_1	105	111	PF00069	0.394
MOD_CK2_1	167	173	PF00069	0.437
MOD_CK2_1	22	28	PF00069	0.448
MOD_CK2_1	57	63	PF00069	0.461
MOD_Cter_Amidation	373	376	PF01082	0.449
MOD_GlcNHglycan	270	273	PF01048	0.616
MOD_GlcNHglycan	483	486	PF01048	0.607
MOD_GlcNHglycan	489	492	PF01048	0.593
MOD_GlcNHglycan	8	11	PF01048	0.686
MOD_GSK3_1	264	271	PF00069	0.701
MOD_GSK3_1	272	279	PF00069	0.719
MOD_GSK3_1	282	289	PF00069	0.598
MOD_GSK3_1	353	360	PF00069	0.527
MOD_GSK3_1	435	442	PF00069	0.533
MOD_GSK3_1	481	488	PF00069	0.518
MOD_GSK3_1	523	530	PF00069	0.679
MOD_GSK3_1	564	571	PF00069	0.656
MOD_GSK3_1	57	64	PF00069	0.551
MOD_GSK3_1	574	581	PF00069	0.601
MOD_GSK3_1	8	15	PF00069	0.541
MOD_GSK3_1	85	92	PF00069	0.452
MOD_N-GLC_1	106	111	PF02516	0.397
MOD_N-GLC_1	504	509	PF02516	0.837
MOD_N-GLC_1	520	525	PF02516	0.554
MOD_N-GLC_1	569	574	PF02516	0.707
MOD_NEK2_1	264	269	PF00069	0.716
MOD_NEK2_1	286	291	PF00069	0.664
MOD_NEK2_1	353	358	PF00069	0.462
MOD_NEK2_1	425	430	PF00069	0.513
MOD_NEK2_1	573	578	PF00069	0.573
MOD_NEK2_1	89	94	PF00069	0.437
MOD_NEK2_1	99	104	PF00069	0.392
MOD_NEK2_2	393	398	PF00069	0.348
MOD_NEK2_2	569	574	PF00069	0.544
MOD_PIKK_1	257	263	PF00454	0.641
MOD_PIKK_1	409	415	PF00454	0.335
MOD_PIKK_1	513	519	PF00454	0.560
MOD_PKA_2	22	28	PF00069	0.448
MOD_PKA_2	226	232	PF00069	0.644
MOD_PKA_2	588	594	PF00069	0.517
MOD_Plk_1	393	399	PF00069	0.356
MOD_Plk_1	569	575	PF00069	0.544
MOD_Plk_2-3	22	28	PF00069	0.448
MOD_Plk_4	12	18	PF00069	0.445
MOD_Plk_4	22	28	PF00069	0.476
MOD_Plk_4	226	232	PF00069	0.632
MOD_Plk_4	307	313	PF00069	0.392
MOD_Plk_4	330	336	PF00069	0.319
MOD_Plk_4	357	363	PF00069	0.453
MOD_Plk_4	529	535	PF00069	0.543
MOD_Plk_4	85	91	PF00069	0.433
MOD_ProDKin_1	106	112	PF00069	0.478
MOD_ProDKin_1	239	245	PF00069	0.637
MOD_ProDKin_1	249	255	PF00069	0.644
MOD_ProDKin_1	354	360	PF00069	0.395
MOD_ProDKin_1	435	441	PF00069	0.678
MOD_ProDKin_1	527	533	PF00069	0.654
MOD_ProDKin_1	576	582	PF00069	0.801
MOD_SUMO_for_1	414	417	PF00179	0.339
TRG_ENDOCYTIC_2	166	169	PF00928	0.388
TRG_ENDOCYTIC_2	180	183	PF00928	0.646
TRG_ENDOCYTIC_2	35	38	PF00928	0.466
TRG_ENDOCYTIC_2	77	80	PF00928	0.373
TRG_ENDOCYTIC_2	96	99	PF00928	0.357
TRG_ER_diArg_1	234	236	PF00400	0.622
TRG_ER_diArg_1	449	452	PF00400	0.618
TRG_ER_diArg_1	586	589	PF00400	0.524
TRG_NES_CRM1_1	111	125	PF08389	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM94	Leptomonas seymouri	61%	94%
A0A3S7WYR7	Leishmania donovani	80%	100%
A4I171	Leishmania infantum	80%	100%
E9AXA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QA67	Leishmania major	80%	99%