Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDX5_LEIBR

TriTrypDb:

LbrM.25.0280 , LBRM2903_250008000

Length:

668

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	587	591	PF00656	0.741
CLV_NRD_NRD_1	139	141	PF00675	0.633
CLV_NRD_NRD_1	251	253	PF00675	0.856
CLV_NRD_NRD_1	261	263	PF00675	0.673
CLV_NRD_NRD_1	315	317	PF00675	0.581
CLV_NRD_NRD_1	520	522	PF00675	0.588
CLV_NRD_NRD_1	561	563	PF00675	0.567
CLV_NRD_NRD_1	567	569	PF00675	0.574
CLV_NRD_NRD_1	64	66	PF00675	0.449
CLV_PCSK_KEX2_1	139	141	PF00082	0.645
CLV_PCSK_KEX2_1	251	253	PF00082	0.755
CLV_PCSK_KEX2_1	261	263	PF00082	0.620
CLV_PCSK_KEX2_1	320	322	PF00082	0.680
CLV_PCSK_KEX2_1	467	469	PF00082	0.682
CLV_PCSK_KEX2_1	520	522	PF00082	0.588
CLV_PCSK_KEX2_1	561	563	PF00082	0.567
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.680
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.527
CLV_PCSK_PC7_1	257	263	PF00082	0.839
CLV_PCSK_PC7_1	316	322	PF00082	0.604
CLV_PCSK_SKI1_1	109	113	PF00082	0.414
CLV_PCSK_SKI1_1	161	165	PF00082	0.392
CLV_PCSK_SKI1_1	262	266	PF00082	0.821
CLV_PCSK_SKI1_1	297	301	PF00082	0.688
CLV_PCSK_SKI1_1	317	321	PF00082	0.367
CLV_PCSK_SKI1_1	341	345	PF00082	0.524
CLV_PCSK_SKI1_1	367	371	PF00082	0.676
CLV_PCSK_SKI1_1	383	387	PF00082	0.406
CLV_PCSK_SKI1_1	499	503	PF00082	0.454
CLV_PCSK_SKI1_1	66	70	PF00082	0.384
DEG_APCC_DBOX_1	498	506	PF00400	0.456
DEG_APCC_DBOX_1	64	72	PF00400	0.633
DEG_SPOP_SBC_1	413	417	PF00917	0.594
DEG_SPOP_SBC_1	484	488	PF00917	0.492
DEG_SPOP_SBC_1	599	603	PF00917	0.634
DOC_CKS1_1	298	303	PF01111	0.554
DOC_CKS1_1	661	666	PF01111	0.646
DOC_CYCLIN_yCln2_LP_2	572	578	PF00134	0.572
DOC_CYCLIN_yCln2_LP_2	661	667	PF00134	0.529
DOC_MAPK_gen_1	261	268	PF00069	0.831
DOC_MAPK_gen_1	568	574	PF00069	0.603
DOC_MAPK_gen_1	63	73	PF00069	0.389
DOC_MAPK_MEF2A_6	261	268	PF00069	0.831
DOC_MAPK_MEF2A_6	568	576	PF00069	0.585
DOC_MAPK_NFAT4_5	569	577	PF00069	0.578
DOC_PP1_RVXF_1	64	71	PF00149	0.383
DOC_PP2B_LxvP_1	264	267	PF13499	0.714
DOC_PP2B_LxvP_1	572	575	PF13499	0.696
DOC_USP7_MATH_1	150	154	PF00917	0.419
DOC_USP7_MATH_1	256	260	PF00917	0.662
DOC_USP7_MATH_1	315	319	PF00917	0.535
DOC_USP7_MATH_1	342	346	PF00917	0.469
DOC_USP7_MATH_1	419	423	PF00917	0.823
DOC_USP7_MATH_1	483	487	PF00917	0.600
DOC_USP7_MATH_1	604	608	PF00917	0.841
DOC_WW_Pin1_4	238	243	PF00397	0.708
DOC_WW_Pin1_4	252	257	PF00397	0.553
DOC_WW_Pin1_4	273	278	PF00397	0.781
DOC_WW_Pin1_4	297	302	PF00397	0.647
DOC_WW_Pin1_4	304	309	PF00397	0.603
DOC_WW_Pin1_4	407	412	PF00397	0.566
DOC_WW_Pin1_4	545	550	PF00397	0.760
DOC_WW_Pin1_4	660	665	PF00397	0.769
LIG_14-3-3_CanoR_1	16	20	PF00244	0.541
LIG_14-3-3_CanoR_1	251	258	PF00244	0.847
LIG_14-3-3_CanoR_1	261	267	PF00244	0.668
LIG_14-3-3_CanoR_1	272	276	PF00244	0.646
LIG_14-3-3_CanoR_1	341	351	PF00244	0.602
LIG_14-3-3_CanoR_1	468	474	PF00244	0.501
LIG_14-3-3_CanoR_1	524	533	PF00244	0.710
LIG_14-3-3_CanoR_1	545	549	PF00244	0.524
LIG_14-3-3_CanoR_1	568	573	PF00244	0.604
LIG_14-3-3_CanoR_1	584	594	PF00244	0.614
LIG_14-3-3_CanoR_1	63	69	PF00244	0.641
LIG_14-3-3_CanoR_1	652	661	PF00244	0.542
LIG_Actin_WH2_2	530	547	PF00022	0.468
LIG_APCC_ABBA_1	82	87	PF00400	0.387
LIG_BIR_II_1	1	5	PF00653	0.513
LIG_BIR_III_3	1	5	PF00653	0.513
LIG_BIR_III_4	482	486	PF00653	0.479
LIG_BRCT_BRCA1_1	231	235	PF00533	0.782
LIG_BRCT_BRCA1_1	615	619	PF00533	0.564
LIG_Clathr_ClatBox_1	359	363	PF01394	0.658
LIG_EVH1_1	574	578	PF00568	0.564
LIG_FHA_1	110	116	PF00498	0.510
LIG_FHA_1	165	171	PF00498	0.395
LIG_FHA_1	263	269	PF00498	0.825
LIG_FHA_1	546	552	PF00498	0.548
LIG_FHA_1	578	584	PF00498	0.701
LIG_FHA_1	59	65	PF00498	0.653
LIG_FHA_1	601	607	PF00498	0.583
LIG_FHA_1	92	98	PF00498	0.657
LIG_FHA_2	103	109	PF00498	0.633
LIG_FHA_2	525	531	PF00498	0.706
LIG_FHA_2	661	667	PF00498	0.765
LIG_GBD_Chelix_1	381	389	PF00786	0.670
LIG_Integrin_isoDGR_2	365	367	PF01839	0.553
LIG_LIR_Gen_1	193	201	PF02991	0.624
LIG_LIR_Gen_1	67	77	PF02991	0.369
LIG_LIR_Nem_3	193	197	PF02991	0.615
LIG_LIR_Nem_3	233	239	PF02991	0.547
LIG_LIR_Nem_3	274	278	PF02991	0.694
LIG_LIR_Nem_3	531	537	PF02991	0.459
LIG_LIR_Nem_3	663	668	PF02991	0.764
LIG_LIR_Nem_3	67	73	PF02991	0.422
LIG_MLH1_MIPbox_1	232	236	PF16413	0.531
LIG_PCNA_yPIPBox_3	341	355	PF02747	0.590
LIG_PCNA_yPIPBox_3	491	499	PF02747	0.722
LIG_Pex14_2	534	538	PF04695	0.458
LIG_SH2_NCK_1	278	282	PF00017	0.793
LIG_SH2_SRC	49	52	PF00017	0.497
LIG_SH2_STAP1	333	337	PF00017	0.468
LIG_SH2_STAT3	333	336	PF00017	0.468
LIG_SH2_STAT5	75	78	PF00017	0.611
LIG_SH3_3	263	269	PF00018	0.607
LIG_SH3_3	547	553	PF00018	0.556
LIG_SH3_3	572	578	PF00018	0.760
LIG_SUMO_SIM_anti_2	358	363	PF11976	0.659
LIG_SUMO_SIM_par_1	358	363	PF11976	0.659
LIG_SUMO_SIM_par_1	397	402	PF11976	0.517
LIG_TRAF2_1	489	492	PF00917	0.740
LIG_TRAF2_1	621	624	PF00917	0.547
LIG_TRAF2_1	639	642	PF00917	0.409
LIG_UBA3_1	114	118	PF00899	0.409
MOD_CDK_SPK_2	252	257	PF00069	0.848
MOD_CDK_SPK_2	407	412	PF00069	0.566
MOD_CK1_1	205	211	PF00069	0.521
MOD_CK1_1	226	232	PF00069	0.638
MOD_CK1_1	245	251	PF00069	0.662
MOD_CK1_1	276	282	PF00069	0.684
MOD_CK1_1	392	398	PF00069	0.477
MOD_CK1_1	40	46	PF00069	0.718
MOD_CK1_1	507	513	PF00069	0.448
MOD_CK1_1	653	659	PF00069	0.660
MOD_CK2_1	276	282	PF00069	0.766
MOD_CK2_1	328	334	PF00069	0.506
MOD_CK2_1	40	46	PF00069	0.546
MOD_CK2_1	419	425	PF00069	0.793
MOD_CK2_1	507	513	PF00069	0.448
MOD_CK2_1	524	530	PF00069	0.406
MOD_DYRK1A_RPxSP_1	545	549	PF00069	0.524
MOD_GlcNHglycan	105	108	PF01048	0.572
MOD_GlcNHglycan	148	151	PF01048	0.404
MOD_GlcNHglycan	204	207	PF01048	0.596
MOD_GlcNHglycan	232	235	PF01048	0.647
MOD_GlcNHglycan	287	290	PF01048	0.759
MOD_GlcNHglycan	312	316	PF01048	0.637
MOD_GlcNHglycan	373	376	PF01048	0.413
MOD_GlcNHglycan	394	397	PF01048	0.734
MOD_GlcNHglycan	460	463	PF01048	0.639
MOD_GlcNHglycan	487	490	PF01048	0.489
MOD_GSK3_1	103	110	PF00069	0.672
MOD_GSK3_1	146	153	PF00069	0.643
MOD_GSK3_1	208	215	PF00069	0.557
MOD_GSK3_1	226	233	PF00069	0.664
MOD_GSK3_1	238	245	PF00069	0.631
MOD_GSK3_1	252	259	PF00069	0.615
MOD_GSK3_1	267	274	PF00069	0.573
MOD_GSK3_1	285	292	PF00069	0.575
MOD_GSK3_1	293	300	PF00069	0.597
MOD_GSK3_1	311	318	PF00069	0.425
MOD_GSK3_1	328	335	PF00069	0.378
MOD_GSK3_1	388	395	PF00069	0.616
MOD_GSK3_1	407	414	PF00069	0.656
MOD_GSK3_1	419	426	PF00069	0.753
MOD_GSK3_1	432	439	PF00069	0.575
MOD_GSK3_1	454	461	PF00069	0.453
MOD_GSK3_1	54	61	PF00069	0.609
MOD_GSK3_1	540	547	PF00069	0.497
MOD_GSK3_1	594	601	PF00069	0.715
MOD_GSK3_1	604	611	PF00069	0.820
MOD_N-GLC_1	229	234	PF02516	0.679
MOD_N-GLC_1	604	609	PF02516	0.588
MOD_N-GLC_1	653	658	PF02516	0.545
MOD_NEK2_1	10	15	PF00069	0.722
MOD_NEK2_1	293	298	PF00069	0.580
MOD_NEK2_1	332	337	PF00069	0.420
MOD_NEK2_1	389	394	PF00069	0.445
MOD_NEK2_1	406	411	PF00069	0.561
MOD_NEK2_1	540	545	PF00069	0.467
MOD_NEK2_1	593	598	PF00069	0.613
MOD_NEK2_1	64	69	PF00069	0.638
MOD_NEK2_2	289	294	PF00069	0.561
MOD_NEK2_2	315	320	PF00069	0.456
MOD_NEK2_2	469	474	PF00069	0.427
MOD_PIKK_1	10	16	PF00454	0.533
MOD_PIKK_1	129	135	PF00454	0.467
MOD_PIKK_1	256	262	PF00454	0.840
MOD_PIKK_1	267	273	PF00454	0.640
MOD_PIKK_1	276	282	PF00454	0.499
MOD_PIKK_1	332	338	PF00454	0.420
MOD_PIKK_1	433	439	PF00454	0.544
MOD_PIKK_1	504	510	PF00454	0.478
MOD_PIKK_1	608	614	PF00454	0.580
MOD_PKA_1	568	574	PF00069	0.589
MOD_PKA_2	15	21	PF00069	0.568
MOD_PKA_2	250	256	PF00069	0.847
MOD_PKA_2	260	266	PF00069	0.670
MOD_PKA_2	271	277	PF00069	0.646
MOD_PKA_2	293	299	PF00069	0.660
MOD_PKA_2	315	321	PF00069	0.460
MOD_PKA_2	371	377	PF00069	0.415
MOD_PKA_2	40	46	PF00069	0.788
MOD_PKA_2	523	529	PF00069	0.713
MOD_PKA_2	544	550	PF00069	0.568
MOD_PKA_2	560	566	PF00069	0.720
MOD_PKA_2	64	70	PF00069	0.503
MOD_Plk_1	107	113	PF00069	0.667
MOD_Plk_1	446	452	PF00069	0.494
MOD_Plk_1	540	546	PF00069	0.727
MOD_Plk_4	15	21	PF00069	0.568
MOD_Plk_4	40	46	PF00069	0.699
MOD_Plk_4	446	452	PF00069	0.476
MOD_ProDKin_1	238	244	PF00069	0.708
MOD_ProDKin_1	252	258	PF00069	0.552
MOD_ProDKin_1	273	279	PF00069	0.780
MOD_ProDKin_1	297	303	PF00069	0.643
MOD_ProDKin_1	304	310	PF00069	0.603
MOD_ProDKin_1	407	413	PF00069	0.568
MOD_ProDKin_1	545	551	PF00069	0.765
MOD_ProDKin_1	660	666	PF00069	0.766
MOD_SUMO_for_1	117	120	PF00179	0.404
MOD_SUMO_for_1	319	322	PF00179	0.443
TRG_DiLeu_BaEn_1	350	355	PF01217	0.666
TRG_DiLeu_BaEn_1	99	104	PF01217	0.672
TRG_DiLeu_BaEn_2	641	647	PF01217	0.509
TRG_ER_diArg_1	138	140	PF00400	0.650
TRG_ER_diArg_1	519	521	PF00400	0.732
TRG_ER_diArg_1	561	564	PF00400	0.571
TRG_NES_CRM1_1	350	363	PF08389	0.663
TRG_NES_CRM1_1	74	88	PF08389	0.373
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	341	346	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID47	Leishmania donovani	60%	97%
A4I170	Leishmania infantum	61%	96%
E9AXA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	97%
Q4QA68	Leishmania major	60%	100%