Dynein light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein light chain

Gene product:

Dynein light chain 1, cytoplasmic, putative

Species:

Leishmania braziliensis

UniProt:

A4HDX3_LEIBR

TriTrypDb:

LbrM.25.0260 , LBRM2903_250007800

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005874	microtubule	6	11
GO:0005875	microtubule associated complex	2	11
GO:0030286	dynein complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11
GO:1902494	catalytic complex	2	11
GO:0005868	cytoplasmic dynein complex	4	1

Expansion

Sequence features

A4HDX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDX3

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.426
CLV_PCSK_KEX2_1	43	45	PF00082	0.219
CLV_PCSK_KEX2_1	48	50	PF00082	0.199
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.219
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.199
CLV_PCSK_PC7_1	44	50	PF00082	0.303
CLV_PCSK_SKI1_1	27	31	PF00082	0.222
DOC_MAPK_gen_1	4	10	PF00069	0.246
DOC_MAPK_MEF2A_6	71	78	PF00069	0.463
DOC_MAPK_NFAT4_5	71	79	PF00069	0.463
DOC_USP7_UBL2_3	5	9	PF12436	0.264
DOC_WW_Pin1_4	11	16	PF00397	0.503
LIG_14-3-3_CanoR_1	4	10	PF00244	0.165
LIG_BIR_II_1	1	5	PF00653	0.494
LIG_FHA_1	24	30	PF00498	0.430
LIG_LIR_Gen_1	53	62	PF02991	0.415
LIG_LIR_Nem_3	53	57	PF02991	0.415
LIG_NRBOX	80	86	PF00104	0.419
LIG_SH2_SRC	75	78	PF00017	0.463
LIG_SH2_STAT5	50	53	PF00017	0.528
LIG_SH2_STAT5	75	78	PF00017	0.409
MOD_PKA_2	3	9	PF00069	0.285
MOD_Plk_4	79	85	PF00069	0.465
MOD_ProDKin_1	11	17	PF00069	0.503
MOD_SUMO_for_1	42	45	PF00179	0.409
MOD_SUMO_rev_2	2	11	PF00179	0.289
MOD_SUMO_rev_2	65	73	PF00179	0.409
TRG_DiLeu_BaEn_2	68	74	PF01217	0.422
TRG_ENDOCYTIC_2	75	78	PF00928	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0W1	Leptomonas seymouri	51%	98%
A0A0N1I1Z7	Leptomonas seymouri	84%	100%
A0A0N1PBY8	Leptomonas seymouri	48%	98%
A0A0N1PCF1	Leptomonas seymouri	31%	83%
A0A0N1PCX2	Leptomonas seymouri	35%	79%
A0A0S4IS05	Bodo saltans	39%	99%
A0A0S4IUR3	Bodo saltans	55%	98%
A0A0S4J005	Bodo saltans	40%	68%
A0A0S4J1R8	Bodo saltans	56%	98%
A0A0S4JE57	Bodo saltans	69%	100%
A0A0S4JH61	Bodo saltans	56%	71%
A0A0S4JKR9	Bodo saltans	40%	88%
A0A0S4JQ28	Bodo saltans	52%	99%
A0A1X0P6I9	Trypanosomatidae	33%	74%
A0A1X0P8I8	Trypanosomatidae	36%	79%
A0A3Q8IDB7	Leishmania donovani	34%	79%
A0A3Q8IDX2	Leishmania donovani	40%	99%
A0A3R7KXV2	Trypanosoma rangeli	37%	79%
A0A3S5H7E1	Leishmania donovani	91%	100%
A0A3S5H7R1	Leishmania donovani	51%	98%
A0A3S7WNY4	Leishmania donovani	48%	98%
A0A3S7WTY9	Leishmania donovani	36%	79%
A0A422NC25	Trypanosoma rangeli	65%	82%
A0A422NHE2	Trypanosoma rangeli	40%	79%
A4F4L4	Sus scrofa	33%	85%
A4H453	Leishmania braziliensis	48%	100%
A4H8L8	Leishmania braziliensis	34%	100%
A4HA47	Leishmania braziliensis	33%	100%
A4HGR7	Leishmania braziliensis	37%	100%
A4HK04	Leishmania braziliensis	51%	100%
A4HSD6	Leishmania infantum	48%	98%
A4HWY9	Leishmania infantum	36%	79%
A4HYB3	Leishmania infantum	34%	79%
A4I168	Leishmania infantum	91%	100%
A4I3U2	Leishmania infantum	40%	99%
A4I7I7	Leishmania infantum	51%	98%
C9ZPY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	99%
D0A0N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	68%
D0A2J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	79%
D0A385	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	71%
D0A5F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	99%
D0A5K4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
E9AKB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	98%
E9AQQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	79%
E9AS46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	79%
E9ASZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	69%
E9AXA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B034	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	99%
E9B2E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	98%
O02414	Heliocidaris crassispina	59%	100%
O94111	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	53%	95%
O96015	Homo sapiens	33%	85%
O96860	Drosophila melanogaster	58%	100%
P61273	Macaca fascicularis	59%	100%
P61285	Bos taurus	59%	100%
P63167	Homo sapiens	59%	100%
P63168	Mus musculus	59%	100%
P63169	Oryctolagus cuniculus	59%	100%
P63170	Rattus norvegicus	59%	100%
Q02647	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	97%
Q21557	Caenorhabditis elegans	33%	99%
Q22799	Caenorhabditis elegans	56%	100%
Q24117	Drosophila melanogaster	58%	100%
Q32KN5	Bos taurus	33%	85%
Q39579	Chlamydomonas reinhardtii	39%	74%
Q39580	Chlamydomonas reinhardtii	57%	98%
Q3MHR3	Bos taurus	58%	100%
Q4Q5R2	Leishmania major	49%	100%
Q4Q852	Leishmania major	40%	100%
Q4QA70	Leishmania major	90%	100%
Q4QDC0	Leishmania major	34%	100%
Q4QES6	Leishmania major	35%	100%
Q4QJJ6	Leishmania major	48%	100%
Q6BZF8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	41%	98%
Q6CWX4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	39%	100%
Q6FUJ0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	47%	100%
Q759T0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	42%	100%
Q78P75	Rattus norvegicus	58%	100%
Q86A88	Dictyostelium discoideum	53%	98%
Q94748	Schistosoma mansoni	49%	100%
Q94758	Schistosoma mansoni	59%	100%
Q96FJ2	Homo sapiens	58%	100%
Q9D0M5	Mus musculus	58%	100%
Q9DCM4	Mus musculus	33%	85%
Q9UR05	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	100%
V5AV01	Trypanosoma cruzi	48%	99%
V5BSX5	Trypanosoma cruzi	53%	99%
V5BV95	Trypanosoma cruzi	36%	79%
V5BXL9	Trypanosoma cruzi	68%	100%