Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDX2_LEIBR

TriTrypDb:

LbrM.25.0250 , LBRM2903_250007700

Length:

878

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.493
CLV_C14_Caspase3-7	493	497	PF00656	0.421
CLV_C14_Caspase3-7	513	517	PF00656	0.379
CLV_NRD_NRD_1	17	19	PF00675	0.475
CLV_NRD_NRD_1	186	188	PF00675	0.348
CLV_NRD_NRD_1	49	51	PF00675	0.402
CLV_NRD_NRD_1	533	535	PF00675	0.411
CLV_NRD_NRD_1	651	653	PF00675	0.476
CLV_NRD_NRD_1	709	711	PF00675	0.494
CLV_NRD_NRD_1	719	721	PF00675	0.516
CLV_NRD_NRD_1	843	845	PF00675	0.557
CLV_NRD_NRD_1	871	873	PF00675	0.678
CLV_NRD_NRD_1	97	99	PF00675	0.553
CLV_PCSK_FUR_1	707	711	PF00082	0.424
CLV_PCSK_KEX2_1	186	188	PF00082	0.348
CLV_PCSK_KEX2_1	502	504	PF00082	0.530
CLV_PCSK_KEX2_1	533	535	PF00082	0.411
CLV_PCSK_KEX2_1	651	653	PF00082	0.476
CLV_PCSK_KEX2_1	709	711	PF00082	0.515
CLV_PCSK_KEX2_1	718	720	PF00082	0.476
CLV_PCSK_KEX2_1	843	845	PF00082	0.557
CLV_PCSK_KEX2_1	870	872	PF00082	0.686
CLV_PCSK_KEX2_1	97	99	PF00082	0.553
CLV_PCSK_PC1ET2_1	502	504	PF00082	0.575
CLV_PCSK_PC1ET2_1	718	720	PF00082	0.545
CLV_PCSK_SKI1_1	186	190	PF00082	0.402
CLV_PCSK_SKI1_1	19	23	PF00082	0.586
CLV_PCSK_SKI1_1	229	233	PF00082	0.566
CLV_PCSK_SKI1_1	495	499	PF00082	0.437
CLV_PCSK_SKI1_1	599	603	PF00082	0.394
CLV_PCSK_SKI1_1	749	753	PF00082	0.563
DEG_APCC_DBOX_1	696	704	PF00400	0.544
DEG_APCC_DBOX_1	709	717	PF00400	0.569
DEG_Nend_Nbox_1	1	3	PF02207	0.345
DEG_SIAH_1	766	774	PF03145	0.508
DOC_CDC14_PxL_1	863	871	PF14671	0.632
DOC_CKS1_1	399	404	PF01111	0.670
DOC_CKS1_1	77	82	PF01111	0.474
DOC_CYCLIN_RxL_1	255	266	PF00134	0.397
DOC_CYCLIN_RxL_1	621	632	PF00134	0.487
DOC_CYCLIN_RxL_1	706	714	PF00134	0.424
DOC_MAPK_gen_1	585	593	PF00069	0.557
DOC_MAPK_gen_1	621	629	PF00069	0.497
DOC_PP2B_LxvP_1	802	805	PF13499	0.501
DOC_USP7_MATH_1	237	241	PF00917	0.421
DOC_USP7_MATH_1	339	343	PF00917	0.638
DOC_USP7_MATH_1	359	363	PF00917	0.671
DOC_USP7_MATH_1	368	372	PF00917	0.614
DOC_USP7_MATH_1	417	421	PF00917	0.631
DOC_USP7_MATH_1	422	426	PF00917	0.627
DOC_USP7_MATH_1	524	528	PF00917	0.528
DOC_USP7_MATH_1	671	675	PF00917	0.555
DOC_USP7_MATH_1	767	771	PF00917	0.580
DOC_USP7_MATH_1	811	815	PF00917	0.662
DOC_USP7_UBL2_3	498	502	PF12436	0.613
DOC_USP7_UBL2_3	644	648	PF12436	0.553
DOC_WW_Pin1_4	19	24	PF00397	0.449
DOC_WW_Pin1_4	246	251	PF00397	0.414
DOC_WW_Pin1_4	277	282	PF00397	0.415
DOC_WW_Pin1_4	324	329	PF00397	0.594
DOC_WW_Pin1_4	360	365	PF00397	0.594
DOC_WW_Pin1_4	398	403	PF00397	0.630
DOC_WW_Pin1_4	76	81	PF00397	0.410
DOC_WW_Pin1_4	781	786	PF00397	0.678
DOC_WW_Pin1_4	800	805	PF00397	0.592
LIG_14-3-3_CanoR_1	18	22	PF00244	0.569
LIG_14-3-3_CanoR_1	186	195	PF00244	0.496
LIG_14-3-3_CanoR_1	229	238	PF00244	0.464
LIG_14-3-3_CanoR_1	28	33	PF00244	0.462
LIG_14-3-3_CanoR_1	305	314	PF00244	0.373
LIG_14-3-3_CanoR_1	48	54	PF00244	0.271
LIG_14-3-3_CanoR_1	585	593	PF00244	0.629
LIG_14-3-3_CanoR_1	60	64	PF00244	0.456
LIG_14-3-3_CanoR_1	688	696	PF00244	0.491
LIG_14-3-3_CanoR_1	82	90	PF00244	0.427
LIG_14-3-3_CanoR_1	843	849	PF00244	0.643
LIG_14-3-3_CanoR_1	97	102	PF00244	0.445
LIG_Actin_WH2_2	480	497	PF00022	0.559
LIG_BIR_III_4	148	152	PF00653	0.460
LIG_BRCT_BRCA1_1	200	204	PF00533	0.404
LIG_BRCT_BRCA1_1	814	818	PF00533	0.625
LIG_CtBP_PxDLS_1	772	776	PF00389	0.530
LIG_FHA_1	255	261	PF00498	0.419
LIG_FHA_1	581	587	PF00498	0.441
LIG_FHA_1	600	606	PF00498	0.673
LIG_FHA_1	706	712	PF00498	0.562
LIG_FHA_1	781	787	PF00498	0.544
LIG_FHA_1	814	820	PF00498	0.633
LIG_FHA_2	129	135	PF00498	0.486
LIG_FHA_2	153	159	PF00498	0.439
LIG_FHA_2	163	169	PF00498	0.448
LIG_FHA_2	221	227	PF00498	0.430
LIG_FHA_2	286	292	PF00498	0.445
LIG_FHA_2	38	44	PF00498	0.432
LIG_FHA_2	675	681	PF00498	0.682
LIG_FHA_2	688	694	PF00498	0.473
LIG_FHA_2	697	703	PF00498	0.465
LIG_FHA_2	782	788	PF00498	0.614
LIG_FHA_2	98	104	PF00498	0.430
LIG_LIR_Gen_1	162	172	PF02991	0.405
LIG_LIR_Gen_1	216	227	PF02991	0.365
LIG_LIR_Gen_1	52	63	PF02991	0.365
LIG_LIR_Gen_1	850	859	PF02991	0.698
LIG_LIR_Nem_3	162	167	PF02991	0.403
LIG_LIR_Nem_3	169	175	PF02991	0.391
LIG_LIR_Nem_3	178	184	PF02991	0.398
LIG_LIR_Nem_3	189	195	PF02991	0.293
LIG_LIR_Nem_3	216	222	PF02991	0.383
LIG_LIR_Nem_3	27	33	PF02991	0.383
LIG_LIR_Nem_3	470	475	PF02991	0.481
LIG_LIR_Nem_3	52	58	PF02991	0.417
LIG_LIR_Nem_3	545	551	PF02991	0.626
LIG_LIR_Nem_3	850	854	PF02991	0.598
LIG_NRBOX	258	264	PF00104	0.399
LIG_PCNA_yPIPBox_3	505	519	PF02747	0.416
LIG_Pex14_1	275	279	PF04695	0.321
LIG_Pex14_1	95	99	PF04695	0.276
LIG_Pex14_2	202	206	PF04695	0.398
LIG_Pex14_2	293	297	PF04695	0.391
LIG_RPA_C_Fungi	230	242	PF08784	0.453
LIG_RPA_C_Fungi	372	384	PF08784	0.551
LIG_SH2_CRK	472	476	PF00017	0.474
LIG_SH2_CRK	55	59	PF00017	0.370
LIG_SH2_NCK_1	414	418	PF00017	0.524
LIG_SH2_PTP2	172	175	PF00017	0.348
LIG_SH2_STAP1	30	34	PF00017	0.319
LIG_SH2_STAP1	307	311	PF00017	0.359
LIG_SH2_STAP1	414	418	PF00017	0.524
LIG_SH2_STAP1	522	526	PF00017	0.543
LIG_SH2_STAP1	744	748	PF00017	0.466
LIG_SH2_STAT3	744	747	PF00017	0.525
LIG_SH2_STAT5	172	175	PF00017	0.411
LIG_SH2_STAT5	261	264	PF00017	0.439
LIG_SH2_STAT5	868	871	PF00017	0.596
LIG_SH2_STAT5	99	102	PF00017	0.399
LIG_SH3_1	870	876	PF00018	0.698
LIG_SH3_3	114	120	PF00018	0.483
LIG_SH3_3	396	402	PF00018	0.683
LIG_SH3_3	436	442	PF00018	0.689
LIG_SH3_3	66	72	PF00018	0.403
LIG_SH3_3	74	80	PF00018	0.361
LIG_SH3_3	870	876	PF00018	0.698
LIG_SUMO_SIM_anti_2	280	286	PF11976	0.453
LIG_SUMO_SIM_anti_2	308	315	PF11976	0.445
LIG_SUMO_SIM_anti_2	35	43	PF11976	0.435
LIG_SUMO_SIM_par_1	280	286	PF11976	0.453
LIG_SUMO_SIM_par_1	40	47	PF11976	0.485
LIG_SUMO_SIM_par_1	625	632	PF11976	0.541
LIG_SUMO_SIM_par_1	86	91	PF11976	0.347
LIG_TRAF2_1	292	295	PF00917	0.462
LIG_TRAF2_1	458	461	PF00917	0.608
LIG_TRAF2_1	497	500	PF00917	0.457
LIG_TRAF2_1	677	680	PF00917	0.530
LIG_TRAF2_1	684	687	PF00917	0.451
LIG_TRAF2_1	729	732	PF00917	0.455
LIG_TRAF2_1	850	853	PF00917	0.538
LIG_TRFH_1	261	265	PF08558	0.338
LIG_TYR_ITIM	53	58	PF00017	0.305
LIG_UBA3_1	259	264	PF00899	0.425
LIG_WRC_WIRS_1	199	204	PF05994	0.326
LIG_WRC_WIRS_1	219	224	PF05994	0.219
LIG_WRC_WIRS_1	848	853	PF05994	0.486
MOD_CDK_SPK_2	360	365	PF00069	0.545
MOD_CDK_SPxK_1	76	82	PF00069	0.470
MOD_CDK_SPxxK_3	360	367	PF00069	0.573
MOD_CDK_SPxxK_3	781	788	PF00069	0.677
MOD_CK1_1	11	17	PF00069	0.601
MOD_CK1_1	128	134	PF00069	0.434
MOD_CK1_1	177	183	PF00069	0.468
MOD_CK1_1	280	286	PF00069	0.399
MOD_CK1_1	376	382	PF00069	0.665
MOD_CK1_1	412	418	PF00069	0.599
MOD_CK1_1	426	432	PF00069	0.745
MOD_CK1_1	674	680	PF00069	0.529
MOD_CK1_1	705	711	PF00069	0.515
MOD_CK1_1	826	832	PF00069	0.646
MOD_CK1_1	847	853	PF00069	0.636
MOD_CK2_1	152	158	PF00069	0.447
MOD_CK2_1	162	168	PF00069	0.454
MOD_CK2_1	220	226	PF00069	0.417
MOD_CK2_1	280	286	PF00069	0.450
MOD_CK2_1	289	295	PF00069	0.419
MOD_CK2_1	343	349	PF00069	0.512
MOD_CK2_1	360	366	PF00069	0.497
MOD_CK2_1	524	530	PF00069	0.463
MOD_CK2_1	674	680	PF00069	0.628
MOD_CK2_1	681	687	PF00069	0.546
MOD_CK2_1	696	702	PF00069	0.529
MOD_CK2_1	847	853	PF00069	0.540
MOD_GlcNHglycan	12	16	PF01048	0.488
MOD_GlcNHglycan	127	130	PF01048	0.430
MOD_GlcNHglycan	239	242	PF01048	0.425
MOD_GlcNHglycan	314	317	PF01048	0.437
MOD_GlcNHglycan	341	344	PF01048	0.563
MOD_GlcNHglycan	345	348	PF01048	0.641
MOD_GlcNHglycan	386	390	PF01048	0.614
MOD_GlcNHglycan	410	414	PF01048	0.566
MOD_GlcNHglycan	420	423	PF01048	0.587
MOD_GlcNHglycan	674	677	PF01048	0.540
MOD_GSK3_1	121	128	PF00069	0.453
MOD_GSK3_1	246	253	PF00069	0.422
MOD_GSK3_1	28	35	PF00069	0.568
MOD_GSK3_1	285	292	PF00069	0.438
MOD_GSK3_1	339	346	PF00069	0.507
MOD_GSK3_1	373	380	PF00069	0.663
MOD_GSK3_1	418	425	PF00069	0.581
MOD_GSK3_1	776	783	PF00069	0.695
MOD_GSK3_1	826	833	PF00069	0.609
MOD_N-GLC_1	134	139	PF02516	0.468
MOD_N-GLC_1	213	218	PF02516	0.369
MOD_N-GLC_1	553	558	PF02516	0.471
MOD_N-GLC_1	780	785	PF02516	0.586
MOD_NEK2_1	109	114	PF00069	0.447
MOD_NEK2_1	206	211	PF00069	0.419
MOD_NEK2_1	231	236	PF00069	0.435
MOD_NEK2_1	254	259	PF00069	0.383
MOD_NEK2_1	306	311	PF00069	0.413
MOD_NEK2_1	373	378	PF00069	0.557
MOD_NEK2_1	58	63	PF00069	0.550
MOD_NEK2_1	73	78	PF00069	0.320
MOD_PIKK_1	456	462	PF00454	0.461
MOD_PIKK_1	535	541	PF00454	0.522
MOD_PIKK_1	573	579	PF00454	0.614
MOD_PIKK_1	81	87	PF00454	0.454
MOD_PK_1	844	850	PF00069	0.535
MOD_PKA_1	186	192	PF00069	0.318
MOD_PKA_1	505	511	PF00069	0.466
MOD_PKA_1	97	103	PF00069	0.433
MOD_PKA_2	17	23	PF00069	0.454
MOD_PKA_2	186	192	PF00069	0.505
MOD_PKA_2	376	382	PF00069	0.689
MOD_PKA_2	49	55	PF00069	0.451
MOD_PKA_2	59	65	PF00069	0.443
MOD_PKA_2	687	693	PF00069	0.531
MOD_PKA_2	696	702	PF00069	0.465
MOD_PKA_2	81	87	PF00069	0.454
MOD_PKA_2	97	103	PF00069	0.462
MOD_PKB_1	383	391	PF00069	0.558
MOD_Plk_1	11	17	PF00069	0.339
MOD_Plk_1	120	126	PF00069	0.540
MOD_Plk_1	134	140	PF00069	0.448
MOD_Plk_1	177	183	PF00069	0.471
MOD_Plk_1	213	219	PF00069	0.365
MOD_Plk_1	35	41	PF00069	0.453
MOD_Plk_1	409	415	PF00069	0.518
MOD_Plk_1	823	829	PF00069	0.565
MOD_Plk_2-3	134	140	PF00069	0.498
MOD_Plk_2-3	289	295	PF00069	0.469
MOD_Plk_2-3	510	516	PF00069	0.565
MOD_Plk_2-3	681	687	PF00069	0.533
MOD_Plk_4	152	158	PF00069	0.502
MOD_Plk_4	263	269	PF00069	0.395
MOD_Plk_4	28	34	PF00069	0.392
MOD_Plk_4	280	286	PF00069	0.495
MOD_Plk_4	368	374	PF00069	0.572
MOD_Plk_4	37	43	PF00069	0.380
MOD_Plk_4	73	79	PF00069	0.436
MOD_Plk_4	97	103	PF00069	0.416
MOD_ProDKin_1	19	25	PF00069	0.446
MOD_ProDKin_1	246	252	PF00069	0.408
MOD_ProDKin_1	277	283	PF00069	0.420
MOD_ProDKin_1	324	330	PF00069	0.596
MOD_ProDKin_1	360	366	PF00069	0.594
MOD_ProDKin_1	398	404	PF00069	0.630
MOD_ProDKin_1	76	82	PF00069	0.419
MOD_ProDKin_1	781	787	PF00069	0.677
MOD_ProDKin_1	800	806	PF00069	0.593
MOD_SUMO_for_1	497	500	PF00179	0.429
MOD_SUMO_for_1	751	754	PF00179	0.485
MOD_SUMO_rev_2	745	753	PF00179	0.480
TRG_DiLeu_BaEn_1	600	605	PF01217	0.534
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.433
TRG_ENDOCYTIC_2	172	175	PF00928	0.375
TRG_ENDOCYTIC_2	29	32	PF00928	0.360
TRG_ENDOCYTIC_2	472	475	PF00928	0.475
TRG_ENDOCYTIC_2	55	58	PF00928	0.463
TRG_ENDOCYTIC_2	99	102	PF00928	0.399
TRG_ER_diArg_1	185	187	PF00400	0.349
TRG_ER_diArg_1	532	534	PF00400	0.434
TRG_ER_diArg_1	622	625	PF00400	0.493
TRG_ER_diArg_1	694	697	PF00400	0.525
TRG_ER_diArg_1	707	710	PF00400	0.536
TRG_ER_diArg_1	843	846	PF00400	0.657
TRG_ER_diArg_1	869	872	PF00400	0.686
TRG_ER_diArg_1	97	99	PF00400	0.474
TRG_NLS_MonoExtC_3	501	506	PF00514	0.472
TRG_NLS_MonoExtN_4	502	509	PF00514	0.475
TRG_Pf-PMV_PEXEL_1	509	514	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	534	539	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	585	590	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	625	630	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	709	714	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	749	754	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP5	Leptomonas seymouri	48%	97%
A0A3Q8IN51	Leishmania donovani	73%	100%
A0A3R7KB27	Trypanosoma rangeli	28%	96%
A4I167	Leishmania infantum	73%	100%
E9AXA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QA71	Leishmania major	71%	100%