Intraflagellar transport protein 46 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA-splicing factor of RES complex, putative

Species:

Leishmania braziliensis

UniProt:

A4HDX1_LEIBR

TriTrypDb:

LbrM.25.0240 , LBRM2903_250007600

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.603
CLV_NRD_NRD_1	137	139	PF00675	0.461
CLV_NRD_NRD_1	159	161	PF00675	0.620
CLV_NRD_NRD_1	9	11	PF00675	0.601
CLV_NRD_NRD_1	97	99	PF00675	0.523
CLV_PCSK_KEX2_1	137	139	PF00082	0.461
CLV_PCSK_KEX2_1	7	9	PF00082	0.608
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.608
CLV_PCSK_SKI1_1	124	128	PF00082	0.492
CLV_Separin_Metazoa	121	125	PF03568	0.408
DEG_SCF_FBW7_1	34	40	PF00400	0.518
DEG_SPOP_SBC_1	152	156	PF00917	0.481
DOC_CKS1_1	34	39	PF01111	0.514
DOC_CYCLIN_RxL_1	121	131	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	126	132	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.517
DOC_MAPK_gen_1	135	144	PF00069	0.442
DOC_MAPK_gen_1	98	104	PF00069	0.517
DOC_PP2B_LxvP_1	126	129	PF13499	0.503
DOC_USP7_MATH_1	151	155	PF00917	0.552
DOC_USP7_MATH_1	22	26	PF00917	0.580
DOC_USP7_MATH_1	94	98	PF00917	0.513
DOC_WW_Pin1_4	154	159	PF00397	0.543
DOC_WW_Pin1_4	24	29	PF00397	0.578
DOC_WW_Pin1_4	33	38	PF00397	0.590
DOC_WW_Pin1_4	72	77	PF00397	0.511
LIG_14-3-3_CanoR_1	115	123	PF00244	0.439
LIG_14-3-3_CanoR_1	137	144	PF00244	0.581
LIG_14-3-3_CanoR_1	63	67	PF00244	0.678
LIG_BIR_II_1	1	5	PF00653	0.593
LIG_BRCT_BRCA1_1	34	38	PF00533	0.639
LIG_FHA_1	138	144	PF00498	0.526
LIG_FHA_1	75	81	PF00498	0.569
LIG_FHA_2	67	73	PF00498	0.673
LIG_FHA_2	80	86	PF00498	0.745
LIG_LIR_Nem_3	113	117	PF02991	0.731
LIG_SH2_CRK	114	118	PF00017	0.495
LIG_SH2_NCK_1	147	151	PF00017	0.471
LIG_SH2_SRC	147	150	PF00017	0.465
LIG_SH2_STAT5	132	135	PF00017	0.527
LIG_SH2_STAT5	20	23	PF00017	0.686
LIG_SH3_3	31	37	PF00018	0.510
LIG_SH3_3	61	67	PF00018	0.523
LIG_SH3_3	97	103	PF00018	0.519
LIG_TRAF2_1	103	106	PF00917	0.513
LIG_UBA3_1	126	135	PF00899	0.578
MOD_CDK_SPxK_1	154	160	PF00069	0.494
MOD_CDK_SPxxK_3	154	161	PF00069	0.494
MOD_CK1_1	154	160	PF00069	0.494
MOD_CK1_1	75	81	PF00069	0.525
MOD_CK2_1	66	72	PF00069	0.657
MOD_Cter_Amidation	158	161	PF01082	0.500
MOD_GlcNHglycan	1	4	PF01048	0.786
MOD_GlcNHglycan	118	121	PF01048	0.548
MOD_GSK3_1	33	40	PF00069	0.555
MOD_GSK3_1	58	65	PF00069	0.608
MOD_GSK3_1	75	82	PF00069	0.493
MOD_NEK2_1	79	84	PF00069	0.511
MOD_PIKK_1	142	148	PF00454	0.650
MOD_PKA_1	137	143	PF00069	0.439
MOD_PKA_2	137	143	PF00069	0.439
MOD_PKA_2	62	68	PF00069	0.514
MOD_PKB_1	8	16	PF00069	0.592
MOD_Plk_2-3	42	48	PF00069	0.741
MOD_Plk_2-3	52	58	PF00069	0.665
MOD_Plk_4	55	61	PF00069	0.584
MOD_Plk_4	75	81	PF00069	0.596
MOD_ProDKin_1	154	160	PF00069	0.546
MOD_ProDKin_1	24	30	PF00069	0.577
MOD_ProDKin_1	33	39	PF00069	0.587
MOD_ProDKin_1	72	78	PF00069	0.513
TRG_DiLeu_BaEn_1	113	118	PF01217	0.524
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.573
TRG_ENDOCYTIC_2	114	117	PF00928	0.529
TRG_ER_diArg_1	179	182	PF00400	0.469
TRG_ER_diArg_1	8	10	PF00400	0.608
TRG_NLS_MonoCore_2	6	11	PF00514	0.602
TRG_NLS_MonoExtC_3	6	12	PF00514	0.600
TRG_NLS_MonoExtN_4	5	11	PF00514	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X4	Leptomonas seymouri	45%	96%
A0A3Q8ICC4	Leishmania donovani	64%	100%
A4I166	Leishmania infantum	63%	100%
E9AXA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QA72	Leishmania major	67%	100%