TYR_PHOSPHATASE_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dual specificity phosphatase, catalytic domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDX0_LEIBR

TriTrypDb:

LbrM.25.0230 , LBRM2903_250007500

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HDX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDX0

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016311	dephosphorylation	5	11
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0016310	phosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004721	phosphoprotein phosphatase activity	3	11
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	8	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	7	1
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	7	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	8	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.354
CLV_NRD_NRD_1	187	189	PF00675	0.335
CLV_NRD_NRD_1	227	229	PF00675	0.423
CLV_NRD_NRD_1	45	47	PF00675	0.548
CLV_PCSK_KEX2_1	154	156	PF00082	0.368
CLV_PCSK_KEX2_1	44	46	PF00082	0.464
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.368
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.454
CLV_PCSK_SKI1_1	294	298	PF00082	0.615
DEG_Nend_UBRbox_3	1	3	PF02207	0.644
DOC_CYCLIN_RxL_1	289	299	PF00134	0.464
DOC_MAPK_gen_1	154	161	PF00069	0.265
DOC_MAPK_gen_1	226	234	PF00069	0.320
DOC_MAPK_MEF2A_6	154	163	PF00069	0.330
DOC_MAPK_RevD_3	214	229	PF00069	0.284
DOC_USP7_MATH_1	275	279	PF00917	0.314
DOC_USP7_MATH_1	64	68	PF00917	0.550
DOC_WW_Pin1_4	206	211	PF00397	0.386
LIG_14-3-3_CanoR_1	155	160	PF00244	0.486
LIG_14-3-3_CanoR_1	228	233	PF00244	0.404
LIG_14-3-3_CanoR_1	280	290	PF00244	0.421
LIG_14-3-3_CanoR_1	45	51	PF00244	0.518
LIG_14-3-3_CanoR_1	80	86	PF00244	0.418
LIG_APCC_ABBA_1	191	196	PF00400	0.193
LIG_BRCT_BRCA1_1	7	11	PF00533	0.642
LIG_eIF4E_1	93	99	PF01652	0.365
LIG_FHA_1	113	119	PF00498	0.539
LIG_FHA_1	122	128	PF00498	0.337
LIG_FHA_1	156	162	PF00498	0.398
LIG_FHA_1	229	235	PF00498	0.404
LIG_FHA_2	10	16	PF00498	0.586
LIG_FHA_2	217	223	PF00498	0.193
LIG_FHA_2	31	37	PF00498	0.502
LIG_FHA_2	47	53	PF00498	0.504
LIG_FHA_2	71	77	PF00498	0.519
LIG_LIR_Gen_1	196	203	PF02991	0.341
LIG_LIR_Gen_1	243	251	PF02991	0.233
LIG_LIR_Nem_3	184	190	PF02991	0.281
LIG_LIR_Nem_3	196	200	PF02991	0.251
LIG_PDZ_Class_3	322	327	PF00595	0.438
LIG_Pex14_2	282	286	PF04695	0.341
LIG_SH2_PTP2	197	200	PF00017	0.205
LIG_SH2_STAT3	20	23	PF00017	0.336
LIG_SH2_STAT5	106	109	PF00017	0.461
LIG_SH2_STAT5	197	200	PF00017	0.210
LIG_SH2_STAT5	20	23	PF00017	0.336
LIG_SH2_STAT5	233	236	PF00017	0.271
LIG_SH2_STAT5	250	253	PF00017	0.271
LIG_SH2_STAT5	93	96	PF00017	0.360
LIG_SH3_3	195	201	PF00018	0.284
LIG_SUMO_SIM_anti_2	261	267	PF11976	0.281
LIG_TRAF2_1	12	15	PF00917	0.559
LIG_TRAF2_1	182	185	PF00917	0.284
LIG_TYR_ITIM	195	200	PF00017	0.289
LIG_WRC_WIRS_1	47	52	PF05994	0.412
MOD_CK2_1	216	222	PF00069	0.321
MOD_CK2_1	255	261	PF00069	0.270
MOD_CK2_1	28	34	PF00069	0.482
MOD_CK2_1	46	52	PF00069	0.442
MOD_CK2_1	70	76	PF00069	0.609
MOD_CK2_1	9	15	PF00069	0.609
MOD_GlcNHglycan	140	143	PF01048	0.441
MOD_GlcNHglycan	211	214	PF01048	0.276
MOD_GlcNHglycan	6	10	PF01048	0.683
MOD_GlcNHglycan	66	69	PF01048	0.608
MOD_GSK3_1	1	8	PF00069	0.650
MOD_GSK3_1	133	140	PF00069	0.430
MOD_GSK3_1	202	209	PF00069	0.245
MOD_GSK3_1	292	299	PF00069	0.365
MOD_GSK3_1	30	37	PF00069	0.567
MOD_GSK3_1	64	71	PF00069	0.586
MOD_GSK3_1	94	101	PF00069	0.319
MOD_NEK2_1	202	207	PF00069	0.341
MOD_NEK2_1	216	221	PF00069	0.382
MOD_NEK2_1	290	295	PF00069	0.466
MOD_NEK2_1	296	301	PF00069	0.503
MOD_NEK2_1	94	99	PF00069	0.412
MOD_OFUCOSY	249	254	PF10250	0.378
MOD_PIKK_1	133	139	PF00454	0.442
MOD_PIKK_1	143	149	PF00454	0.414
MOD_PIKK_1	273	279	PF00454	0.316
MOD_PIKK_1	38	44	PF00454	0.558
MOD_PKA_1	228	234	PF00069	0.335
MOD_Plk_1	14	20	PF00069	0.560
MOD_Plk_1	38	44	PF00069	0.488
MOD_Plk_2-3	28	34	PF00069	0.579
MOD_Plk_4	228	234	PF00069	0.390
MOD_Plk_4	46	52	PF00069	0.464
MOD_Plk_4	94	100	PF00069	0.374
MOD_ProDKin_1	206	212	PF00069	0.386
MOD_SUMO_for_1	182	185	PF00179	0.193
MOD_SUMO_rev_2	222	231	PF00179	0.215
TRG_DiLeu_BaEn_1	186	191	PF01217	0.335
TRG_DiLeu_BaEn_1	261	266	PF01217	0.281
TRG_DiLeu_BaEn_1	53	58	PF01217	0.603
TRG_DiLeu_LyEn_5	53	58	PF01217	0.467
TRG_ENDOCYTIC_2	197	200	PF00928	0.289
TRG_ENDOCYTIC_2	47	50	PF00928	0.428
TRG_ER_diArg_1	45	47	PF00400	0.460
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A1	Leptomonas seymouri	64%	100%
A0A0S4JDL0	Bodo saltans	48%	87%
A0A1X0P5C5	Trypanosomatidae	50%	100%
A0A3Q8IF49	Leishmania donovani	82%	100%
A0A3R7ME04	Trypanosoma rangeli	54%	100%
A4I165	Leishmania infantum	82%	100%
E9AX99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QA73	Leishmania major	80%	100%
V5B7P3	Trypanosoma cruzi	53%	96%