MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDW9_LEIBR

TriTrypDb:

LbrM.25.0220 , LBRM2903_250007400

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.548
CLV_C14_Caspase3-7	267	271	PF00656	0.480
CLV_C14_Caspase3-7	38	42	PF00656	0.549
CLV_C14_Caspase3-7	507	511	PF00656	0.485
CLV_NRD_NRD_1	142	144	PF00675	0.670
CLV_NRD_NRD_1	237	239	PF00675	0.560
CLV_NRD_NRD_1	253	255	PF00675	0.561
CLV_NRD_NRD_1	418	420	PF00675	0.464
CLV_NRD_NRD_1	475	477	PF00675	0.463
CLV_PCSK_FUR_1	237	241	PF00082	0.566
CLV_PCSK_KEX2_1	237	239	PF00082	0.560
CLV_PCSK_KEX2_1	262	264	PF00082	0.600
CLV_PCSK_KEX2_1	313	315	PF00082	0.556
CLV_PCSK_KEX2_1	418	420	PF00082	0.464
CLV_PCSK_KEX2_1	447	449	PF00082	0.540
CLV_PCSK_KEX2_1	475	477	PF00082	0.474
CLV_PCSK_KEX2_1	629	631	PF00082	0.609
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.568
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.711
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.556
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.540
CLV_PCSK_PC1ET2_1	629	631	PF00082	0.609
CLV_PCSK_SKI1_1	178	182	PF00082	0.530
CLV_PCSK_SKI1_1	360	364	PF00082	0.454
CLV_PCSK_SKI1_1	37	41	PF00082	0.339
CLV_PCSK_SKI1_1	419	423	PF00082	0.313
CLV_PCSK_SKI1_1	447	451	PF00082	0.516
CLV_PCSK_SKI1_1	55	59	PF00082	0.404
CLV_PCSK_SKI1_1	64	68	PF00082	0.411
CLV_Separin_Metazoa	304	308	PF03568	0.507
DEG_APCC_DBOX_1	237	245	PF00400	0.573
DEG_APCC_DBOX_1	36	44	PF00400	0.325
DEG_APCC_DBOX_1	54	62	PF00400	0.502
DOC_CYCLIN_RxL_1	444	454	PF00134	0.577
DOC_MAPK_gen_1	143	153	PF00069	0.679
DOC_MAPK_gen_1	313	321	PF00069	0.506
DOC_MAPK_gen_1	634	643	PF00069	0.643
DOC_MAPK_gen_1	64	72	PF00069	0.339
DOC_MAPK_MEF2A_6	104	111	PF00069	0.445
DOC_MAPK_MEF2A_6	314	323	PF00069	0.487
DOC_MAPK_MEF2A_6	564	572	PF00069	0.558
DOC_PP2B_LxvP_1	303	306	PF13499	0.523
DOC_PP4_FxxP_1	559	562	PF00568	0.546
DOC_PP4_FxxP_1	609	612	PF00568	0.595
DOC_USP7_MATH_1	400	404	PF00917	0.436
DOC_USP7_MATH_1	516	520	PF00917	0.498
DOC_USP7_MATH_1	90	94	PF00917	0.539
DOC_WW_Pin1_4	364	369	PF00397	0.590
LIG_14-3-3_CanoR_1	143	153	PF00244	0.712
LIG_14-3-3_CanoR_1	173	181	PF00244	0.622
LIG_14-3-3_CanoR_1	343	348	PF00244	0.466
LIG_14-3-3_CanoR_1	418	427	PF00244	0.418
LIG_14-3-3_CanoR_1	448	453	PF00244	0.515
LIG_14-3-3_CanoR_1	550	558	PF00244	0.502
LIG_14-3-3_CanoR_1	569	573	PF00244	0.581
LIG_14-3-3_CanoR_1	634	639	PF00244	0.646
LIG_14-3-3_CanoR_1	91	99	PF00244	0.552
LIG_Actin_RPEL_3	526	545	PF02755	0.520
LIG_AP_GAE_1	596	602	PF02883	0.643
LIG_APCC_ABBA_1	524	529	PF00400	0.505
LIG_BIR_II_1	1	5	PF00653	0.478
LIG_BRCT_BRCA1_1	107	111	PF00533	0.546
LIG_BRCT_BRCA1_1	366	370	PF00533	0.571
LIG_deltaCOP1_diTrp_1	94	99	PF00928	0.452
LIG_FHA_1	164	170	PF00498	0.633
LIG_FHA_1	277	283	PF00498	0.516
LIG_FHA_1	367	373	PF00498	0.462
LIG_FHA_1	420	426	PF00498	0.412
LIG_FHA_1	550	556	PF00498	0.548
LIG_FHA_1	626	632	PF00498	0.587
LIG_FHA_1	661	667	PF00498	0.513
LIG_FHA_2	512	518	PF00498	0.535
LIG_FHA_2	652	658	PF00498	0.590
LIG_FHA_2	90	96	PF00498	0.566
LIG_LIR_Apic_2	608	612	PF02991	0.623
LIG_LIR_Gen_1	287	296	PF02991	0.590
LIG_LIR_Gen_1	361	370	PF02991	0.448
LIG_LIR_Gen_1	657	666	PF02991	0.706
LIG_LIR_Gen_1	93	103	PF02991	0.439
LIG_LIR_Nem_3	287	291	PF02991	0.617
LIG_LIR_Nem_3	295	299	PF02991	0.554
LIG_LIR_Nem_3	355	359	PF02991	0.449
LIG_LIR_Nem_3	361	365	PF02991	0.446
LIG_LIR_Nem_3	367	373	PF02991	0.446
LIG_LIR_Nem_3	482	488	PF02991	0.469
LIG_LIR_Nem_3	575	579	PF02991	0.451
LIG_LIR_Nem_3	657	662	PF02991	0.677
LIG_LIR_Nem_3	93	99	PF02991	0.448
LIG_MAD2	554	562	PF02301	0.412
LIG_Pex14_2	620	624	PF04695	0.619
LIG_SH2_SRC	198	201	PF00017	0.623
LIG_SH2_STAT3	707	710	PF00017	0.556
LIG_SH3_3	197	203	PF00018	0.622
LIG_SH3_3	288	294	PF00018	0.587
LIG_SH3_3	552	558	PF00018	0.502
LIG_SH3_3	559	565	PF00018	0.539
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.433
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.419
LIG_SUMO_SIM_anti_2	98	106	PF11976	0.421
LIG_SUMO_SIM_par_1	448	454	PF11976	0.586
LIG_SUMO_SIM_par_1	611	618	PF11976	0.587
LIG_UBA3_1	119	128	PF00899	0.597
LIG_WW_3	561	565	PF00397	0.553
MOD_CDK_SPxxK_3	364	371	PF00069	0.605
MOD_CK1_1	105	111	PF00069	0.549
MOD_CK1_1	14	20	PF00069	0.605
MOD_CK1_1	193	199	PF00069	0.739
MOD_CK1_1	342	348	PF00069	0.527
MOD_CK1_1	618	624	PF00069	0.701
MOD_CK2_1	448	454	PF00069	0.586
MOD_CK2_1	590	596	PF00069	0.615
MOD_CK2_1	597	603	PF00069	0.634
MOD_CK2_1	651	657	PF00069	0.612
MOD_CK2_1	89	95	PF00069	0.580
MOD_GlcNHglycan	131	134	PF01048	0.763
MOD_GlcNHglycan	276	279	PF01048	0.741
MOD_GlcNHglycan	3	6	PF01048	0.573
MOD_GlcNHglycan	49	52	PF01048	0.576
MOD_GlcNHglycan	669	672	PF01048	0.743
MOD_GlcNHglycan	690	693	PF01048	0.774
MOD_GSK3_1	107	114	PF00069	0.476
MOD_GSK3_1	11	18	PF00069	0.549
MOD_GSK3_1	129	136	PF00069	0.579
MOD_GSK3_1	145	152	PF00069	0.690
MOD_GSK3_1	158	165	PF00069	0.602
MOD_GSK3_1	190	197	PF00069	0.756
MOD_GSK3_1	272	279	PF00069	0.743
MOD_GSK3_1	339	346	PF00069	0.428
MOD_GSK3_1	43	50	PF00069	0.521
MOD_GSK3_1	98	105	PF00069	0.500
MOD_NEK2_1	1	6	PF00069	0.458
MOD_NEK2_1	102	107	PF00069	0.424
MOD_NEK2_1	111	116	PF00069	0.429
MOD_NEK2_1	158	163	PF00069	0.637
MOD_NEK2_1	190	195	PF00069	0.645
MOD_NEK2_1	43	48	PF00069	0.465
MOD_NEK2_1	442	447	PF00069	0.301
MOD_NEK2_1	479	484	PF00069	0.537
MOD_NEK2_1	662	667	PF00069	0.736
MOD_PIKK_1	17	23	PF00454	0.442
MOD_PIKK_1	185	191	PF00454	0.610
MOD_PIKK_1	649	655	PF00454	0.606
MOD_PKA_2	129	135	PF00069	0.624
MOD_PKA_2	145	151	PF00069	0.678
MOD_PKA_2	158	164	PF00069	0.565
MOD_PKA_2	172	178	PF00069	0.643
MOD_PKA_2	342	348	PF00069	0.435
MOD_PKA_2	549	555	PF00069	0.489
MOD_PKA_2	568	574	PF00069	0.541
MOD_PKA_2	625	631	PF00069	0.585
MOD_PKA_2	90	96	PF00069	0.566
MOD_PKB_1	263	271	PF00069	0.698
MOD_PKB_1	476	484	PF00069	0.613
MOD_Plk_1	286	292	PF00069	0.679
MOD_Plk_1	390	396	PF00069	0.615
MOD_Plk_1	43	49	PF00069	0.545
MOD_Plk_1	516	522	PF00069	0.483
MOD_Plk_2-3	590	596	PF00069	0.620
MOD_Plk_2-3	597	603	PF00069	0.626
MOD_Plk_4	111	117	PF00069	0.395
MOD_Plk_4	615	621	PF00069	0.638
MOD_Plk_4	98	104	PF00069	0.464
MOD_ProDKin_1	364	370	PF00069	0.579
MOD_SUMO_rev_2	125	129	PF00179	0.680
MOD_SUMO_rev_2	172	180	PF00179	0.711
MOD_SUMO_rev_2	625	631	PF00179	0.585
TRG_DiLeu_BaEn_1	176	181	PF01217	0.496
TRG_DiLeu_BaEn_2	574	580	PF01217	0.466
TRG_DiLeu_BaEn_2	94	100	PF01217	0.542
TRG_ENDOCYTIC_2	293	296	PF00928	0.617
TRG_ENDOCYTIC_2	576	579	PF00928	0.452
TRG_ENDOCYTIC_2	659	662	PF00928	0.685
TRG_ER_diArg_1	237	240	PF00400	0.562
TRG_ER_diArg_1	406	409	PF00400	0.436
TRG_ER_diArg_1	474	476	PF00400	0.448
TRG_ER_diArg_1	684	687	PF00400	0.711
TRG_ER_diArg_1	709	712	PF00400	0.772
TRG_NES_CRM1_1	113	126	PF08389	0.614
TRG_NLS_MonoExtC_3	237	242	PF00514	0.567
TRG_NLS_MonoExtC_3	261	267	PF00514	0.716
TRG_NLS_MonoExtN_4	140	147	PF00514	0.508
TRG_NLS_MonoExtN_4	237	242	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	645	650	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I765	Leptomonas seymouri	79%	100%
A0A0S4JHQ3	Bodo saltans	41%	82%
A0A1X0P4I5	Trypanosomatidae	59%	100%
A0A3S7WYX6	Leishmania donovani	88%	100%
A0A422NF47	Trypanosoma rangeli	59%	100%
A4I164	Leishmania infantum	88%	100%
D0A5F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AX98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QA74	Leishmania major	88%	100%
V5DPB1	Trypanosoma cruzi	58%	100%