Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania braziliensis

UniProt:

A4HDW6_LEIBR

TriTrypDb:

LbrM.25.0190 , LBRM2903_250007100

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDW6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901575	organic substance catabolic process	3	11
GO:0016579	protein deubiquitination	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004843	cysteine-type deubiquitinase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008234	cysteine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0019783	ubiquitin-like protein peptidase activity	4	11
GO:0101005	deubiquitinase activity	5	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.391
CLV_C14_Caspase3-7	197	201	PF00656	0.421
CLV_NRD_NRD_1	187	189	PF00675	0.316
CLV_NRD_NRD_1	78	80	PF00675	0.219
CLV_PCSK_KEX2_1	144	146	PF00082	0.176
CLV_PCSK_KEX2_1	61	63	PF00082	0.388
CLV_PCSK_KEX2_1	78	80	PF00082	0.388
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.176
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.306
CLV_PCSK_SKI1_1	215	219	PF00082	0.231
CLV_PCSK_SKI1_1	82	86	PF00082	0.433
DEG_Nend_Nbox_1	1	3	PF02207	0.388
DOC_MAPK_gen_1	78	85	PF00069	0.176
DOC_PP1_RVXF_1	23	29	PF00149	0.275
DOC_PP1_RVXF_1	80	86	PF00149	0.176
DOC_USP7_MATH_1	4	8	PF00917	0.291
DOC_USP7_UBL2_3	134	138	PF12436	0.260
DOC_WW_Pin1_4	41	46	PF00397	0.382
LIG_14-3-3_CanoR_1	14	21	PF00244	0.333
LIG_14-3-3_CanoR_1	82	91	PF00244	0.234
LIG_CSL_BTD_1	1	4	PF09270	0.336
LIG_EH1_1	224	232	PF00400	0.495
LIG_FHA_1	200	206	PF00498	0.181
LIG_FHA_1	226	232	PF00498	0.540
LIG_FHA_1	94	100	PF00498	0.220
LIG_SH2_STAT5	15	18	PF00017	0.257
LIG_SH3_3	39	45	PF00018	0.259
LIG_SUMO_SIM_anti_2	96	101	PF11976	0.271
LIG_TRAF2_1	153	156	PF00917	0.336
LIG_TRAF2_1	211	214	PF00917	0.380
MOD_Cter_Amidation	186	189	PF01082	0.313
MOD_GlcNHglycan	120	123	PF01048	0.333
MOD_GlcNHglycan	16	19	PF01048	0.415
MOD_GSK3_1	114	121	PF00069	0.250
MOD_GSK3_1	52	59	PF00069	0.193
MOD_N-GLC_1	200	205	PF02516	0.333
MOD_N-GLC_2	92	94	PF02516	0.257
MOD_NEK2_1	225	230	PF00069	0.539
MOD_PIKK_1	83	89	PF00454	0.176
MOD_Plk_1	127	133	PF00069	0.176
MOD_Plk_1	199	205	PF00069	0.337
MOD_Plk_4	114	120	PF00069	0.344
MOD_Plk_4	200	206	PF00069	0.272
MOD_ProDKin_1	41	47	PF00069	0.382
MOD_SUMO_rev_2	128	136	PF00179	0.200
MOD_SUMO_rev_2	17	26	PF00179	0.435
TRG_DiLeu_BaEn_4	72	78	PF01217	0.260
TRG_ER_diArg_1	77	79	PF00400	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E1	Leptomonas seymouri	65%	99%
A0A0N1I1H5	Leptomonas seymouri	28%	76%
A0A0S4J7R4	Bodo saltans	22%	75%
A0A0S4JHD6	Bodo saltans	47%	99%
A0A1X0P4J5	Trypanosomatidae	42%	99%
A0A3Q8IGE5	Leishmania donovani	77%	100%
A0A3S7WY30	Leishmania donovani	26%	76%
A4HD98	Leishmania braziliensis	25%	100%
A4I161	Leishmania infantum	78%	100%
D0A5E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	99%
D0A712	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	75%
E9AH53	Leishmania infantum	26%	76%
E9AWN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	76%
E9AX95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
O01391	Aplysia californica	35%	100%
P09936	Homo sapiens	34%	100%
P15374	Homo sapiens	36%	100%
P23356	Bos taurus	29%	92%
P35122	Drosophila melanogaster	36%	100%
P35127	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	99%
P50103	Monodelphis domestica	35%	100%
P58321	Mus musculus	34%	100%
Q00981	Rattus norvegicus	33%	100%
Q06AB3	Sus scrofa	36%	100%
Q06AT3	Sus scrofa	24%	71%
Q09444	Caenorhabditis elegans	23%	73%
Q10171	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q2TBG8	Bos taurus	36%	100%
Q4QA77	Leishmania major	78%	100%
Q4QAT9	Leishmania major	26%	100%
Q54N38	Dictyostelium discoideum	24%	68%
Q54T48	Dictyostelium discoideum	31%	91%
Q60HC8	Macaca fascicularis	34%	100%
Q6SEG5	Sus scrofa	33%	100%
Q8GWE1	Arabidopsis thaliana	38%	100%
Q8IKM8	Plasmodium falciparum (isolate 3D7)	34%	100%
Q91Y78	Rattus norvegicus	36%	100%
Q9FFF2	Arabidopsis thaliana	24%	70%
Q9GM50	Equus caballus	33%	100%
Q9JKB1	Mus musculus	36%	100%
Q9R0P9	Mus musculus	33%	100%
Q9UUB6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	78%
Q9WUP7	Mus musculus	23%	71%
Q9XSJ0	Bos taurus	24%	71%
Q9Y5K5	Homo sapiens	24%	71%
V5BN93	Trypanosoma cruzi	44%	99%