Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDW5_LEIBR

TriTrypDb:

LbrM.25.0180 , LBRM2903_250007000

Length:

1049

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDW5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	920	924	PF00656	0.346
CLV_NRD_NRD_1	14	16	PF00675	0.611
CLV_NRD_NRD_1	219	221	PF00675	0.379
CLV_NRD_NRD_1	344	346	PF00675	0.391
CLV_NRD_NRD_1	534	536	PF00675	0.498
CLV_NRD_NRD_1	557	559	PF00675	0.335
CLV_NRD_NRD_1	607	609	PF00675	0.389
CLV_NRD_NRD_1	976	978	PF00675	0.493
CLV_PCSK_KEX2_1	14	16	PF00082	0.611
CLV_PCSK_KEX2_1	219	221	PF00082	0.379
CLV_PCSK_KEX2_1	344	346	PF00082	0.310
CLV_PCSK_KEX2_1	557	559	PF00082	0.318
CLV_PCSK_KEX2_1	881	883	PF00082	0.344
CLV_PCSK_KEX2_1	978	980	PF00082	0.541
CLV_PCSK_PC1ET2_1	881	883	PF00082	0.344
CLV_PCSK_PC1ET2_1	978	980	PF00082	0.541
CLV_PCSK_SKI1_1	159	163	PF00082	0.497
CLV_PCSK_SKI1_1	219	223	PF00082	0.417
CLV_PCSK_SKI1_1	298	302	PF00082	0.440
CLV_PCSK_SKI1_1	340	344	PF00082	0.377
CLV_PCSK_SKI1_1	345	349	PF00082	0.372
CLV_PCSK_SKI1_1	435	439	PF00082	0.547
CLV_PCSK_SKI1_1	462	466	PF00082	0.432
CLV_PCSK_SKI1_1	48	52	PF00082	0.547
CLV_PCSK_SKI1_1	892	896	PF00082	0.428
DEG_COP1_1	255	267	PF00400	0.310
DEG_Nend_Nbox_1	1	3	PF02207	0.562
DOC_CYCLIN_RxL_1	154	166	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.484
DOC_MAPK_gen_1	322	330	PF00069	0.442
DOC_MAPK_gen_1	51	60	PF00069	0.502
DOC_MAPK_MEF2A_6	154	162	PF00069	0.417
DOC_MAPK_MEF2A_6	324	332	PF00069	0.449
DOC_MAPK_MEF2A_6	371	380	PF00069	0.369
DOC_MAPK_MEF2A_6	54	62	PF00069	0.523
DOC_PP2B_LxvP_1	122	125	PF13499	0.492
DOC_PP2B_LxvP_1	330	333	PF13499	0.426
DOC_PP2B_LxvP_1	718	721	PF13499	0.431
DOC_PP2B_PxIxI_1	998	1004	PF00149	0.287
DOC_PP4_FxxP_1	913	916	PF00568	0.564
DOC_USP7_MATH_1	1024	1028	PF00917	0.644
DOC_USP7_MATH_1	1042	1046	PF00917	0.508
DOC_USP7_MATH_1	234	238	PF00917	0.535
DOC_USP7_MATH_1	253	257	PF00917	0.341
DOC_USP7_MATH_1	291	295	PF00917	0.519
DOC_USP7_MATH_1	399	403	PF00917	0.316
DOC_USP7_MATH_1	443	447	PF00917	0.580
DOC_USP7_MATH_1	521	525	PF00917	0.589
DOC_USP7_MATH_1	595	599	PF00917	0.389
DOC_USP7_MATH_1	635	639	PF00917	0.604
DOC_USP7_MATH_1	649	653	PF00917	0.381
DOC_USP7_MATH_1	675	679	PF00917	0.423
DOC_USP7_MATH_1	707	711	PF00917	0.518
DOC_USP7_MATH_1	761	765	PF00917	0.425
DOC_USP7_MATH_1	917	921	PF00917	0.340
DOC_USP7_MATH_1	971	975	PF00917	0.481
DOC_WW_Pin1_4	1	6	PF00397	0.536
DOC_WW_Pin1_4	1012	1017	PF00397	0.599
DOC_WW_Pin1_4	1020	1025	PF00397	0.697
DOC_WW_Pin1_4	113	118	PF00397	0.741
DOC_WW_Pin1_4	124	129	PF00397	0.527
DOC_WW_Pin1_4	265	270	PF00397	0.574
DOC_WW_Pin1_4	323	328	PF00397	0.478
DOC_WW_Pin1_4	449	454	PF00397	0.388
DOC_WW_Pin1_4	571	576	PF00397	0.390
DOC_WW_Pin1_4	721	726	PF00397	0.399
DOC_WW_Pin1_4	757	762	PF00397	0.382
DOC_WW_Pin1_4	790	795	PF00397	0.569
DOC_WW_Pin1_4	912	917	PF00397	0.568
LIG_14-3-3_CanoR_1	1035	1043	PF00244	0.417
LIG_14-3-3_CanoR_1	112	117	PF00244	0.639
LIG_14-3-3_CanoR_1	138	147	PF00244	0.516
LIG_14-3-3_CanoR_1	14	21	PF00244	0.615
LIG_14-3-3_CanoR_1	163	170	PF00244	0.679
LIG_14-3-3_CanoR_1	31	40	PF00244	0.571
LIG_14-3-3_CanoR_1	322	327	PF00244	0.600
LIG_14-3-3_CanoR_1	442	451	PF00244	0.384
LIG_14-3-3_CanoR_1	467	473	PF00244	0.463
LIG_14-3-3_CanoR_1	535	544	PF00244	0.508
LIG_14-3-3_CanoR_1	557	561	PF00244	0.313
LIG_14-3-3_CanoR_1	59	69	PF00244	0.470
LIG_14-3-3_CanoR_1	788	794	PF00244	0.316
LIG_14-3-3_CanoR_1	854	863	PF00244	0.549
LIG_14-3-3_CanoR_1	957	961	PF00244	0.405
LIG_Actin_WH2_2	33	50	PF00022	0.457
LIG_Actin_WH2_2	98	114	PF00022	0.581
LIG_AP2alpha_1	420	424	PF02296	0.436
LIG_AP2alpha_2	599	601	PF02296	0.371
LIG_APCC_ABBA_1	147	152	PF00400	0.345
LIG_APCC_ABBA_1	247	252	PF00400	0.272
LIG_BIR_III_2	448	452	PF00653	0.542
LIG_BIR_III_2	722	726	PF00653	0.363
LIG_BIR_III_4	570	574	PF00653	0.488
LIG_BIR_III_4	666	670	PF00653	0.507
LIG_BRCT_BRCA1_1	255	259	PF00533	0.457
LIG_BRCT_BRCA1_1	3	7	PF00533	0.586
LIG_BRCT_BRCA1_1	597	601	PF00533	0.417
LIG_BRCT_BRCA1_1	791	795	PF00533	0.346
LIG_BRCT_BRCA1_1	909	913	PF00533	0.394
LIG_CaM_IQ_9	37	53	PF13499	0.534
LIG_Clathr_ClatBox_1	862	866	PF01394	0.479
LIG_deltaCOP1_diTrp_1	252	259	PF00928	0.286
LIG_deltaCOP1_diTrp_1	858	865	PF00928	0.409
LIG_EH_1	775	779	PF12763	0.443
LIG_eIF4E_1	155	161	PF01652	0.473
LIG_FHA_1	113	119	PF00498	0.667
LIG_FHA_1	121	127	PF00498	0.565
LIG_FHA_1	193	199	PF00498	0.593
LIG_FHA_1	239	245	PF00498	0.634
LIG_FHA_1	381	387	PF00498	0.473
LIG_FHA_1	405	411	PF00498	0.564
LIG_FHA_1	474	480	PF00498	0.496
LIG_FHA_1	55	61	PF00498	0.414
LIG_FHA_1	700	706	PF00498	0.448
LIG_FHA_1	740	746	PF00498	0.476
LIG_FHA_1	791	797	PF00498	0.424
LIG_FHA_2	1017	1023	PF00498	0.551
LIG_FHA_2	130	136	PF00498	0.517
LIG_FHA_2	305	311	PF00498	0.437
LIG_FHA_2	442	448	PF00498	0.487
LIG_FHA_2	482	488	PF00498	0.365
LIG_FHA_2	758	764	PF00498	0.286
LIG_FHA_2	95	101	PF00498	0.495
LIG_GBD_Chelix_1	190	198	PF00786	0.346
LIG_LIR_Apic_2	910	916	PF02991	0.476
LIG_LIR_Gen_1	598	607	PF02991	0.479
LIG_LIR_Gen_1	857	865	PF02991	0.415
LIG_LIR_Nem_3	152	158	PF02991	0.411
LIG_LIR_Nem_3	387	393	PF02991	0.448
LIG_LIR_Nem_3	418	423	PF02991	0.488
LIG_LIR_Nem_3	598	604	PF02991	0.467
LIG_LIR_Nem_3	857	863	PF02991	0.443
LIG_LYPXL_yS_3	155	158	PF13949	0.459
LIG_NBox_RRM_1	795	805	PF00076	0.261
LIG_NRBOX	157	163	PF00104	0.329
LIG_NRBOX	296	302	PF00104	0.442
LIG_NRBOX	342	348	PF00104	0.371
LIG_NRBOX	683	689	PF00104	0.258
LIG_PAM2_1	245	257	PF00658	0.366
LIG_Pex14_1	90	94	PF04695	0.493
LIG_Pex14_2	390	394	PF04695	0.324
LIG_Pex14_2	420	424	PF04695	0.360
LIG_SH2_SRC	250	253	PF00017	0.362
LIG_SH2_STAP1	1032	1036	PF00017	0.452
LIG_SH2_STAP1	250	254	PF00017	0.473
LIG_SH2_STAT3	503	506	PF00017	0.296
LIG_SH2_STAT5	214	217	PF00017	0.326
LIG_SH2_STAT5	503	506	PF00017	0.453
LIG_SH2_STAT5	654	657	PF00017	0.488
LIG_SH2_STAT5	752	755	PF00017	0.350
LIG_SH2_STAT5	785	788	PF00017	0.257
LIG_SH2_STAT5	968	971	PF00017	0.413
LIG_SH2_STAT5	993	996	PF00017	0.483
LIG_SH3_3	114	120	PF00018	0.601
LIG_SH3_3	122	128	PF00018	0.582
LIG_SH3_3	447	453	PF00018	0.390
LIG_SUMO_SIM_anti_2	240	248	PF11976	0.440
LIG_SUMO_SIM_par_1	132	137	PF11976	0.554
LIG_SUMO_SIM_par_1	405	412	PF11976	0.539
LIG_SUMO_SIM_par_1	670	676	PF11976	0.412
LIG_SUMO_SIM_par_1	715	722	PF11976	0.417
LIG_TRAF2_1	690	693	PF00917	0.308
LIG_TRAF2_2	453	458	PF00917	0.365
LIG_TYR_ITIM	348	353	PF00017	0.415
LIG_WRC_WIRS_1	862	867	PF05994	0.330
MOD_CDC14_SPxK_1	915	918	PF00782	0.345
MOD_CDK_SPxK_1	1020	1026	PF00069	0.675
MOD_CDK_SPxK_1	912	918	PF00069	0.327
MOD_CK1_1	1020	1026	PF00069	0.571
MOD_CK1_1	16	22	PF00069	0.607
MOD_CK1_1	237	243	PF00069	0.670
MOD_CK1_1	245	251	PF00069	0.434
MOD_CK1_1	284	290	PF00069	0.508
MOD_CK1_1	402	408	PF00069	0.522
MOD_CK1_1	699	705	PF00069	0.453
MOD_CK1_1	708	714	PF00069	0.524
MOD_CK1_1	771	777	PF00069	0.555
MOD_CK1_1	871	877	PF00069	0.510
MOD_CK1_1	906	912	PF00069	0.522
MOD_CK2_1	1016	1022	PF00069	0.596
MOD_CK2_1	1024	1030	PF00069	0.546
MOD_CK2_1	1038	1044	PF00069	0.607
MOD_CK2_1	304	310	PF00069	0.502
MOD_CK2_1	403	409	PF00069	0.391
MOD_CK2_1	481	487	PF00069	0.368
MOD_CK2_1	621	627	PF00069	0.511
MOD_CK2_1	687	693	PF00069	0.324
MOD_CK2_1	757	763	PF00069	0.286
MOD_CK2_1	94	100	PF00069	0.510
MOD_Cter_Amidation	533	536	PF01082	0.435
MOD_Cter_Amidation	879	882	PF01082	0.342
MOD_GlcNHglycan	1019	1022	PF01048	0.607
MOD_GlcNHglycan	1040	1043	PF01048	0.493
MOD_GlcNHglycan	1046	1049	PF01048	0.481
MOD_GlcNHglycan	165	168	PF01048	0.629
MOD_GlcNHglycan	178	181	PF01048	0.525
MOD_GlcNHglycan	226	229	PF01048	0.489
MOD_GlcNHglycan	23	26	PF01048	0.559
MOD_GlcNHglycan	365	368	PF01048	0.536
MOD_GlcNHglycan	570	574	PF01048	0.396
MOD_GlcNHglycan	616	619	PF01048	0.555
MOD_GlcNHglycan	763	766	PF01048	0.463
MOD_GlcNHglycan	878	881	PF01048	0.412
MOD_GlcNHglycan	919	922	PF01048	0.356
MOD_GlcNHglycan	973	976	PF01048	0.479
MOD_GSK3_1	1012	1019	PF00069	0.536
MOD_GSK3_1	1020	1027	PF00069	0.518
MOD_GSK3_1	1034	1041	PF00069	0.398
MOD_GSK3_1	1042	1049	PF00069	0.543
MOD_GSK3_1	120	127	PF00069	0.739
MOD_GSK3_1	13	20	PF00069	0.577
MOD_GSK3_1	134	141	PF00069	0.645
MOD_GSK3_1	170	177	PF00069	0.519
MOD_GSK3_1	233	240	PF00069	0.622
MOD_GSK3_1	253	260	PF00069	0.474
MOD_GSK3_1	281	288	PF00069	0.535
MOD_GSK3_1	399	406	PF00069	0.503
MOD_GSK3_1	437	444	PF00069	0.399
MOD_GSK3_1	489	496	PF00069	0.336
MOD_GSK3_1	614	621	PF00069	0.445
MOD_GSK3_1	635	642	PF00069	0.500
MOD_GSK3_1	696	703	PF00069	0.726
MOD_GSK3_1	721	728	PF00069	0.405
MOD_GSK3_1	757	764	PF00069	0.447
MOD_GSK3_1	876	883	PF00069	0.454
MOD_GSK3_1	90	97	PF00069	0.577
MOD_GSK3_1	903	910	PF00069	0.485
MOD_GSK3_1	956	963	PF00069	0.386
MOD_N-GLC_1	1016	1021	PF02516	0.587
MOD_N-GLC_1	468	473	PF02516	0.442
MOD_N-GLC_1	481	486	PF02516	0.341
MOD_N-GLC_1	511	516	PF02516	0.485
MOD_N-GLC_1	635	640	PF02516	0.360
MOD_NEK2_1	1043	1048	PF00069	0.485
MOD_NEK2_1	111	116	PF00069	0.550
MOD_NEK2_1	13	18	PF00069	0.607
MOD_NEK2_1	162	167	PF00069	0.487
MOD_NEK2_1	170	175	PF00069	0.549
MOD_NEK2_1	190	195	PF00069	0.308
MOD_NEK2_1	21	26	PF00069	0.501
MOD_NEK2_1	238	243	PF00069	0.452
MOD_NEK2_1	285	290	PF00069	0.511
MOD_NEK2_1	365	370	PF00069	0.529
MOD_NEK2_1	378	383	PF00069	0.377
MOD_NEK2_1	639	644	PF00069	0.426
MOD_NEK2_1	687	692	PF00069	0.475
MOD_NEK2_1	739	744	PF00069	0.355
MOD_NEK2_1	94	99	PF00069	0.553
MOD_NEK2_2	415	420	PF00069	0.409
MOD_NEK2_2	649	654	PF00069	0.343
MOD_PIKK_1	170	176	PF00454	0.555
MOD_PIKK_1	497	503	PF00454	0.346
MOD_PIKK_1	830	836	PF00454	0.414
MOD_PK_1	315	321	PF00069	0.422
MOD_PKA_1	978	984	PF00069	0.447
MOD_PKA_2	1034	1040	PF00069	0.375
MOD_PKA_2	111	117	PF00069	0.637
MOD_PKA_2	13	19	PF00069	0.680
MOD_PKA_2	162	168	PF00069	0.553
MOD_PKA_2	199	205	PF00069	0.557
MOD_PKA_2	441	447	PF00069	0.492
MOD_PKA_2	556	562	PF00069	0.310
MOD_PKA_2	630	636	PF00069	0.498
MOD_PKA_2	699	705	PF00069	0.453
MOD_PKA_2	771	777	PF00069	0.587
MOD_PKA_2	903	909	PF00069	0.457
MOD_PKA_2	917	923	PF00069	0.522
MOD_PKA_2	956	962	PF00069	0.342
MOD_PKA_2	978	984	PF00069	0.580
MOD_Plk_1	134	140	PF00069	0.616
MOD_Plk_1	272	278	PF00069	0.490
MOD_Plk_1	468	474	PF00069	0.462
MOD_Plk_1	622	628	PF00069	0.582
MOD_Plk_1	700	706	PF00069	0.473
MOD_Plk_1	708	714	PF00069	0.360
MOD_Plk_1	871	877	PF00069	0.398
MOD_Plk_4	129	135	PF00069	0.536
MOD_Plk_4	210	216	PF00069	0.398
MOD_Plk_4	242	248	PF00069	0.508
MOD_Plk_4	3	9	PF00069	0.546
MOD_Plk_4	415	421	PF00069	0.414
MOD_Plk_4	468	474	PF00069	0.534
MOD_Plk_4	493	499	PF00069	0.290
MOD_Plk_4	635	641	PF00069	0.552
MOD_Plk_4	701	707	PF00069	0.525
MOD_Plk_4	708	714	PF00069	0.515
MOD_Plk_4	748	754	PF00069	0.321
MOD_Plk_4	79	85	PF00069	0.625
MOD_Plk_4	909	915	PF00069	0.522
MOD_Plk_4	956	962	PF00069	0.317
MOD_ProDKin_1	1	7	PF00069	0.537
MOD_ProDKin_1	1012	1018	PF00069	0.607
MOD_ProDKin_1	1020	1026	PF00069	0.700
MOD_ProDKin_1	113	119	PF00069	0.744
MOD_ProDKin_1	124	130	PF00069	0.523
MOD_ProDKin_1	265	271	PF00069	0.569
MOD_ProDKin_1	323	329	PF00069	0.479
MOD_ProDKin_1	449	455	PF00069	0.385
MOD_ProDKin_1	571	577	PF00069	0.398
MOD_ProDKin_1	721	727	PF00069	0.397
MOD_ProDKin_1	757	763	PF00069	0.395
MOD_ProDKin_1	790	796	PF00069	0.565
MOD_ProDKin_1	912	918	PF00069	0.572
MOD_SUMO_for_1	205	208	PF00179	0.516
MOD_SUMO_rev_2	539	544	PF00179	0.387
MOD_SUMO_rev_2	842	851	PF00179	0.292
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.377
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.253
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.302
TRG_DiLeu_LyEn_5	71	76	PF01217	0.396
TRG_ENDOCYTIC_2	155	158	PF00928	0.459
TRG_ENDOCYTIC_2	350	353	PF00928	0.418
TRG_ER_diArg_1	13	15	PF00400	0.652
TRG_ER_diArg_1	218	220	PF00400	0.467
TRG_ER_diArg_1	343	345	PF00400	0.356
TRG_ER_diArg_1	976	979	PF00400	0.488
TRG_NES_CRM1_1	363	375	PF08389	0.455
TRG_NLS_MonoExtC_3	534	540	PF00514	0.512
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	582	586	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM25	Leptomonas seymouri	43%	98%
A0A1X0P4U5	Trypanosomatidae	26%	96%
A0A3S5IR32	Trypanosoma rangeli	28%	100%
A0A3S7WYR4	Leishmania donovani	74%	100%
A4I160	Leishmania infantum	74%	100%
D0A5E5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AX94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QA78	Leishmania major	73%	100%
V5B7P7	Trypanosoma cruzi	27%	100%