Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDW3_LEIBR

TriTrypDb:

LbrM.25.0160 , LBRM2903_250006800

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.548
CLV_NRD_NRD_1	154	156	PF00675	0.634
CLV_NRD_NRD_1	179	181	PF00675	0.519
CLV_NRD_NRD_1	39	41	PF00675	0.616
CLV_PCSK_FUR_1	37	41	PF00082	0.609
CLV_PCSK_KEX2_1	154	156	PF00082	0.634
CLV_PCSK_KEX2_1	39	41	PF00082	0.617
CLV_PCSK_SKI1_1	133	137	PF00082	0.493
CLV_PCSK_SKI1_1	154	158	PF00082	0.632
CLV_PCSK_SKI1_1	82	86	PF00082	0.553
CLV_Separin_Metazoa	34	38	PF03568	0.595
DOC_MAPK_gen_1	133	141	PF00069	0.491
DOC_USP7_MATH_1	104	108	PF00917	0.555
DOC_USP7_MATH_1	148	152	PF00917	0.504
DOC_USP7_MATH_1	41	45	PF00917	0.651
DOC_WW_Pin1_4	108	113	PF00397	0.552
DOC_WW_Pin1_4	209	214	PF00397	0.643
LIG_14-3-3_CanoR_1	113	121	PF00244	0.425
LIG_14-3-3_CanoR_1	203	209	PF00244	0.613
LIG_Actin_WH2_2	24	41	PF00022	0.570
LIG_BIR_II_1	1	5	PF00653	0.519
LIG_BIR_III_1	1	5	PF00653	0.389
LIG_BIR_III_3	1	5	PF00653	0.608
LIG_BRCT_BRCA1_1	106	110	PF00533	0.586
LIG_Clathr_ClatBox_1	9	13	PF01394	0.479
LIG_FHA_1	124	130	PF00498	0.486
LIG_FHA_1	65	71	PF00498	0.692
LIG_LIR_Gen_1	179	189	PF02991	0.559
LIG_LIR_Gen_1	83	93	PF02991	0.488
LIG_LIR_Nem_3	179	185	PF02991	0.541
LIG_LIR_Nem_3	83	88	PF02991	0.488
LIG_NRBOX	87	93	PF00104	0.419
LIG_SH3_1	51	57	PF00018	0.503
LIG_SH3_3	205	211	PF00018	0.642
LIG_SH3_3	51	57	PF00018	0.631
LIG_SH3_3	58	64	PF00018	0.671
LIG_SUMO_SIM_anti_2	6	11	PF11976	0.394
LIG_SUMO_SIM_par_1	6	11	PF11976	0.540
LIG_TYR_ITIM	173	178	PF00017	0.335
MOD_CDC14_SPxK_1	212	215	PF00782	0.470
MOD_CDK_SPK_2	108	113	PF00069	0.573
MOD_CDK_SPxK_1	209	215	PF00069	0.459
MOD_GlcNHglycan	115	118	PF01048	0.440
MOD_GlcNHglycan	75	78	PF01048	0.522
MOD_GSK3_1	104	111	PF00069	0.510
MOD_GSK3_1	113	120	PF00069	0.351
MOD_NEK2_2	41	46	PF00069	0.408
MOD_PIKK_1	22	28	PF00454	0.614
MOD_Plk_1	104	110	PF00069	0.489
MOD_Plk_1	117	123	PF00069	0.615
MOD_Plk_1	41	47	PF00069	0.666
MOD_Plk_4	41	47	PF00069	0.666
MOD_ProDKin_1	108	114	PF00069	0.554
MOD_ProDKin_1	209	215	PF00069	0.650
TRG_DiLeu_BaEn_4	130	136	PF01217	0.586
TRG_ENDOCYTIC_2	175	178	PF00928	0.578
TRG_ENDOCYTIC_2	182	185	PF00928	0.543
TRG_ER_diArg_1	153	155	PF00400	0.640
TRG_ER_diArg_1	36	39	PF00400	0.608
TRG_ER_diArg_1	98	101	PF00400	0.594
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM96	Leptomonas seymouri	49%	96%
A0A1X0P602	Trypanosomatidae	32%	69%
A0A3Q8ID59	Leishmania donovani	74%	100%
A0A422NF37	Trypanosoma rangeli	35%	69%
A4I158	Leishmania infantum	74%	100%
D0A5E3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	68%
E9AX92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QA80	Leishmania major	74%	100%
V5BXK9	Trypanosoma cruzi	33%	69%