Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDW2_LEIBR

TriTrypDb:

LbrM.25.0150 , LBRM2903_250006700

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.268
CLV_C14_Caspase3-7	2	6	PF00656	0.474
CLV_C14_Caspase3-7	45	49	PF00656	0.476
CLV_NRD_NRD_1	101	103	PF00675	0.588
CLV_NRD_NRD_1	243	245	PF00675	0.591
CLV_NRD_NRD_1	298	300	PF00675	0.504
CLV_NRD_NRD_1	493	495	PF00675	0.374
CLV_NRD_NRD_1	518	520	PF00675	0.377
CLV_NRD_NRD_1	97	99	PF00675	0.539
CLV_PCSK_FUR_1	98	102	PF00082	0.591
CLV_PCSK_KEX2_1	243	245	PF00082	0.591
CLV_PCSK_KEX2_1	298	300	PF00082	0.504
CLV_PCSK_KEX2_1	493	495	PF00082	0.346
CLV_PCSK_KEX2_1	518	520	PF00082	0.377
CLV_PCSK_KEX2_1	99	101	PF00082	0.567
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.627
CLV_PCSK_SKI1_1	186	190	PF00082	0.583
CLV_PCSK_SKI1_1	451	455	PF00082	0.362
CLV_PCSK_SKI1_1	503	507	PF00082	0.420
CLV_PCSK_SKI1_1	555	559	PF00082	0.397
CLV_PCSK_SKI1_1	674	678	PF00082	0.595
CLV_Separin_Metazoa	200	204	PF03568	0.336
DEG_APCC_DBOX_1	185	193	PF00400	0.376
DEG_APCC_DBOX_1	197	205	PF00400	0.262
DEG_Nend_UBRbox_2	1	3	PF02207	0.489
DOC_CKS1_1	683	688	PF01111	0.334
DOC_CYCLIN_RxL_1	183	190	PF00134	0.292
DOC_CYCLIN_RxL_1	448	458	PF00134	0.558
DOC_CYCLIN_RxL_1	500	509	PF00134	0.517
DOC_CYCLIN_yClb5_NLxxxL_5	485	491	PF00134	0.508
DOC_MAPK_gen_1	518	528	PF00069	0.577
DOC_MAPK_MEF2A_6	116	123	PF00069	0.263
DOC_MAPK_MEF2A_6	198	206	PF00069	0.443
DOC_MAPK_MEF2A_6	519	528	PF00069	0.575
DOC_MAPK_MEF2A_6	86	93	PF00069	0.309
DOC_MAPK_RevD_3	87	100	PF00069	0.333
DOC_PP1_RVXF_1	449	456	PF00149	0.492
DOC_PP4_FxxP_1	575	578	PF00568	0.517
DOC_PP4_FxxP_1	609	612	PF00568	0.264
DOC_USP7_MATH_1	104	108	PF00917	0.355
DOC_USP7_MATH_1	169	173	PF00917	0.441
DOC_USP7_MATH_1	235	239	PF00917	0.512
DOC_USP7_MATH_1	267	271	PF00917	0.451
DOC_USP7_MATH_1	415	419	PF00917	0.385
DOC_USP7_MATH_1	443	447	PF00917	0.434
DOC_USP7_MATH_1	474	478	PF00917	0.661
DOC_USP7_MATH_1	549	553	PF00917	0.271
DOC_USP7_MATH_1	567	571	PF00917	0.345
DOC_USP7_MATH_1	582	586	PF00917	0.438
DOC_USP7_MATH_1	637	641	PF00917	0.465
DOC_USP7_MATH_2	386	392	PF00917	0.432
DOC_WW_Pin1_4	578	583	PF00397	0.398
DOC_WW_Pin1_4	682	687	PF00397	0.404
DOC_WW_Pin1_4	691	696	PF00397	0.383
DOC_WW_Pin1_4	70	75	PF00397	0.404
LIG_14-3-3_CanoR_1	408	414	PF00244	0.402
LIG_14-3-3_CanoR_1	441	450	PF00244	0.538
LIG_14-3-3_CanoR_1	566	575	PF00244	0.445
LIG_14-3-3_CanoR_1	631	635	PF00244	0.415
LIG_Actin_WH2_2	135	151	PF00022	0.347
LIG_Actin_WH2_2	285	303	PF00022	0.322
LIG_Actin_WH2_2	425	443	PF00022	0.323
LIG_APCC_ABBA_1	89	94	PF00400	0.313
LIG_BIR_III_2	150	154	PF00653	0.380
LIG_BRCT_BRCA1_1	107	111	PF00533	0.403
LIG_Clathr_ClatBox_1	368	372	PF01394	0.458
LIG_FHA_1	129	135	PF00498	0.369
LIG_FHA_1	292	298	PF00498	0.412
LIG_FHA_2	112	118	PF00498	0.395
LIG_FHA_2	210	216	PF00498	0.432
LIG_FHA_2	271	277	PF00498	0.536
LIG_FHA_2	43	49	PF00498	0.325
LIG_FHA_2	675	681	PF00498	0.445
LIG_GBD_Chelix_1	524	532	PF00786	0.352
LIG_LIR_Apic_2	573	578	PF02991	0.506
LIG_LIR_Apic_2	606	612	PF02991	0.281
LIG_LIR_Gen_1	259	269	PF02991	0.439
LIG_LIR_Gen_1	31	40	PF02991	0.363
LIG_LIR_Gen_1	492	502	PF02991	0.501
LIG_LIR_Gen_1	85	96	PF02991	0.315
LIG_LIR_LC3C_4	611	615	PF02991	0.361
LIG_LIR_Nem_3	259	265	PF02991	0.387
LIG_LIR_Nem_3	283	289	PF02991	0.439
LIG_LIR_Nem_3	31	35	PF02991	0.349
LIG_LIR_Nem_3	492	498	PF02991	0.506
LIG_LIR_Nem_3	85	91	PF02991	0.288
LIG_LYPXL_yS_3	550	553	PF13949	0.404
LIG_MYND_3	22	26	PF01753	0.387
LIG_NRBOX	449	455	PF00104	0.580
LIG_Pex14_1	257	261	PF04695	0.397
LIG_Pex14_2	557	561	PF04695	0.238
LIG_Rb_LxCxE_1	467	482	PF01857	0.574
LIG_SH2_CRK	227	231	PF00017	0.383
LIG_SH2_NCK_1	232	236	PF00017	0.273
LIG_SH2_PTP2	88	91	PF00017	0.324
LIG_SH2_STAP1	421	425	PF00017	0.434
LIG_SH2_STAP1	495	499	PF00017	0.571
LIG_SH2_STAT5	195	198	PF00017	0.304
LIG_SH2_STAT5	232	235	PF00017	0.307
LIG_SH2_STAT5	421	424	PF00017	0.321
LIG_SH2_STAT5	436	439	PF00017	0.302
LIG_SH2_STAT5	466	469	PF00017	0.546
LIG_SH2_STAT5	80	83	PF00017	0.255
LIG_SH2_STAT5	88	91	PF00017	0.260
LIG_SH3_3	163	169	PF00018	0.527
LIG_SH3_3	64	70	PF00018	0.443
LIG_Sin3_3	219	226	PF02671	0.306
LIG_Sin3_3	399	406	PF02671	0.346
LIG_SUMO_SIM_anti_2	521	527	PF11976	0.425
LIG_SUMO_SIM_anti_2	611	617	PF11976	0.222
LIG_SUMO_SIM_par_1	366	372	PF11976	0.451
LIG_SUMO_SIM_par_1	387	393	PF11976	0.420
LIG_SUMO_SIM_par_1	399	405	PF11976	0.306
LIG_SUMO_SIM_par_1	504	509	PF11976	0.499
LIG_SUMO_SIM_par_1	521	527	PF11976	0.509
LIG_SUMO_SIM_par_1	62	68	PF11976	0.357
LIG_SUMO_SIM_par_1	694	700	PF11976	0.406
LIG_TRAF2_1	385	388	PF00917	0.440
LIG_TRAF2_1	513	516	PF00917	0.470
LIG_TYR_ITIM	284	289	PF00017	0.445
MOD_CK1_1	105	111	PF00069	0.619
MOD_CK1_1	159	165	PF00069	0.656
MOD_CK1_1	238	244	PF00069	0.647
MOD_CK1_1	270	276	PF00069	0.751
MOD_CK1_1	424	430	PF00069	0.278
MOD_CK1_1	489	495	PF00069	0.591
MOD_CK1_1	603	609	PF00069	0.502
MOD_CK2_1	170	176	PF00069	0.530
MOD_CK2_1	209	215	PF00069	0.628
MOD_CK2_1	270	276	PF00069	0.598
MOD_CK2_1	656	662	PF00069	0.455
MOD_CK2_1	674	680	PF00069	0.435
MOD_Cter_Amidation	241	244	PF01082	0.484
MOD_GlcNHglycan	161	164	PF01048	0.566
MOD_GlcNHglycan	212	215	PF01048	0.621
MOD_GlcNHglycan	240	243	PF01048	0.518
MOD_GlcNHglycan	423	426	PF01048	0.485
MOD_GlcNHglycan	445	448	PF01048	0.441
MOD_GlcNHglycan	460	463	PF01048	0.321
MOD_GlcNHglycan	481	484	PF01048	0.529
MOD_GlcNHglycan	508	511	PF01048	0.377
MOD_GlcNHglycan	569	572	PF01048	0.460
MOD_GlcNHglycan	603	606	PF01048	0.503
MOD_GlcNHglycan	61	64	PF01048	0.423
MOD_GlcNHglycan	639	642	PF01048	0.553
MOD_GSK3_1	1	8	PF00069	0.623
MOD_GSK3_1	152	159	PF00069	0.630
MOD_GSK3_1	170	177	PF00069	0.483
MOD_GSK3_1	246	253	PF00069	0.645
MOD_GSK3_1	267	274	PF00069	0.533
MOD_GSK3_1	314	321	PF00069	0.361
MOD_GSK3_1	415	422	PF00069	0.563
MOD_GSK3_1	42	49	PF00069	0.527
MOD_GSK3_1	578	585	PF00069	0.557
MOD_GSK3_1	59	66	PF00069	0.415
MOD_GSK3_1	597	604	PF00069	0.228
MOD_GSK3_1	685	692	PF00069	0.468
MOD_N-GLC_1	179	184	PF02516	0.534
MOD_N-GLC_1	271	276	PF02516	0.606
MOD_NEK2_1	111	116	PF00069	0.490
MOD_NEK2_1	138	143	PF00069	0.427
MOD_NEK2_1	246	251	PF00069	0.593
MOD_NEK2_1	318	323	PF00069	0.440
MOD_NEK2_1	390	395	PF00069	0.359
MOD_NEK2_1	419	424	PF00069	0.454
MOD_NEK2_1	506	511	PF00069	0.359
MOD_NEK2_1	540	545	PF00069	0.198
MOD_NEK2_1	65	70	PF00069	0.487
MOD_NEK2_1	656	661	PF00069	0.249
MOD_NEK2_1	699	704	PF00069	0.390
MOD_PIKK_1	111	117	PF00454	0.453
MOD_PIKK_1	474	480	PF00454	0.441
MOD_PIKK_1	597	603	PF00454	0.398
MOD_PIKK_1	622	628	PF00454	0.355
MOD_PIKK_1	651	657	PF00454	0.462
MOD_PK_1	645	651	PF00069	0.387
MOD_PKA_1	518	524	PF00069	0.266
MOD_PKA_2	156	162	PF00069	0.702
MOD_PKA_2	209	215	PF00069	0.421
MOD_PKA_2	246	252	PF00069	0.575
MOD_PKA_2	342	348	PF00069	0.710
MOD_PKA_2	479	485	PF00069	0.605
MOD_PKA_2	518	524	PF00069	0.436
MOD_PKA_2	52	58	PF00069	0.503
MOD_PKA_2	565	571	PF00069	0.471
MOD_PKA_2	573	579	PF00069	0.546
MOD_PKA_2	630	636	PF00069	0.515
MOD_PKB_1	100	108	PF00069	0.503
MOD_Plk_1	363	369	PF00069	0.475
MOD_Plk_1	689	695	PF00069	0.461
MOD_Plk_4	138	144	PF00069	0.419
MOD_Plk_4	364	370	PF00069	0.634
MOD_Plk_4	424	430	PF00069	0.278
MOD_Plk_4	540	546	PF00069	0.286
MOD_Plk_4	674	680	PF00069	0.637
MOD_ProDKin_1	578	584	PF00069	0.490
MOD_ProDKin_1	682	688	PF00069	0.501
MOD_ProDKin_1	691	697	PF00069	0.470
MOD_ProDKin_1	70	76	PF00069	0.498
TRG_DiLeu_BaEn_1	200	205	PF01217	0.468
TRG_DiLeu_BaEn_1	364	369	PF01217	0.567
TRG_DiLeu_BaEn_4	387	393	PF01217	0.447
TRG_DiLeu_BaLyEn_6	660	665	PF01217	0.266
TRG_ENDOCYTIC_2	124	127	PF00928	0.300
TRG_ENDOCYTIC_2	227	230	PF00928	0.476
TRG_ENDOCYTIC_2	286	289	PF00928	0.433
TRG_ENDOCYTIC_2	495	498	PF00928	0.462
TRG_ENDOCYTIC_2	550	553	PF00928	0.324
TRG_ENDOCYTIC_2	80	83	PF00928	0.321
TRG_ENDOCYTIC_2	88	91	PF00928	0.369
TRG_ER_diArg_1	257	260	PF00400	0.559
TRG_ER_diArg_1	297	299	PF00400	0.371
TRG_ER_diArg_1	493	495	PF00400	0.525
TRG_ER_diArg_1	518	520	PF00400	0.520
TRG_ER_diArg_1	535	538	PF00400	0.259
TRG_ER_diArg_1	98	101	PF00400	0.448
TRG_NES_CRM1_1	611	623	PF08389	0.409
TRG_NLS_MonoCore_2	98	103	PF00514	0.427
TRG_NLS_MonoExtN_4	98	103	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	101	106	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAE2	Leptomonas seymouri	39%	85%
A0A1X0P4U7	Trypanosomatidae	22%	98%
A0A3Q8ID38	Leishmania donovani	68%	100%
A0A422NF62	Trypanosoma rangeli	24%	99%
A4I157	Leishmania infantum	69%	100%
D0A5E2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	97%
E9AX91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QA81	Leishmania major	69%	100%
V5BN98	Trypanosoma cruzi	25%	99%