DNA-directed RNA polymerase subunit K

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-directed RNA polymerase I subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HDW1_LEIBR

TriTrypDb:

LbrM.25.0140 , LBRM2903_250006600

Length:

129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	9
GO:0030880	RNA polymerase complex	3	9
GO:0032991	protein-containing complex	1	9
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	9
GO:0140535	intracellular protein-containing complex	2	9
GO:1902494	catalytic complex	2	9
GO:1990234	transferase complex	3	9
GO:0005665	RNA polymerase II, core complex	4	1
GO:0005666	RNA polymerase III complex	4	1
GO:0005736	RNA polymerase I complex	4	1
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HDW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDW1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006351	DNA-templated transcription	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0032774	RNA biosynthetic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:0097659	nucleic acid-templated transcription	6	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003824	catalytic activity	1	10
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	10
GO:0005488	binding	1	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016779	nucleotidyltransferase activity	4	10
GO:0034062	5'-3' RNA polymerase activity	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097747	RNA polymerase activity	4	10
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.335
CLV_C14_Caspase3-7	5	9	PF00656	0.626
CLV_C14_Caspase3-7	63	67	PF00656	0.560
CLV_NRD_NRD_1	102	104	PF00675	0.425
CLV_NRD_NRD_1	28	30	PF00675	0.462
CLV_NRD_NRD_1	94	96	PF00675	0.310
CLV_PCSK_KEX2_1	102	104	PF00082	0.425
CLV_PCSK_KEX2_1	28	30	PF00082	0.513
CLV_PCSK_PC7_1	98	104	PF00082	0.562
CLV_PCSK_SKI1_1	48	52	PF00082	0.353
DEG_Nend_Nbox_1	1	3	PF02207	0.571
DEG_SCF_FBW7_2	22	27	PF00400	0.575
DEG_SPOP_SBC_1	59	63	PF00917	0.407
DOC_ANK_TNKS_1	102	109	PF00023	0.464
DOC_MAPK_DCC_7	78	87	PF00069	0.530
DOC_MAPK_gen_1	28	34	PF00069	0.486
DOC_MAPK_gen_1	95	101	PF00069	0.602
DOC_MAPK_RevD_3	80	96	PF00069	0.530
DOC_USP7_MATH_1	54	58	PF00917	0.530
DOC_WW_Pin1_4	20	25	PF00397	0.546
LIG_14-3-3_CanoR_1	102	106	PF00244	0.337
LIG_APCC_ABBA_1	22	27	PF00400	0.648
LIG_EH1_1	36	44	PF00400	0.469
LIG_FHA_1	110	116	PF00498	0.483
LIG_FHA_1	60	66	PF00498	0.441
LIG_FHA_2	102	108	PF00498	0.343
LIG_FHA_2	33	39	PF00498	0.462
LIG_FHA_2	61	67	PF00498	0.379
LIG_PTB_Phospho_1	123	129	PF10480	0.373
LIG_SH2_CRK	90	94	PF00017	0.530
LIG_SH2_STAT5	33	36	PF00017	0.459
LIG_SUMO_SIM_par_1	117	123	PF11976	0.564
MOD_CK2_1	32	38	PF00069	0.318
MOD_GlcNHglycan	18	21	PF01048	0.651
MOD_GlcNHglycan	29	32	PF01048	0.503
MOD_GlcNHglycan	51	54	PF01048	0.320
MOD_GSK3_1	16	23	PF00069	0.626
MOD_GSK3_1	54	61	PF00069	0.502
MOD_GSK3_1	72	79	PF00069	0.324
MOD_NEK2_1	32	37	PF00069	0.413
MOD_PKA_2	101	107	PF00069	0.333
MOD_PKA_2	27	33	PF00069	0.479
MOD_PKA_2	72	78	PF00069	0.467
MOD_Plk_1	120	126	PF00069	0.566
MOD_Plk_4	120	126	PF00069	0.545
MOD_ProDKin_1	20	26	PF00069	0.539
TRG_ENDOCYTIC_2	90	93	PF00928	0.530
TRG_ER_diArg_1	101	103	PF00400	0.402
TRG_NES_CRM1_1	117	128	PF08389	0.567
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X7	Leptomonas seymouri	81%	100%
A0A0S4JLU1	Bodo saltans	34%	96%
A0A1X0P4L0	Trypanosomatidae	53%	98%
A0A3Q8IDA2	Leishmania donovani	92%	100%
A0A3Q8IKT1	Leishmania donovani	32%	81%
A0A422NF56	Trypanosoma rangeli	49%	99%
A4HAK2	Leishmania braziliensis	30%	100%
A4I156	Leishmania infantum	92%	100%
A4I9P6	Leishmania infantum	32%	81%
D0A5E1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AX90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B4R0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	81%
O88828	Rattus norvegicus	31%	100%
P20435	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	83%
P36595	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	91%
P61217	Cricetulus griseus	31%	100%
P61218	Homo sapiens	31%	100%
P61219	Mus musculus	31%	100%
Q17684	Caenorhabditis elegans	33%	94%
Q4Q3B6	Leishmania major	32%	100%
Q4QA82	Leishmania major	91%	100%
Q5R592	Pongo abelii	31%	100%