TauD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDV8_LEIBR

TriTrypDb:

LbrM.25.0110 , LBRM2903_250006300

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDV8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.601
CLV_NRD_NRD_1	270	272	PF00675	0.574
CLV_NRD_NRD_1	32	34	PF00675	0.409
CLV_NRD_NRD_1	341	343	PF00675	0.675
CLV_PCSK_KEX2_1	154	156	PF00082	0.601
CLV_PCSK_KEX2_1	270	272	PF00082	0.574
CLV_PCSK_KEX2_1	32	34	PF00082	0.409
CLV_PCSK_KEX2_1	341	343	PF00082	0.511
CLV_PCSK_KEX2_1	379	381	PF00082	0.383
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.383
CLV_PCSK_SKI1_1	372	376	PF00082	0.520
CLV_PCSK_SKI1_1	402	406	PF00082	0.460
CLV_PCSK_SKI1_1	81	85	PF00082	0.339
DEG_APCC_DBOX_1	62	70	PF00400	0.377
DEG_COP1_1	253	262	PF00400	0.525
DOC_CKS1_1	192	197	PF01111	0.390
DOC_CKS1_1	299	304	PF01111	0.521
DOC_CYCLIN_RxL_1	309	320	PF00134	0.263
DOC_MAPK_gen_1	13	21	PF00069	0.393
DOC_MAPK_gen_1	151	160	PF00069	0.621
DOC_MAPK_gen_1	379	387	PF00069	0.356
DOC_MAPK_gen_1	397	407	PF00069	0.377
DOC_MAPK_MEF2A_6	15	23	PF00069	0.321
DOC_MAPK_MEF2A_6	154	162	PF00069	0.477
DOC_MAPK_MEF2A_6	400	407	PF00069	0.305
DOC_PP4_FxxP_1	299	302	PF00568	0.387
DOC_PP4_FxxP_1	383	386	PF00568	0.375
DOC_PP4_FxxP_1	70	73	PF00568	0.294
DOC_USP7_MATH_1	145	149	PF00917	0.609
DOC_USP7_MATH_1	186	190	PF00917	0.449
DOC_USP7_MATH_1	433	437	PF00917	0.713
DOC_USP7_MATH_2	442	448	PF00917	0.493
DOC_WW_Pin1_4	191	196	PF00397	0.431
DOC_WW_Pin1_4	298	303	PF00397	0.560
DOC_WW_Pin1_4	452	457	PF00397	0.471
LIG_14-3-3_CanoR_1	102	109	PF00244	0.381
LIG_14-3-3_CanoR_1	15	20	PF00244	0.257
LIG_14-3-3_CanoR_1	173	182	PF00244	0.524
LIG_14-3-3_CanoR_1	270	276	PF00244	0.459
LIG_14-3-3_CanoR_1	36	45	PF00244	0.283
LIG_14-3-3_CanoR_1	414	420	PF00244	0.432
LIG_AP2alpha_2	438	440	PF02296	0.497
LIG_APCC_ABBA_1	200	205	PF00400	0.383
LIG_BRCT_BRCA1_1	263	267	PF00533	0.463
LIG_BRCT_BRCA1_1	3	7	PF00533	0.373
LIG_deltaCOP1_diTrp_1	54	60	PF00928	0.330
LIG_DLG_GKlike_1	15	22	PF00625	0.413
LIG_FAT_LD_1	19	27	PF03623	0.467
LIG_FHA_1	124	130	PF00498	0.405
LIG_FHA_1	188	194	PF00498	0.457
LIG_FHA_1	306	312	PF00498	0.561
LIG_FHA_1	318	324	PF00498	0.419
LIG_FHA_1	369	375	PF00498	0.513
LIG_FHA_1	40	46	PF00498	0.435
LIG_FHA_2	15	21	PF00498	0.463
LIG_FHA_2	430	436	PF00498	0.399
LIG_FHA_2	441	447	PF00498	0.485
LIG_FHA_2	7	13	PF00498	0.529
LIG_FHA_2	84	90	PF00498	0.368
LIG_LIR_Apic_2	68	73	PF02991	0.293
LIG_LIR_Gen_1	4	12	PF02991	0.383
LIG_LIR_Gen_1	54	61	PF02991	0.413
LIG_LIR_Nem_3	165	171	PF02991	0.490
LIG_LIR_Nem_3	325	330	PF02991	0.391
LIG_LIR_Nem_3	4	10	PF02991	0.382
LIG_LIR_Nem_3	46	51	PF02991	0.404
LIG_LIR_Nem_3	54	58	PF02991	0.360
LIG_MYND_1	312	316	PF01753	0.423
LIG_NRBOX	18	24	PF00104	0.412
LIG_PCNA_yPIPBox_3	228	242	PF02747	0.377
LIG_PDZ_Class_1	452	457	PF00595	0.471
LIG_Pex14_2	383	387	PF04695	0.368
LIG_SH2_NCK_1	263	267	PF00017	0.458
LIG_SH2_STAP1	198	202	PF00017	0.272
LIG_SH2_STAP1	263	267	PF00017	0.458
LIG_SH2_STAP1	377	381	PF00017	0.366
LIG_SH2_STAT5	130	133	PF00017	0.383
LIG_SH2_STAT5	29	32	PF00017	0.496
LIG_SH2_STAT5	390	393	PF00017	0.332
LIG_SH3_1	201	207	PF00018	0.410
LIG_SH3_1	313	319	PF00018	0.247
LIG_SH3_3	189	195	PF00018	0.393
LIG_SH3_3	201	207	PF00018	0.460
LIG_SH3_3	254	260	PF00018	0.441
LIG_SH3_3	313	319	PF00018	0.322
LIG_SH3_3	436	442	PF00018	0.487
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.461
LIG_SUMO_SIM_par_1	319	326	PF11976	0.453
LIG_SUMO_SIM_par_1	64	71	PF11976	0.391
LIG_TRAF2_1	364	367	PF00917	0.558
LIG_TRAF2_1	443	446	PF00917	0.501
LIG_UBA3_1	84	91	PF00899	0.375
MOD_CK1_1	39	45	PF00069	0.430
MOD_CK1_1	6	12	PF00069	0.439
MOD_CK2_1	14	20	PF00069	0.303
MOD_CK2_1	289	295	PF00069	0.665
MOD_CK2_1	429	435	PF00069	0.353
MOD_CK2_1	440	446	PF00069	0.476
MOD_CK2_1	83	89	PF00069	0.294
MOD_Cter_Amidation	30	33	PF01082	0.399
MOD_GlcNHglycan	264	267	PF01048	0.513
MOD_GlcNHglycan	289	292	PF01048	0.585
MOD_GlcNHglycan	335	338	PF01048	0.523
MOD_GlcNHglycan	426	429	PF01048	0.288
MOD_GlcNHglycan	70	73	PF01048	0.456
MOD_GSK3_1	187	194	PF00069	0.420
MOD_GSK3_1	2	9	PF00069	0.526
MOD_GSK3_1	262	269	PF00069	0.414
MOD_GSK3_1	424	431	PF00069	0.512
MOD_GSK3_1	440	447	PF00069	0.678
MOD_GSK3_1	97	104	PF00069	0.387
MOD_LATS_1	268	274	PF00433	0.570
MOD_N-GLC_1	173	178	PF02516	0.477
MOD_N-GLC_2	357	359	PF02516	0.434
MOD_NEK2_1	1	6	PF00069	0.394
MOD_NEK2_1	289	294	PF00069	0.538
MOD_NEK2_1	323	328	PF00069	0.269
MOD_NEK2_1	348	353	PF00069	0.278
MOD_NEK2_2	415	420	PF00069	0.406
MOD_PIKK_1	39	45	PF00454	0.430
MOD_PKA_1	270	276	PF00069	0.601
MOD_PKA_2	14	20	PF00069	0.403
MOD_PKA_2	172	178	PF00069	0.598
MOD_PKA_2	269	275	PF00069	0.604
MOD_PKA_2	305	311	PF00069	0.595
MOD_PKA_2	368	374	PF00069	0.458
MOD_PKA_2	429	435	PF00069	0.465
MOD_PKA_2	440	446	PF00069	0.665
MOD_PKA_2	97	103	PF00069	0.394
MOD_Plk_1	348	354	PF00069	0.359
MOD_Plk_4	187	193	PF00069	0.536
MOD_Plk_4	317	323	PF00069	0.335
MOD_Plk_4	408	414	PF00069	0.431
MOD_Plk_4	415	421	PF00069	0.365
MOD_ProDKin_1	191	197	PF00069	0.431
MOD_ProDKin_1	298	304	PF00069	0.566
MOD_SUMO_rev_2	54	61	PF00179	0.330
TRG_DiLeu_BaEn_1	408	413	PF01217	0.488
TRG_DiLeu_BaEn_1	80	85	PF01217	0.292
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.516
TRG_ENDOCYTIC_2	390	393	PF00928	0.332
TRG_ER_diArg_1	341	343	PF00400	0.511
TRG_NES_CRM1_1	43	57	PF08389	0.425
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X3	Leptomonas seymouri	72%	98%
A0A1X0P4R6	Trypanosomatidae	59%	97%
A0A3Q8IN33	Leishmania donovani	86%	96%
A0A3R7MKC3	Trypanosoma rangeli	58%	97%
A4I153	Leishmania infantum	86%	96%
D0A5D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
D0A5D8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	99%
E9AX87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	96%
Q4QA85	Leishmania major	86%	100%
V5BSX0	Trypanosoma cruzi	58%	97%