t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qc-SNARE protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDV6_LEIBR

TriTrypDb:

LbrM.25.0090 , LBRM2903_250006100

Length:

120

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HDV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDV6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0008104	protein localization	4	8
GO:0009987	cellular process	1	8
GO:0015031	protein transport	4	8
GO:0033036	macromolecule localization	2	8
GO:0045184	establishment of protein localization	3	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0051641	cellular localization	2	8
GO:0070727	cellular macromolecule localization	3	8
GO:0071702	organic substance transport	4	8
GO:0071705	nitrogen compound transport	4	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	118	120	PF00082	0.635
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.635
CLV_PCSK_SKI1_1	45	49	PF00082	0.336
DEG_Nend_UBRbox_3	1	3	PF02207	0.744
DEG_SPOP_SBC_1	39	43	PF00917	0.482
DOC_USP7_MATH_1	14	18	PF00917	0.723
DOC_USP7_MATH_1	39	43	PF00917	0.650
DOC_USP7_MATH_1	82	86	PF00917	0.661
DOC_USP7_UBL2_3	66	70	PF12436	0.605
LIG_14-3-3_CanoR_1	96	104	PF00244	0.402
LIG_LIR_Gen_1	19	29	PF02991	0.696
LIG_PCNA_PIPBox_1	47	56	PF02747	0.671
LIG_RPA_C_Fungi	71	83	PF08784	0.599
LIG_SH2_CRK	97	101	PF00017	0.444
LIG_SH2_NCK_1	97	101	PF00017	0.252
LIG_SH2_STAP1	113	117	PF00017	0.410
LIG_SH2_STAP1	97	101	PF00017	0.451
LIG_SH2_STAT5	110	113	PF00017	0.370
LIG_SH2_STAT5	97	100	PF00017	0.435
LIG_UBA3_1	36	45	PF00899	0.460
LIG_UBA3_1	64	70	PF00899	0.633
MOD_CK1_1	16	22	PF00069	0.392
MOD_CK1_1	85	91	PF00069	0.591
MOD_CK1_1	9	15	PF00069	0.436
MOD_GlcNHglycan	16	19	PF01048	0.521
MOD_GlcNHglycan	80	83	PF01048	0.599
MOD_GSK3_1	78	85	PF00069	0.595
MOD_GSK3_1	9	16	PF00069	0.640
MOD_NEK2_1	1	6	PF00069	0.602
MOD_NEK2_1	40	45	PF00069	0.461
MOD_NEK2_2	82	87	PF00069	0.580
MOD_PKA_2	9	15	PF00069	0.465
MOD_PKA_2	95	101	PF00069	0.223
MOD_Plk_4	1	7	PF00069	0.563
MOD_Plk_4	85	91	PF00069	0.538
TRG_DiLeu_BaEn_1	60	65	PF01217	0.602
TRG_ENDOCYTIC_2	113	116	PF00928	0.340
TRG_ENDOCYTIC_2	22	25	PF00928	0.600
TRG_ENDOCYTIC_2	97	100	PF00928	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I772	Leptomonas seymouri	73%	98%
A0A0S4IMR3	Bodo saltans	35%	82%
A0A1X0P4K2	Trypanosomatidae	44%	99%
A0A3S7WYP8	Leishmania donovani	79%	100%
A0A422NF19	Trypanosoma rangeli	44%	100%
A4I151	Leishmania infantum	79%	100%
D0A5D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AX85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QA87	Leishmania major	80%	100%