ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDV4_LEIBR

TriTrypDb:

LbrM.25.0070 , LBRM2903_250005800

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	116	122	PF00089	0.322
CLV_NRD_NRD_1	13	15	PF00675	0.676
CLV_NRD_NRD_1	2	4	PF00675	0.787
CLV_NRD_NRD_1	207	209	PF00675	0.286
CLV_NRD_NRD_1	261	263	PF00675	0.429
CLV_NRD_NRD_1	294	296	PF00675	0.753
CLV_PCSK_KEX2_1	12	14	PF00082	0.659
CLV_PCSK_KEX2_1	2	4	PF00082	0.725
CLV_PCSK_KEX2_1	207	209	PF00082	0.397
CLV_PCSK_KEX2_1	260	262	PF00082	0.439
CLV_PCSK_PC7_1	9	15	PF00082	0.508
CLV_PCSK_SKI1_1	108	112	PF00082	0.517
CLV_PCSK_SKI1_1	127	131	PF00082	0.203
CLV_PCSK_SKI1_1	19	23	PF00082	0.771
CLV_PCSK_SKI1_1	225	229	PF00082	0.411
CLV_PCSK_SKI1_1	25	29	PF00082	0.720
DEG_APCC_DBOX_1	207	215	PF00400	0.284
DEG_Nend_UBRbox_1	1	4	PF02207	0.732
DEG_SPOP_SBC_1	288	292	PF00917	0.517
DOC_CDC14_PxL_1	39	47	PF14671	0.455
DOC_CKS1_1	238	243	PF01111	0.407
DOC_MAPK_FxFP_2	79	82	PF00069	0.533
DOC_MAPK_gen_1	124	132	PF00069	0.498
DOC_MAPK_JIP1_4	99	105	PF00069	0.312
DOC_MAPK_MEF2A_6	124	132	PF00069	0.443
DOC_PP1_RVXF_1	259	266	PF00149	0.438
DOC_PP2B_LxvP_1	159	162	PF13499	0.464
DOC_PP2B_LxvP_1	285	288	PF13499	0.519
DOC_PP4_FxxP_1	193	196	PF00568	0.401
DOC_PP4_FxxP_1	79	82	PF00568	0.497
DOC_USP7_MATH_1	288	292	PF00917	0.761
DOC_USP7_MATH_1	8	12	PF00917	0.740
DOC_USP7_UBL2_3	276	280	PF12436	0.497
DOC_WW_Pin1_4	103	108	PF00397	0.497
DOC_WW_Pin1_4	142	147	PF00397	0.544
DOC_WW_Pin1_4	192	197	PF00397	0.397
DOC_WW_Pin1_4	237	242	PF00397	0.634
DOC_WW_Pin1_4	275	280	PF00397	0.700
DOC_WW_Pin1_4	48	53	PF00397	0.663
LIG_14-3-3_CanoR_1	144	153	PF00244	0.313
LIG_14-3-3_CanoR_1	19	28	PF00244	0.649
LIG_14-3-3_CanoR_1	2	8	PF00244	0.561
LIG_14-3-3_CanoR_1	207	212	PF00244	0.548
LIG_14-3-3_CanoR_1	57	66	PF00244	0.333
LIG_AP2alpha_2	70	72	PF02296	0.481
LIG_BRCT_BRCA1_1	114	118	PF00533	0.388
LIG_BRCT_BRCA1_1	225	229	PF00533	0.525
LIG_CaM_IQ_9	212	227	PF13499	0.277
LIG_eIF4E_1	183	189	PF01652	0.493
LIG_FHA_1	228	234	PF00498	0.566
LIG_FHA_2	238	244	PF00498	0.478
LIG_GBD_Chelix_1	128	136	PF00786	0.477
LIG_IRF3_LxIS_1	100	106	PF10401	0.303
LIG_LIR_Apic_2	191	196	PF02991	0.400
LIG_LIR_Apic_2	78	82	PF02991	0.403
LIG_LIR_Gen_1	75	84	PF02991	0.452
LIG_LIR_Gen_1	93	100	PF02991	0.329
LIG_LIR_Nem_3	226	232	PF02991	0.455
LIG_LIR_Nem_3	68	72	PF02991	0.420
LIG_LIR_Nem_3	75	79	PF02991	0.378
LIG_LIR_Nem_3	80	84	PF02991	0.381
LIG_LIR_Nem_3	93	97	PF02991	0.301
LIG_MYND_1	158	162	PF01753	0.457
LIG_MYND_1	43	47	PF01753	0.469
LIG_NRBOX	131	137	PF00104	0.415
LIG_NRBOX	184	190	PF00104	0.280
LIG_NRBOX	210	216	PF00104	0.365
LIG_Pex14_2	65	69	PF04695	0.469
LIG_REV1ctd_RIR_1	25	35	PF16727	0.495
LIG_SH2_SRC	199	202	PF00017	0.559
LIG_SH2_STAT3	122	125	PF00017	0.315
LIG_SH2_STAT5	183	186	PF00017	0.462
LIG_SH2_STAT5	199	202	PF00017	0.474
LIG_SH2_STAT5	76	79	PF00017	0.400
LIG_SH3_3	152	158	PF00018	0.497
LIG_SH3_3	173	179	PF00018	0.452
LIG_UBA3_1	228	236	PF00899	0.531
LIG_WRC_WIRS_1	66	71	PF05994	0.433
LIG_WRC_WIRS_1	76	81	PF05994	0.433
MOD_CDK_SPK_2	103	108	PF00069	0.540
MOD_CDK_SPK_2	275	280	PF00069	0.632
MOD_CDK_SPxxK_3	50	57	PF00069	0.387
MOD_CK1_1	106	112	PF00069	0.495
MOD_CK1_1	142	148	PF00069	0.538
MOD_CK1_1	170	176	PF00069	0.394
MOD_CK1_1	75	81	PF00069	0.312
MOD_GlcNHglycan	190	193	PF01048	0.510
MOD_GlcNHglycan	225	228	PF01048	0.495
MOD_GlcNHglycan	291	294	PF01048	0.522
MOD_GSK3_1	15	22	PF00069	0.657
MOD_GSK3_1	188	195	PF00069	0.524
MOD_GSK3_1	223	230	PF00069	0.460
MOD_GSK3_1	99	106	PF00069	0.488
MOD_N-GLC_1	251	256	PF02516	0.320
MOD_NEK2_1	111	116	PF00069	0.499
MOD_NEK2_1	188	193	PF00069	0.447
MOD_NEK2_1	289	294	PF00069	0.697
MOD_NEK2_1	72	77	PF00069	0.398
MOD_PIKK_1	170	176	PF00454	0.488
MOD_PK_1	3	9	PF00069	0.496
MOD_PKA_1	207	213	PF00069	0.398
MOD_PKA_2	207	213	PF00069	0.389
MOD_PKA_2	8	14	PF00069	0.644
MOD_Plk_1	251	257	PF00069	0.479
MOD_Plk_4	106	112	PF00069	0.402
MOD_Plk_4	131	137	PF00069	0.482
MOD_Plk_4	80	86	PF00069	0.472
MOD_Plk_4	99	105	PF00069	0.401
MOD_ProDKin_1	103	109	PF00069	0.500
MOD_ProDKin_1	142	148	PF00069	0.540
MOD_ProDKin_1	192	198	PF00069	0.391
MOD_ProDKin_1	237	243	PF00069	0.628
MOD_ProDKin_1	275	281	PF00069	0.702
MOD_ProDKin_1	48	54	PF00069	0.664
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.460
TRG_ENDOCYTIC_2	76	79	PF00928	0.366
TRG_ENDOCYTIC_2	94	97	PF00928	0.435
TRG_ER_diArg_1	1	3	PF00400	0.760
TRG_ER_diArg_1	12	14	PF00400	0.547
TRG_ER_diArg_1	260	262	PF00400	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM27	Leptomonas seymouri	52%	100%
A0A1X0NV12	Trypanosomatidae	30%	100%
A0A3Q8IC57	Leishmania donovani	72%	100%
A0A422N5J2	Trypanosoma rangeli	28%	100%
A4I149	Leishmania infantum	72%	100%
D0A975	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	80%
E9AX83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QA89	Leishmania major	70%	100%