Vesicle transport protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Got1/Sft2-like family, putative

Species:

Leishmania braziliensis

UniProt:

A4HDV3_LEIBR

TriTrypDb:

LbrM.25.0060 , LBRM2903_250005600

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A4HDV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDV3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	17
GO:0008104	protein localization	4	17
GO:0009987	cellular process	1	17
GO:0015031	protein transport	4	17
GO:0016192	vesicle-mediated transport	4	17
GO:0033036	macromolecule localization	2	17
GO:0045184	establishment of protein localization	3	17
GO:0051179	localization	1	17
GO:0051234	establishment of localization	2	17
GO:0051641	cellular localization	2	17
GO:0070727	cellular macromolecule localization	3	17
GO:0071702	organic substance transport	4	17
GO:0071705	nitrogen compound transport	4	17

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	114	118	PF00082	0.442
CLV_PCSK_SKI1_1	22	26	PF00082	0.449
DEG_APCC_DBOX_1	113	121	PF00400	0.161
DEG_APCC_DBOX_1	141	149	PF00400	0.641
DOC_MAPK_MEF2A_6	142	150	PF00069	0.667
DOC_PP1_RVXF_1	20	27	PF00149	0.597
LIG_14-3-3_CanoR_1	92	98	PF00244	0.432
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_deltaCOP1_diTrp_1	23	33	PF00928	0.570
LIG_eIF4E_1	140	146	PF01652	0.646
LIG_FHA_1	25	31	PF00498	0.606
LIG_FHA_1	72	78	PF00498	0.321
LIG_LIR_Gen_1	102	112	PF02991	0.313
LIG_LIR_Gen_1	67	76	PF02991	0.337
LIG_LIR_Nem_3	102	107	PF02991	0.336
LIG_LIR_Nem_3	134	140	PF02991	0.310
LIG_LIR_Nem_3	18	24	PF02991	0.619
LIG_LIR_Nem_3	47	51	PF02991	0.330
LIG_NRBOX	116	122	PF00104	0.246
LIG_NRP_CendR_1	151	152	PF00754	0.473
LIG_Pex14_2	104	108	PF04695	0.328
LIG_Rb_pABgroove_1	82	90	PF01858	0.422
LIG_REV1ctd_RIR_1	18	26	PF16727	0.547
LIG_SH2_CRK	127	131	PF00017	0.272
LIG_SH2_CRK	59	63	PF00017	0.251
LIG_SH2_STAP1	127	131	PF00017	0.351
LIG_SH2_STAP1	133	137	PF00017	0.316
LIG_SH2_STAT5	137	140	PF00017	0.319
LIG_SH2_STAT5	99	102	PF00017	0.316
LIG_SUMO_SIM_anti_2	73	79	PF11976	0.351
LIG_TYR_ITIM	125	130	PF00017	0.291
LIG_WRC_WIRS_1	65	70	PF05994	0.367
MOD_CK1_1	60	66	PF00069	0.282
MOD_CK1_1	70	76	PF00069	0.256
MOD_GlcNHglycan	1	4	PF01048	0.476
MOD_GlcNHglycan	59	62	PF01048	0.172
MOD_GlcNHglycan	80	83	PF01048	0.318
MOD_GSK3_1	40	47	PF00069	0.341
MOD_GSK3_1	57	64	PF00069	0.264
MOD_GSK3_1	67	74	PF00069	0.303
MOD_N-GLC_1	93	98	PF02516	0.402
MOD_NEK2_1	24	29	PF00069	0.575
MOD_NEK2_1	41	46	PF00069	0.323
MOD_NEK2_1	71	76	PF00069	0.283
MOD_NEK2_1	93	98	PF00069	0.282
MOD_NEK2_2	99	104	PF00069	0.323
MOD_PIKK_1	24	30	PF00454	0.646
MOD_PKA_2	141	147	PF00069	0.665
MOD_Plk_1	22	28	PF00069	0.622
MOD_Plk_1	93	99	PF00069	0.351
MOD_Plk_4	133	139	PF00069	0.316
MOD_Plk_4	141	147	PF00069	0.581
MOD_Plk_4	41	47	PF00069	0.324
MOD_Plk_4	64	70	PF00069	0.303
MOD_Plk_4	71	77	PF00069	0.325
MOD_Plk_4	93	99	PF00069	0.297
TRG_ENDOCYTIC_2	127	130	PF00928	0.245
TRG_ENDOCYTIC_2	59	62	PF00928	0.251
TRG_ER_diArg_1	150	152	PF00400	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I1	Leptomonas seymouri	34%	69%
A0A0N0P8A7	Leptomonas seymouri	80%	100%
A0A0N1I3M5	Leptomonas seymouri	27%	86%
A0A0N1I5N1	Leptomonas seymouri	31%	90%
A0A0S4JF33	Bodo saltans	50%	96%
A0A0S4JFY8	Bodo saltans	34%	97%
A0A1X0NLN3	Trypanosomatidae	32%	89%
A0A1X0P315	Trypanosomatidae	36%	90%
A0A1X0P7F6	Trypanosomatidae	53%	98%
A0A1X0P987	Trypanosomatidae	31%	72%
A0A3Q8IBK0	Leishmania donovani	88%	100%
A0A3S5H567	Leishmania donovani	40%	70%
A0A3S5H5K3	Leishmania donovani	34%	93%
A0A422MRP4	Trypanosoma rangeli	55%	97%
A0A422N175	Trypanosoma rangeli	32%	86%
A0A422NC91	Trypanosoma rangeli	34%	89%
A0A422NJC0	Trypanosoma rangeli	34%	90%
A4H3Q4	Leishmania braziliensis	38%	70%
A4HRX8	Leishmania infantum	40%	70%
A4HSK3	Leishmania infantum	34%	93%
A4I148	Leishmania infantum	88%	100%
C9ZJ62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	98%
C9ZU90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	92%
D0A8W1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	88%
E9ACN7	Leishmania major	40%	70%
E9AJX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	70%
E9AKI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	93%
E9AX82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O95562	Homo sapiens	32%	95%
P38166	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	71%
Q4FZV2	Rattus norvegicus	37%	97%
Q4QA90	Leishmania major	86%	100%
Q4QJC1	Leishmania major	36%	100%
Q5SSN7	Mus musculus	33%	96%
Q5U3Y5	Rattus norvegicus	33%	96%
Q8VD57	Mus musculus	37%	96%
Q8WV19	Homo sapiens	32%	96%