LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDV2_LEIBR

TriTrypDb:

LbrM.25.0050 , LBRM2903_250005500

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.520
CLV_NRD_NRD_1	169	171	PF00675	0.591
CLV_PCSK_KEX2_1	161	163	PF00082	0.522
CLV_PCSK_KEX2_1	169	171	PF00082	0.584
CLV_PCSK_SKI1_1	116	120	PF00082	0.520
CLV_PCSK_SKI1_1	143	147	PF00082	0.546
DEG_APCC_DBOX_1	161	169	PF00400	0.614
DEG_Nend_UBRbox_2	1	3	PF02207	0.483
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.459
DOC_PP1_RVXF_1	14	20	PF00149	0.419
DOC_USP7_MATH_1	132	136	PF00917	0.721
DOC_USP7_MATH_1	149	153	PF00917	0.551
DOC_USP7_UBL2_3	139	143	PF12436	0.463
DOC_WW_Pin1_4	116	121	PF00397	0.537
DOC_WW_Pin1_4	134	139	PF00397	0.563
LIG_14-3-3_CanoR_1	113	119	PF00244	0.438
LIG_14-3-3_CterR_2	169	171	PF00244	0.496
LIG_Clathr_ClatBox_1	79	83	PF01394	0.355
LIG_FHA_1	123	129	PF00498	0.472
LIG_FHA_1	135	141	PF00498	0.480
LIG_FHA_1	35	41	PF00498	0.419
LIG_FHA_1	51	57	PF00498	0.344
LIG_FHA_1	74	80	PF00498	0.426
LIG_FHA_1	85	91	PF00498	0.493
LIG_LIR_Gen_1	21	30	PF02991	0.437
LIG_LIR_Gen_1	37	46	PF02991	0.280
LIG_LIR_Gen_1	5	14	PF02991	0.412
LIG_LIR_Nem_3	21	25	PF02991	0.450
LIG_LIR_Nem_3	37	41	PF02991	0.340
LIG_LIR_Nem_3	5	10	PF02991	0.416
LIG_LIR_Nem_3	61	65	PF02991	0.470
LIG_NRBOX	110	116	PF00104	0.396
LIG_OCRL_FandH_1	6	18	PF00620	0.412
LIG_SH2_STAP1	38	42	PF00017	0.431
LIG_SUMO_SIM_par_1	78	83	PF11976	0.377
MOD_CDK_SPK_2	134	139	PF00069	0.458
MOD_CK1_1	122	128	PF00069	0.562
MOD_CK1_1	5	11	PF00069	0.521
MOD_CK2_1	21	27	PF00069	0.498
MOD_DYRK1A_RPxSP_1	116	120	PF00069	0.561
MOD_GlcNHglycan	101	104	PF01048	0.451
MOD_GlcNHglycan	90	93	PF01048	0.502
MOD_GSK3_1	164	171	PF00069	0.647
MOD_GSK3_1	84	91	PF00069	0.364
MOD_NEK2_1	107	112	PF00069	0.456
MOD_NEK2_1	114	119	PF00069	0.448
MOD_NEK2_1	3	8	PF00069	0.335
MOD_NEK2_2	73	78	PF00069	0.463
MOD_Plk_1	20	26	PF00069	0.386
MOD_Plk_2-3	21	27	PF00069	0.456
MOD_Plk_4	107	113	PF00069	0.475
MOD_Plk_4	143	149	PF00069	0.460
MOD_ProDKin_1	116	122	PF00069	0.550
MOD_ProDKin_1	134	140	PF00069	0.563
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.444
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.370
TRG_ENDOCYTIC_2	38	41	PF00928	0.396
TRG_ENDOCYTIC_2	46	49	PF00928	0.398
TRG_ER_diArg_1	168	170	PF00400	0.680
TRG_Pf-PMV_PEXEL_1	116	121	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW6	Leptomonas seymouri	52%	98%
A0A0S4IX66	Bodo saltans	31%	99%
A0A3Q8ID49	Leishmania donovani	78%	100%
A4I147	Leishmania infantum	78%	100%
E9AX81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QA91	Leishmania major	78%	100%
V5D433	Trypanosoma cruzi	42%	98%