DUF2431 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF2431), putative

Species:

Leishmania braziliensis

UniProt:

A4HDV0_LEIBR

TriTrypDb:

LbrM.25.0030 , LBRM2903_250005200 , LBRM2903_250005300

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDV0

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	6
GO:0001510	RNA methylation	4	6
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006364	rRNA processing	8	6
GO:0006396	RNA processing	6	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009451	RNA modification	5	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0016072	rRNA metabolic process	7	6
GO:0031167	rRNA methylation	5	6
GO:0032259	methylation	2	6
GO:0034470	ncRNA processing	7	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034660	ncRNA metabolic process	6	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0043414	macromolecule methylation	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0070475	rRNA base methylation	6	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0008168	methyltransferase activity	4	6
GO:0008170	N-methyltransferase activity	5	6
GO:0008173	RNA methyltransferase activity	4	6
GO:0008649	rRNA methyltransferase activity	5	6
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	6
GO:0016436	rRNA (uridine) methyltransferase activity	6	6
GO:0016740	transferase activity	2	6
GO:0016741	transferase activity, transferring one-carbon groups	3	6
GO:0070042	rRNA (uridine-N3-)-methyltransferase activity	6	6
GO:0140098	catalytic activity, acting on RNA	3	6
GO:0140102	catalytic activity, acting on a rRNA	4	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.469
CLV_C14_Caspase3-7	57	61	PF00656	0.294
CLV_NRD_NRD_1	214	216	PF00675	0.402
CLV_NRD_NRD_1	257	259	PF00675	0.416
CLV_NRD_NRD_1	433	435	PF00675	0.624
CLV_NRD_NRD_1	51	53	PF00675	0.419
CLV_NRD_NRD_1	557	559	PF00675	0.521
CLV_NRD_NRD_1	575	577	PF00675	0.490
CLV_NRD_NRD_1	64	66	PF00675	0.362
CLV_NRD_NRD_1	83	85	PF00675	0.391
CLV_PCSK_KEX2_1	214	216	PF00082	0.402
CLV_PCSK_KEX2_1	257	259	PF00082	0.416
CLV_PCSK_KEX2_1	279	281	PF00082	0.356
CLV_PCSK_KEX2_1	42	44	PF00082	0.386
CLV_PCSK_KEX2_1	433	435	PF00082	0.624
CLV_PCSK_KEX2_1	51	53	PF00082	0.335
CLV_PCSK_KEX2_1	557	559	PF00082	0.521
CLV_PCSK_KEX2_1	63	65	PF00082	0.370
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.356
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.386
CLV_PCSK_PC7_1	429	435	PF00082	0.455
CLV_PCSK_SKI1_1	146	150	PF00082	0.235
CLV_PCSK_SKI1_1	276	280	PF00082	0.536
CLV_PCSK_SKI1_1	405	409	PF00082	0.550
CLV_PCSK_SKI1_1	468	472	PF00082	0.444
CLV_PCSK_SKI1_1	51	55	PF00082	0.440
CLV_PCSK_SKI1_1	552	556	PF00082	0.521
CLV_PCSK_SKI1_1	557	561	PF00082	0.471
CLV_PCSK_SKI1_1	577	581	PF00082	0.474
CLV_PCSK_SKI1_1	91	95	PF00082	0.235
DOC_CKS1_1	487	492	PF01111	0.414
DOC_CYCLIN_RxL_1	143	150	PF00134	0.235
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.429
DOC_MAPK_DCC_7	18	26	PF00069	0.361
DOC_MAPK_gen_1	63	71	PF00069	0.386
DOC_PP1_RVXF_1	202	209	PF00149	0.235
DOC_PP4_FxxP_1	132	135	PF00568	0.386
DOC_PP4_FxxP_1	232	235	PF00568	0.423
DOC_PP4_FxxP_1	345	348	PF00568	0.558
DOC_USP7_MATH_1	190	194	PF00917	0.372
DOC_USP7_MATH_1	202	206	PF00917	0.288
DOC_USP7_MATH_1	298	302	PF00917	0.490
DOC_USP7_MATH_1	303	307	PF00917	0.450
DOC_USP7_MATH_1	346	350	PF00917	0.573
DOC_USP7_MATH_1	53	57	PF00917	0.235
DOC_WW_Pin1_4	122	127	PF00397	0.235
DOC_WW_Pin1_4	378	383	PF00397	0.548
DOC_WW_Pin1_4	437	442	PF00397	0.467
DOC_WW_Pin1_4	486	491	PF00397	0.431
DOC_WW_Pin1_4	577	582	PF00397	0.571
LIG_14-3-3_CanoR_1	144	149	PF00244	0.235
LIG_14-3-3_CanoR_1	214	224	PF00244	0.418
LIG_14-3-3_CanoR_1	268	275	PF00244	0.398
LIG_14-3-3_CanoR_1	302	311	PF00244	0.477
LIG_14-3-3_CanoR_1	362	366	PF00244	0.349
LIG_14-3-3_CanoR_1	43	50	PF00244	0.335
LIG_14-3-3_CanoR_1	434	444	PF00244	0.454
LIG_14-3-3_CanoR_1	504	508	PF00244	0.469
LIG_14-3-3_CanoR_1	52	62	PF00244	0.399
LIG_14-3-3_CanoR_1	91	96	PF00244	0.235
LIG_Actin_WH2_2	491	506	PF00022	0.459
LIG_APCC_ABBA_1	237	242	PF00400	0.325
LIG_APCC_ABBA_1	394	399	PF00400	0.561
LIG_BRCT_BRCA1_1	149	153	PF00533	0.386
LIG_BRCT_BRCA1_1	204	208	PF00533	0.386
LIG_BRCT_BRCA1_1	307	311	PF00533	0.471
LIG_eIF4E_1	143	149	PF01652	0.386
LIG_EVH1_2	451	455	PF00568	0.390
LIG_FHA_1	15	21	PF00498	0.586
LIG_FHA_1	35	41	PF00498	0.287
LIG_FHA_1	57	63	PF00498	0.235
LIG_FHA_2	11	17	PF00498	0.509
LIG_FHA_2	173	179	PF00498	0.328
LIG_FHA_2	2	8	PF00498	0.539
LIG_FHA_2	268	274	PF00498	0.470
LIG_FHA_2	328	334	PF00498	0.352
LIG_FHA_2	406	412	PF00498	0.543
LIG_FHA_2	455	461	PF00498	0.480
LIG_FHA_2	52	58	PF00498	0.386
LIG_FHA_2	65	71	PF00498	0.356
LIG_FHA_2	72	78	PF00498	0.453
LIG_LIR_Gen_1	193	203	PF02991	0.468
LIG_LIR_Gen_1	273	282	PF02991	0.432
LIG_LIR_Gen_1	35	44	PF02991	0.349
LIG_LIR_Gen_1	363	371	PF02991	0.462
LIG_LIR_Gen_1	478	487	PF02991	0.566
LIG_LIR_Gen_1	508	519	PF02991	0.403
LIG_LIR_Nem_3	193	198	PF02991	0.477
LIG_LIR_Nem_3	205	211	PF02991	0.309
LIG_LIR_Nem_3	273	277	PF02991	0.414
LIG_LIR_Nem_3	35	41	PF02991	0.349
LIG_LIR_Nem_3	363	368	PF02991	0.391
LIG_LIR_Nem_3	478	483	PF02991	0.579
LIG_LIR_Nem_3	508	514	PF02991	0.417
LIG_LIR_Nem_3	516	522	PF02991	0.352
LIG_MLH1_MIPbox_1	149	153	PF16413	0.386
LIG_MYND_1	325	329	PF01753	0.495
LIG_MYND_1	392	396	PF01753	0.582
LIG_PCNA_PIPBox_1	145	154	PF02747	0.363
LIG_Pex14_1	365	369	PF04695	0.457
LIG_REV1ctd_RIR_1	150	158	PF16727	0.386
LIG_SH2_CRK	38	42	PF00017	0.386
LIG_SH2_CRK	480	484	PF00017	0.572
LIG_SH2_GRB2like	211	214	PF00017	0.386
LIG_SH2_NCK_1	269	273	PF00017	0.470
LIG_SH2_NCK_1	480	484	PF00017	0.421
LIG_SH2_SRC	525	528	PF00017	0.474
LIG_SH2_STAP1	525	529	PF00017	0.481
LIG_SH2_STAT3	369	372	PF00017	0.473
LIG_SH2_STAT5	106	109	PF00017	0.325
LIG_SH2_STAT5	195	198	PF00017	0.526
LIG_SH2_STAT5	211	214	PF00017	0.265
LIG_SH2_STAT5	231	234	PF00017	0.224
LIG_SH2_STAT5	269	272	PF00017	0.467
LIG_SH2_STAT5	359	362	PF00017	0.473
LIG_SH2_STAT5	418	421	PF00017	0.548
LIG_SH2_STAT5	511	514	PF00017	0.394
LIG_SH2_STAT5	531	534	PF00017	0.408
LIG_SH2_STAT5	92	95	PF00017	0.370
LIG_SH3_1	389	395	PF00018	0.555
LIG_SH3_3	163	169	PF00018	0.235
LIG_SH3_3	203	209	PF00018	0.235
LIG_SH3_3	337	343	PF00018	0.442
LIG_SH3_3	355	361	PF00018	0.452
LIG_SH3_3	376	382	PF00018	0.523
LIG_SH3_3	389	395	PF00018	0.582
LIG_SH3_3	544	550	PF00018	0.492
LIG_SH3_5	164	168	PF00018	0.235
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.314
LIG_SUMO_SIM_par_1	171	179	PF11976	0.328
LIG_SUMO_SIM_par_1	25	31	PF11976	0.436
LIG_SUMO_SIM_par_1	66	72	PF11976	0.235
LIG_SxIP_EBH_1	377	391	PF03271	0.500
LIG_TRAF2_1	524	527	PF00917	0.469
LIG_TYR_ITIM	228	233	PF00017	0.408
LIG_TYR_ITSM	476	483	PF00017	0.589
LIG_WW_2	392	395	PF00397	0.591
LIG_WW_3	450	454	PF00397	0.405
MOD_CDK_SPxK_1	577	583	PF00069	0.516
MOD_CDK_SPxxK_3	486	493	PF00069	0.412
MOD_CK1_1	114	120	PF00069	0.505
MOD_CK1_1	147	153	PF00069	0.235
MOD_CK1_1	409	415	PF00069	0.381
MOD_CK1_1	56	62	PF00069	0.235
MOD_CK2_1	10	16	PF00069	0.610
MOD_CK2_1	256	262	PF00069	0.416
MOD_CK2_1	267	273	PF00069	0.463
MOD_CK2_1	405	411	PF00069	0.548
MOD_CK2_1	64	70	PF00069	0.270
MOD_GlcNHglycan	118	121	PF01048	0.455
MOD_GlcNHglycan	154	157	PF01048	0.386
MOD_GlcNHglycan	192	195	PF01048	0.372
MOD_GlcNHglycan	217	220	PF01048	0.499
MOD_GlcNHglycan	246	249	PF01048	0.366
MOD_GlcNHglycan	318	321	PF01048	0.532
MOD_GlcNHglycan	382	385	PF01048	0.532
MOD_GlcNHglycan	46	49	PF01048	0.386
MOD_GlcNHglycan	77	80	PF01048	0.235
MOD_GSK3_1	10	17	PF00069	0.625
MOD_GSK3_1	110	117	PF00069	0.519
MOD_GSK3_1	305	312	PF00069	0.530
MOD_GSK3_1	360	367	PF00069	0.347
MOD_GSK3_1	405	412	PF00069	0.514
MOD_GSK3_1	71	78	PF00069	0.523
MOD_N-GLC_1	110	115	PF02516	0.386
MOD_N-GLC_1	313	318	PF02516	0.603
MOD_N-GLC_1	32	37	PF02516	0.386
MOD_NEK2_1	152	157	PF00069	0.421
MOD_NEK2_1	34	39	PF00069	0.357
MOD_NEK2_1	44	49	PF00069	0.322
MOD_NEK2_1	470	475	PF00069	0.471
MOD_PIKK_1	10	16	PF00454	0.533
MOD_PIKK_1	470	476	PF00454	0.473
MOD_PKA_1	42	48	PF00069	0.386
MOD_PKA_1	51	57	PF00069	0.311
MOD_PKA_1	64	70	PF00069	0.340
MOD_PKA_2	256	262	PF00069	0.565
MOD_PKA_2	267	273	PF00069	0.406
MOD_PKA_2	361	367	PF00069	0.348
MOD_PKA_2	409	415	PF00069	0.381
MOD_PKA_2	42	48	PF00069	0.396
MOD_PKA_2	503	509	PF00069	0.447
MOD_PKA_2	51	57	PF00069	0.311
MOD_PKA_2	64	70	PF00069	0.340
MOD_Plk_1	110	116	PF00069	0.386
MOD_Plk_1	32	38	PF00069	0.386
MOD_Plk_2-3	162	168	PF00069	0.235
MOD_Plk_2-3	3	9	PF00069	0.539
MOD_Plk_4	22	28	PF00069	0.386
MOD_Plk_4	327	333	PF00069	0.494
MOD_Plk_4	336	342	PF00069	0.476
MOD_Plk_4	361	367	PF00069	0.474
MOD_Plk_4	475	481	PF00069	0.603
MOD_Plk_4	566	572	PF00069	0.434
MOD_Plk_4	64	70	PF00069	0.235
MOD_Plk_4	91	97	PF00069	0.256
MOD_ProDKin_1	122	128	PF00069	0.235
MOD_ProDKin_1	378	384	PF00069	0.553
MOD_ProDKin_1	437	443	PF00069	0.458
MOD_ProDKin_1	486	492	PF00069	0.434
MOD_ProDKin_1	577	583	PF00069	0.574
MOD_SUMO_rev_2	406	415	PF00179	0.406
TRG_DiLeu_BaEn_4	241	247	PF01217	0.297
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.511
TRG_ENDOCYTIC_2	195	198	PF00928	0.491
TRG_ENDOCYTIC_2	230	233	PF00928	0.502
TRG_ENDOCYTIC_2	269	272	PF00928	0.467
TRG_ENDOCYTIC_2	38	41	PF00928	0.386
TRG_ENDOCYTIC_2	480	483	PF00928	0.574
TRG_ENDOCYTIC_2	511	514	PF00928	0.394
TRG_ER_diArg_1	101	104	PF00400	0.393
TRG_ER_diArg_1	143	146	PF00400	0.235
TRG_ER_diArg_1	257	260	PF00400	0.408
TRG_ER_diArg_1	50	52	PF00400	0.427
TRG_ER_diArg_1	62	65	PF00400	0.366
TRG_NES_CRM1_1	241	256	PF08389	0.331
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.235
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	558	562	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID26	Leishmania donovani	68%	100%
A4I145	Leishmania infantum	68%	100%
E9AXY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QA93	Leishmania major	67%	100%