Putative n-terminal acetyltransferase complex ard1 subunit homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

n-terminal acetyltransferase complex ard1 subunit homolog, putative

Species:

Leishmania braziliensis

UniProt:

A4HDU9_LEIBR

TriTrypDb:

LbrM.25.0020 , LBRM2903_250005100

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0031248	protein acetyltransferase complex	3	1
GO:0031414	N-terminal protein acetyltransferase complex	4	1
GO:0031416	NatB complex	5	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902493	acetyltransferase complex	4	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HDU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDU9

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	1
GO:0006474	N-terminal protein amino acid acetylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0017196	N-terminal peptidyl-methionine acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0031365	N-terminal protein amino acid modification	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016407	acetyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0004596	peptide alpha-N-acetyltransferase activity	8	1
GO:0008080	N-acetyltransferase activity	6	1
GO:0016410	N-acyltransferase activity	5	1
GO:0034212	peptide N-acetyltransferase activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.404
CLV_NRD_NRD_1	132	134	PF00675	0.158
CLV_NRD_NRD_1	83	85	PF00675	0.309
CLV_PCSK_KEX2_1	132	134	PF00082	0.253
CLV_PCSK_KEX2_1	83	85	PF00082	0.309
CLV_PCSK_SKI1_1	132	136	PF00082	0.349
CLV_PCSK_SKI1_1	157	161	PF00082	0.487
CLV_PCSK_SKI1_1	176	180	PF00082	0.446
CLV_PCSK_SKI1_1	5	9	PF00082	0.394
CLV_PCSK_SKI1_1	84	88	PF00082	0.421
DOC_CYCLIN_yCln2_LP_2	174	180	PF00134	0.437
DOC_MAPK_gen_1	166	174	PF00069	0.456
DOC_USP7_MATH_1	96	100	PF00917	0.421
DOC_USP7_UBL2_3	144	148	PF12436	0.494
LIG_14-3-3_CanoR_1	166	172	PF00244	0.478
LIG_14-3-3_CanoR_1	5	10	PF00244	0.440
LIG_AP2alpha_1	107	111	PF02296	0.309
LIG_FHA_1	113	119	PF00498	0.291
LIG_FHA_1	48	54	PF00498	0.407
LIG_FHA_1	88	94	PF00498	0.325
LIG_FHA_2	6	12	PF00498	0.382
LIG_LIR_Gen_1	12	23	PF02991	0.445
LIG_LIR_Gen_1	121	131	PF02991	0.344
LIG_LIR_Gen_1	41	49	PF02991	0.372
LIG_LIR_Nem_3	12	18	PF02991	0.422
LIG_LIR_Nem_3	121	126	PF02991	0.300
LIG_LIR_Nem_3	29	35	PF02991	0.379
LIG_LIR_Nem_3	37	42	PF02991	0.363
LIG_LIR_Nem_3	81	85	PF02991	0.304
LIG_PDZ_Class_3	181	186	PF00595	0.590
LIG_PDZ_Wminus1_1	184	186	PF00595	0.630
LIG_Pex14_2	107	111	PF04695	0.300
LIG_PTB_Apo_2	101	108	PF02174	0.298
LIG_SH2_CRK	123	127	PF00017	0.309
LIG_SH2_CRK	131	135	PF00017	0.346
LIG_SH2_STAT5	106	109	PF00017	0.304
LIG_SH2_STAT5	128	131	PF00017	0.329
LIG_SH2_STAT5	35	38	PF00017	0.371
LIG_SH2_STAT5	57	60	PF00017	0.358
LIG_SH3_2	143	148	PF14604	0.587
LIG_SH3_3	140	146	PF00018	0.577
LIG_SH3_3	174	180	PF00018	0.421
LIG_SUMO_SIM_par_1	89	94	PF11976	0.398
LIG_TYR_ITIM	129	134	PF00017	0.352
MOD_CK1_1	74	80	PF00069	0.309
MOD_GlcNHglycan	73	76	PF01048	0.309
MOD_GSK3_1	23	30	PF00069	0.408
MOD_GSK3_1	3	10	PF00069	0.491
MOD_GSK3_1	74	81	PF00069	0.301
MOD_N-GLC_1	27	32	PF02516	0.498
MOD_NEK2_1	23	28	PF00069	0.384
MOD_NEK2_1	55	60	PF00069	0.357
MOD_NEK2_1	87	92	PF00069	0.316
MOD_NEK2_1	9	14	PF00069	0.496
MOD_NEK2_2	27	32	PF00069	0.449
MOD_PKA_2	112	118	PF00069	0.324
MOD_PKA_2	167	173	PF00069	0.513
MOD_Plk_1	27	33	PF00069	0.493
MOD_Plk_4	167	173	PF00069	0.472
MOD_Plk_4	27	33	PF00069	0.426
MOD_Plk_4	87	93	PF00069	0.360
TRG_ENDOCYTIC_2	123	126	PF00928	0.309
TRG_ENDOCYTIC_2	131	134	PF00928	0.332
TRG_ENDOCYTIC_2	4	7	PF00928	0.399
TRG_ENDOCYTIC_2	42	45	PF00928	0.356
TRG_ER_diArg_1	131	133	PF00400	0.218
TRG_ER_diArg_1	82	84	PF00400	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P642	Leptomonas seymouri	27%	70%
A0A0N1I212	Leptomonas seymouri	88%	100%
A0A0S4KNL4	Bodo saltans	65%	100%
A0A1X0NPT1	Trypanosomatidae	28%	72%
A0A1X0NYV1	Trypanosomatidae	76%	100%
A0A3Q8ID89	Leishmania donovani	92%	82%
A0A3R7M1B7	Trypanosoma rangeli	29%	74%
A0A3S7WSC5	Leishmania donovani	27%	72%
A0A422MUX3	Trypanosoma rangeli	48%	100%
A0A422N4M9	Trypanosoma rangeli	77%	100%
A4HHS3	Leishmania braziliensis	27%	70%
A4HVG9	Leishmania infantum	27%	72%
A4I144	Leishmania infantum	92%	82%
C9ZKU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
D0A6U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	70%
E9AP60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	72%
E9AXY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	78%
O61219	Caenorhabditis elegans	27%	100%
O74457	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
P36416	Dictyostelium discoideum	26%	92%
P41227	Homo sapiens	28%	79%
P61599	Homo sapiens	50%	100%
P61600	Mus musculus	50%	100%
Q05885	Leishmania donovani	91%	100%
Q06504	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	95%
Q2KI14	Bos taurus	28%	79%
Q2PFM2	Macaca fascicularis	50%	100%
Q3UX61	Mus musculus	27%	85%
Q4QA94	Leishmania major	91%	100%
Q4QGC8	Leishmania major	27%	72%
Q4V8K3	Rattus norvegicus	26%	76%
Q58ED9	Danio rerio	50%	100%
Q6P632	Xenopus tropicalis	49%	100%
Q7ZXR3	Xenopus laevis	49%	100%
Q8LGI8	Arabidopsis thaliana	52%	100%
Q8SSN5	Dictyostelium discoideum	49%	100%
Q9BSU3	Homo sapiens	28%	81%
Q9FKI4	Arabidopsis thaliana	32%	97%
Q9QY36	Mus musculus	28%	79%
Q9UTI3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
V5BDZ0	Trypanosoma cruzi	27%	72%