RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA binding protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDU7_LEIBR

TriTrypDb:

LbrM.24.2450 , LBRM2903_240023300

Length:

681

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDU7

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.519
CLV_C14_Caspase3-7	195	199	PF00656	0.581
CLV_NRD_NRD_1	423	425	PF00675	0.534
CLV_NRD_NRD_1	430	432	PF00675	0.585
CLV_PCSK_KEX2_1	423	425	PF00082	0.534
CLV_PCSK_KEX2_1	430	432	PF00082	0.585
CLV_PCSK_SKI1_1	161	165	PF00082	0.508
CLV_PCSK_SKI1_1	246	250	PF00082	0.275
CLV_PCSK_SKI1_1	262	266	PF00082	0.334
DEG_Nend_UBRbox_3	1	3	PF02207	0.663
DEG_SCF_FBW7_1	164	171	PF00400	0.665
DEG_SCF_FBW7_1	183	189	PF00400	0.523
DOC_ANK_TNKS_1	172	179	PF00023	0.515
DOC_CKS1_1	114	119	PF01111	0.632
DOC_CKS1_1	183	188	PF01111	0.680
DOC_CKS1_1	4	9	PF01111	0.537
DOC_CKS1_1	589	594	PF01111	0.681
DOC_CYCLIN_yClb3_PxF_3	665	671	PF00134	0.501
DOC_MAPK_FxFP_2	154	157	PF00069	0.586
DOC_MAPK_gen_1	244	251	PF00069	0.529
DOC_MAPK_gen_1	271	280	PF00069	0.607
DOC_PP1_RVXF_1	271	278	PF00149	0.529
DOC_PP2B_LxvP_1	501	504	PF13499	0.699
DOC_PP4_FxxP_1	154	157	PF00568	0.586
DOC_PP4_FxxP_1	222	225	PF00568	0.486
DOC_PP4_FxxP_1	611	614	PF00568	0.670
DOC_PP4_MxPP_1	1	4	PF00568	0.529
DOC_PP4_MxPP_1	473	476	PF00568	0.626
DOC_PP4_MxPP_1	663	666	PF00568	0.495
DOC_USP7_MATH_1	126	130	PF00917	0.639
DOC_USP7_MATH_1	168	172	PF00917	0.527
DOC_USP7_MATH_1	190	194	PF00917	0.689
DOC_USP7_MATH_1	212	216	PF00917	0.594
DOC_USP7_MATH_1	29	33	PF00917	0.681
DOC_USP7_MATH_1	371	375	PF00917	0.464
DOC_USP7_MATH_1	488	492	PF00917	0.641
DOC_USP7_MATH_1	537	541	PF00917	0.572
DOC_USP7_MATH_1	551	555	PF00917	0.649
DOC_USP7_MATH_1	644	648	PF00917	0.530
DOC_USP7_UBL2_3	402	406	PF12436	0.476
DOC_WW_Pin1_4	100	105	PF00397	0.616
DOC_WW_Pin1_4	113	118	PF00397	0.547
DOC_WW_Pin1_4	12	17	PF00397	0.676
DOC_WW_Pin1_4	164	169	PF00397	0.680
DOC_WW_Pin1_4	182	187	PF00397	0.682
DOC_WW_Pin1_4	25	30	PF00397	0.507
DOC_WW_Pin1_4	3	8	PF00397	0.648
DOC_WW_Pin1_4	400	405	PF00397	0.466
DOC_WW_Pin1_4	459	464	PF00397	0.587
DOC_WW_Pin1_4	494	499	PF00397	0.715
DOC_WW_Pin1_4	588	593	PF00397	0.680
DOC_WW_Pin1_4	665	670	PF00397	0.499
DOC_WW_Pin1_4	74	79	PF00397	0.546
LIG_14-3-3_CanoR_1	334	338	PF00244	0.486
LIG_14-3-3_CanoR_1	431	437	PF00244	0.563
LIG_BRCT_BRCA1_1	231	235	PF00533	0.405
LIG_BRCT_BRCA1_1	334	338	PF00533	0.417
LIG_BRCT_BRCA1_1	553	557	PF00533	0.693
LIG_BRCT_BRCA1_1	667	671	PF00533	0.506
LIG_CtBP_PxDLS_1	16	20	PF00389	0.531
LIG_CtBP_PxDLS_1	498	502	PF00389	0.530
LIG_EVH1_1	611	615	PF00568	0.594
LIG_EVH1_2	485	489	PF00568	0.650
LIG_FHA_1	150	156	PF00498	0.578
LIG_FHA_1	302	308	PF00498	0.604
LIG_FHA_1	6	12	PF00498	0.562
LIG_FHA_2	193	199	PF00498	0.525
LIG_FHA_2	334	340	PF00498	0.475
LIG_FHA_2	35	41	PF00498	0.557
LIG_FHA_2	368	374	PF00498	0.655
LIG_FHA_2	509	515	PF00498	0.523
LIG_GSK3_LRP6_1	186	191	PF00069	0.503
LIG_LIR_Apic_2	151	157	PF02991	0.581
LIG_LIR_Apic_2	219	225	PF02991	0.501
LIG_LIR_Gen_1	335	344	PF02991	0.488
LIG_LIR_Gen_1	517	527	PF02991	0.490
LIG_LIR_Gen_1	61	68	PF02991	0.510
LIG_LIR_Gen_1	668	679	PF02991	0.501
LIG_LIR_Nem_3	153	159	PF02991	0.597
LIG_LIR_Nem_3	24	30	PF02991	0.690
LIG_LIR_Nem_3	335	341	PF02991	0.488
LIG_LIR_Nem_3	517	522	PF02991	0.495
LIG_LIR_Nem_3	61	66	PF02991	0.510
LIG_LRP6_Inhibitor_1	155	161	PF00058	0.472
LIG_MLH1_MIPbox_1	553	557	PF16413	0.693
LIG_MLH1_MIPbox_1	667	671	PF16413	0.506
LIG_MYND_1	615	619	PF01753	0.656
LIG_MYND_1	662	666	PF01753	0.496
LIG_SH2_CRK	544	548	PF00017	0.669
LIG_SH2_NCK_1	528	532	PF00017	0.608
LIG_SH2_NCK_1	544	548	PF00017	0.593
LIG_SH2_SRC	314	317	PF00017	0.506
LIG_SH2_STAT3	340	343	PF00017	0.475
LIG_SH2_STAT5	159	162	PF00017	0.502
LIG_SH2_STAT5	314	317	PF00017	0.506
LIG_SH2_STAT5	340	343	PF00017	0.475
LIG_SH2_STAT5	670	673	PF00017	0.663
LIG_SH3_3	1	7	PF00018	0.532
LIG_SH3_3	180	186	PF00018	0.668
LIG_SH3_3	215	221	PF00018	0.523
LIG_SH3_3	313	319	PF00018	0.516
LIG_SH3_3	464	470	PF00018	0.621
LIG_SH3_3	487	493	PF00018	0.718
LIG_SH3_3	529	535	PF00018	0.728
LIG_SH3_3	558	564	PF00018	0.640
LIG_SH3_3	569	575	PF00018	0.562
LIG_SH3_3	609	615	PF00018	0.575
LIG_SH3_3	659	665	PF00018	0.500
LIG_SH3_3	98	104	PF00018	0.525
LIG_SUMO_SIM_par_1	239	245	PF11976	0.486
LIG_SUMO_SIM_par_1	247	253	PF11976	0.536
LIG_SUMO_SIM_par_1	263	269	PF11976	0.422
LIG_SUMO_SIM_par_1	328	333	PF11976	0.475
LIG_SUMO_SIM_par_1	563	568	PF11976	0.541
LIG_UBA3_1	248	254	PF00899	0.312
LIG_WRC_WIRS_1	60	65	PF05994	0.499
MOD_CDK_SPxK_1	400	406	PF00069	0.475
MOD_CK1_1	121	127	PF00069	0.700
MOD_CK1_1	129	135	PF00069	0.616
MOD_CK1_1	149	155	PF00069	0.487
MOD_CK1_1	171	177	PF00069	0.626
MOD_CK1_1	20	26	PF00069	0.537
MOD_CK1_1	216	222	PF00069	0.640
MOD_CK1_1	333	339	PF00069	0.312
MOD_CK1_1	351	357	PF00069	0.312
MOD_CK1_1	364	370	PF00069	0.677
MOD_CK1_1	449	455	PF00069	0.669
MOD_CK1_1	491	497	PF00069	0.776
MOD_CK1_1	508	514	PF00069	0.637
MOD_CK1_1	74	80	PF00069	0.630
MOD_CK2_1	34	40	PF00069	0.560
MOD_CK2_1	384	390	PF00069	0.503
MOD_CK2_1	55	61	PF00069	0.583
MOD_GlcNHglycan	120	123	PF01048	0.608
MOD_GlcNHglycan	129	132	PF01048	0.675
MOD_GlcNHglycan	135	138	PF01048	0.680
MOD_GlcNHglycan	148	151	PF01048	0.433
MOD_GlcNHglycan	200	203	PF01048	0.545
MOD_GlcNHglycan	215	218	PF01048	0.619
MOD_GlcNHglycan	259	262	PF01048	0.312
MOD_GlcNHglycan	363	366	PF01048	0.608
MOD_GlcNHglycan	448	451	PF01048	0.615
MOD_GlcNHglycan	529	532	PF01048	0.585
MOD_GlcNHglycan	539	542	PF01048	0.561
MOD_GlcNHglycan	557	560	PF01048	0.646
MOD_GlcNHglycan	569	572	PF01048	0.581
MOD_GlcNHglycan	625	628	PF01048	0.696
MOD_GlcNHglycan	73	76	PF01048	0.772
MOD_GlcNHglycan	91	94	PF01048	0.474
MOD_GSK3_1	126	133	PF00069	0.637
MOD_GSK3_1	146	153	PF00069	0.415
MOD_GSK3_1	162	169	PF00069	0.572
MOD_GSK3_1	17	24	PF00069	0.568
MOD_GSK3_1	182	189	PF00069	0.654
MOD_GSK3_1	198	205	PF00069	0.598
MOD_GSK3_1	212	219	PF00069	0.635
MOD_GSK3_1	25	32	PF00069	0.510
MOD_GSK3_1	328	335	PF00069	0.388
MOD_GSK3_1	367	374	PF00069	0.607
MOD_GSK3_1	396	403	PF00069	0.486
MOD_GSK3_1	502	509	PF00069	0.586
MOD_GSK3_1	522	529	PF00069	0.547
MOD_GSK3_1	533	540	PF00069	0.517
MOD_GSK3_1	55	62	PF00069	0.583
MOD_GSK3_1	551	558	PF00069	0.707
MOD_GSK3_1	563	570	PF00069	0.598
MOD_GSK3_1	640	647	PF00069	0.513
MOD_GSK3_1	70	77	PF00069	0.626
MOD_N-GLC_1	124	129	PF02516	0.694
MOD_N-GLC_1	198	203	PF02516	0.541
MOD_N-GLC_1	20	25	PF02516	0.537
MOD_N-GLC_1	293	298	PF02516	0.312
MOD_N-GLC_1	320	325	PF02516	0.410
MOD_N-GLC_1	361	366	PF02516	0.537
MOD_N-GLC_1	522	527	PF02516	0.485
MOD_N-GLC_1	644	649	PF02516	0.468
MOD_NEK2_1	118	123	PF00069	0.727
MOD_NEK2_1	200	205	PF00069	0.502
MOD_NEK2_1	293	298	PF00069	0.319
MOD_NEK2_1	330	335	PF00069	0.321
MOD_NEK2_1	506	511	PF00069	0.551
MOD_NEK2_1	555	560	PF00069	0.676
MOD_NEK2_1	565	570	PF00069	0.597
MOD_NEK2_1	89	94	PF00069	0.678
MOD_NEK2_2	168	173	PF00069	0.529
MOD_NEK2_2	418	423	PF00069	0.563
MOD_PIKK_1	166	172	PF00454	0.525
MOD_PIKK_1	202	208	PF00454	0.683
MOD_PIKK_1	220	226	PF00454	0.463
MOD_PIKK_1	5	11	PF00454	0.700
MOD_PIKK_1	55	61	PF00454	0.659
MOD_PIKK_1	565	571	PF00454	0.662
MOD_PIKK_1	621	627	PF00454	0.676
MOD_PK_1	279	285	PF00069	0.231
MOD_PKA_2	127	133	PF00069	0.645
MOD_PKA_2	333	339	PF00069	0.352
MOD_PKA_2	426	432	PF00069	0.535
MOD_Plk_1	150	156	PF00069	0.506
MOD_Plk_1	320	326	PF00069	0.412
MOD_Plk_1	348	354	PF00069	0.312
MOD_Plk_1	418	424	PF00069	0.567
MOD_Plk_2-3	372	378	PF00069	0.431
MOD_Plk_4	150	156	PF00069	0.578
MOD_Plk_4	320	326	PF00069	0.412
MOD_Plk_4	333	339	PF00069	0.407
MOD_Plk_4	502	508	PF00069	0.640
MOD_Plk_4	523	529	PF00069	0.497
MOD_Plk_4	551	557	PF00069	0.719
MOD_Plk_4	59	65	PF00069	0.581
MOD_Plk_4	644	650	PF00069	0.516
MOD_ProDKin_1	100	106	PF00069	0.620
MOD_ProDKin_1	113	119	PF00069	0.546
MOD_ProDKin_1	12	18	PF00069	0.676
MOD_ProDKin_1	164	170	PF00069	0.682
MOD_ProDKin_1	182	188	PF00069	0.683
MOD_ProDKin_1	25	31	PF00069	0.501
MOD_ProDKin_1	3	9	PF00069	0.653
MOD_ProDKin_1	400	406	PF00069	0.475
MOD_ProDKin_1	459	465	PF00069	0.587
MOD_ProDKin_1	494	500	PF00069	0.719
MOD_ProDKin_1	588	594	PF00069	0.683
MOD_ProDKin_1	665	671	PF00069	0.501
MOD_ProDKin_1	74	80	PF00069	0.540
MOD_SUMO_rev_2	372	379	PF00179	0.499
TRG_DiLeu_BaLyEn_6	409	414	PF01217	0.445
TRG_DiLeu_BaLyEn_6	613	618	PF01217	0.584
TRG_ENDOCYTIC_2	670	673	PF00928	0.587
TRG_ER_diArg_1	422	424	PF00400	0.566
TRG_ER_diArg_1	430	433	PF00400	0.524
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1V6	Leptomonas seymouri	42%	90%
A0A3S7WYI1	Leishmania donovani	70%	99%
E9AH64	Leishmania infantum	69%	98%
E9AX02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	98%
Q4QAH4	Leishmania major	70%	99%