Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDU6_LEIBR

TriTrypDb:

LbrM.24.2440 , LBRM2903_240010400

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDU6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.608
CLV_NRD_NRD_1	133	135	PF00675	0.353
CLV_NRD_NRD_1	195	197	PF00675	0.455
CLV_NRD_NRD_1	338	340	PF00675	0.549
CLV_NRD_NRD_1	368	370	PF00675	0.523
CLV_PCSK_KEX2_1	195	197	PF00082	0.492
CLV_PCSK_KEX2_1	338	340	PF00082	0.549
CLV_PCSK_KEX2_1	368	370	PF00082	0.523
CLV_PCSK_SKI1_1	134	138	PF00082	0.401
CLV_PCSK_SKI1_1	50	54	PF00082	0.467
DEG_Nend_UBRbox_2	1	3	PF02207	0.479
DEG_SCF_FBW7_1	434	439	PF00400	0.563
DEG_SPOP_SBC_1	475	479	PF00917	0.560
DOC_CKS1_1	433	438	PF01111	0.564
DOC_MAPK_gen_1	134	140	PF00069	0.464
DOC_MAPK_gen_1	481	488	PF00069	0.558
DOC_MAPK_MEF2A_6	448	456	PF00069	0.523
DOC_MAPK_MEF2A_6	462	471	PF00069	0.496
DOC_PP4_FxxP_1	326	329	PF00568	0.600
DOC_PP4_FxxP_1	38	41	PF00568	0.460
DOC_PP4_FxxP_1	94	97	PF00568	0.500
DOC_USP7_MATH_1	311	315	PF00917	0.571
DOC_USP7_MATH_1	352	356	PF00917	0.627
DOC_USP7_MATH_1	387	391	PF00917	0.639
DOC_USP7_MATH_1	434	438	PF00917	0.585
DOC_USP7_MATH_1	475	479	PF00917	0.680
DOC_USP7_MATH_1	492	496	PF00917	0.618
DOC_USP7_MATH_1	66	70	PF00917	0.457
DOC_USP7_MATH_1	97	101	PF00917	0.485
DOC_WW_Pin1_4	342	347	PF00397	0.540
DOC_WW_Pin1_4	353	358	PF00397	0.584
DOC_WW_Pin1_4	37	42	PF00397	0.460
DOC_WW_Pin1_4	432	437	PF00397	0.595
DOC_WW_Pin1_4	476	481	PF00397	0.586
DOC_WW_Pin1_4	54	59	PF00397	0.426
DOC_WW_Pin1_4	8	13	PF00397	0.471
LIG_14-3-3_CanoR_1	304	312	PF00244	0.779
LIG_14-3-3_CanoR_1	385	394	PF00244	0.610
LIG_14-3-3_CanoR_1	474	480	PF00244	0.592
LIG_14-3-3_CanoR_1	483	489	PF00244	0.635
LIG_Actin_WH2_2	123	141	PF00022	0.407
LIG_APCC_ABBA_1	147	152	PF00400	0.383
LIG_APCC_ABBA_1	166	171	PF00400	0.416
LIG_BRCT_BRCA1_1	344	348	PF00533	0.549
LIG_CtBP_PxDLS_1	468	472	PF00389	0.548
LIG_DLG_GKlike_1	448	456	PF00625	0.602
LIG_FHA_1	123	129	PF00498	0.336
LIG_FHA_1	14	20	PF00498	0.469
LIG_FHA_1	141	147	PF00498	0.391
LIG_FHA_1	192	198	PF00498	0.402
LIG_FHA_1	223	229	PF00498	0.472
LIG_FHA_1	281	287	PF00498	0.514
LIG_FHA_1	387	393	PF00498	0.537
LIG_FHA_1	401	407	PF00498	0.529
LIG_FHA_1	49	55	PF00498	0.462
LIG_FHA_2	290	296	PF00498	0.545
LIG_LIR_Apic_2	187	192	PF02991	0.476
LIG_LIR_Apic_2	272	278	PF02991	0.643
LIG_LIR_Apic_2	92	97	PF02991	0.501
LIG_LIR_Gen_1	107	117	PF02991	0.431
LIG_LIR_Gen_1	11	22	PF02991	0.460
LIG_LIR_Gen_1	30	41	PF02991	0.423
LIG_LIR_Nem_3	107	112	PF02991	0.416
LIG_LIR_Nem_3	11	17	PF02991	0.538
LIG_LIR_Nem_3	116	122	PF02991	0.486
LIG_LIR_Nem_3	30	36	PF02991	0.419
LIG_LIR_Nem_3	345	351	PF02991	0.563
LIG_NRBOX	223	229	PF00104	0.326
LIG_Pex14_1	33	37	PF04695	0.451
LIG_PTAP_UEV_1	356	361	PF05743	0.508
LIG_SH2_CRK	275	279	PF00017	0.638
LIG_SH2_PTP2	341	344	PF00017	0.629
LIG_SH2_SRC	190	193	PF00017	0.416
LIG_SH2_STAT3	201	204	PF00017	0.376
LIG_SH2_STAT3	420	423	PF00017	0.534
LIG_SH2_STAT5	190	193	PF00017	0.416
LIG_SH2_STAT5	341	344	PF00017	0.609
LIG_SH2_STAT5	37	40	PF00017	0.465
LIG_SH3_1	462	468	PF00018	0.517
LIG_SH3_3	167	173	PF00018	0.416
LIG_SH3_3	328	334	PF00018	0.489
LIG_SH3_3	340	346	PF00018	0.754
LIG_SH3_3	354	360	PF00018	0.704
LIG_SH3_3	462	468	PF00018	0.517
LIG_SH3_3	6	12	PF00018	0.472
LIG_SH3_3	60	66	PF00018	0.614
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.429
LIG_SUMO_SIM_par_1	125	132	PF11976	0.429
LIG_SUMO_SIM_par_1	467	473	PF11976	0.547
LIG_SUMO_SIM_par_1	484	489	PF11976	0.521
LIG_SxIP_EBH_1	385	398	PF03271	0.525
LIG_TRAF2_1	235	238	PF00917	0.617
LIG_TRFH_1	37	41	PF08558	0.459
LIG_TRFH_1	420	424	PF08558	0.527
LIG_WRC_WIRS_1	53	58	PF05994	0.455
MOD_CDK_SPK_2	476	481	PF00069	0.559
MOD_CDK_SPxxK_3	476	483	PF00069	0.572
MOD_CK1_1	13	19	PF00069	0.461
MOD_CK1_1	174	180	PF00069	0.543
MOD_CK1_1	207	213	PF00069	0.468
MOD_CK1_1	226	232	PF00069	0.405
MOD_CK1_1	236	242	PF00069	0.612
MOD_CK1_1	314	320	PF00069	0.653
MOD_CK1_1	355	361	PF00069	0.650
MOD_CK1_1	470	476	PF00069	0.622
MOD_CK2_1	289	295	PF00069	0.543
MOD_CK2_1	426	432	PF00069	0.559
MOD_Cter_Amidation	366	369	PF01082	0.528
MOD_GlcNHglycan	206	209	PF01048	0.539
MOD_GlcNHglycan	214	217	PF01048	0.440
MOD_GlcNHglycan	228	231	PF01048	0.387
MOD_GlcNHglycan	271	274	PF01048	0.558
MOD_GlcNHglycan	289	292	PF01048	0.571
MOD_GlcNHglycan	307	310	PF01048	0.618
MOD_GlcNHglycan	316	319	PF01048	0.535
MOD_GlcNHglycan	321	324	PF01048	0.525
MOD_GlcNHglycan	357	360	PF01048	0.513
MOD_GlcNHglycan	389	392	PF01048	0.619
MOD_GSK3_1	204	211	PF00069	0.463
MOD_GSK3_1	222	229	PF00069	0.289
MOD_GSK3_1	248	255	PF00069	0.509
MOD_GSK3_1	280	287	PF00069	0.550
MOD_GSK3_1	37	44	PF00069	0.459
MOD_GSK3_1	396	403	PF00069	0.674
MOD_GSK3_1	406	413	PF00069	0.598
MOD_GSK3_1	432	439	PF00069	0.629
MOD_GSK3_1	470	477	PF00069	0.668
MOD_GSK3_1	48	55	PF00069	0.443
MOD_NEK2_1	122	127	PF00069	0.436
MOD_NEK2_1	129	134	PF00069	0.448
MOD_NEK2_1	145	150	PF00069	0.375
MOD_NEK2_1	27	32	PF00069	0.459
MOD_NEK2_1	280	285	PF00069	0.745
MOD_NEK2_1	312	317	PF00069	0.612
MOD_NEK2_1	319	324	PF00069	0.542
MOD_NEK2_1	406	411	PF00069	0.643
MOD_NEK2_1	469	474	PF00069	0.681
MOD_NEK2_1	48	53	PF00069	0.463
MOD_NEK2_2	18	23	PF00069	0.457
MOD_PIKK_1	27	33	PF00454	0.455
MOD_PIKK_1	426	432	PF00454	0.592
MOD_PKA_2	287	293	PF00069	0.529
MOD_PKA_2	406	412	PF00069	0.556
MOD_PKA_2	447	453	PF00069	0.557
MOD_Plk_1	104	110	PF00069	0.490
MOD_Plk_1	448	454	PF00069	0.599
MOD_Plk_4	104	110	PF00069	0.445
MOD_Plk_4	223	229	PF00069	0.408
MOD_Plk_4	252	258	PF00069	0.532
MOD_Plk_4	406	412	PF00069	0.685
MOD_Plk_4	448	454	PF00069	0.523
MOD_ProDKin_1	342	348	PF00069	0.541
MOD_ProDKin_1	353	359	PF00069	0.585
MOD_ProDKin_1	37	43	PF00069	0.460
MOD_ProDKin_1	432	438	PF00069	0.595
MOD_ProDKin_1	476	482	PF00069	0.586
MOD_ProDKin_1	54	60	PF00069	0.428
MOD_ProDKin_1	8	14	PF00069	0.472
MOD_SUMO_rev_2	174	184	PF00179	0.467
TRG_ER_diArg_1	195	197	PF00400	0.450
TRG_ER_diArg_1	337	339	PF00400	0.553
TRG_ER_diArg_1	480	483	PF00400	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEP2	Leptomonas seymouri	34%	100%
A0A3S7WY45	Leishmania donovani	61%	100%
A4I0N7	Leishmania infantum	61%	100%
E9AWN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4QAT4	Leishmania major	61%	98%