BRO1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HDU1_LEIBR

TriTrypDb:

LbrM.24.2380 , LBRM2903_240031400

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDU1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	64	66	PF00675	0.627
CLV_PCSK_KEX2_1	64	66	PF00082	0.559
CLV_PCSK_SKI1_1	138	142	PF00082	0.755
CLV_PCSK_SKI1_1	169	173	PF00082	0.690
DEG_APCC_DBOX_1	137	145	PF00400	0.750
DEG_APCC_DBOX_1	168	176	PF00400	0.750
DEG_Nend_UBRbox_2	1	3	PF02207	0.779
DOC_PP2B_LxvP_1	123	126	PF13499	0.515
DOC_USP7_MATH_1	136	140	PF00917	0.676
DOC_USP7_MATH_1	27	31	PF00917	0.675
DOC_USP7_MATH_1	43	47	PF00917	0.530
DOC_USP7_MATH_1	66	70	PF00917	0.515
DOC_USP7_UBL2_3	107	111	PF12436	0.692
DOC_WW_Pin1_4	23	28	PF00397	0.513
LIG_14-3-3_CanoR_1	80	84	PF00244	0.516
LIG_Actin_WH2_2	141	157	PF00022	0.739
LIG_Actin_WH2_2	50	66	PF00022	0.653
LIG_FHA_1	9	15	PF00498	0.513
LIG_FHA_2	125	131	PF00498	0.674
LIG_FHA_2	199	205	PF00498	0.533
LIG_LIR_Gen_1	146	154	PF02991	0.639
LIG_LIR_Gen_1	2	8	PF02991	0.705
LIG_LIR_Gen_1	219	225	PF02991	0.567
LIG_LIR_Nem_3	146	150	PF02991	0.640
LIG_LIR_Nem_3	159	164	PF02991	0.523
LIG_LIR_Nem_3	219	223	PF02991	0.535
LIG_NRBOX	182	188	PF00104	0.490
LIG_PTB_Apo_2	155	162	PF02174	0.467
LIG_SH2_GRB2like	33	36	PF00017	0.772
LIG_SH2_SRC	33	36	PF00017	0.772
LIG_SH2_STAP1	33	37	PF00017	0.657
LIG_SH2_STAP1	4	8	PF00017	0.764
LIG_SH2_STAT5	39	42	PF00017	0.684
LIG_SH2_STAT5	48	51	PF00017	0.716
LIG_SUMO_SIM_anti_2	139	146	PF11976	0.612
LIG_TRAF2_1	201	204	PF00917	0.560
LIG_WRC_WIRS_1	144	149	PF05994	0.642
LIG_WRC_WIRS_1	164	169	PF05994	0.497
MOD_CK1_1	131	137	PF00069	0.629
MOD_CK1_1	146	152	PF00069	0.516
MOD_CK1_1	163	169	PF00069	0.616
MOD_CK1_1	213	219	PF00069	0.700
MOD_CK1_1	23	29	PF00069	0.694
MOD_CK1_1	92	98	PF00069	0.732
MOD_CK2_1	116	122	PF00069	0.734
MOD_CK2_1	124	130	PF00069	0.630
MOD_CK2_1	197	203	PF00069	0.596
MOD_CK2_1	3	9	PF00069	0.660
MOD_GlcNHglycan	133	136	PF01048	0.762
MOD_GlcNHglycan	138	141	PF01048	0.676
MOD_GlcNHglycan	212	215	PF01048	0.642
MOD_GlcNHglycan	22	25	PF01048	0.702
MOD_GlcNHglycan	27	30	PF01048	0.720
MOD_GlcNHglycan	94	97	PF01048	0.631
MOD_GSK3_1	124	131	PF00069	0.775
MOD_GSK3_1	146	153	PF00069	0.604
MOD_GSK3_1	187	194	PF00069	0.558
MOD_GSK3_1	209	216	PF00069	0.637
MOD_GSK3_1	227	234	PF00069	0.573
MOD_GSK3_1	23	30	PF00069	0.731
MOD_GSK3_1	85	92	PF00069	0.754
MOD_GSK3_1	97	104	PF00069	0.606
MOD_N-GLC_1	128	133	PF02516	0.773
MOD_N-GLC_1	150	155	PF02516	0.481
MOD_N-GLC_1	92	97	PF02516	0.559
MOD_N-GLC_2	87	89	PF02516	0.535
MOD_NEK2_1	13	18	PF00069	0.676
MOD_NEK2_1	150	155	PF00069	0.699
MOD_NEK2_1	187	192	PF00069	0.530
MOD_NEK2_1	20	25	PF00069	0.681
MOD_NEK2_1	209	214	PF00069	0.741
MOD_PIKK_1	97	103	PF00454	0.501
MOD_PKA_2	210	216	PF00069	0.730
MOD_PKA_2	43	49	PF00069	0.509
MOD_PKA_2	79	85	PF00069	0.514
MOD_Plk_1	105	111	PF00069	0.695
MOD_Plk_1	128	134	PF00069	0.688
MOD_Plk_1	150	156	PF00069	0.480
MOD_Plk_1	179	185	PF00069	0.627
MOD_Plk_4	143	149	PF00069	0.656
MOD_Plk_4	3	9	PF00069	0.511
MOD_Plk_4	66	72	PF00069	0.740
MOD_ProDKin_1	23	29	PF00069	0.513
MOD_SUMO_rev_2	190	200	PF00179	0.678
TRG_DiLeu_BaEn_2	8	14	PF01217	0.507
TRG_ENDOCYTIC_2	4	7	PF00928	0.755
TRG_ER_diArg_1	63	65	PF00400	0.574
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.661
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C0	Leptomonas seymouri	29%	100%
A0A3S7WYM3	Leishmania donovani	60%	100%
A4I138	Leishmania infantum	60%	100%
E9AX76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4QAA0	Leishmania major	62%	100%