Cullin-like protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cullin-like protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HDU0_LEIBR

TriTrypDb:

LbrM.24.2370 , LBRM2903_240031300

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0005737	cytoplasm	2	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HDU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDU0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12
GO:0016567	protein ubiquitination	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0070647	protein modification by small protein conjugation or removal	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0019899	enzyme binding	3	12
GO:0031625	ubiquitin protein ligase binding	5	12
GO:0044389	ubiquitin-like protein ligase binding	4	12
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.529
CLV_MEL_PAP_1	705	711	PF00089	0.294
CLV_NRD_NRD_1	241	243	PF00675	0.323
CLV_NRD_NRD_1	298	300	PF00675	0.296
CLV_NRD_NRD_1	35	37	PF00675	0.446
CLV_NRD_NRD_1	622	624	PF00675	0.341
CLV_NRD_NRD_1	647	649	PF00675	0.481
CLV_NRD_NRD_1	673	675	PF00675	0.275
CLV_NRD_NRD_1	689	691	PF00675	0.250
CLV_NRD_NRD_1	725	727	PF00675	0.257
CLV_NRD_NRD_1	9	11	PF00675	0.430
CLV_PCSK_FUR_1	645	649	PF00082	0.581
CLV_PCSK_KEX2_1	206	208	PF00082	0.370
CLV_PCSK_KEX2_1	241	243	PF00082	0.330
CLV_PCSK_KEX2_1	298	300	PF00082	0.296
CLV_PCSK_KEX2_1	35	37	PF00082	0.427
CLV_PCSK_KEX2_1	647	649	PF00082	0.542
CLV_PCSK_KEX2_1	689	691	PF00082	0.273
CLV_PCSK_KEX2_1	725	727	PF00082	0.316
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.370
CLV_PCSK_PC7_1	237	243	PF00082	0.360
CLV_PCSK_SKI1_1	156	160	PF00082	0.335
CLV_PCSK_SKI1_1	251	255	PF00082	0.302
CLV_PCSK_SKI1_1	443	447	PF00082	0.273
CLV_PCSK_SKI1_1	549	553	PF00082	0.265
CLV_PCSK_SKI1_1	6	10	PF00082	0.459
CLV_PCSK_SKI1_1	619	623	PF00082	0.316
CLV_PCSK_SKI1_1	627	631	PF00082	0.351
CLV_PCSK_SKI1_1	684	688	PF00082	0.255
CLV_PCSK_SKI1_1	714	718	PF00082	0.246
CLV_PCSK_SKI1_1	90	94	PF00082	0.276
CLV_Separin_Metazoa	536	540	PF03568	0.560
DEG_APCC_DBOX_1	5	13	PF00400	0.537
DEG_COP1_1	520	530	PF00400	0.518
DEG_Nend_Nbox_1	1	3	PF02207	0.466
DEG_SPOP_SBC_1	380	384	PF00917	0.551
DOC_CKS1_1	591	596	PF01111	0.560
DOC_CYCLIN_RxL_1	153	161	PF00134	0.541
DOC_MAPK_gen_1	298	305	PF00069	0.497
DOC_MAPK_gen_1	623	632	PF00069	0.460
DOC_MAPK_MEF2A_6	518	527	PF00069	0.512
DOC_MAPK_MEF2A_6	708	715	PF00069	0.532
DOC_PP1_RVXF_1	441	447	PF00149	0.394
DOC_PP1_RVXF_1	547	554	PF00149	0.455
DOC_PP4_FxxP_1	197	200	PF00568	0.469
DOC_USP7_MATH_1	484	488	PF00917	0.380
DOC_USP7_MATH_1	544	548	PF00917	0.508
DOC_USP7_MATH_1	656	660	PF00917	0.601
DOC_USP7_UBL2_3	104	108	PF12436	0.466
DOC_USP7_UBL2_3	156	160	PF12436	0.541
DOC_WW_Pin1_4	260	265	PF00397	0.514
DOC_WW_Pin1_4	270	275	PF00397	0.516
DOC_WW_Pin1_4	498	503	PF00397	0.380
DOC_WW_Pin1_4	586	591	PF00397	0.505
DOC_WW_Pin1_4	610	615	PF00397	0.539
DOC_WW_Pin1_4	707	712	PF00397	0.456
LIG_14-3-3_CanoR_1	165	174	PF00244	0.503
LIG_14-3-3_CanoR_1	241	247	PF00244	0.484
LIG_14-3-3_CanoR_1	251	260	PF00244	0.495
LIG_14-3-3_CanoR_1	418	424	PF00244	0.502
LIG_14-3-3_CanoR_1	431	440	PF00244	0.482
LIG_14-3-3_CanoR_1	49	57	PF00244	0.505
LIG_14-3-3_CanoR_1	518	526	PF00244	0.480
LIG_14-3-3_CanoR_1	549	554	PF00244	0.466
LIG_14-3-3_CanoR_1	600	606	PF00244	0.528
LIG_14-3-3_CanoR_1	657	661	PF00244	0.598
LIG_14-3-3_CanoR_1	689	693	PF00244	0.480
LIG_APCC_ABBA_1	135	140	PF00400	0.455
LIG_APCC_ABBA_1	198	203	PF00400	0.516
LIG_APCC_ABBA_1	390	395	PF00400	0.516
LIG_APCC_Cbox_2	430	436	PF00515	0.541
LIG_BRCT_BRCA1_1	352	356	PF00533	0.496
LIG_BRCT_BRCA1_1	484	488	PF00533	0.516
LIG_BRCT_BRCA1_1	705	709	PF00533	0.480
LIG_Clathr_ClatBox_1	629	633	PF01394	0.560
LIG_Clathr_ClatBox_1	65	69	PF01394	0.496
LIG_CtBP_PxDLS_1	652	656	PF00389	0.586
LIG_deltaCOP1_diTrp_1	481	488	PF00928	0.561
LIG_EH1_1	502	510	PF00400	0.541
LIG_eIF4E_1	60	66	PF01652	0.480
LIG_FHA_1	152	158	PF00498	0.449
LIG_FHA_1	187	193	PF00498	0.541
LIG_FHA_1	273	279	PF00498	0.470
LIG_FHA_1	470	476	PF00498	0.466
LIG_FHA_1	578	584	PF00498	0.440
LIG_FHA_1	73	79	PF00498	0.460
LIG_FHA_2	203	209	PF00498	0.530
LIG_FHA_2	252	258	PF00498	0.469
LIG_FHA_2	425	431	PF00498	0.509
LIG_FHA_2	433	439	PF00498	0.462
LIG_FHA_2	635	641	PF00498	0.560
LIG_GBD_Chelix_1	149	157	PF00786	0.341
LIG_LIR_Apic_2	195	200	PF02991	0.471
LIG_LIR_Gen_1	15	23	PF02991	0.440
LIG_LIR_Gen_1	208	213	PF02991	0.501
LIG_LIR_Gen_1	604	612	PF02991	0.560
LIG_LIR_Gen_1	69	78	PF02991	0.469
LIG_LIR_Nem_3	113	117	PF02991	0.392
LIG_LIR_Nem_3	118	124	PF02991	0.324
LIG_LIR_Nem_3	15	19	PF02991	0.430
LIG_LIR_Nem_3	208	212	PF02991	0.479
LIG_LIR_Nem_3	25	30	PF02991	0.491
LIG_LIR_Nem_3	346	351	PF02991	0.459
LIG_LIR_Nem_3	56	60	PF02991	0.466
LIG_LIR_Nem_3	604	608	PF02991	0.560
LIG_LIR_Nem_3	64	70	PF02991	0.445
LIG_LIR_Nem_3	98	103	PF02991	0.461
LIG_LYPXL_S_1	347	351	PF13949	0.341
LIG_LYPXL_yS_3	348	351	PF13949	0.541
LIG_PCNA_yPIPBox_3	71	82	PF02747	0.455
LIG_PCNA_yPIPBox_3	731	742	PF02747	0.501
LIG_PDZ_Class_2	738	743	PF00595	0.391
LIG_Pex14_1	396	400	PF04695	0.541
LIG_Pex14_2	212	216	PF04695	0.547
LIG_Pex14_2	356	360	PF04695	0.541
LIG_PTB_Apo_2	21	28	PF02174	0.474
LIG_PTB_Apo_2	290	297	PF02174	0.560
LIG_PTB_Apo_2	399	406	PF02174	0.560
LIG_REV1ctd_RIR_1	293	303	PF16727	0.541
LIG_SH2_CRK	103	107	PF00017	0.466
LIG_SH2_CRK	40	44	PF00017	0.455
LIG_SH2_CRK	739	743	PF00017	0.482
LIG_SH2_GRB2like	400	403	PF00017	0.541
LIG_SH2_NCK_1	40	44	PF00017	0.455
LIG_SH2_SRC	400	403	PF00017	0.459
LIG_SH2_STAP1	209	213	PF00017	0.520
LIG_SH2_STAT5	116	119	PF00017	0.448
LIG_SH2_STAT5	121	124	PF00017	0.443
LIG_SH2_STAT5	193	196	PF00017	0.464
LIG_SH2_STAT5	201	204	PF00017	0.443
LIG_SH2_STAT5	243	246	PF00017	0.477
LIG_SH2_STAT5	337	340	PF00017	0.538
LIG_SH2_STAT5	400	403	PF00017	0.484
LIG_SH2_STAT5	425	428	PF00017	0.466
LIG_SH2_STAT5	44	47	PF00017	0.478
LIG_SH2_STAT5	542	545	PF00017	0.466
LIG_SH2_STAT5	565	568	PF00017	0.380
LIG_SH2_STAT5	611	614	PF00017	0.560
LIG_SH2_STAT5	728	731	PF00017	0.480
LIG_SH2_STAT5	77	80	PF00017	0.511
LIG_SH3_3	258	264	PF00018	0.541
LIG_SH3_3	268	274	PF00018	0.541
LIG_SH3_3	531	537	PF00018	0.553
LIG_SH3_3	588	594	PF00018	0.560
LIG_SH3_4	127	134	PF00018	0.480
LIG_SUMO_SIM_anti_2	300	307	PF11976	0.541
LIG_SUMO_SIM_anti_2	331	336	PF11976	0.546
LIG_SUMO_SIM_anti_2	580	585	PF11976	0.380
LIG_SUMO_SIM_par_1	95	101	PF11976	0.541
LIG_TRAF2_2	594	599	PF00917	0.560
LIG_UBA3_1	305	312	PF00899	0.541
LIG_WRC_WIRS_1	111	116	PF05994	0.516
LIG_WRC_WIRS_1	30	35	PF05994	0.565
LIG_WRC_WIRS_1	527	532	PF05994	0.478
MOD_CDK_SPxxK_3	260	267	PF00069	0.540
MOD_CDK_SPxxK_3	610	617	PF00069	0.539
MOD_CDK_SPxxK_3	707	714	PF00069	0.494
MOD_CK1_1	126	132	PF00069	0.496
MOD_CK1_1	151	157	PF00069	0.447
MOD_CK1_1	263	269	PF00069	0.480
MOD_CK1_1	294	300	PF00069	0.487
MOD_CK1_1	379	385	PF00069	0.452
MOD_CK1_1	517	523	PF00069	0.560
MOD_CK1_1	707	713	PF00069	0.531
MOD_CK1_1	730	736	PF00069	0.380
MOD_CK1_1	85	91	PF00069	0.549
MOD_CK2_1	225	231	PF00069	0.547
MOD_CK2_1	251	257	PF00069	0.458
MOD_CK2_1	294	300	PF00069	0.484
MOD_CK2_1	381	387	PF00069	0.406
MOD_CK2_1	432	438	PF00069	0.541
MOD_CK2_1	498	504	PF00069	0.496
MOD_CK2_1	555	561	PF00069	0.541
MOD_Cter_Amidation	687	690	PF01082	0.341
MOD_GlcNHglycan	300	303	PF01048	0.302
MOD_GlcNHglycan	383	386	PF01048	0.316
MOD_GlcNHglycan	412	415	PF01048	0.343
MOD_GlcNHglycan	546	549	PF01048	0.321
MOD_GlcNHglycan	558	561	PF01048	0.217
MOD_GlcNHglycan	624	627	PF01048	0.341
MOD_GlcNHglycan	83	87	PF01048	0.343
MOD_GSK3_1	188	195	PF00069	0.541
MOD_GSK3_1	231	238	PF00069	0.512
MOD_GSK3_1	256	263	PF00069	0.523
MOD_GSK3_1	294	301	PF00069	0.536
MOD_GSK3_1	376	383	PF00069	0.427
MOD_GSK3_1	45	52	PF00069	0.492
MOD_GSK3_1	551	558	PF00069	0.450
MOD_GSK3_1	586	593	PF00069	0.503
MOD_GSK3_1	615	622	PF00069	0.500
MOD_GSK3_1	656	663	PF00069	0.585
MOD_GSK3_1	703	710	PF00069	0.458
MOD_N-GLC_1	49	54	PF02516	0.329
MOD_N-GLC_1	586	591	PF02516	0.303
MOD_NEK2_1	180	185	PF00069	0.459
MOD_NEK2_1	202	207	PF00069	0.487
MOD_NEK2_1	225	230	PF00069	0.532
MOD_NEK2_1	291	296	PF00069	0.546
MOD_NEK2_1	358	363	PF00069	0.483
MOD_NEK2_1	432	437	PF00069	0.532
MOD_NEK2_1	615	620	PF00069	0.479
MOD_NEK2_1	73	78	PF00069	0.503
MOD_NEK2_2	484	489	PF00069	0.482
MOD_PIKK_1	151	157	PF00454	0.464
MOD_PIKK_1	186	192	PF00454	0.541
MOD_PIKK_1	567	573	PF00454	0.541
MOD_PKA_1	298	304	PF00069	0.541
MOD_PKA_1	567	573	PF00069	0.541
MOD_PKA_2	298	304	PF00069	0.517
MOD_PKA_2	48	54	PF00069	0.466
MOD_PKA_2	517	523	PF00069	0.541
MOD_PKA_2	622	628	PF00069	0.516
MOD_PKA_2	656	662	PF00069	0.592
MOD_PKA_2	664	670	PF00069	0.520
MOD_PKA_2	688	694	PF00069	0.541
MOD_PKA_2	730	736	PF00069	0.476
MOD_PKB_1	617	625	PF00069	0.560
MOD_PKB_1	80	88	PF00069	0.560
MOD_Plk_1	235	241	PF00069	0.491
MOD_Plk_1	256	262	PF00069	0.500
MOD_Plk_1	328	334	PF00069	0.534
MOD_Plk_1	358	364	PF00069	0.506
MOD_Plk_1	634	640	PF00069	0.555
MOD_Plk_2-3	328	334	PF00069	0.530
MOD_Plk_2-3	634	640	PF00069	0.541
MOD_Plk_4	133	139	PF00069	0.483
MOD_Plk_4	188	194	PF00069	0.516
MOD_Plk_4	256	262	PF00069	0.485
MOD_Plk_4	291	297	PF00069	0.506
MOD_Plk_4	39	45	PF00069	0.466
MOD_Plk_4	474	480	PF00069	0.486
MOD_Plk_4	526	532	PF00069	0.465
MOD_Plk_4	577	583	PF00069	0.552
MOD_Plk_4	656	662	PF00069	0.570
MOD_Plk_4	73	79	PF00069	0.529
MOD_ProDKin_1	260	266	PF00069	0.514
MOD_ProDKin_1	270	276	PF00069	0.516
MOD_ProDKin_1	498	504	PF00069	0.380
MOD_ProDKin_1	586	592	PF00069	0.505
MOD_ProDKin_1	610	616	PF00069	0.539
MOD_ProDKin_1	707	713	PF00069	0.456
MOD_SUMO_for_1	325	328	PF00179	0.541
MOD_SUMO_rev_2	164	174	PF00179	0.505
MOD_SUMO_rev_2	667	677	PF00179	0.466
MOD_SUMO_rev_2	706	716	PF00179	0.456
TRG_DiLeu_BaEn_1	504	509	PF01217	0.560
TRG_DiLeu_BaEn_1	693	698	PF01217	0.433
TRG_DiLeu_BaEn_2	427	433	PF01217	0.541
TRG_DiLeu_BaLyEn_6	611	616	PF01217	0.480
TRG_ENDOCYTIC_2	103	106	PF00928	0.454
TRG_ENDOCYTIC_2	120	123	PF00928	0.411
TRG_ENDOCYTIC_2	209	212	PF00928	0.474
TRG_ENDOCYTIC_2	243	246	PF00928	0.476
TRG_ENDOCYTIC_2	30	33	PF00928	0.493
TRG_ENDOCYTIC_2	348	351	PF00928	0.516
TRG_ENDOCYTIC_2	40	43	PF00928	0.418
TRG_ENDOCYTIC_2	70	73	PF00928	0.463
TRG_ENDOCYTIC_2	739	742	PF00928	0.466
TRG_ENDOCYTIC_2	81	84	PF00928	0.475
TRG_ER_diArg_1	241	243	PF00400	0.549
TRG_ER_diArg_1	281	284	PF00400	0.491
TRG_ER_diArg_1	35	37	PF00400	0.446
TRG_ER_diArg_1	463	466	PF00400	0.523
TRG_ER_diArg_1	616	619	PF00400	0.541
TRG_ER_diArg_1	645	648	PF00400	0.593
TRG_ER_diArg_1	724	726	PF00400	0.516
TRG_NLS_MonoExtC_3	9	15	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.322
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I048	Leptomonas seymouri	82%	100%
A0A0S4J5R6	Bodo saltans	23%	90%
A0A0S4KHD2	Bodo saltans	22%	100%
A0A0S4KHS5	Bodo saltans	33%	100%
A0A1X0NXD6	Trypanosomatidae	45%	100%
A0A3Q8IF31	Leishmania donovani	92%	100%
A0A3R7K785	Trypanosoma rangeli	45%	100%
A0A3R7K7T8	Trypanosoma rangeli	21%	92%
A2A432	Mus musculus	24%	77%
A4I137	Leishmania infantum	91%	100%
A4IHP4	Xenopus tropicalis	25%	97%
B5DF89	Rattus norvegicus	25%	97%
C9ZW70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AX75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O13790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	97%
O14122	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
O60999	Dictyostelium discoideum	24%	96%
P0CH31	Arabidopsis thaliana	25%	100%
Q09760	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	95%
Q12018	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	91%
Q13616	Homo sapiens	24%	96%
Q13617	Homo sapiens	22%	100%
Q13618	Homo sapiens	25%	97%
Q13619	Homo sapiens	24%	98%
Q13620	Homo sapiens	24%	81%
Q17389	Caenorhabditis elegans	24%	95%
Q17390	Caenorhabditis elegans	22%	94%
Q17391	Caenorhabditis elegans	25%	96%
Q21346	Caenorhabditis elegans	25%	100%
Q23639	Caenorhabditis elegans	21%	97%
Q24311	Drosophila melanogaster	23%	96%
Q29425	Oryctolagus cuniculus	21%	95%
Q3TCH7	Mus musculus	23%	98%
Q4QAA1	Leishmania major	92%	100%
Q54CS2	Dictyostelium discoideum	23%	93%
Q54NZ5	Dictyostelium discoideum	22%	97%
Q54XF7	Dictyostelium discoideum	21%	99%
Q5R4G6	Pongo abelii	24%	96%
Q5RB36	Pongo abelii	21%	95%
Q5RCF3	Pongo abelii	22%	100%
Q5ZC88	Oryza sativa subsp. japonica	26%	100%
Q6DE95	Xenopus laevis	25%	97%
Q6GPF3	Xenopus laevis	25%	97%
Q8LGH4	Arabidopsis thaliana	24%	94%
Q93034	Homo sapiens	22%	95%
Q94AH6	Arabidopsis thaliana	27%	100%
Q9C9L0	Arabidopsis thaliana	24%	100%
Q9D4H8	Mus musculus	23%	100%
Q9D5V5	Mus musculus	22%	95%
Q9JJ31	Rattus norvegicus	22%	95%
Q9JLV5	Mus musculus	25%	97%
Q9SRZ0	Arabidopsis thaliana	27%	100%
Q9WTX6	Mus musculus	24%	96%
Q9XZJ3	Dictyostelium discoideum	22%	96%
Q9ZVH4	Arabidopsis thaliana	24%	100%
V5APS6	Trypanosoma cruzi	45%	100%