Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger multi-pass transmembrane protein

Species:

Leishmania braziliensis

UniProt:

A4HDT8_LEIBR

TriTrypDb:

LbrM.24.2350 , LBRM2903_240031100

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HDT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDT8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016409	palmitoyltransferase activity	5	8
GO:0016417	S-acyltransferase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016746	acyltransferase activity	3	8
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	8
GO:0019707	protein-cysteine S-acyltransferase activity	3	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.299
CLV_NRD_NRD_1	165	167	PF00675	0.298
CLV_NRD_NRD_1	190	192	PF00675	0.315
CLV_NRD_NRD_1	249	251	PF00675	0.303
CLV_NRD_NRD_1	261	263	PF00675	0.381
CLV_PCSK_FUR_1	188	192	PF00082	0.298
CLV_PCSK_FUR_1	259	263	PF00082	0.382
CLV_PCSK_KEX2_1	165	167	PF00082	0.309
CLV_PCSK_KEX2_1	190	192	PF00082	0.294
CLV_PCSK_KEX2_1	249	251	PF00082	0.303
CLV_PCSK_KEX2_1	259	261	PF00082	0.418
CLV_PCSK_PC7_1	255	261	PF00082	0.363
CLV_PCSK_SKI1_1	190	194	PF00082	0.256
CLV_PCSK_SKI1_1	210	214	PF00082	0.584
CLV_PCSK_SKI1_1	255	259	PF00082	0.305
CLV_PCSK_SKI1_1	270	274	PF00082	0.380
DEG_APCC_DBOX_1	190	198	PF00400	0.498
DOC_CDC14_PxL_1	103	111	PF14671	0.293
DOC_CKS1_1	147	152	PF01111	0.527
DOC_CYCLIN_yClb1_LxF_4	93	99	PF00134	0.343
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.348
DOC_MAPK_MEF2A_6	110	118	PF00069	0.377
DOC_MAPK_MEF2A_6	270	277	PF00069	0.521
DOC_MAPK_NFAT4_5	270	278	PF00069	0.531
DOC_MAPK_RevD_3	235	250	PF00069	0.243
DOC_PP1_RVXF_1	272	278	PF00149	0.478
DOC_PP2B_LxvP_1	18	21	PF13499	0.348
DOC_PP4_FxxP_1	143	146	PF00568	0.416
DOC_USP7_MATH_1	7	11	PF00917	0.374
DOC_WW_Pin1_4	146	151	PF00397	0.522
DOC_WW_Pin1_4	43	48	PF00397	0.620
LIG_14-3-3_CanoR_1	249	258	PF00244	0.498
LIG_14-3-3_CanoR_1	81	90	PF00244	0.333
LIG_14-3-3_CterR_2	274	278	PF00244	0.482
LIG_Actin_WH2_2	233	251	PF00022	0.352
LIG_BRCT_BRCA1_1	139	143	PF00533	0.352
LIG_FHA_1	124	130	PF00498	0.242
LIG_FHA_2	1	7	PF00498	0.406
LIG_FHA_2	251	257	PF00498	0.500
LIG_FHA_2	80	86	PF00498	0.322
LIG_LIR_Apic_2	140	146	PF02991	0.352
LIG_LIR_Gen_1	124	135	PF02991	0.301
LIG_LIR_Nem_3	124	130	PF02991	0.301
LIG_LIR_Nem_3	205	209	PF02991	0.366
LIG_LIR_Nem_3	68	74	PF02991	0.343
LIG_LIR_Nem_3	9	14	PF02991	0.256
LIG_NRBOX	203	209	PF00104	0.348
LIG_NRBOX	236	242	PF00104	0.348
LIG_Pex14_1	11	15	PF04695	0.290
LIG_Pex14_2	31	35	PF04695	0.460
LIG_PTB_Apo_2	200	207	PF02174	0.290
LIG_PTB_Apo_2	25	32	PF02174	0.348
LIG_PTB_Apo_2	91	98	PF02174	0.339
LIG_PTB_Phospho_1	200	206	PF10480	0.348
LIG_SH2_PTP2	15	18	PF00017	0.243
LIG_SH2_PTP2	61	64	PF00017	0.230
LIG_SH2_STAP1	138	142	PF00017	0.348
LIG_SH2_STAP1	211	215	PF00017	0.259
LIG_SH2_STAT5	108	111	PF00017	0.402
LIG_SH2_STAT5	127	130	PF00017	0.171
LIG_SH2_STAT5	15	18	PF00017	0.246
LIG_SH2_STAT5	163	166	PF00017	0.597
LIG_SH2_STAT5	179	182	PF00017	0.439
LIG_SH2_STAT5	206	209	PF00017	0.348
LIG_SH2_STAT5	61	64	PF00017	0.416
LIG_SH2_STAT5	74	77	PF00017	0.328
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.220
LIG_SUMO_SIM_par_1	228	234	PF11976	0.245
LIG_SUMO_SIM_par_1	63	68	PF11976	0.290
LIG_TRAF2_1	3	6	PF00917	0.383
LIG_TYR_ITIM	125	130	PF00017	0.352
MOD_CK1_1	123	129	PF00069	0.229
MOD_CK1_1	49	55	PF00069	0.618
MOD_CK2_1	250	256	PF00069	0.498
MOD_GlcNHglycan	151	154	PF01048	0.435
MOD_GSK3_1	119	126	PF00069	0.300
MOD_GSK3_1	137	144	PF00069	0.377
MOD_N-GLC_1	202	207	PF02516	0.348
MOD_NEK2_1	112	117	PF00069	0.331
MOD_NEK2_1	137	142	PF00069	0.421
MOD_PIKK_1	79	85	PF00454	0.258
MOD_Plk_1	123	129	PF00069	0.283
MOD_Plk_1	202	208	PF00069	0.348
MOD_Plk_4	112	118	PF00069	0.414
MOD_Plk_4	123	129	PF00069	0.228
MOD_Plk_4	202	208	PF00069	0.348
MOD_ProDKin_1	146	152	PF00069	0.531
MOD_ProDKin_1	43	49	PF00069	0.622
TRG_ENDOCYTIC_2	127	130	PF00928	0.348
TRG_ENDOCYTIC_2	15	18	PF00928	0.297
TRG_ENDOCYTIC_2	61	64	PF00928	0.411
TRG_ENDOCYTIC_2	73	76	PF00928	0.321
TRG_ER_diArg_1	188	191	PF00400	0.515
TRG_ER_diArg_1	248	250	PF00400	0.498
TRG_ER_diArg_1	258	261	PF00400	0.606
TRG_ER_diArg_1	53	56	PF00400	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSZ8	Leptomonas seymouri	61%	99%
A0A1X0NW18	Trypanosomatidae	35%	100%
A0A3Q8IC46	Leishmania donovani	85%	100%
E9AH93	Leishmania infantum	85%	100%
E9AX73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAA3	Leishmania major	82%	100%