Putative fatty-acid desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty-acid desaturase, putative

Species:

Leishmania braziliensis

UniProt:

A4HDT6_LEIBR

TriTrypDb:

LbrM.24.2330 , LBRM2903_240030900

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0031090	organelle membrane	3	2

Expansion

Sequence features

A4HDT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDT6

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	16
GO:0006629	lipid metabolic process	3	17
GO:0006631	fatty acid metabolic process	4	16
GO:0006633	fatty acid biosynthetic process	5	16
GO:0006636	unsaturated fatty acid biosynthetic process	6	16
GO:0008152	metabolic process	1	17
GO:0008610	lipid biosynthetic process	4	16
GO:0009058	biosynthetic process	2	16
GO:0009987	cellular process	1	16
GO:0016053	organic acid biosynthetic process	4	16
GO:0019752	carboxylic acid metabolic process	5	16
GO:0032787	monocarboxylic acid metabolic process	6	16
GO:0033559	unsaturated fatty acid metabolic process	5	16
GO:0043436	oxoacid metabolic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	17
GO:0044249	cellular biosynthetic process	3	16
GO:0044255	cellular lipid metabolic process	3	16
GO:0044281	small molecule metabolic process	2	16
GO:0044283	small molecule biosynthetic process	3	16
GO:0046394	carboxylic acid biosynthetic process	5	16
GO:0071704	organic substance metabolic process	2	17
GO:0072330	monocarboxylic acid biosynthetic process	6	16
GO:1901576	organic substance biosynthetic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0004768	stearoyl-CoA 9-desaturase activity	6	16
GO:0016215	acyl-CoA desaturase activity	5	16
GO:0016491	oxidoreductase activity	2	17
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	17
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	17
GO:0005488	binding	1	6
GO:0005506	iron ion binding	6	2
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.484
CLV_NRD_NRD_1	16	18	PF00675	0.440
CLV_NRD_NRD_1	313	315	PF00675	0.416
CLV_NRD_NRD_1	347	349	PF00675	0.349
CLV_PCSK_KEX2_1	16	18	PF00082	0.440
CLV_PCSK_SKI1_1	207	211	PF00082	0.317
CLV_PCSK_SKI1_1	307	311	PF00082	0.293
CLV_PCSK_SKI1_1	375	379	PF00082	0.312
CLV_PCSK_SKI1_1	396	400	PF00082	0.255
CLV_PCSK_SKI1_1	421	425	PF00082	0.212
CLV_PCSK_SKI1_1	426	430	PF00082	0.336
CLV_PCSK_SKI1_1	8	12	PF00082	0.416
CLV_Separin_Metazoa	13	17	PF03568	0.520
DOC_CKS1_1	294	299	PF01111	0.488
DOC_CYCLIN_RxL_1	304	313	PF00134	0.598
DOC_MAPK_gen_1	346	353	PF00069	0.412
DOC_MAPK_MEF2A_6	323	331	PF00069	0.605
DOC_PP1_RVXF_1	205	211	PF00149	0.242
DOC_PP1_RVXF_1	373	380	PF00149	0.550
DOC_PP2B_LxvP_1	327	330	PF13499	0.560
DOC_PP2B_LxvP_1	36	39	PF13499	0.284
DOC_USP7_MATH_1	222	226	PF00917	0.401
DOC_USP7_MATH_1	365	369	PF00917	0.510
DOC_USP7_UBL2_3	307	311	PF12436	0.523
DOC_WW_Pin1_4	293	298	PF00397	0.461
LIG_14-3-3_CanoR_1	236	244	PF00244	0.434
LIG_14-3-3_CanoR_1	282	287	PF00244	0.556
LIG_14-3-3_CanoR_1	79	86	PF00244	0.471
LIG_Actin_WH2_2	413	428	PF00022	0.508
LIG_BRCT_BRCA1_1	88	92	PF00533	0.508
LIG_deltaCOP1_diTrp_1	195	201	PF00928	0.253
LIG_deltaCOP1_diTrp_1	334	337	PF00928	0.534
LIG_FHA_1	213	219	PF00498	0.229
LIG_FHA_1	275	281	PF00498	0.434
LIG_FHA_1	401	407	PF00498	0.467
LIG_FHA_1	58	64	PF00498	0.288
LIG_FHA_2	122	128	PF00498	0.453
LIG_FHA_2	18	24	PF00498	0.577
LIG_FHA_2	247	253	PF00498	0.456
LIG_FHA_2	294	300	PF00498	0.517
LIG_FHA_2	320	326	PF00498	0.559
LIG_LIR_Gen_1	148	157	PF02991	0.461
LIG_LIR_Gen_1	159	168	PF02991	0.414
LIG_LIR_Gen_1	252	262	PF02991	0.427
LIG_LIR_Gen_1	27	38	PF02991	0.429
LIG_LIR_Gen_1	302	310	PF02991	0.555
LIG_LIR_Gen_1	334	344	PF02991	0.516
LIG_LIR_Gen_1	74	81	PF02991	0.259
LIG_LIR_Gen_1	89	99	PF02991	0.453
LIG_LIR_Nem_3	148	152	PF02991	0.444
LIG_LIR_Nem_3	159	165	PF02991	0.414
LIG_LIR_Nem_3	252	257	PF02991	0.427
LIG_LIR_Nem_3	27	33	PF02991	0.429
LIG_LIR_Nem_3	334	340	PF02991	0.508
LIG_LIR_Nem_3	74	80	PF02991	0.277
LIG_LIR_Nem_3	89	95	PF02991	0.467
LIG_PCNA_yPIPBox_3	348	361	PF02747	0.545
LIG_Pex14_1	196	200	PF04695	0.241
LIG_Pex14_1	94	98	PF04695	0.467
LIG_Pex14_2	257	261	PF04695	0.414
LIG_REV1ctd_RIR_1	171	179	PF16727	0.412
LIG_SH2_CRK	149	153	PF00017	0.459
LIG_SH2_CRK	162	166	PF00017	0.445
LIG_SH2_CRK	202	206	PF00017	0.229
LIG_SH2_CRK	77	81	PF00017	0.467
LIG_SH2_GRB2like	254	257	PF00017	0.441
LIG_SH2_GRB2like	380	383	PF00017	0.488
LIG_SH2_PTP2	30	33	PF00017	0.376
LIG_SH2_STAP1	202	206	PF00017	0.259
LIG_SH2_STAP1	26	30	PF00017	0.480
LIG_SH2_STAT3	129	132	PF00017	0.427
LIG_SH2_STAT3	164	167	PF00017	0.427
LIG_SH2_STAT5	121	124	PF00017	0.453
LIG_SH2_STAT5	164	167	PF00017	0.534
LIG_SH2_STAT5	200	203	PF00017	0.229
LIG_SH2_STAT5	30	33	PF00017	0.376
LIG_SH2_STAT5	370	373	PF00017	0.564
LIG_SH2_STAT5	416	419	PF00017	0.519
LIG_SH2_STAT5	86	89	PF00017	0.475
LIG_SH3_3	179	185	PF00018	0.319
LIG_SH3_3	291	297	PF00018	0.515
LIG_SUMO_SIM_anti_2	356	363	PF11976	0.551
LIG_TYR_ITIM	28	33	PF00017	0.508
LIG_TYR_ITIM	75	80	PF00017	0.283
LIG_UBA3_1	389	396	PF00899	0.441
LIG_WRC_WIRS_1	247	252	PF05994	0.429
MOD_CK1_1	239	245	PF00069	0.412
MOD_CK1_1	363	369	PF00069	0.532
MOD_CK1_1	400	406	PF00069	0.483
MOD_CK1_1	82	88	PF00069	0.467
MOD_CK2_1	17	23	PF00069	0.614
MOD_CK2_1	246	252	PF00069	0.403
MOD_CK2_1	310	316	PF00069	0.584
MOD_CMANNOS	193	196	PF00535	0.426
MOD_Cter_Amidation	346	349	PF01082	0.353
MOD_GlcNHglycan	105	109	PF01048	0.213
MOD_GlcNHglycan	179	182	PF01048	0.264
MOD_GlcNHglycan	367	370	PF01048	0.326
MOD_GlcNHglycan	399	402	PF01048	0.246
MOD_GSK3_1	100	107	PF00069	0.396
MOD_GSK3_1	217	224	PF00069	0.294
MOD_GSK3_1	231	238	PF00069	0.422
MOD_GSK3_1	325	332	PF00069	0.524
MOD_GSK3_1	396	403	PF00069	0.475
MOD_GSK3_1	82	89	PF00069	0.484
MOD_N-GLC_1	231	236	PF02516	0.224
MOD_N-GLC_2	68	70	PF02516	0.376
MOD_NEK2_1	104	109	PF00069	0.455
MOD_NEK2_1	135	140	PF00069	0.453
MOD_NEK2_1	217	222	PF00069	0.299
MOD_NEK2_1	310	315	PF00069	0.593
MOD_NEK2_1	360	365	PF00069	0.537
MOD_NEK2_1	378	383	PF00069	0.467
MOD_NEK2_1	71	76	PF00069	0.352
MOD_NEK2_2	222	227	PF00069	0.401
MOD_PKA_2	235	241	PF00069	0.424
MOD_Plk_1	147	153	PF00069	0.508
MOD_Plk_1	325	331	PF00069	0.543
MOD_Plk_1	333	339	PF00069	0.509
MOD_Plk_4	147	153	PF00069	0.520
MOD_Plk_4	183	189	PF00069	0.229
MOD_Plk_4	212	218	PF00069	0.242
MOD_Plk_4	222	228	PF00069	0.427
MOD_Plk_4	239	245	PF00069	0.473
MOD_Plk_4	282	288	PF00069	0.571
MOD_Plk_4	54	60	PF00069	0.214
MOD_ProDKin_1	293	299	PF00069	0.464
TRG_ENDOCYTIC_2	149	152	PF00928	0.471
TRG_ENDOCYTIC_2	162	165	PF00928	0.448
TRG_ENDOCYTIC_2	202	205	PF00928	0.229
TRG_ENDOCYTIC_2	254	257	PF00928	0.414
TRG_ENDOCYTIC_2	30	33	PF00928	0.418
TRG_ENDOCYTIC_2	77	80	PF00928	0.453
TRG_ER_diArg_1	15	17	PF00400	0.575
TRG_NLS_MonoExtC_3	310	315	PF00514	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI5	Leptomonas seymouri	83%	100%
A0A0S4KNP4	Bodo saltans	59%	97%
A0A1X0NW01	Trypanosomatidae	67%	100%
A0A3Q8I9W7	Leishmania donovani	46%	92%
A0A3Q8IBJ0	Leishmania donovani	93%	100%
A0A3R7MEL0	Trypanosoma rangeli	67%	99%
A4H6I1	Leishmania braziliensis	47%	100%
A4HVZ3	Leishmania infantum	46%	92%
A4I134	Leishmania infantum	93%	100%
B7SB91	Acheta domesticus	30%	100%
C9ZW73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9APP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	95%
E9AX71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
G5ED44	Caenorhabditis elegans	32%	100%
O00767	Homo sapiens	31%	100%
O02858	Sus scrofa	30%	100%
O44390	Trichoplusia ni	30%	100%
O62849	Ovis aries	31%	100%
O94523	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	90%
P0DOW2	Anemone leveillei	25%	100%
P0DOW3	Anemone leveillei	27%	100%
P13011	Mus musculus	29%	100%
P21147	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	84%
Q12618	Ajellomyces capsulatus	39%	90%
Q4QAA5	Leishmania major	92%	100%
Q4QFT4	Leishmania major	47%	100%
Q6P7B9	Rattus norvegicus	29%	100%
Q95MI7	Capra hircus	32%	100%
Q99PL7	Mus musculus	30%	100%
Q9FPD5	Arabidopsis thaliana	26%	100%
Q9SID2	Arabidopsis thaliana	28%	100%
Q9TT94	Bos taurus	29%	100%
V5D5L9	Trypanosoma cruzi	69%	100%