Cob_adeno_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP:cob(I)alamin adenosyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HDT5_LEIBR

TriTrypDb:

LbrM.24.2320 , LBRM2903_240030800

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HDT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDT5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008817	corrinoid adenosyltransferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.463
CLV_NRD_NRD_1	195	197	PF00675	0.267
CLV_NRD_NRD_1	229	231	PF00675	0.214
CLV_NRD_NRD_1	32	34	PF00675	0.467
CLV_NRD_NRD_1	324	326	PF00675	0.269
CLV_NRD_NRD_1	328	330	PF00675	0.269
CLV_NRD_NRD_1	372	374	PF00675	0.411
CLV_NRD_NRD_1	67	69	PF00675	0.415
CLV_PCSK_KEX2_1	127	129	PF00082	0.448
CLV_PCSK_KEX2_1	174	176	PF00082	0.397
CLV_PCSK_KEX2_1	195	197	PF00082	0.269
CLV_PCSK_KEX2_1	229	231	PF00082	0.214
CLV_PCSK_KEX2_1	31	33	PF00082	0.487
CLV_PCSK_KEX2_1	324	326	PF00082	0.269
CLV_PCSK_KEX2_1	328	330	PF00082	0.269
CLV_PCSK_KEX2_1	67	69	PF00082	0.415
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.448
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.397
CLV_PCSK_PC7_1	320	326	PF00082	0.269
CLV_PCSK_SKI1_1	105	109	PF00082	0.316
CLV_PCSK_SKI1_1	128	132	PF00082	0.482
CLV_PCSK_SKI1_1	220	224	PF00082	0.326
CLV_PCSK_SKI1_1	3	7	PF00082	0.588
CLV_PCSK_SKI1_1	329	333	PF00082	0.316
CLV_PCSK_SKI1_1	346	350	PF00082	0.316
CLV_PCSK_SKI1_1	67	71	PF00082	0.361
DEG_Nend_Nbox_1	1	3	PF02207	0.488
DOC_CKS1_1	254	259	PF01111	0.469
DOC_CYCLIN_RxL_1	64	72	PF00134	0.511
DOC_MAPK_gen_1	324	333	PF00069	0.469
DOC_MAPK_gen_1	67	73	PF00069	0.509
DOC_MAPK_MEF2A_6	296	304	PF00069	0.516
DOC_PP4_FxxP_1	303	306	PF00568	0.469
DOC_USP7_MATH_1	139	143	PF00917	0.628
DOC_USP7_MATH_1	146	150	PF00917	0.699
DOC_USP7_MATH_1	173	177	PF00917	0.617
DOC_USP7_MATH_1	235	239	PF00917	0.500
DOC_USP7_MATH_1	362	366	PF00917	0.516
DOC_WW_Pin1_4	253	258	PF00397	0.469
DOC_WW_Pin1_4	295	300	PF00397	0.429
DOC_WW_Pin1_4	47	52	PF00397	0.714
DOC_WW_Pin1_4	6	11	PF00397	0.478
LIG_14-3-3_CanoR_1	11	19	PF00244	0.345
LIG_14-3-3_CanoR_1	128	137	PF00244	0.684
LIG_14-3-3_CanoR_1	3	10	PF00244	0.441
LIG_14-3-3_CanoR_1	346	351	PF00244	0.512
LIG_14-3-3_CanoR_1	354	361	PF00244	0.435
LIG_14-3-3_CanoR_1	36	43	PF00244	0.677
LIG_14-3-3_CanoR_1	67	72	PF00244	0.526
LIG_Actin_WH2_2	209	226	PF00022	0.516
LIG_BRCT_BRCA1_1	187	191	PF00533	0.469
LIG_BRCT_BRCA1_1	355	359	PF00533	0.469
LIG_FHA_1	11	17	PF00498	0.329
LIG_FHA_1	185	191	PF00498	0.453
LIG_FHA_1	281	287	PF00498	0.439
LIG_FHA_1	340	346	PF00498	0.516
LIG_FHA_1	347	353	PF00498	0.469
LIG_FHA_1	68	74	PF00498	0.568
LIG_FHA_2	130	136	PF00498	0.640
LIG_FHA_2	146	152	PF00498	0.812
LIG_FHA_2	270	276	PF00498	0.414
LIG_FHA_2	338	344	PF00498	0.422
LIG_FHA_2	85	91	PF00498	0.468
LIG_KLC1_Yacidic_2	85	90	PF13176	0.516
LIG_LIR_Apic_2	85	91	PF02991	0.444
LIG_LIR_Gen_1	200	209	PF02991	0.469
LIG_LIR_Gen_1	93	103	PF02991	0.461
LIG_LIR_Nem_3	200	206	PF02991	0.469
LIG_LIR_Nem_3	275	280	PF02991	0.414
LIG_LIR_Nem_3	356	361	PF02991	0.474
LIG_LIR_Nem_3	93	98	PF02991	0.461
LIG_MLH1_MIPbox_1	355	359	PF16413	0.469
LIG_PCNA_PIPBox_1	330	339	PF02747	0.516
LIG_SH2_CRK	27	31	PF00017	0.298
LIG_SH2_GRB2like	351	354	PF00017	0.492
LIG_SH2_PTP2	88	91	PF00017	0.516
LIG_SH2_SRC	88	91	PF00017	0.414
LIG_SH2_STAP1	341	345	PF00017	0.532
LIG_SH2_STAT5	179	182	PF00017	0.469
LIG_SH2_STAT5	27	30	PF00017	0.314
LIG_SH2_STAT5	341	344	PF00017	0.469
LIG_SH2_STAT5	351	354	PF00017	0.495
LIG_SH2_STAT5	88	91	PF00017	0.474
LIG_SH3_3	251	257	PF00018	0.518
LIG_TYR_ITIM	25	30	PF00017	0.298
LIG_UBA3_1	103	108	PF00899	0.516
MOD_CDK_SPK_2	6	11	PF00069	0.473
MOD_CDK_SPxK_1	295	301	PF00069	0.414
MOD_CDK_SPxxK_3	253	260	PF00069	0.516
MOD_CK1_1	142	148	PF00069	0.729
MOD_CK1_1	295	301	PF00069	0.414
MOD_CK1_1	44	50	PF00069	0.589
MOD_CK2_1	129	135	PF00069	0.674
MOD_CK2_1	145	151	PF00069	0.638
MOD_CK2_1	222	228	PF00069	0.574
MOD_CK2_1	235	241	PF00069	0.443
MOD_CK2_1	269	275	PF00069	0.442
MOD_CK2_1	362	368	PF00069	0.477
MOD_GlcNHglycan	141	144	PF01048	0.529
MOD_GlcNHglycan	148	151	PF01048	0.402
MOD_GlcNHglycan	153	156	PF01048	0.499
MOD_GlcNHglycan	167	170	PF01048	0.401
MOD_GlcNHglycan	187	190	PF01048	0.309
MOD_GlcNHglycan	22	25	PF01048	0.369
MOD_GlcNHglycan	224	227	PF01048	0.323
MOD_GlcNHglycan	312	315	PF01048	0.297
MOD_GlcNHglycan	43	46	PF01048	0.397
MOD_GSK3_1	138	145	PF00069	0.693
MOD_GSK3_1	146	153	PF00069	0.734
MOD_GSK3_1	173	180	PF00069	0.635
MOD_GSK3_1	185	192	PF00069	0.535
MOD_GSK3_1	249	256	PF00069	0.483
MOD_GSK3_1	47	54	PF00069	0.688
MOD_GSK3_1	6	13	PF00069	0.421
MOD_LATS_1	344	350	PF00433	0.516
MOD_LATS_1	39	45	PF00433	0.603
MOD_N-GLC_1	184	189	PF02516	0.261
MOD_N-GLC_2	112	114	PF02516	0.316
MOD_NEK2_1	129	134	PF00069	0.671
MOD_NEK2_1	138	143	PF00069	0.678
MOD_NEK2_1	177	182	PF00069	0.556
MOD_NEK2_1	20	25	PF00069	0.485
MOD_NEK2_1	222	227	PF00069	0.516
MOD_NEK2_2	319	324	PF00069	0.469
MOD_PKA_1	67	73	PF00069	0.509
MOD_PKA_2	10	16	PF00069	0.261
MOD_PKA_2	319	325	PF00069	0.469
MOD_PKA_2	35	41	PF00069	0.604
MOD_PKA_2	353	359	PF00069	0.469
MOD_PKA_2	67	73	PF00069	0.509
MOD_Plk_1	84	90	PF00069	0.469
MOD_Plk_4	235	241	PF00069	0.500
MOD_Plk_4	249	255	PF00069	0.516
MOD_Plk_4	269	275	PF00069	0.383
MOD_Plk_4	346	352	PF00069	0.617
MOD_Plk_4	84	90	PF00069	0.514
MOD_ProDKin_1	253	259	PF00069	0.469
MOD_ProDKin_1	295	301	PF00069	0.429
MOD_ProDKin_1	47	53	PF00069	0.714
MOD_ProDKin_1	6	12	PF00069	0.476
MOD_SUMO_rev_2	66	76	PF00179	0.699
TRG_DiLeu_BaEn_2	274	280	PF01217	0.434
TRG_ENDOCYTIC_2	27	30	PF00928	0.298
TRG_ENDOCYTIC_2	277	280	PF00928	0.414
TRG_ER_diArg_1	30	33	PF00400	0.606
TRG_ER_diArg_1	328	330	PF00400	0.516
TRG_ER_diArg_1	67	69	PF00400	0.615
TRG_Pf-PMV_PEXEL_1	334	339	PF00026	0.214
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.245
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KL87	Bodo saltans	43%	100%
A0A3Q8ID37	Leishmania donovani	83%	100%
A4I133	Leishmania infantum	83%	100%
E9AX70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QAA6	Leishmania major	81%	100%