Hypothetical predicted multi-pass transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted multi-pass transmembrane protein

Species:

Leishmania braziliensis

UniProt:

A4HDT4_LEIBR

TriTrypDb:

LbrM.24.2310 , LBRM2903_240030700

Length:

173

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HDT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDT4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.479
CLV_NRD_NRD_1	5	7	PF00675	0.480
CLV_PCSK_FUR_1	9	13	PF00082	0.477
CLV_PCSK_KEX2_1	11	13	PF00082	0.516
CLV_PCSK_KEX2_1	5	7	PF00082	0.513
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.497
CLV_PCSK_SKI1_1	126	130	PF00082	0.395
CLV_PCSK_SKI1_1	55	59	PF00082	0.492
DEG_Nend_UBRbox_3	1	3	PF02207	0.769
DOC_CKS1_1	59	64	PF01111	0.665
DOC_MAPK_gen_1	5	15	PF00069	0.626
DOC_MAPK_MEF2A_6	9	17	PF00069	0.586
DOC_PP1_RVXF_1	148	154	PF00149	0.551
DOC_PP4_FxxP_1	59	62	PF00568	0.598
DOC_WW_Pin1_4	58	63	PF00397	0.513
LIG_Actin_WH2_2	42	57	PF00022	0.497
LIG_EVH1_2	71	75	PF00568	0.679
LIG_FHA_1	130	136	PF00498	0.513
LIG_FHA_1	80	86	PF00498	0.583
LIG_FHA_2	140	146	PF00498	0.709
LIG_LIR_Gen_1	82	92	PF02991	0.489
LIG_LIR_Nem_3	43	49	PF02991	0.328
LIG_LIR_Nem_3	82	87	PF02991	0.428
LIG_Pex14_1	14	18	PF04695	0.530
LIG_SH2_PTP2	18	21	PF00017	0.277
LIG_SH2_SRC	18	21	PF00017	0.277
LIG_SH2_STAT5	114	117	PF00017	0.427
LIG_SH2_STAT5	18	21	PF00017	0.406
LIG_SH2_STAT5	25	28	PF00017	0.399
LIG_SH3_3	128	134	PF00018	0.476
LIG_Sin3_3	46	53	PF02671	0.277
LIG_TRAF2_1	142	145	PF00917	0.678
LIG_UBA3_1	118	126	PF00899	0.277
LIG_WRC_WIRS_1	80	85	PF05994	0.612
MOD_CDK_SPxxK_3	58	65	PF00069	0.548
MOD_CK1_1	162	168	PF00069	0.737
MOD_CK2_1	139	145	PF00069	0.692
MOD_GlcNHglycan	161	164	PF01048	0.584
MOD_NEK2_1	129	134	PF00069	0.377
MOD_NEK2_1	87	92	PF00069	0.308
MOD_NEK2_2	79	84	PF00069	0.612
MOD_PKA_2	159	165	PF00069	0.646
MOD_Plk_1	139	145	PF00069	0.706
MOD_Plk_4	110	116	PF00069	0.313
MOD_Plk_4	79	85	PF00069	0.576
MOD_ProDKin_1	58	64	PF00069	0.511
TRG_DiLeu_BaEn_1	144	149	PF01217	0.703
TRG_DiLeu_BaEn_4	144	150	PF01217	0.549
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.631
TRG_ENDOCYTIC_2	18	21	PF00928	0.405
TRG_ENDOCYTIC_2	67	70	PF00928	0.625
TRG_ENDOCYTIC_2	80	83	PF00928	0.563
TRG_ER_diArg_1	11	13	PF00400	0.589
TRG_NLS_MonoExtC_3	4	9	PF00514	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C1	Leptomonas seymouri	64%	100%
A0A0S4IMU6	Bodo saltans	28%	78%
A0A1X0NWM1	Trypanosomatidae	37%	100%
A0A3R7LPV2	Trypanosoma rangeli	32%	100%
A0A3S7WYQ2	Leishmania donovani	68%	99%
A4I132	Leishmania infantum	69%	99%
C9ZW76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AX69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	99%
Q4QAA7	Leishmania major	69%	100%