Hypothetical predicted multi-pass transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted multi-pass transmembrane protein

Species:

Leishmania braziliensis

UniProt:

A4HDT4_LEIBR

TriTrypDb:

LbrM.24.2310 , LBRM2903_240030700

Length:

173

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

A4HDT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDT4

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.479
CLV_NRD_NRD_1	5	7	PF00675	0.480
CLV_PCSK_FUR_1	9	13	PF00082	0.477
CLV_PCSK_KEX2_1	11	13	PF00082	0.516
CLV_PCSK_KEX2_1	5	7	PF00082	0.513
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.497
CLV_PCSK_SKI1_1	126	130	PF00082	0.395
CLV_PCSK_SKI1_1	55	59	PF00082	0.492
DEG_Nend_UBRbox_3	1	3	PF02207	0.769
DOC_CKS1_1	59	64	PF01111	0.665

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C1	Leptomonas seymouri	64%	100%
A0A0S4IMU6	Bodo saltans	28%	78%
A0A1X0NWM1	Trypanosomatidae	37%	100%
A0A3R7LPV2	Trypanosoma rangeli	32%	100%
A0A3S7WYQ2	Leishmania donovani	68%	99%
A4I132	Leishmania infantum	69%	99%
C9ZW76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AX69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	99%
Q4QAA7	Leishmania major	69%	100%

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