ClpB_D2-small domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDT3_LEIBR

TriTrypDb:

LbrM.24.2300 , LBRM2903_240030600

Length:

236

Annotations

LeishMANIAdb annotations

Probably a secreted protein, similarly to its distant eukaryotic torsin homologs, involved in secretory processes. Also similar to bacterial ClpB ATPases, with chaperoning function.. Might be associated to known or unknown protein secretion pathways.. Localization: Endosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDT3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0016462	pyrophosphatase activity	5	3
GO:0016787	hydrolase activity	2	3
GO:0016817	hydrolase activity, acting on acid anhydrides	3	3
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	3
GO:0016887	ATP hydrolysis activity	7	3
GO:0017076	purine nucleotide binding	4	3
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.250
CLV_NRD_NRD_1	208	210	PF00675	0.253
CLV_PCSK_KEX2_1	208	210	PF00082	0.253
CLV_PCSK_SKI1_1	155	159	PF00082	0.286
CLV_PCSK_SKI1_1	41	45	PF00082	0.260
CLV_PCSK_SKI1_1	81	85	PF00082	0.383
DEG_APCC_DBOX_1	40	48	PF00400	0.252
DOC_CYCLIN_RxL_1	152	161	PF00134	0.285
DOC_CYCLIN_RxL_1	77	85	PF00134	0.306
DOC_MAPK_DCC_7	7	15	PF00069	0.248
DOC_MAPK_gen_1	208	214	PF00069	0.240
DOC_MAPK_gen_1	39	46	PF00069	0.253
DOC_MAPK_MEF2A_6	107	116	PF00069	0.279
DOC_MAPK_MEF2A_6	39	46	PF00069	0.249
DOC_MAPK_MEF2A_6	7	15	PF00069	0.248
DOC_PP1_RVXF_1	162	169	PF00149	0.259
DOC_USP7_MATH_1	57	61	PF00917	0.254
LIG_14-3-3_CanoR_1	79	84	PF00244	0.310
LIG_14-3-3_CanoR_1	87	97	PF00244	0.264
LIG_14-3-3_CterR_2	232	236	PF00244	0.480
LIG_APCC_ABBA_1	26	31	PF00400	0.278
LIG_CtBP_PxDLS_1	113	117	PF00389	0.273
LIG_FHA_1	152	158	PF00498	0.290
LIG_FHA_1	192	198	PF00498	0.426
LIG_FHA_1	209	215	PF00498	0.209
LIG_FHA_1	217	223	PF00498	0.255
LIG_FHA_2	116	122	PF00498	0.237
LIG_FHA_2	139	145	PF00498	0.243
LIG_FHA_2	191	197	PF00498	0.420
LIG_FHA_2	31	37	PF00498	0.275
LIG_Integrin_isoDGR_2	162	164	PF01839	0.278
LIG_IRF3_LxIS_1	109	115	PF10401	0.283
LIG_LIR_Gen_1	195	202	PF02991	0.400
LIG_LIR_Gen_1	91	102	PF02991	0.275
LIG_LIR_Nem_3	108	114	PF02991	0.272
LIG_LIR_Nem_3	195	201	PF02991	0.403
LIG_LIR_Nem_3	51	56	PF02991	0.264
LIG_LIR_Nem_3	91	97	PF02991	0.271
LIG_LYPXL_yS_3	56	59	PF13949	0.265
LIG_SH2_STAP1	98	102	PF00017	0.279
LIG_SH3_1	107	113	PF00018	0.288
LIG_SH3_3	107	113	PF00018	0.288
LIG_SH3_3	39	45	PF00018	0.250
LIG_SH3_3	51	57	PF00018	0.264
LIG_SUMO_SIM_par_1	112	118	PF11976	0.270
LIG_SUMO_SIM_par_1	210	215	PF11976	0.237
LIG_SUMO_SIM_par_1	63	71	PF11976	0.257
MOD_CK1_1	115	121	PF00069	0.329
MOD_CK2_1	190	196	PF00069	0.530
MOD_CK2_1	30	36	PF00069	0.278
MOD_CK2_1	79	85	PF00069	0.307
MOD_GlcNHglycan	132	135	PF01048	0.288
MOD_GlcNHglycan	144	147	PF01048	0.232
MOD_GSK3_1	101	108	PF00069	0.395
MOD_GSK3_1	138	145	PF00069	0.359
MOD_GSK3_1	224	231	PF00069	0.391
MOD_GSK3_1	75	82	PF00069	0.315
MOD_GSK3_1	88	95	PF00069	0.252
MOD_LATS_1	230	236	PF00433	0.472
MOD_N-GLC_1	142	147	PF02516	0.234
MOD_NEK2_1	138	143	PF00069	0.235
MOD_PKA_1	208	214	PF00069	0.240
MOD_PKA_2	208	214	PF00069	0.240
MOD_PKA_2	48	54	PF00069	0.271
MOD_PKB_1	77	85	PF00069	0.303
MOD_Plk_1	142	148	PF00069	0.241
MOD_Plk_1	30	36	PF00069	0.278
MOD_Plk_2-3	31	37	PF00069	0.271
MOD_Plk_4	208	214	PF00069	0.240
MOD_Plk_4	79	85	PF00069	0.310
TRG_DiLeu_BaEn_2	84	90	PF01217	0.264
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.292
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.495
TRG_ENDOCYTIC_2	198	201	PF00928	0.386
TRG_ENDOCYTIC_2	56	59	PF00928	0.265
TRG_ER_diArg_1	207	209	PF00400	0.280
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R1	Leptomonas seymouri	57%	72%