Putative 60S ribosomal protein L12

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L12, putative

Species:

Leishmania braziliensis

UniProt:

A4HDT2_LEIBR

TriTrypDb:

LbrM.24.2290 , LBRM2903_240030500

Length:

164

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 16
Pissara et al.	yes	yes: 32

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 42

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	14
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	14
GO:0043228	non-membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043232	intracellular non-membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	14
GO:1990904	ribonucleoprotein complex	2	15
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

A4HDT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDT2

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	15
GO:0006518	peptide metabolic process	4	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009058	biosynthetic process	2	15
GO:0009059	macromolecule biosynthetic process	4	15
GO:0009987	cellular process	1	15
GO:0019538	protein metabolic process	3	15
GO:0034641	cellular nitrogen compound metabolic process	3	15
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	15
GO:0043043	peptide biosynthetic process	5	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043603	amide metabolic process	3	15
GO:0043604	amide biosynthetic process	4	15
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	15
GO:0044249	cellular biosynthetic process	3	15
GO:0044260	obsolete cellular macromolecule metabolic process	3	15
GO:0044271	cellular nitrogen compound biosynthetic process	4	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15
GO:1901566	organonitrogen compound biosynthetic process	4	15
GO:1901576	organic substance biosynthetic process	3	15

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	15
GO:0005198	structural molecule activity	1	15
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0019843	rRNA binding	5	1
GO:0070180	large ribosomal subunit rRNA binding	6	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	91	93	PF00675	0.382
CLV_PCSK_SKI1_1	111	115	PF00082	0.183
CLV_PCSK_SKI1_1	54	58	PF00082	0.366
CLV_PCSK_SKI1_1	67	71	PF00082	0.507
CLV_PCSK_SKI1_1	83	87	PF00082	0.341
CLV_PCSK_SKI1_1	93	97	PF00082	0.334
CLV_Separin_Metazoa	87	91	PF03568	0.366
DOC_CKS1_1	72	77	PF01111	0.487
DOC_MAPK_gen_1	48	58	PF00069	0.370
DOC_MAPK_gen_1	65	73	PF00069	0.478
DOC_MAPK_gen_1	96	106	PF00069	0.362
DOC_MAPK_RevD_3	26	41	PF00069	0.382
DOC_PP2B_LxvP_1	160	163	PF13499	0.602
DOC_USP7_MATH_1	113	117	PF00917	0.423
DOC_USP7_MATH_1	24	28	PF00917	0.382
DOC_WW_Pin1_4	144	149	PF00397	0.551
DOC_WW_Pin1_4	71	76	PF00397	0.477
LIG_14-3-3_CanoR_1	67	72	PF00244	0.504
LIG_FHA_1	23	29	PF00498	0.396
LIG_FHA_1	57	63	PF00498	0.366
LIG_FHA_1	68	74	PF00498	0.483
LIG_GBD_Chelix_1	77	85	PF00786	0.366
LIG_LIR_Nem_3	50	56	PF02991	0.368
LIG_SH3_3	69	75	PF00018	0.602
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.530
LIG_SUMO_SIM_par_1	69	74	PF11976	0.540
LIG_TRAF2_1	7	10	PF00917	0.585
LIG_UBA3_1	81	86	PF00899	0.366
LIG_Vh1_VBS_1	11	29	PF01044	0.512
LIG_WW_3	87	91	PF00397	0.366
MOD_CDK_SPK_2	144	149	PF00069	0.495
MOD_CK1_1	120	126	PF00069	0.463
MOD_CK1_1	76	82	PF00069	0.366
MOD_GlcNHglycan	100	103	PF01048	0.477
MOD_GSK3_1	113	120	PF00069	0.375
MOD_GSK3_1	135	142	PF00069	0.416
MOD_GSK3_1	67	74	PF00069	0.494
MOD_PIKK_1	113	119	PF00454	0.512
MOD_Plk_4	67	73	PF00069	0.622
MOD_ProDKin_1	144	150	PF00069	0.552
MOD_ProDKin_1	71	77	PF00069	0.366
MOD_SUMO_rev_2	120	128	PF00179	0.512
MOD_SUMO_rev_2	87	95	PF00179	0.366
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.366
TRG_ER_diLys_1	159	164	PF00400	0.620
TRG_NLS_MonoExtN_4	90	97	PF00514	0.366
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JD32	Bodo saltans	81%	100%
A0A0S4KHT4	Bodo saltans	82%	100%
A0A1X0NW72	Trypanosomatidae	86%	100%
A0A3Q8ID78	Leishmania donovani	96%	100%
A0A3R7K3J4	Trypanosoma rangeli	83%	100%
A0A3S7X989	Leishmania donovani	96%	100%
A0A422N899	Trypanosoma rangeli	87%	100%
A0B923	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	30%	100%
A2BN63	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	34%	98%
A2STU0	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	33%	100%
A3CSJ5	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	33%	100%
A4FW91	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	31%	100%
A4HMP1	Leishmania braziliensis	99%	100%
A4I130	Leishmania infantum	96%	100%
A4YH87	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	32%	98%
A5UKV0	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	30%	100%
A6UQ78	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	34%	100%
A6UVR5	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	34%	100%
A6VH19	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	32%	100%
A7IAK5	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	33%	100%
A9A582	Nitrosopumilus maritimus (strain SCM1)	28%	100%
A9A9N0	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	32%	100%
B1L6L2	Korarchaeum cryptofilum (strain OPF8)	35%	100%
B6YSX7	Thermococcus onnurineus (strain NA1)	35%	100%
B8D5P9	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	33%	96%
B8GIY2	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	32%	100%
C3MR83	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	30%	96%
C3MXH2	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	30%	96%
C3MZB8	Sulfolobus islandicus (strain M.16.27)	30%	96%
C3N7D9	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	30%	96%
C3NG95	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	30%	96%
C4KIJ7	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	30%	96%
C5A426	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	35%	99%
C9ZW78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	89%	100%
E2RR58	Canis lupus familiaris	56%	99%
E9AHW0	Leishmania infantum	96%	100%
E9AX67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O27715	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	30%	100%
O29712	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	34%	100%
O50003	Prunus armeniaca	58%	99%
O57779	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	36%	100%
P0CT83	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	99%
P0CT84	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	99%
P0CX53	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	57%	99%
P0CX54	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	57%	99%
P23358	Rattus norvegicus	55%	99%
P30050	Homo sapiens	56%	99%
P35025	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	29%	96%
P35979	Mus musculus	56%	99%
P50883	Arabidopsis thaliana	59%	99%
P50884	Chlamydomonas reinhardtii	55%	100%
P54030	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	32%	100%
P61284	Bos taurus	56%	99%
P61865	Caenorhabditis briggsae	59%	99%
P61866	Caenorhabditis elegans	59%	99%
P62445	Methanococcus maripaludis (strain S2 / LL)	35%	100%
P62446	Nanoarchaeum equitans (strain Kin4-M)	29%	100%
P96037	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	31%	96%
Q0W049	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	31%	100%
Q12UQ0	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	31%	100%
Q18G74	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	23%	100%
Q2FQ31	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	34%	100%
Q2NEW0	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	26%	100%
Q46EU7	Methanosarcina barkeri (strain Fusaro / DSM 804)	36%	100%
Q4QAA9	Leishmania major	96%	100%
Q54J50	Dictyostelium discoideum	56%	99%
Q5AJF7	Candida albicans (strain SC5314 / ATCC MYA-2876)	60%	99%
Q5JH34	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	33%	99%
Q6L1Y0	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	31%	100%
Q6QMZ7	Chinchilla lanigera	55%	99%
Q8PY53	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	34%	100%
Q8SR84	Encephalitozoon cuniculi (strain GB-M1)	49%	99%
Q8TI82	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	33%	100%
Q8TX52	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	33%	99%
Q8TZK0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	37%	100%
Q971J0	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	35%	96%
Q97BN1	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	28%	100%
Q9C285	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	57%	99%
Q9FF52	Arabidopsis thaliana	59%	99%
Q9HL70	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	32%	100%
Q9LFH5	Arabidopsis thaliana	59%	99%
Q9V2S3	Pyrococcus abyssi (strain GE5 / Orsay)	36%	100%