PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDT1_LEIBR

TriTrypDb:

LbrM.24.2280 , LBRM2903_240030400

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDT1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.539
CLV_NRD_NRD_1	209	211	PF00675	0.605
CLV_PCSK_KEX2_1	209	211	PF00082	0.503
CLV_PCSK_KEX2_1	86	88	PF00082	0.322
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.410
CLV_PCSK_SKI1_1	122	126	PF00082	0.538
CLV_PCSK_SKI1_1	199	203	PF00082	0.329
CLV_PCSK_SKI1_1	219	223	PF00082	0.652
CLV_Separin_Metazoa	184	188	PF03568	0.362
DOC_AGCK_PIF_1	161	166	PF00069	0.433
DOC_CYCLIN_RxL_1	216	226	PF00134	0.682
DOC_PP1_SILK_1	63	68	PF00149	0.330
DOC_USP7_MATH_1	215	219	PF00917	0.549
DOC_USP7_MATH_1	231	235	PF00917	0.639
DOC_USP7_MATH_1	3	7	PF00917	0.439
DOC_USP7_MATH_1	35	39	PF00917	0.375
LIG_14-3-3_CanoR_1	187	196	PF00244	0.416
LIG_BRCT_BRCA1_1	37	41	PF00533	0.295
LIG_eIF4E_1	164	170	PF01652	0.357
LIG_FHA_1	121	127	PF00498	0.537
LIG_FHA_1	165	171	PF00498	0.297
LIG_FHA_1	61	67	PF00498	0.314
LIG_LIR_Gen_1	114	125	PF02991	0.413
LIG_LIR_Gen_1	128	137	PF02991	0.274
LIG_LIR_Gen_1	165	172	PF02991	0.302
LIG_LIR_Gen_1	60	70	PF02991	0.325
LIG_LIR_Nem_3	114	120	PF02991	0.364
LIG_LIR_Nem_3	128	134	PF02991	0.331
LIG_LIR_Nem_3	165	169	PF02991	0.302
LIG_LIR_Nem_3	38	44	PF02991	0.298
LIG_LIR_Nem_3	60	65	PF02991	0.326
LIG_Pex14_1	18	22	PF04695	0.397
LIG_SH2_STAP1	166	170	PF00017	0.322
LIG_SH2_STAP1	181	185	PF00017	0.410
LIG_SH2_STAT3	26	29	PF00017	0.363
LIG_SH2_STAT5	131	134	PF00017	0.245
LIG_SH2_STAT5	164	167	PF00017	0.302
LIG_SH3_3	157	163	PF00018	0.436
LIG_SH3_3	214	220	PF00018	0.639
LIG_SUMO_SIM_par_1	200	206	PF11976	0.513
LIG_TRAF2_1	137	140	PF00917	0.468
LIG_TRAF2_1	50	53	PF00917	0.410
LIG_TYR_ITIM	129	134	PF00017	0.277
MOD_CK1_1	225	231	PF00069	0.595
MOD_CK1_1	60	66	PF00069	0.410
MOD_Cter_Amidation	207	210	PF01082	0.475
MOD_GlcNHglycan	140	143	PF01048	0.580
MOD_GlcNHglycan	176	181	PF01048	0.197
MOD_GlcNHglycan	34	38	PF01048	0.521
MOD_GlcNHglycan	5	8	PF01048	0.503
MOD_GSK3_1	221	228	PF00069	0.581
MOD_GSK3_1	231	238	PF00069	0.598
MOD_GSK3_1	57	64	PF00069	0.420
MOD_N-GLC_1	57	62	PF02516	0.357
MOD_NEK2_1	120	125	PF00069	0.502
MOD_NEK2_1	235	240	PF00069	0.744
MOD_NEK2_1	46	51	PF00069	0.289
MOD_NEK2_1	57	62	PF00069	0.264
MOD_PIKK_1	194	200	PF00454	0.410
MOD_PKA_2	3	9	PF00069	0.376
MOD_PKB_1	136	144	PF00069	0.435
MOD_Plk_1	176	182	PF00069	0.197
MOD_Plk_1	57	63	PF00069	0.349
MOD_Plk_4	120	126	PF00069	0.523
MOD_Plk_4	61	67	PF00069	0.368
MOD_SUMO_for_1	85	88	PF00179	0.410
TRG_DiLeu_BaEn_2	156	162	PF01217	0.346
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.529
TRG_ENDOCYTIC_2	110	113	PF00928	0.524
TRG_ENDOCYTIC_2	131	134	PF00928	0.241
TRG_ENDOCYTIC_2	166	169	PF00928	0.322
TRG_ER_diArg_1	135	138	PF00400	0.450
TRG_NES_CRM1_1	114	127	PF08389	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTQ2	Leptomonas seymouri	78%	98%
A0A0S4KKY6	Bodo saltans	50%	100%
A0A1X0NXK5	Trypanosomatidae	63%	100%
A0A3Q8IF22	Leishmania donovani	89%	100%
A4I129	Leishmania infantum	88%	100%
C9ZW80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AX66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QAB0	Leishmania major	87%	100%
V5DLI8	Trypanosoma cruzi	24%	80%