Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDT0_LEIBR

TriTrypDb:

LbrM.24.2270 , LBRM2903_240030300

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005635	nuclear envelope	4	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1

Expansion

Sequence features

A4HDT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.430
CLV_NRD_NRD_1	126	128	PF00675	0.594
CLV_NRD_NRD_1	68	70	PF00675	0.476
CLV_PCSK_KEX2_1	126	128	PF00082	0.594
CLV_PCSK_KEX2_1	16	18	PF00082	0.544
CLV_PCSK_KEX2_1	68	70	PF00082	0.470
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.595
CLV_PCSK_SKI1_1	118	122	PF00082	0.630
CLV_PCSK_SKI1_1	170	174	PF00082	0.645
CLV_PCSK_SKI1_1	221	225	PF00082	0.549
DEG_SPOP_SBC_1	112	116	PF00917	0.471
DOC_CKS1_1	188	193	PF01111	0.432
DOC_MAPK_gen_1	178	188	PF00069	0.381
DOC_MAPK_gen_1	68	77	PF00069	0.552
DOC_PP1_RVXF_1	181	188	PF00149	0.333
DOC_PP1_RVXF_1	60	67	PF00149	0.684
DOC_PP2B_LxvP_1	173	176	PF13499	0.435
DOC_USP7_MATH_1	113	117	PF00917	0.357
DOC_USP7_MATH_1	162	166	PF00917	0.389
DOC_USP7_MATH_1	217	221	PF00917	0.420
DOC_USP7_MATH_1	27	31	PF00917	0.746
DOC_USP7_MATH_2	95	101	PF00917	0.373
DOC_USP7_UBL2_3	3	7	PF12436	0.730
DOC_WW_Pin1_4	187	192	PF00397	0.402
DOC_WW_Pin1_4	2	7	PF00397	0.618
DOC_WW_Pin1_4	91	96	PF00397	0.681
LIG_14-3-3_CanoR_1	58	66	PF00244	0.640
LIG_Actin_WH2_2	222	238	PF00022	0.392
LIG_APCC_ABBA_1	174	179	PF00400	0.298
LIG_BIR_II_1	1	5	PF00653	0.773
LIG_BRCT_BRCA1_1	143	147	PF00533	0.460
LIG_EH1_1	240	248	PF00400	0.394
LIG_FHA_1	88	94	PF00498	0.491
LIG_FHA_2	138	144	PF00498	0.431
LIG_FHA_2	156	162	PF00498	0.369
LIG_FHA_2	187	193	PF00498	0.388
LIG_LIR_Gen_1	160	171	PF02991	0.329
LIG_LIR_Nem_3	160	166	PF02991	0.314
LIG_PDZ_Class_1	245	250	PF00595	0.460
LIG_SH3_3	185	191	PF00018	0.423
LIG_SUMO_SIM_par_1	222	228	PF11976	0.357
LIG_SUMO_SIM_par_1	89	94	PF11976	0.343
LIG_UBA3_1	223	227	PF00899	0.248
LIG_ULM_U2AF65_1	68	73	PF00076	0.666
MOD_CDK_SPK_2	2	7	PF00069	0.618
MOD_CDK_SPxxK_3	2	9	PF00069	0.620
MOD_CK1_1	12	18	PF00069	0.682
MOD_CK1_1	2	8	PF00069	0.625
MOD_CK1_1	228	234	PF00069	0.365
MOD_CK1_1	30	36	PF00069	0.714
MOD_CK1_1	60	66	PF00069	0.621
MOD_CK2_1	155	161	PF00069	0.277
MOD_CK2_1	186	192	PF00069	0.388
MOD_CK2_1	91	97	PF00069	0.618
MOD_GlcNHglycan	130	133	PF01048	0.580
MOD_GlcNHglycan	151	154	PF01048	0.624
MOD_GlcNHglycan	210	213	PF01048	0.676
MOD_GlcNHglycan	32	35	PF01048	0.507
MOD_GSK3_1	137	144	PF00069	0.444
MOD_GSK3_1	26	33	PF00069	0.679
MOD_GSK3_1	5	12	PF00069	0.803
MOD_GSK3_1	87	94	PF00069	0.436
MOD_NEK2_1	235	240	PF00069	0.427
MOD_PIKK_1	42	48	PF00454	0.680
MOD_PKA_2	57	63	PF00069	0.719
MOD_Plk_1	60	66	PF00069	0.535
MOD_Plk_4	87	93	PF00069	0.481
MOD_ProDKin_1	187	193	PF00069	0.400
MOD_ProDKin_1	2	8	PF00069	0.618
MOD_ProDKin_1	91	97	PF00069	0.687
TRG_ER_diArg_1	67	69	PF00400	0.678
TRG_NLS_MonoExtN_4	13	20	PF00514	0.803
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II61	Leptomonas seymouri	53%	97%
A0A1X0NXC1	Trypanosomatidae	35%	100%
A0A3Q8IC37	Leishmania donovani	74%	100%
A0A422MRD3	Trypanosoma rangeli	37%	100%
A4I128	Leishmania infantum	74%	100%
C9ZW81	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	99%
E9AX65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QAB1	Leishmania major	73%	100%