GP-PDE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glycerophosphoryl diester phosphodiesterase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HDS7_LEIBR

TriTrypDb:

LbrM.24.2240 , LBRM2903_240030000

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDS7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0006066	alcohol metabolic process	3	1
GO:0006576	biogenic amine metabolic process	5	1
GO:0006580	ethanolamine metabolic process	5	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009308	amine metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034308	primary alcohol metabolic process	4	1
GO:0042439	ethanolamine-containing compound metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0070291	N-acylethanolamine metabolic process	5	1
GO:1901160	primary amino compound metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008081	phosphoric diester hydrolase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0008889	glycerophosphodiester phosphodiesterase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.323
CLV_NRD_NRD_1	187	189	PF00675	0.399
CLV_NRD_NRD_1	260	262	PF00675	0.323
CLV_NRD_NRD_1	99	101	PF00675	0.353
CLV_PCSK_KEX2_1	149	151	PF00082	0.283
CLV_PCSK_KEX2_1	163	165	PF00082	0.215
CLV_PCSK_KEX2_1	187	189	PF00082	0.392
CLV_PCSK_KEX2_1	259	261	PF00082	0.338
CLV_PCSK_KEX2_1	328	330	PF00082	0.396
CLV_PCSK_KEX2_1	99	101	PF00082	0.270
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.383
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.440
CLV_PCSK_SKI1_1	146	150	PF00082	0.376
CLV_PCSK_SKI1_1	2	6	PF00082	0.474
CLV_PCSK_SKI1_1	261	265	PF00082	0.454
CLV_PCSK_SKI1_1	44	48	PF00082	0.240
DEG_Nend_UBRbox_1	1	4	PF02207	0.481
DOC_CKS1_1	279	284	PF01111	0.491
DOC_CKS1_1	300	305	PF01111	0.441
DOC_MAPK_gen_1	187	195	PF00069	0.260
DOC_MAPK_gen_1	73	83	PF00069	0.260
DOC_MAPK_gen_1	99	106	PF00069	0.293
DOC_PP4_FxxP_1	300	303	PF00568	0.426
DOC_USP7_MATH_1	242	246	PF00917	0.226
DOC_USP7_MATH_1	26	30	PF00917	0.334
DOC_USP7_MATH_1	86	90	PF00917	0.177
DOC_WW_Pin1_4	278	283	PF00397	0.461
DOC_WW_Pin1_4	299	304	PF00397	0.432
LIG_Actin_WH2_2	136	151	PF00022	0.398
LIG_Actin_WH2_2	7	22	PF00022	0.481
LIG_AP2alpha_1	83	87	PF02296	0.398
LIG_APCC_ABBA_1	80	85	PF00400	0.260
LIG_FHA_1	117	123	PF00498	0.260
LIG_FHA_1	153	159	PF00498	0.374
LIG_FHA_1	171	177	PF00498	0.143
LIG_FHA_1	199	205	PF00498	0.345
LIG_FHA_1	262	268	PF00498	0.335
LIG_FHA_2	103	109	PF00498	0.329
LIG_FHA_2	124	130	PF00498	0.260
LIG_LIR_Apic_2	298	303	PF02991	0.400
LIG_LIR_Gen_1	294	305	PF02991	0.454
LIG_LIR_Nem_3	160	165	PF02991	0.260
LIG_LIR_Nem_3	294	300	PF02991	0.493
LIG_LIR_Nem_3	324	330	PF02991	0.518
LIG_Pex14_2	83	87	PF04695	0.398
LIG_SH2_CRK	327	331	PF00017	0.455
LIG_SH2_STAP1	165	169	PF00017	0.260
LIG_SH2_STAP1	199	203	PF00017	0.360
LIG_SH2_STAP1	297	301	PF00017	0.277
LIG_SH2_STAT5	152	155	PF00017	0.398
LIG_SH2_STAT5	18	21	PF00017	0.374
LIG_SH2_STAT5	270	273	PF00017	0.425
LIG_SH3_2	25	30	PF14604	0.325
LIG_SH3_3	22	28	PF00018	0.331
LIG_SH3_3	300	306	PF00018	0.427
LIG_SUMO_SIM_par_1	141	147	PF11976	0.260
LIG_TRAF2_1	126	129	PF00917	0.283
LIG_WRC_WIRS_1	175	180	PF05994	0.320
LIG_WW_1	306	309	PF00397	0.585
MOD_CDK_SPK_2	299	304	PF00069	0.472
MOD_CDK_SPxxK_3	278	285	PF00069	0.445
MOD_CK1_1	177	183	PF00069	0.360
MOD_CK1_1	206	212	PF00069	0.353
MOD_CK2_1	102	108	PF00069	0.320
MOD_CK2_1	123	129	PF00069	0.275
MOD_GlcNHglycan	179	182	PF01048	0.360
MOD_GlcNHglycan	291	294	PF01048	0.215
MOD_GlcNHglycan	33	36	PF01048	0.236
MOD_GlcNHglycan	88	91	PF01048	0.177
MOD_GSK3_1	170	177	PF00069	0.320
MOD_N-GLC_2	266	268	PF02516	0.440
MOD_NEK2_1	14	19	PF00069	0.408
MOD_NEK2_1	198	203	PF00069	0.403
MOD_PIKK_1	206	212	PF00454	0.294
MOD_PKA_1	163	169	PF00069	0.177
MOD_PKA_2	163	169	PF00069	0.200
MOD_PKA_2	72	78	PF00069	0.260
MOD_PKB_1	259	267	PF00069	0.457
MOD_Plk_1	102	108	PF00069	0.301
MOD_Plk_1	170	176	PF00069	0.261
MOD_Plk_1	50	56	PF00069	0.260
MOD_Plk_2-3	102	108	PF00069	0.320
MOD_Plk_4	102	108	PF00069	0.295
MOD_Plk_4	171	177	PF00069	0.261
MOD_Plk_4	203	209	PF00069	0.485
MOD_Plk_4	242	248	PF00069	0.285
MOD_ProDKin_1	278	284	PF00069	0.457
MOD_ProDKin_1	299	305	PF00069	0.437
MOD_SUMO_rev_2	144	151	PF00179	0.398
TRG_ENDOCYTIC_2	251	254	PF00928	0.266
TRG_ENDOCYTIC_2	297	300	PF00928	0.520
TRG_ENDOCYTIC_2	309	312	PF00928	0.525
TRG_ENDOCYTIC_2	327	330	PF00928	0.554
TRG_ER_diArg_1	162	164	PF00400	0.329
TRG_ER_diArg_1	187	189	PF00400	0.210
TRG_ER_diArg_1	259	261	PF00400	0.342
TRG_ER_diArg_1	329	332	PF00400	0.428
TRG_ER_diArg_1	98	100	PF00400	0.354
TRG_NLS_MonoExtC_3	327	333	PF00514	0.381
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.260
TRG_Pf-PMV_PEXEL_1	317	322	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S0	Leptomonas seymouri	75%	100%
A0A0S4KJA2	Bodo saltans	51%	100%
A0A1X0NVZ2	Trypanosomatidae	58%	100%
A0A3Q8IGB4	Leishmania donovani	80%	100%
A0A422NWY6	Trypanosoma rangeli	55%	100%
A4I125	Leishmania infantum	80%	100%
C9ZW84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AX62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q3T0T0	Bos taurus	29%	100%
Q4QAB4	Leishmania major	78%	100%
V5B577	Trypanosoma cruzi	56%	97%