UBC core domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme, putative

Species:

Leishmania braziliensis

UniProt:

A4HDS5_LEIBR

TriTrypDb:

LbrM.24.2220 , LBRM2903_240029800

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDS5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.567
CLV_NRD_NRD_1	189	191	PF00675	0.394
CLV_NRD_NRD_1	253	255	PF00675	0.427
CLV_NRD_NRD_1	258	260	PF00675	0.404
CLV_NRD_NRD_1	26	28	PF00675	0.367
CLV_PCSK_KEX2_1	189	191	PF00082	0.512
CLV_PCSK_KEX2_1	253	255	PF00082	0.427
CLV_PCSK_KEX2_1	258	260	PF00082	0.404
CLV_PCSK_KEX2_1	26	28	PF00082	0.367
CLV_PCSK_PC7_1	254	260	PF00082	0.505
CLV_PCSK_SKI1_1	189	193	PF00082	0.495
CLV_PCSK_SKI1_1	259	263	PF00082	0.446
CLV_PCSK_SKI1_1	27	31	PF00082	0.419
CLV_PCSK_SKI1_1	312	316	PF00082	0.618
DEG_APCC_DBOX_1	311	319	PF00400	0.532
DEG_SCF_FBW7_1	81	88	PF00400	0.426
DEG_SPOP_SBC_1	111	115	PF00917	0.221
DEG_SPOP_SBC_1	179	183	PF00917	0.463
DEG_SPOP_SBC_1	61	65	PF00917	0.484
DOC_CYCLIN_RxL_1	16	28	PF00134	0.376
DOC_CYCLIN_yCln2_LP_2	71	74	PF00134	0.375
DOC_MAPK_DCC_7	132	142	PF00069	0.393
DOC_MAPK_gen_1	189	195	PF00069	0.419
DOC_MAPK_gen_1	26	32	PF00069	0.479
DOC_MAPK_MEF2A_6	206	214	PF00069	0.443
DOC_PP2B_LxvP_1	171	174	PF13499	0.480
DOC_PP2B_LxvP_1	70	73	PF13499	0.387
DOC_PP4_FxxP_1	135	138	PF00568	0.310
DOC_USP7_MATH_1	145	149	PF00917	0.300
DOC_USP7_MATH_1	241	245	PF00917	0.450
DOC_USP7_MATH_1	4	8	PF00917	0.544
DOC_USP7_MATH_1	61	65	PF00917	0.511
DOC_USP7_MATH_1	85	89	PF00917	0.504
DOC_WW_Pin1_4	113	118	PF00397	0.305
DOC_WW_Pin1_4	81	86	PF00397	0.718
LIG_14-3-3_CanoR_1	110	118	PF00244	0.252
LIG_14-3-3_CanoR_1	206	210	PF00244	0.336
LIG_14-3-3_CanoR_1	231	236	PF00244	0.615
LIG_14-3-3_CanoR_1	258	268	PF00244	0.467
LIG_AP_GAE_1	90	96	PF02883	0.433
LIG_APCC_ABBA_1	192	197	PF00400	0.348
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BIR_III_1	1	5	PF00653	0.495
LIG_BIR_III_3	1	5	PF00653	0.495
LIG_deltaCOP1_diTrp_1	225	230	PF00928	0.449
LIG_FHA_1	20	26	PF00498	0.315
LIG_FHA_1	260	266	PF00498	0.477
LIG_FHA_1	299	305	PF00498	0.592
LIG_FHA_1	309	315	PF00498	0.469
LIG_FHA_2	12	18	PF00498	0.476
LIG_FHA_2	238	244	PF00498	0.515
LIG_FHA_2	301	307	PF00498	0.547
LIG_FHA_2	35	41	PF00498	0.513
LIG_FHA_2	42	48	PF00498	0.608
LIG_FHA_2	55	61	PF00498	0.496
LIG_FHA_2	63	69	PF00498	0.362
LIG_LIR_Gen_1	196	207	PF02991	0.420
LIG_LIR_Gen_1	281	289	PF02991	0.461
LIG_LIR_Nem_3	102	108	PF02991	0.338
LIG_LIR_Nem_3	17	23	PF02991	0.435
LIG_LIR_Nem_3	196	202	PF02991	0.356
LIG_LIR_Nem_3	281	286	PF02991	0.458
LIG_Pex14_2	125	129	PF04695	0.363
LIG_Pex14_2	283	287	PF04695	0.578
LIG_SH2_NCK_1	199	203	PF00017	0.470
LIG_SH2_STAP1	310	314	PF00017	0.629
LIG_SH2_STAT5	126	129	PF00017	0.340
LIG_SH2_STAT5	18	21	PF00017	0.411
LIG_SH2_STAT5	24	27	PF00017	0.327
LIG_SH2_STAT5	274	277	PF00017	0.462
LIG_SH2_STAT5	310	313	PF00017	0.580
LIG_SH3_3	124	130	PF00018	0.264
LIG_SH3_3	131	137	PF00018	0.352
LIG_SH3_3	188	194	PF00018	0.441
LIG_SH3_4	269	276	PF00018	0.529
LIG_SUMO_SIM_anti_2	264	269	PF11976	0.559
LIG_SUMO_SIM_anti_2	68	73	PF11976	0.425
LIG_SUMO_SIM_par_1	28	34	PF11976	0.487
LIG_TRAF2_1	194	197	PF00917	0.466
LIG_WW_1	73	76	PF00397	0.526
MOD_CDK_SPxxK_3	113	120	PF00069	0.300
MOD_CK1_1	113	119	PF00069	0.341
MOD_CK1_1	12	18	PF00069	0.532
MOD_CK1_1	175	181	PF00069	0.708
MOD_CK1_1	208	214	PF00069	0.466
MOD_CK1_1	39	45	PF00069	0.661
MOD_CK1_1	54	60	PF00069	0.628
MOD_CK1_1	88	94	PF00069	0.527
MOD_CK2_1	300	306	PF00069	0.512
MOD_CK2_1	34	40	PF00069	0.568
MOD_CK2_1	4	10	PF00069	0.467
MOD_CK2_1	41	47	PF00069	0.701
MOD_CK2_1	54	60	PF00069	0.508
MOD_GlcNHglycan	163	166	PF01048	0.680
MOD_GlcNHglycan	177	180	PF01048	0.715
MOD_GlcNHglycan	184	187	PF01048	0.404
MOD_GlcNHglycan	54	57	PF01048	0.724
MOD_GlcNHglycan	85	88	PF01048	0.615
MOD_GlcNHglycan	89	93	PF01048	0.609
MOD_GSK3_1	175	182	PF00069	0.686
MOD_GSK3_1	237	244	PF00069	0.690
MOD_GSK3_1	296	303	PF00069	0.726
MOD_GSK3_1	36	43	PF00069	0.533
MOD_GSK3_1	5	12	PF00069	0.494
MOD_GSK3_1	51	58	PF00069	0.737
MOD_GSK3_1	79	86	PF00069	0.638
MOD_NEK2_1	19	24	PF00069	0.308
MOD_NEK2_1	205	210	PF00069	0.344
MOD_NEK2_1	31	36	PF00069	0.380
MOD_PIKK_1	259	265	PF00454	0.461
MOD_PKA_2	111	117	PF00069	0.305
MOD_PKA_2	205	211	PF00069	0.342
MOD_PKA_2	257	263	PF00069	0.440
MOD_PKB_1	110	118	PF00069	0.199
MOD_Plk_1	242	248	PF00069	0.408
MOD_Plk_1	88	94	PF00069	0.454
MOD_Plk_2-3	300	306	PF00069	0.757
MOD_Plk_4	205	211	PF00069	0.342
MOD_ProDKin_1	113	119	PF00069	0.305
MOD_ProDKin_1	81	87	PF00069	0.718
TRG_AP2beta_CARGO_1	17	27	PF09066	0.440
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.225
TRG_ENDOCYTIC_2	126	129	PF00928	0.334
TRG_ENDOCYTIC_2	199	202	PF00928	0.352
TRG_ER_diArg_1	109	112	PF00400	0.199
TRG_ER_diArg_1	189	191	PF00400	0.317
TRG_ER_diArg_1	25	27	PF00400	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S2	Leptomonas seymouri	48%	100%
A0A1X0NWL0	Trypanosomatidae	32%	100%
A0A3Q8ID23	Leishmania donovani	72%	98%
A0A3S5IS47	Trypanosoma rangeli	35%	100%
A4I123	Leishmania infantum	72%	98%
E9AX60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	98%
Q4QAB6	Leishmania major	73%	100%
V5BEA3	Trypanosoma cruzi	34%	99%