Putative ubiquitin-conjugating enzyme e2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme E2, putative

Species:

Leishmania braziliensis

UniProt:

A4HDS4_LEIBR

TriTrypDb:

LbrM.24.2210 , LBRM2903_240029700

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDS4

PDB structure(s): 1yf9_A , 1yf9_B , 1yf9_C

Function

Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	1
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010965	regulation of mitotic sister chromatid separation	6	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030071	regulation of mitotic metaphase/anaphase transition	7	1
GO:0030163	protein catabolic process	4	1
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0033043	regulation of organelle organization	5	1
GO:0033044	regulation of chromosome organization	6	1
GO:0033045	regulation of sister chromatid segregation	5	1
GO:0036211	protein modification process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051726	regulation of cell cycle	4	1
GO:0051983	regulation of chromosome segregation	4	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901990	regulation of mitotic cell cycle phase transition	6	1
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	6	1
GO:1905818	regulation of chromosome separation	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016740	transferase activity	2	9
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0061631	ubiquitin conjugating enzyme activity	5	2
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0016746	acyltransferase activity	3	1
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_3	1	3	PF02207	0.610
DEG_SCF_FBW7_2	48	55	PF00400	0.457
DOC_CKS1_1	49	54	PF01111	0.415
DOC_CKS1_1	77	82	PF01111	0.316
DOC_MAPK_gen_1	13	21	PF00069	0.340
DOC_MAPK_MEF2A_6	16	23	PF00069	0.340
DOC_MAPK_MEF2A_6	89	96	PF00069	0.398
DOC_MAPK_NFAT4_5	89	97	PF00069	0.398
DOC_PP4_FxxP_1	77	80	PF00568	0.327
DOC_WW_Pin1_4	122	127	PF00397	0.307
DOC_WW_Pin1_4	48	53	PF00397	0.367
DOC_WW_Pin1_4	76	81	PF00397	0.312
LIG_14-3-3_CanoR_1	146	153	PF00244	0.678
LIG_BIR_III_4	25	29	PF00653	0.415
LIG_EH1_1	104	112	PF00400	0.340
LIG_FHA_1	140	146	PF00498	0.415
LIG_FHA_2	49	55	PF00498	0.316
LIG_LIR_Apic_2	74	80	PF02991	0.363
LIG_LIR_Gen_1	51	61	PF02991	0.394
LIG_LIR_Gen_1	99	107	PF02991	0.316
LIG_LIR_Nem_3	36	42	PF02991	0.369
LIG_LIR_Nem_3	51	56	PF02991	0.316
LIG_LIR_Nem_3	57	61	PF02991	0.315
LIG_LIR_Nem_3	99	104	PF02991	0.314
LIG_PCNA_yPIPBox_3	13	22	PF02747	0.415
LIG_Pex14_1	101	105	PF04695	0.316
LIG_PTB_Apo_2	47	54	PF02174	0.409
LIG_PTB_Phospho_1	47	53	PF10480	0.409
LIG_SH2_CRK	58	62	PF00017	0.388
LIG_SH2_NCK_1	70	74	PF00017	0.372
LIG_SH3_1	46	52	PF00018	0.415
LIG_SH3_3	46	52	PF00018	0.408
LIG_SH3_3	60	66	PF00018	0.319
LIG_SUMO_SIM_anti_2	17	25	PF11976	0.457
LIG_SUMO_SIM_par_1	141	148	PF11976	0.204
LIG_TRAF2_1	52	55	PF00917	0.457
LIG_TYR_ITIM	56	61	PF00017	0.415
LIG_UBA3_1	38	46	PF00899	0.415
LIG_WW_1	65	68	PF00397	0.415
MOD_CK1_1	106	112	PF00069	0.415
MOD_CK2_1	21	27	PF00069	0.415
MOD_CK2_1	48	54	PF00069	0.316
MOD_GlcNHglycan	101	104	PF01048	0.316
MOD_GlcNHglycan	29	32	PF01048	0.316
MOD_GlcNHglycan	7	10	PF01048	0.578
MOD_GSK3_1	99	106	PF00069	0.316
MOD_N-GLC_1	122	127	PF02516	0.316
MOD_N-GLC_1	5	10	PF02516	0.597
MOD_NEK2_2	41	46	PF00069	0.415
MOD_PKA_2	145	151	PF00069	0.685
MOD_Plk_4	106	112	PF00069	0.415
MOD_Plk_4	73	79	PF00069	0.398
MOD_ProDKin_1	122	128	PF00069	0.307
MOD_ProDKin_1	48	54	PF00069	0.367
MOD_ProDKin_1	76	82	PF00069	0.312
TRG_DiLeu_BaEn_1	57	62	PF01217	0.415
TRG_ENDOCYTIC_2	53	56	PF00928	0.316
TRG_ENDOCYTIC_2	58	61	PF00928	0.316
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P683	Leptomonas seymouri	36%	69%
A0A0N0P6R4	Leptomonas seymouri	44%	85%
A0A0N1I1I8	Leptomonas seymouri	32%	68%
A0A0N1I1Z1	Leptomonas seymouri	88%	100%
A0A0N1I707	Leptomonas seymouri	38%	100%
A0A0N1PB60	Leptomonas seymouri	39%	100%
A0A0S4IJE0	Bodo saltans	43%	70%
A0A0S4IWQ9	Bodo saltans	31%	80%
A0A0S4J8W6	Bodo saltans	41%	100%
A0A0S4JGV6	Bodo saltans	35%	100%
A0A0S4JJB5	Bodo saltans	32%	88%
A0A0S4JK56	Bodo saltans	31%	100%
A0A0S4JQY0	Bodo saltans	33%	73%
A0A0S4JRZ8	Bodo saltans	50%	96%
A0A0S4JS17	Bodo saltans	33%	100%
A0A0S4KHH6	Bodo saltans	28%	70%
A0A0S4KHR4	Bodo saltans	28%	89%
A0A0S4KIJ1	Bodo saltans	43%	86%
A0A0S4KJ33	Bodo saltans	38%	100%
A0A1B0GUS4	Homo sapiens	34%	100%
A0A1X0NH68	Trypanosomatidae	38%	100%
A0A1X0NLS0	Trypanosomatidae	39%	100%
A0A1X0NPI5	Trypanosomatidae	39%	96%
A0A1X0NT81	Trypanosomatidae	40%	74%
A0A1X0NVW4	Trypanosomatidae	28%	72%
A0A1X0NW06	Trypanosomatidae	67%	99%
A0A1X0NW44	Trypanosomatidae	32%	73%
A0A1X0PAA1	Trypanosomatidae	32%	66%
A0A3Q8IFB8	Leishmania donovani	33%	66%
A0A3Q8II46	Leishmania donovani	37%	100%
A0A3R7K708	Trypanosoma rangeli	40%	100%
A0A3R7L4E4	Trypanosoma rangeli	38%	68%
A0A3R7ND33	Trypanosoma rangeli	30%	68%
A0A3S5H5C0	Leishmania donovani	39%	100%
A0A3S5H604	Leishmania donovani	39%	85%
A0A3S7WYK3	Leishmania donovani	97%	100%
A0A422MVJ2	Trypanosoma rangeli	37%	100%
A0A422MY24	Trypanosoma rangeli	39%	97%
A0A422NDI3	Trypanosoma rangeli	37%	73%
A0A422NJI9	Trypanosoma rangeli	33%	73%
A0A422NWQ7	Trypanosoma rangeli	64%	100%
A0A451EJH5	Leishmania donovani	35%	100%
A1L3K1	Xenopus laevis	33%	70%
A3KN22	Bos taurus	34%	85%
A4H3D5	Leishmania braziliensis	36%	70%
A4H402	Leishmania braziliensis	40%	100%
A4H533	Leishmania braziliensis	43%	100%
A4HK50	Leishmania braziliensis	33%	67%
A4HLY8	Leishmania braziliensis	35%	100%
A4HMF2	Leishmania braziliensis	39%	100%
A4HRN6	Leishmania infantum	35%	100%
A4HS64	Leishmania infantum	39%	100%
A4HTB1	Leishmania infantum	39%	85%
A4I122	Leishmania infantum	97%	100%
A4I7L2	Leishmania infantum	33%	66%
A4IB24	Leishmania infantum	37%	100%
A5PJC4	Bos taurus	33%	100%
A5PKP9	Xenopus laevis	38%	100%
A6H795	Bos taurus	36%	100%
A7SE05	Nematostella vectensis	36%	76%
B3MQV3	Drosophila ananassae	32%	74%
B3NWW9	Drosophila erecta	32%	74%
B4H9W2	Drosophila persimilis	32%	74%
B4IF39	Drosophila sechellia	32%	74%
B4JKB7	Drosophila grimshawi	32%	75%
B4L7V4	Drosophila mojavensis	32%	75%
B4MA02	Drosophila virilis	32%	75%
B4N208	Drosophila willistoni	32%	75%
B4Q2J2	Drosophila yakuba	32%	74%
B4R6G1	Drosophila simulans	32%	74%
B5DEI4	Rattus norvegicus	36%	100%
B5DFI8	Rattus norvegicus	33%	70%
B5DKM4	Drosophila pseudoobscura pseudoobscura	32%	74%
C1C3R6	Lithobates catesbeianus	33%	73%
C3Z724	Branchiostoma floridae	34%	73%
C9ZJ18	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	78%
C9ZMW8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	70%
C9ZMZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	93%
C9ZNM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZRM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	70%
C9ZUL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	90%
C9ZW85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
C9ZY61	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
D0A9T7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	72%
D3ZDK2	Rattus norvegicus	38%	100%
E9ACB4	Leishmania major	35%	100%
E9AJK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AK51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9ALA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	85%
E9AX59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B2J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	66%
E9B609	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
O00102	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	93%
O00103	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	56%	88%
O00762	Homo sapiens	58%	87%
O09181	Mesocricetus auratus	30%	98%
O13685	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
O14933	Homo sapiens	34%	100%
O42646	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	68%
O45495	Caenorhabditis elegans	37%	100%
O60015	Pichia angusta	34%	82%
O74196	Colletotrichum gloeosporioides	36%	100%
O74201	Candida albicans (strain SC5314 / ATCC MYA-2876)	43%	87%
O74810	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	71%
P06104	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	90%
P0C8G3	African swine fever virus (isolate Pig/Kenya/KEN-50/1950)	34%	71%
P0C8G4	African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)	33%	71%
P0C8G5	African swine fever virus (isolate Warthog/Namibia/Wart80/1980)	30%	70%
P0CS16	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	41%	92%
P0CS17	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	41%	92%
P15731	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P15732	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P16577	Triticum aestivum	29%	84%
P21734	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	72%
P23566	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
P25153	Drosophila melanogaster	41%	100%
P25865	Arabidopsis thaliana	38%	100%
P25866	Triticum aestivum	38%	100%
P25867	Drosophila melanogaster	38%	100%
P25868	Triticum aestivum	37%	92%
P25869	African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983)	33%	73%
P27949	African swine fever virus (strain Badajoz 1971 Vero-adapted)	34%	72%
P28263	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	71%
P34477	Caenorhabditis elegans	36%	95%
P35128	Drosophila melanogaster	41%	100%
P35129	Caenorhabditis elegans	39%	100%
P35130	Medicago sativa	38%	100%
P35131	Arabidopsis thaliana	38%	100%
P35132	Arabidopsis thaliana	37%	100%
P35133	Arabidopsis thaliana	37%	100%
P35134	Arabidopsis thaliana	37%	100%
P35135	Solanum lycopersicum	37%	100%
P40984	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	99%
P42745	Arabidopsis thaliana	38%	100%
P42746	Arabidopsis thaliana	38%	100%
P42747	Arabidopsis thaliana	38%	93%
P42748	Arabidopsis thaliana	29%	83%
P42749	Arabidopsis thaliana	31%	84%
P42750	Arabidopsis thaliana	29%	85%
P43102	Candida albicans	36%	100%
P46595	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
P49459	Homo sapiens	41%	100%
P50623	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	99%
P51668	Homo sapiens	38%	100%
P51965	Homo sapiens	39%	80%
P52478	Caenorhabditis elegans	41%	81%
P52482	Mus musculus	39%	80%
P52483	Mus musculus	39%	75%
P52484	Caenorhabditis elegans	36%	72%
P52485	Drosophila melanogaster	41%	67%
P52486	Drosophila melanogaster	36%	78%
P52487	Drosophila melanogaster	33%	100%
P52490	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
P52492	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	51%	99%
P52493	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	38%	100%
P56616	Xenopus laevis	57%	87%
P60604	Homo sapiens	36%	94%
P60605	Mus musculus	36%	94%
P61077	Homo sapiens	36%	100%
P61078	Rattus norvegicus	36%	100%
P61079	Mus musculus	36%	100%
P61080	Mus musculus	38%	100%
P61081	Homo sapiens	34%	85%
P61082	Mus musculus	34%	85%
P61085	Bos taurus	36%	78%
P61086	Homo sapiens	36%	78%
P61087	Mus musculus	36%	78%
P61088	Homo sapiens	40%	100%
P61089	Mus musculus	40%	100%
P62253	Homo sapiens	35%	91%
P62254	Mus musculus	35%	91%
P62255	Rattus norvegicus	35%	91%
P62256	Homo sapiens	33%	85%
P62257	Mus musculus	33%	85%
P62837	Homo sapiens	37%	100%
P62838	Mus musculus	37%	100%
P62839	Rattus norvegicus	37%	100%
P62840	Xenopus laevis	37%	100%
P63146	Homo sapiens	41%	100%
P63147	Mus musculus	41%	100%
P63148	Oryctolagus cuniculus	41%	100%
P63149	Rattus norvegicus	41%	100%
P63279	Homo sapiens	33%	98%
P63280	Mus musculus	33%	98%
P63281	Rattus norvegicus	33%	98%
P63282	Xenopus laevis	33%	98%
P63283	Gallus gallus	33%	98%
P68036	Homo sapiens	33%	100%
P68037	Mus musculus	33%	100%
P70711	Rattus norvegicus	37%	100%
P78717	Fusarium solani	39%	100%
Q02159	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	94%
Q06AA9	Sus scrofa	36%	100%
Q08BH7	Danio rerio	36%	80%
Q0P5K3	Bos taurus	40%	100%
Q13404	Homo sapiens	29%	100%
Q15819	Homo sapiens	29%	100%
Q16763	Homo sapiens	33%	70%
Q17QG5	Bos taurus	36%	94%
Q1JPX4	Danio rerio	35%	100%
Q1RML1	Bos taurus	32%	70%
Q1RMX2	Bos taurus	37%	100%
Q21633	Caenorhabditis elegans	31%	100%
Q28CQ4	Xenopus tropicalis	33%	98%
Q28F89	Xenopus tropicalis	34%	73%
Q28FC1	Xenopus tropicalis	36%	100%
Q2EF73	Ictidomys tridecemlineatus	33%	98%
Q2T9X7	Bos taurus	39%	75%
Q2TA10	Bos taurus	38%	100%
Q32LD2	Bos taurus	36%	79%
Q32LN1	Bos taurus	33%	85%
Q32P99	Bos taurus	41%	100%
Q32PA5	Bos taurus	57%	87%
Q3MHP1	Bos taurus	33%	100%
Q3SZ43	Bos taurus	29%	100%
Q3SZ52	Bos taurus	29%	100%
Q3ZCF7	Bos taurus	36%	100%
Q42540	Arabidopsis thaliana	39%	93%
Q42541	Arabidopsis thaliana	37%	93%
Q42551	Arabidopsis thaliana	32%	97%
Q4PFA5	Ustilago maydis (strain 521 / FGSC 9021)	41%	84%
Q4Q5L3	Leishmania major	33%	66%
Q4QAB7	Leishmania major	98%	100%
Q4QIK2	Leishmania major	42%	100%
Q4R4I1	Macaca fascicularis	40%	100%
Q4R5N4	Macaca fascicularis	36%	100%
Q4R5Y8	Macaca fascicularis	35%	91%
Q4R9D1	Macaca fascicularis	57%	87%
Q4V8J2	Rattus norvegicus	29%	100%
Q4V908	Danio rerio	36%	70%
Q4VBH4	Danio rerio	34%	100%
Q4WLA7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	39%	100%
Q54I43	Dictyostelium discoideum	38%	72%
Q54TI6	Dictyostelium discoideum	29%	67%
Q54XS6	Dictyostelium discoideum	52%	100%
Q553F3	Dictyostelium discoideum	37%	100%
Q55EY8	Dictyostelium discoideum	39%	100%
Q58FS2	Trichoderma harzianum	38%	100%
Q5F3Z3	Gallus gallus	31%	100%
Q5JXB2	Homo sapiens	38%	100%
Q5R4V7	Pongo abelii	36%	100%
Q5R5I4	Pongo abelii	33%	100%
Q5R6C9	Pongo abelii	29%	100%
Q5R7J6	Pongo abelii	40%	100%
Q5RF84	Pongo abelii	36%	94%
Q5UQC9	Acanthamoeba polyphaga mimivirus	35%	98%
Q6BU36	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	44%	92%
Q6C093	Yarrowia lipolytica (strain CLIB 122 / E 150)	39%	100%
Q6C9W0	Yarrowia lipolytica (strain CLIB 122 / E 150)	31%	87%
Q6CSW8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	33%	84%
Q6CUD9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	41%	95%
Q6DCZ9	Xenopus laevis	34%	85%
Q6FR76	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	41%	93%
Q6FVQ8	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	30%	83%
Q6P8D9	Xenopus tropicalis	34%	85%
Q6Y1Z4	Pagrus major	33%	98%
Q6ZWY6	Mus musculus	37%	100%
Q75AF2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	30%	84%
Q75EB8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	91%
Q76EZ2	Xenopus laevis	33%	73%
Q7K738	Drosophila melanogaster	34%	100%
Q7ZY08	Xenopus laevis	36%	81%
Q7ZYP0	Xenopus laevis	31%	100%
Q86IZ3	Dictyostelium discoideum	45%	100%
Q86K32	Dictyostelium discoideum	42%	100%
Q8AVU2	Xenopus laevis	33%	73%
Q8L7T3	Arabidopsis thaliana	53%	86%
Q8LGF7	Arabidopsis thaliana	39%	99%
Q8S919	Oryza sativa subsp. japonica	37%	100%
Q8S920	Oryza sativa subsp. japonica	38%	100%
Q8VDW4	Mus musculus	36%	100%
Q90879	Gallus gallus	29%	100%
Q91W82	Mus musculus	39%	77%
Q921J4	Mus musculus	33%	70%
Q94490	Dictyostelium discoideum	34%	100%
Q94A97	Arabidopsis thaliana	42%	100%
Q94F47	Arabidopsis thaliana	38%	100%
Q95017	Caenorhabditis elegans	32%	93%
Q95044	Spisula solidissima	47%	88%
Q95XX0	Caenorhabditis elegans	40%	100%
Q969T4	Homo sapiens	39%	75%
Q96B02	Homo sapiens	36%	100%
Q96LR5	Homo sapiens	39%	77%
Q96UP5	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	39%	100%
Q9C8X7	Arabidopsis thaliana	38%	100%
Q9C9Y7	Arabidopsis thaliana	36%	100%
Q9CQ37	Mus musculus	40%	76%
Q9CZY3	Mus musculus	29%	100%
Q9D1C1	Mus musculus	56%	87%
Q9DDJ0	Danio rerio	33%	99%
Q9EQX9	Rattus norvegicus	40%	100%
Q9FI61	Arabidopsis thaliana	37%	81%
Q9FKT3	Arabidopsis thaliana	38%	100%
Q9FZ48	Arabidopsis thaliana	41%	100%
Q9GNC1	Leishmania major	37%	100%
Q9LJD7	Arabidopsis thaliana	34%	85%
Q9LJZ5	Arabidopsis thaliana	53%	86%
Q9NED4	Leishmania major	39%	100%
Q9NGP4	Dictyostelium discoideum	32%	97%
Q9NPD8	Homo sapiens	36%	79%
Q9P6I1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	97%
Q9P7R4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	84%
Q9QZU9	Mus musculus	29%	100%
Q9SDY5	Arabidopsis thaliana	32%	84%
Q9SLE4	Arabidopsis thaliana	37%	100%
Q9UTN8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q9UVR2	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	36%	100%
Q9VSF3	Drosophila melanogaster	33%	86%
Q9VTY6	Drosophila melanogaster	56%	87%
Q9VX25	Drosophila melanogaster	32%	74%
Q9W6H5	Danio rerio	33%	98%
Q9XWF6	Caenorhabditis elegans	31%	100%
Q9Y2X8	Homo sapiens	39%	100%
Q9Y818	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	93%
Q9Z255	Mus musculus	41%	100%
Q9ZU75	Arabidopsis thaliana	32%	84%
V5BDP3	Trypanosoma cruzi	39%	100%
V5BVS1	Trypanosoma cruzi	40%	70%
V5BYE2	Trypanosoma cruzi	41%	97%