HMG_CoA_synt_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-hydroxy-3-methylglutaryl-CoA synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4HDS2_LEIBR

TriTrypDb:

LbrM.24.2190 , LBRM2903_240029500

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDS2

Function

Biological processes
Term	Name	Level	Count
GO:0006084	acetyl-CoA metabolic process	5	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006163	purine nucleotide metabolic process	5	2
GO:0006629	lipid metabolic process	3	2
GO:0006637	acyl-CoA metabolic process	4	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006720	isoprenoid metabolic process	4	2
GO:0006721	terpenoid metabolic process	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006790	sulfur compound metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008299	isoprenoid biosynthetic process	4	2
GO:0008610	lipid biosynthetic process	4	2
GO:0008654	phospholipid biosynthetic process	5	2
GO:0009058	biosynthetic process	2	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009150	purine ribonucleotide metabolic process	6	2
GO:0009259	ribonucleotide metabolic process	5	2
GO:0009987	cellular process	1	2
GO:0010142	farnesyl diphosphate biosynthetic process, mevalonate pathway	6	2
GO:0016114	terpenoid biosynthetic process	5	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019693	ribose phosphate metabolic process	4	2
GO:0033865	nucleoside bisphosphate metabolic process	5	2
GO:0033875	ribonucleoside bisphosphate metabolic process	6	2
GO:0034032	purine nucleoside bisphosphate metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0035383	thioester metabolic process	3	2
GO:0043603	amide metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0045337	farnesyl diphosphate biosynthetic process	6	2
GO:0045338	farnesyl diphosphate metabolic process	5	2
GO:0046483	heterocycle metabolic process	3	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072521	purine-containing compound metabolic process	4	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1902767	isoprenoid biosynthetic process via mevalonate	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0004421	hydroxymethylglutaryl-CoA synthase activity	5	3
GO:0046912	acyltransferase activity, acyl groups converted into alkyl on transfer	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.466
CLV_NRD_NRD_1	205	207	PF00675	0.411
CLV_NRD_NRD_1	210	212	PF00675	0.467
CLV_NRD_NRD_1	354	356	PF00675	0.481
CLV_NRD_NRD_1	399	401	PF00675	0.488
CLV_NRD_NRD_1	471	473	PF00675	0.474
CLV_PCSK_KEX2_1	210	212	PF00082	0.443
CLV_PCSK_PC7_1	206	212	PF00082	0.433
CLV_PCSK_SKI1_1	341	345	PF00082	0.436
CLV_PCSK_SKI1_1	349	353	PF00082	0.393
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.422
DOC_MAPK_gen_1	182	191	PF00069	0.387
DOC_MAPK_gen_1	206	216	PF00069	0.575
DOC_MAPK_gen_1	355	363	PF00069	0.456
DOC_PP1_RVXF_1	301	307	PF00149	0.410
DOC_PP1_RVXF_1	76	82	PF00149	0.466
DOC_PP4_FxxP_1	205	208	PF00568	0.411
DOC_PP4_FxxP_1	234	237	PF00568	0.404
DOC_PP4_FxxP_1	274	277	PF00568	0.336
DOC_USP7_MATH_1	10	14	PF00917	0.380
DOC_USP7_MATH_1	134	138	PF00917	0.497
DOC_USP7_MATH_1	153	157	PF00917	0.406
DOC_USP7_MATH_1	162	166	PF00917	0.448
DOC_USP7_MATH_1	419	423	PF00917	0.479
DOC_USP7_MATH_1	468	472	PF00917	0.321
DOC_USP7_UBL2_3	352	356	PF12436	0.486
DOC_USP7_UBL2_3	469	473	PF12436	0.520
DOC_WW_Pin1_4	2	7	PF00397	0.538
DOC_WW_Pin1_4	258	263	PF00397	0.459
DOC_WW_Pin1_4	369	374	PF00397	0.479
DOC_WW_Pin1_4	443	448	PF00397	0.317
LIG_14-3-3_CanoR_1	296	304	PF00244	0.443
LIG_BIR_III_2	342	346	PF00653	0.535
LIG_CtBP_PxDLS_1	6	10	PF00389	0.350
LIG_deltaCOP1_diTrp_1	27	32	PF00928	0.482
LIG_FAT_LD_1	251	259	PF03623	0.385
LIG_FHA_1	246	252	PF00498	0.351
LIG_FHA_1	345	351	PF00498	0.381
LIG_FHA_1	381	387	PF00498	0.316
LIG_FHA_1	397	403	PF00498	0.518
LIG_FHA_2	296	302	PF00498	0.438
LIG_FHA_2	458	464	PF00498	0.456
LIG_FHA_2	486	492	PF00498	0.438
LIG_LIR_Apic_2	198	203	PF02991	0.420
LIG_LIR_Apic_2	204	208	PF02991	0.404
LIG_LIR_Gen_1	235	243	PF02991	0.380
LIG_LIR_Gen_1	357	368	PF02991	0.376
LIG_LIR_Gen_1	486	497	PF02991	0.387
LIG_LIR_Nem_3	230	234	PF02991	0.416
LIG_LIR_Nem_3	235	241	PF02991	0.408
LIG_LIR_Nem_3	357	363	PF02991	0.372
LIG_LIR_Nem_3	486	492	PF02991	0.400
LIG_LIR_Nem_3	495	500	PF02991	0.348
LIG_REV1ctd_RIR_1	271	276	PF16727	0.327
LIG_SH2_CRK	238	242	PF00017	0.434
LIG_SH2_CRK	497	501	PF00017	0.378
LIG_SH2_NCK_1	266	270	PF00017	0.388
LIG_SH2_NCK_1	58	62	PF00017	0.466
LIG_SH2_SRC	18	21	PF00017	0.498
LIG_SH2_SRC	266	269	PF00017	0.505
LIG_SH2_STAP1	238	242	PF00017	0.356
LIG_SH2_STAP1	382	386	PF00017	0.316
LIG_SH2_STAP1	398	402	PF00017	0.396
LIG_SH2_STAP1	58	62	PF00017	0.466
LIG_SH2_STAT3	330	333	PF00017	0.529
LIG_SH2_STAT5	219	222	PF00017	0.511
LIG_SH2_STAT5	330	333	PF00017	0.415
LIG_SH2_STAT5	382	385	PF00017	0.316
LIG_SH2_STAT5	398	401	PF00017	0.402
LIG_SH2_STAT5	58	61	PF00017	0.466
LIG_SH3_3	14	20	PF00018	0.466
LIG_SH3_3	421	427	PF00018	0.379
LIG_SUMO_SIM_par_1	245	252	PF11976	0.483
LIG_TRAF2_1	298	301	PF00917	0.484
MOD_CDC14_SPxK_1	261	264	PF00782	0.454
MOD_CDK_SPxK_1	258	264	PF00069	0.463
MOD_CK1_1	369	375	PF00069	0.385
MOD_CK1_1	90	96	PF00069	0.309
MOD_CK2_1	162	168	PF00069	0.301
MOD_CK2_1	295	301	PF00069	0.414
MOD_CK2_1	457	463	PF00069	0.512
MOD_CMANNOS	29	32	PF00535	0.301
MOD_GlcNHglycan	12	15	PF01048	0.315
MOD_GlcNHglycan	136	139	PF01048	0.345
MOD_GlcNHglycan	193	196	PF01048	0.377
MOD_GlcNHglycan	222	225	PF01048	0.511
MOD_GlcNHglycan	234	237	PF01048	0.355
MOD_GlcNHglycan	335	338	PF01048	0.505
MOD_GlcNHglycan	415	418	PF01048	0.374
MOD_GlcNHglycan	91	95	PF01048	0.301
MOD_GSK3_1	1	8	PF00069	0.603
MOD_GSK3_1	163	170	PF00069	0.326
MOD_GSK3_1	191	198	PF00069	0.403
MOD_GSK3_1	232	239	PF00069	0.385
MOD_GSK3_1	413	420	PF00069	0.379
MOD_GSK3_1	44	51	PF00069	0.335
MOD_GSK3_1	83	90	PF00069	0.301
MOD_N-GLC_1	438	443	PF02516	0.416
MOD_NEK2_1	1	6	PF00069	0.553
MOD_NEK2_1	191	196	PF00069	0.452
MOD_NEK2_1	48	53	PF00069	0.339
MOD_PIKK_1	167	173	PF00454	0.301
MOD_PK_1	39	45	PF00069	0.344
MOD_PKA_1	366	372	PF00069	0.470
MOD_PKA_2	295	301	PF00069	0.395
MOD_PKA_2	48	54	PF00069	0.380
MOD_Plk_1	245	251	PF00069	0.414
MOD_Plk_1	267	273	PF00069	0.478
MOD_Plk_1	417	423	PF00069	0.490
MOD_Plk_1	485	491	PF00069	0.322
MOD_Plk_1	54	60	PF00069	0.315
MOD_Plk_4	237	243	PF00069	0.364
MOD_Plk_4	284	290	PF00069	0.331
MOD_Plk_4	39	45	PF00069	0.344
MOD_ProDKin_1	2	8	PF00069	0.522
MOD_ProDKin_1	258	264	PF00069	0.463
MOD_ProDKin_1	369	375	PF00069	0.475
MOD_ProDKin_1	443	449	PF00069	0.320
MOD_SUMO_rev_2	120	127	PF00179	0.301
MOD_SUMO_rev_2	181	187	PF00179	0.486
MOD_SUMO_rev_2	299	304	PF00179	0.538
MOD_SUMO_rev_2	335	343	PF00179	0.476
MOD_SUMO_rev_2	362	369	PF00179	0.508
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.319
TRG_ENDOCYTIC_2	238	241	PF00928	0.378
TRG_ENDOCYTIC_2	266	269	PF00928	0.372
TRG_ENDOCYTIC_2	278	281	PF00928	0.352
TRG_ENDOCYTIC_2	455	458	PF00928	0.367
TRG_ENDOCYTIC_2	497	500	PF00928	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ7	Leptomonas seymouri	87%	100%
A0A0S4IYM8	Bodo saltans	65%	100%
A0A1D8PTW6	Candida albicans (strain SC5314 / ATCC MYA-2876)	25%	100%
A0A1X0NXJ5	Trypanosomatidae	69%	100%
A0A3S7WYS5	Leishmania donovani	94%	100%
A0A6S5ZZ88	Fusarium sp.	25%	100%
A4I120	Leishmania infantum	93%	100%
C9ZW88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	95%
D4GWR6	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	24%	100%
E9AX57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
F9X3D9	Zymoseptoria tritici (strain CBS 115943 / IPO323)	24%	100%
I1RY35	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	25%	100%
K7PL94	Ganoderma lucidum	25%	100%
P23228	Gallus gallus	24%	96%
P54839	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P54871	Caenorhabditis elegans	22%	100%
P54873	Arabidopsis thaliana	26%	100%
P54874	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P54961	Blattella germanica	25%	100%
Q4P3F1	Ustilago maydis (strain 521 / FGSC 9021)	24%	100%
Q4QAB9	Leishmania major	94%	100%
Q4WBQ3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
V5B9Q1	Trypanosoma cruzi	67%	100%