CID domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDS1_LEIBR

TriTrypDb:

LbrM.24.2180 , LBRM2903_240029400

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.563
CLV_NRD_NRD_1	289	291	PF00675	0.629
CLV_NRD_NRD_1	294	296	PF00675	0.622
CLV_NRD_NRD_1	60	62	PF00675	0.434
CLV_PCSK_FUR_1	287	291	PF00082	0.604
CLV_PCSK_KEX2_1	287	289	PF00082	0.640
CLV_PCSK_KEX2_1	293	295	PF00082	0.619
CLV_PCSK_PC7_1	289	295	PF00082	0.643
CLV_PCSK_SKI1_1	198	202	PF00082	0.689
CLV_PCSK_SKI1_1	61	65	PF00082	0.446
DEG_Nend_Nbox_1	1	3	PF02207	0.598
DOC_MAPK_DCC_7	274	283	PF00069	0.707
DOC_MAPK_gen_1	274	283	PF00069	0.707
DOC_MAPK_MEF2A_6	274	283	PF00069	0.707
DOC_MAPK_MEF2A_6	87	96	PF00069	0.402
DOC_PP2B_LxvP_1	281	284	PF13499	0.719
DOC_PP2B_LxvP_1	96	99	PF13499	0.439
DOC_PP4_FxxP_1	223	226	PF00568	0.516
DOC_USP7_MATH_1	147	151	PF00917	0.563
DOC_USP7_MATH_1	196	200	PF00917	0.636
DOC_USP7_MATH_1	217	221	PF00917	0.641
DOC_USP7_MATH_1	244	248	PF00917	0.739
DOC_WW_Pin1_4	263	268	PF00397	0.758
DOC_WW_Pin1_4	8	13	PF00397	0.665
LIG_14-3-3_CanoR_1	117	122	PF00244	0.625
LIG_14-3-3_CanoR_1	13	19	PF00244	0.525
LIG_14-3-3_CanoR_1	204	213	PF00244	0.699
LIG_BRCT_BRCA1_1	219	223	PF00533	0.519
LIG_Clathr_ClatBox_1	121	125	PF01394	0.535
LIG_eIF4E_1	80	86	PF01652	0.366
LIG_FHA_1	19	25	PF00498	0.540
LIG_FHA_1	205	211	PF00498	0.748
LIG_FHA_2	206	212	PF00498	0.566
LIG_LIR_Apic_2	220	226	PF02991	0.589
LIG_LIR_Gen_1	130	139	PF02991	0.475
LIG_LIR_Gen_1	183	191	PF02991	0.493
LIG_LIR_Gen_1	55	65	PF02991	0.421
LIG_LIR_Nem_3	130	134	PF02991	0.390
LIG_LIR_Nem_3	183	188	PF02991	0.487
LIG_LIR_Nem_3	55	60	PF02991	0.400
LIG_MYND_1	95	99	PF01753	0.441
LIG_NRBOX	155	161	PF00104	0.606
LIG_PALB2_WD40_1	119	127	PF16756	0.534
LIG_SH2_CRK	140	144	PF00017	0.496
LIG_SH2_CRK	26	30	PF00017	0.536
LIG_SH2_STAP1	20	24	PF00017	0.582
LIG_SH2_STAT3	104	107	PF00017	0.428
LIG_SH2_STAT5	104	107	PF00017	0.410
LIG_SH2_STAT5	20	23	PF00017	0.559
LIG_SH2_STAT5	265	268	PF00017	0.636
LIG_SH2_STAT5	80	83	PF00017	0.359
LIG_SH3_3	89	95	PF00018	0.412
LIG_SH3_3	9	15	PF00018	0.670
LIG_SUMO_SIM_anti_2	206	216	PF11976	0.606
LIG_TYR_ITIM	24	29	PF00017	0.529
MOD_CDK_SPK_2	8	13	PF00069	0.707
MOD_CK1_1	172	178	PF00069	0.522
MOD_CK1_1	221	227	PF00069	0.727
MOD_CK1_1	238	244	PF00069	0.657
MOD_CK1_1	53	59	PF00069	0.503
MOD_CK2_1	149	155	PF00069	0.467
MOD_CK2_1	205	211	PF00069	0.663
MOD_Cter_Amidation	291	294	PF01082	0.776
MOD_GlcNHglycan	140	143	PF01048	0.485
MOD_GlcNHglycan	151	154	PF01048	0.302
MOD_GlcNHglycan	171	174	PF01048	0.689
MOD_GlcNHglycan	2	5	PF01048	0.722
MOD_GlcNHglycan	223	226	PF01048	0.755
MOD_GlcNHglycan	246	249	PF01048	0.713
MOD_GlcNHglycan	52	55	PF01048	0.449
MOD_GSK3_1	14	21	PF00069	0.535
MOD_GSK3_1	168	175	PF00069	0.578
MOD_GSK3_1	217	224	PF00069	0.726
MOD_GSK3_1	231	238	PF00069	0.452
MOD_LATS_1	202	208	PF00433	0.610
MOD_NEK2_1	102	107	PF00069	0.519
MOD_NEK2_1	160	165	PF00069	0.551
MOD_NEK2_2	196	201	PF00069	0.721
MOD_PIKK_1	160	166	PF00454	0.579
MOD_PIKK_1	251	257	PF00454	0.795
MOD_PKA_2	203	209	PF00069	0.617
MOD_PKA_2	239	245	PF00069	0.616
MOD_Plk_1	102	108	PF00069	0.517
MOD_Plk_4	117	123	PF00069	0.568
MOD_Plk_4	14	20	PF00069	0.454
MOD_Plk_4	196	202	PF00069	0.686
MOD_ProDKin_1	263	269	PF00069	0.757
MOD_ProDKin_1	8	14	PF00069	0.658
TRG_DiLeu_BaEn_1	155	160	PF01217	0.604
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.411
TRG_ENDOCYTIC_2	140	143	PF00928	0.516
TRG_ENDOCYTIC_2	26	29	PF00928	0.527
TRG_ER_diArg_1	287	290	PF00400	0.653
TRG_ER_diArg_1	293	295	PF00400	0.639
TRG_NES_CRM1_1	119	132	PF08389	0.549
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R9	Leptomonas seymouri	65%	98%
A0A0S4IT31	Bodo saltans	26%	100%
A0A1X0NWE2	Trypanosomatidae	38%	100%
A0A3R7MR43	Trypanosoma rangeli	38%	100%
A0A3S7WYL9	Leishmania donovani	86%	98%
A4I119	Leishmania infantum	85%	98%
C9ZW91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AX56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QAC0	Leishmania major	84%	100%
V5AV25	Trypanosoma cruzi	39%	98%