Kelch domain-containing protein 10

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kelch motif/Galactose oxidase, central domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDS0_LEIBR

TriTrypDb:

LbrM.24.2170 , LBRM2903_240029300

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDS0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.611
CLV_NRD_NRD_1	224	226	PF00675	0.451
CLV_NRD_NRD_1	286	288	PF00675	0.351
CLV_PCSK_KEX2_1	157	159	PF00082	0.323
CLV_PCSK_KEX2_1	224	226	PF00082	0.474
CLV_PCSK_KEX2_1	286	288	PF00082	0.351
CLV_PCSK_KEX2_1	66	68	PF00082	0.448
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.376
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.448
CLV_PCSK_PC7_1	153	159	PF00082	0.323
CLV_PCSK_SKI1_1	123	127	PF00082	0.544
DEG_APCC_DBOX_1	122	130	PF00400	0.523
DEG_APCC_DBOX_1	224	232	PF00400	0.559
DEG_ODPH_VHL_1	342	354	PF01847	0.414
DOC_AGCK_PIF_1	213	218	PF00069	0.451
DOC_MAPK_DCC_7	224	233	PF00069	0.556
DOC_MAPK_gen_1	257	265	PF00069	0.401
DOC_MAPK_gen_1	286	293	PF00069	0.379
DOC_MAPK_gen_1	66	73	PF00069	0.514
DOC_MAPK_MEF2A_6	224	233	PF00069	0.556
DOC_MAPK_RevD_3	53	67	PF00069	0.448
DOC_USP7_MATH_1	237	241	PF00917	0.323
DOC_USP7_MATH_1	34	38	PF00917	0.448
DOC_WW_Pin1_4	18	23	PF00397	0.490
DOC_WW_Pin1_4	2	7	PF00397	0.621
LIG_14-3-3_CanoR_1	131	139	PF00244	0.323
LIG_14-3-3_CanoR_1	185	193	PF00244	0.397
LIG_14-3-3_CanoR_1	236	245	PF00244	0.309
LIG_14-3-3_CanoR_1	25	31	PF00244	0.270
LIG_14-3-3_CanoR_1	296	300	PF00244	0.474
LIG_14-3-3_CanoR_1	81	89	PF00244	0.340
LIG_14-3-3_CanoR_1	9	14	PF00244	0.443
LIG_APCC_ABBA_1	51	56	PF00400	0.448
LIG_FHA_1	140	146	PF00498	0.439
LIG_FHA_1	194	200	PF00498	0.508
LIG_FHA_1	296	302	PF00498	0.365
LIG_FHA_1	312	318	PF00498	0.255
LIG_FHA_1	46	52	PF00498	0.446
LIG_FHA_2	321	327	PF00498	0.572
LIG_Integrin_isoDGR_2	100	102	PF01839	0.401
LIG_LIR_Apic_2	359	363	PF02991	0.715
LIG_LIR_Gen_1	272	279	PF02991	0.484
LIG_LIR_Gen_1	330	339	PF02991	0.624
LIG_LIR_Nem_3	211	216	PF02991	0.368
LIG_LIR_Nem_3	220	226	PF02991	0.307
LIG_PCNA_yPIPBox_3	149	163	PF02747	0.338
LIG_PDZ_Class_3	365	370	PF00595	0.441
LIG_Pex14_2	105	109	PF04695	0.361
LIG_Pex14_2	214	218	PF04695	0.422
LIG_Pex14_2	302	306	PF04695	0.369
LIG_PTB_Apo_2	138	145	PF02174	0.401
LIG_PTB_Phospho_1	138	144	PF10480	0.401
LIG_SH2_CRK	245	249	PF00017	0.412
LIG_SH2_CRK	42	46	PF00017	0.338
LIG_SH2_CRK	61	65	PF00017	0.430
LIG_SH2_NCK_1	61	65	PF00017	0.448
LIG_SH2_PTP2	360	363	PF00017	0.681
LIG_SH2_SRC	40	43	PF00017	0.401
LIG_SH2_STAP1	193	197	PF00017	0.510
LIG_SH2_STAP1	89	93	PF00017	0.455
LIG_SH2_STAT5	110	113	PF00017	0.318
LIG_SH2_STAT5	132	135	PF00017	0.346
LIG_SH2_STAT5	144	147	PF00017	0.270
LIG_SH2_STAT5	318	321	PF00017	0.525
LIG_SH2_STAT5	360	363	PF00017	0.706
LIG_SH2_STAT5	40	43	PF00017	0.354
LIG_SH2_STAT5	54	57	PF00017	0.199
LIG_SH2_STAT5	94	97	PF00017	0.332
LIG_SH3_1	360	366	PF00018	0.713
LIG_SH3_2	4	9	PF14604	0.624
LIG_SH3_3	1	7	PF00018	0.670
LIG_SH3_3	11	17	PF00018	0.534
LIG_SH3_3	226	232	PF00018	0.554
LIG_SH3_3	341	347	PF00018	0.405
LIG_SH3_3	360	366	PF00018	0.681
LIG_TRAF2_1	17	20	PF00917	0.330
LIG_TYR_ITIM	243	248	PF00017	0.430
LIG_WRC_WIRS_1	215	220	PF05994	0.446
LIG_WW_3	182	186	PF00397	0.448
MOD_CDK_SPxxK_3	18	25	PF00069	0.512
MOD_CDK_SPxxK_3	2	9	PF00069	0.642
MOD_CK1_1	18	24	PF00069	0.521
MOD_CK1_1	186	192	PF00069	0.365
MOD_CK1_1	217	223	PF00069	0.384
MOD_CK2_1	165	171	PF00069	0.405
MOD_CK2_1	202	208	PF00069	0.439
MOD_CK2_1	282	288	PF00069	0.414
MOD_Cter_Amidation	255	258	PF01082	0.323
MOD_GlcNHglycan	134	137	PF01048	0.374
MOD_GlcNHglycan	185	188	PF01048	0.325
MOD_GlcNHglycan	204	207	PF01048	0.356
MOD_GlcNHglycan	239	242	PF01048	0.401
MOD_GSK3_1	189	196	PF00069	0.505
MOD_GSK3_1	214	221	PF00069	0.432
MOD_GSK3_1	320	327	PF00069	0.562
MOD_GSK3_1	45	52	PF00069	0.410
MOD_N-GLC_1	311	316	PF02516	0.469
MOD_N-GLC_1	45	50	PF02516	0.387
MOD_NEK2_1	139	144	PF00069	0.406
MOD_NEK2_1	218	223	PF00069	0.435
MOD_NEK2_2	324	329	PF00069	0.617
MOD_PKA_2	152	158	PF00069	0.323
MOD_PKA_2	202	208	PF00069	0.461
MOD_PKA_2	237	243	PF00069	0.310
MOD_PKA_2	295	301	PF00069	0.461
MOD_Plk_1	193	199	PF00069	0.496
MOD_Plk_1	218	224	PF00069	0.478
MOD_Plk_2-3	15	21	PF00069	0.310
MOD_Plk_2-3	269	275	PF00069	0.356
MOD_Plk_4	139	145	PF00069	0.406
MOD_Plk_4	218	224	PF00069	0.417
MOD_Plk_4	295	301	PF00069	0.365
MOD_Plk_4	49	55	PF00069	0.459
MOD_ProDKin_1	18	24	PF00069	0.483
MOD_ProDKin_1	2	8	PF00069	0.616
TRG_ENDOCYTIC_2	245	248	PF00928	0.395
TRG_ENDOCYTIC_2	42	45	PF00928	0.334
TRG_ENDOCYTIC_2	61	64	PF00928	0.387
TRG_ER_diArg_1	102	105	PF00400	0.409
TRG_ER_diArg_1	223	225	PF00400	0.462
TRG_NLS_MonoExtC_3	256	262	PF00514	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAU5	Leptomonas seymouri	83%	100%
A0A0S4JB96	Bodo saltans	47%	100%
A0A0S4JFE6	Bodo saltans	28%	92%
A0A1X0NIK1	Trypanosomatidae	25%	67%
A0A1X0NVZ5	Trypanosomatidae	56%	94%
A0A1X0NY29	Trypanosomatidae	27%	93%
A0A3Q8ID09	Leishmania donovani	97%	98%
A0A422NEH9	Trypanosoma rangeli	24%	92%
A0A422NWK7	Trypanosoma rangeli	60%	94%
A4I118	Leishmania infantum	97%	98%
C9ZHV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	87%
C9ZW92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	94%
E9AX55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	98%
O04318	Arabidopsis thaliana	22%	79%
O49326	Arabidopsis thaliana	22%	79%
Q0IIC2	Bos taurus	25%	84%
Q10AZ7	Oryza sativa subsp. japonica	27%	74%
Q28DE7	Xenopus tropicalis	24%	90%
Q3KRE6	Rattus norvegicus	26%	91%
Q4G5Y1	Mus musculus	26%	91%
Q4QAC1	Leishmania major	96%	100%
Q4V8F4	Rattus norvegicus	25%	99%
Q58CV6	Bos taurus	27%	97%
Q5E9A7	Bos taurus	26%	91%
Q5EA50	Bos taurus	25%	99%
Q5U3Y0	Rattus norvegicus	25%	90%
Q5U580	Xenopus laevis	25%	90%
Q5ZJ37	Gallus gallus	25%	100%
Q6AXB2	Xenopus laevis	24%	100%
Q6PAR0	Mus musculus	25%	84%
Q6PID8	Homo sapiens	25%	84%
Q7Z6M1	Homo sapiens	25%	99%
Q80YG3	Mus musculus	25%	91%
Q8N7A1	Homo sapiens	26%	91%
Q8VCH5	Mus musculus	24%	97%
Q93XW5	Arabidopsis thaliana	22%	100%
Q9BQ90	Homo sapiens	27%	97%
Q9SDM9	Arabidopsis thaliana	24%	79%
Q9Y2U9	Homo sapiens	26%	91%
V5BAH1	Trypanosoma cruzi	59%	94%
V5BAQ7	Trypanosoma cruzi	24%	76%
V5DS74	Trypanosoma cruzi	24%	92%