Transketolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Transketolase

Gene product:

transketolase

Species:

Leishmania braziliensis

UniProt:

A4HDR8_LEIBR

TriTrypDb:

LbrM.24.2140 , LBRM2903_240029100

Length:

671

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	1
GO:0020015	glycosome	7	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDR8

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006098	pentose-phosphate shunt	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006739	NADP metabolic process	7	1
GO:0006740	NADPH regeneration	4	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009052	pentose-phosphate shunt, non-oxidative branch	4	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009987	cellular process	1	1
GO:0019362	pyridine nucleotide metabolic process	5	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046496	nicotinamide nucleotide metabolic process	6	1
GO:0051156	glucose 6-phosphate metabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072524	pyridine-containing compound metabolic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004802	transketolase activity	4	11
GO:0005488	binding	1	11
GO:0016740	transferase activity	2	11
GO:0016744	transketolase or transaldolase activity	3	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	225	227	PF00675	0.399
CLV_NRD_NRD_1	352	354	PF00675	0.309
CLV_NRD_NRD_1	590	592	PF00675	0.385
CLV_PCSK_KEX2_1	533	535	PF00082	0.557
CLV_PCSK_KEX2_1	88	90	PF00082	0.333
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.557
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.254
CLV_PCSK_SKI1_1	103	107	PF00082	0.382
CLV_PCSK_SKI1_1	226	230	PF00082	0.369
CLV_PCSK_SKI1_1	292	296	PF00082	0.507
CLV_PCSK_SKI1_1	312	316	PF00082	0.177
CLV_PCSK_SKI1_1	592	596	PF00082	0.327
DEG_SPOP_SBC_1	243	247	PF00917	0.507
DOC_CDC14_PxL_1	364	372	PF14671	0.540
DOC_CKS1_1	27	32	PF01111	0.435
DOC_CYCLIN_yCln2_LP_2	382	388	PF00134	0.589
DOC_MAPK_gen_1	233	243	PF00069	0.362
DOC_MAPK_MEF2A_6	481	488	PF00069	0.509
DOC_PP1_RVXF_1	399	406	PF00149	0.523
DOC_PP4_FxxP_1	137	140	PF00568	0.474
DOC_SPAK_OSR1_1	404	408	PF12202	0.509
DOC_USP7_MATH_1	322	326	PF00917	0.254
DOC_USP7_MATH_1	504	508	PF00917	0.613
DOC_USP7_MATH_1	525	529	PF00917	0.427
DOC_USP7_MATH_1	551	555	PF00917	0.545
DOC_USP7_MATH_1	600	604	PF00917	0.561
DOC_USP7_UBL2_3	236	240	PF12436	0.384
DOC_USP7_UBL2_3	297	301	PF12436	0.406
DOC_WW_Pin1_4	26	31	PF00397	0.435
DOC_WW_Pin1_4	345	350	PF00397	0.524
DOC_WW_Pin1_4	375	380	PF00397	0.517
DOC_WW_Pin1_4	507	512	PF00397	0.580
DOC_WW_Pin1_4	94	99	PF00397	0.362
LIG_14-3-3_CanoR_1	103	111	PF00244	0.319
LIG_14-3-3_CanoR_1	353	362	PF00244	0.513
LIG_14-3-3_CanoR_1	384	393	PF00244	0.535
LIG_14-3-3_CanoR_1	518	523	PF00244	0.509
LIG_14-3-3_CanoR_1	571	575	PF00244	0.557
LIG_14-3-3_CanoR_1	591	595	PF00244	0.585
LIG_APCC_ABBAyCdc20_2	591	597	PF00400	0.432
LIG_BIR_II_1	1	5	PF00653	0.457
LIG_BIR_III_4	420	424	PF00653	0.585
LIG_BRCT_BRCA1_1	206	210	PF00533	0.401
LIG_CtBP_PxDLS_1	473	477	PF00389	0.589
LIG_deltaCOP1_diTrp_1	51	60	PF00928	0.362
LIG_EH1_1	409	417	PF00400	0.523
LIG_FHA_1	104	110	PF00498	0.362
LIG_FHA_1	111	117	PF00498	0.362
LIG_FHA_1	243	249	PF00498	0.449
LIG_FHA_1	255	261	PF00498	0.303
LIG_FHA_1	508	514	PF00498	0.594
LIG_FHA_1	640	646	PF00498	0.443
LIG_FHA_1	658	664	PF00498	0.588
LIG_FHA_2	639	645	PF00498	0.613
LIG_FHA_2	81	87	PF00498	0.474
LIG_LIR_Apic_2	136	140	PF02991	0.325
LIG_LIR_Gen_1	202	213	PF02991	0.291
LIG_LIR_Gen_1	399	407	PF02991	0.613
LIG_LIR_Gen_1	431	440	PF02991	0.509
LIG_LIR_Gen_1	605	615	PF02991	0.589
LIG_LIR_Gen_1	666	671	PF02991	0.652
LIG_LIR_Nem_3	207	213	PF02991	0.358
LIG_LIR_Nem_3	219	225	PF02991	0.345
LIG_LIR_Nem_3	399	405	PF02991	0.591
LIG_LIR_Nem_3	431	435	PF02991	0.509
LIG_LIR_Nem_3	605	610	PF02991	0.514
LIG_LIR_Nem_3	666	671	PF02991	0.585
LIG_PDZ_Class_1	666	671	PF00595	0.462
LIG_Pex14_2	428	432	PF04695	0.523
LIG_PTB_Apo_2	662	669	PF02174	0.595
LIG_SH2_CRK	222	226	PF00017	0.468
LIG_SH2_CRK	72	76	PF00017	0.405
LIG_SH2_NCK_1	438	442	PF00017	0.432
LIG_SH2_STAP1	438	442	PF00017	0.432
LIG_SH2_STAT3	47	50	PF00017	0.487
LIG_SH2_STAT5	152	155	PF00017	0.359
LIG_SH2_STAT5	205	208	PF00017	0.267
LIG_SH2_STAT5	402	405	PF00017	0.509
LIG_SH2_STAT5	455	458	PF00017	0.540
LIG_SH2_STAT5	607	610	PF00017	0.551
LIG_SH3_2	98	103	PF14604	0.362
LIG_SH3_3	24	30	PF00018	0.362
LIG_SH3_3	485	491	PF00018	0.509
LIG_SH3_3	519	525	PF00018	0.547
LIG_SH3_3	539	545	PF00018	0.397
LIG_SH3_3	572	578	PF00018	0.498
LIG_SH3_3	95	101	PF00018	0.362
LIG_SUMO_SIM_anti_2	176	184	PF11976	0.435
LIG_SUMO_SIM_par_1	176	184	PF11976	0.412
LIG_SUMO_SIM_par_1	546	552	PF11976	0.487
LIG_SUMO_SIM_par_1	600	605	PF11976	0.500
LIG_TRAF2_1	578	581	PF00917	0.509
LIG_TYR_ITIM	70	75	PF00017	0.362
LIG_WRC_WIRS_1	607	612	PF05994	0.589
MOD_CK1_1	272	278	PF00069	0.514
MOD_CK1_1	380	386	PF00069	0.510
MOD_CK1_1	492	498	PF00069	0.523
MOD_CK1_1	507	513	PF00069	0.509
MOD_CK1_1	554	560	PF00069	0.526
MOD_CK1_1	573	579	PF00069	0.519
MOD_CK2_1	104	110	PF00069	0.376
MOD_CK2_1	193	199	PF00069	0.474
MOD_CK2_1	524	530	PF00069	0.431
MOD_CK2_1	549	555	PF00069	0.511
MOD_GlcNHglycan	106	109	PF01048	0.395
MOD_GlcNHglycan	23	26	PF01048	0.370
MOD_GlcNHglycan	292	295	PF01048	0.517
MOD_GlcNHglycan	323	327	PF01048	0.411
MOD_GlcNHglycan	36	39	PF01048	0.362
MOD_GlcNHglycan	373	376	PF01048	0.301
MOD_GlcNHglycan	386	389	PF01048	0.308
MOD_GlcNHglycan	496	500	PF01048	0.309
MOD_GlcNHglycan	506	509	PF01048	0.309
MOD_GlcNHglycan	551	554	PF01048	0.311
MOD_GlcNHglycan	566	569	PF01048	0.389
MOD_GlcNHglycan	622	625	PF01048	0.323
MOD_GlcNHglycan	627	630	PF01048	0.295
MOD_GSK3_1	189	196	PF00069	0.298
MOD_GSK3_1	250	257	PF00069	0.486
MOD_GSK3_1	345	352	PF00069	0.471
MOD_GSK3_1	371	378	PF00069	0.498
MOD_GSK3_1	380	387	PF00069	0.499
MOD_GSK3_1	503	510	PF00069	0.529
MOD_GSK3_1	514	521	PF00069	0.462
MOD_N-GLC_1	345	350	PF02516	0.613
MOD_N-GLC_1	380	385	PF02516	0.309
MOD_N-GLC_1	388	393	PF02516	0.309
MOD_N-GLC_1	657	662	PF02516	0.518
MOD_N-GLC_1	664	669	PF02516	0.528
MOD_NEK2_1	104	109	PF00069	0.471
MOD_NEK2_1	133	138	PF00069	0.342
MOD_NEK2_1	197	202	PF00069	0.254
MOD_NEK2_1	428	433	PF00069	0.523
MOD_NEK2_1	514	519	PF00069	0.542
MOD_NEK2_1	570	575	PF00069	0.529
MOD_NEK2_1	60	65	PF00069	0.362
MOD_NEK2_1	625	630	PF00069	0.520
MOD_NEK2_1	638	643	PF00069	0.498
MOD_NEK2_1	663	668	PF00069	0.566
MOD_NEK2_2	590	595	PF00069	0.439
MOD_PIKK_1	199	205	PF00454	0.254
MOD_PIKK_1	46	52	PF00454	0.487
MOD_PKA_1	353	359	PF00069	0.523
MOD_PKA_2	489	495	PF00069	0.523
MOD_PKA_2	570	576	PF00069	0.476
MOD_PKA_2	590	596	PF00069	0.585
MOD_Plk_1	193	199	PF00069	0.468
MOD_Plk_1	554	560	PF00069	0.509
MOD_Plk_1	664	670	PF00069	0.613
MOD_Plk_1	80	86	PF00069	0.382
MOD_Plk_4	428	434	PF00069	0.500
MOD_Plk_4	509	515	PF00069	0.502
MOD_Plk_4	570	576	PF00069	0.476
MOD_Plk_4	590	596	PF00069	0.515
MOD_ProDKin_1	26	32	PF00069	0.435
MOD_ProDKin_1	345	351	PF00069	0.515
MOD_ProDKin_1	375	381	PF00069	0.517
MOD_ProDKin_1	507	513	PF00069	0.580
MOD_ProDKin_1	94	100	PF00069	0.362
MOD_SUMO_for_1	331	334	PF00179	0.371
MOD_SUMO_rev_2	300	308	PF00179	0.410
MOD_SUMO_rev_2	334	344	PF00179	0.538
MOD_SUMO_rev_2	81	90	PF00179	0.364
TRG_DiLeu_BaEn_2	322	328	PF01217	0.474
TRG_ENDOCYTIC_2	205	208	PF00928	0.259
TRG_ENDOCYTIC_2	222	225	PF00928	0.362
TRG_ENDOCYTIC_2	402	405	PF00928	0.523
TRG_ENDOCYTIC_2	607	610	PF00928	0.589
TRG_ENDOCYTIC_2	635	638	PF00928	0.511
TRG_ENDOCYTIC_2	72	75	PF00928	0.362
TRG_NLS_MonoExtC_3	87	93	PF00514	0.316
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.474
TRG_PTS1	668	671	PF00515	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0I9QGZ2	Geobacillus stearothermophilus	48%	100%
A0A0N1HR26	Leptomonas seymouri	81%	100%
A0A1X0NVW8	Trypanosomatidae	68%	100%
A0A3R7M6C6	Trypanosoma rangeli	68%	100%
A0A3S5H7D7	Leishmania donovani	87%	100%
A4I115	Leishmania infantum	87%	100%
A6YB01	Physarum polycephalum	41%	100%
B0RC26	Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1)	24%	100%
C9ZW96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
D5AV94	Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)	45%	100%
E9AX52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
F4IW47	Arabidopsis thaliana	51%	91%
O20250	Spinacia oleracea	49%	91%
O67642	Aquifex aeolicus (strain VF5)	43%	97%
O83571	Treponema pallidum (strain Nichols)	42%	100%
O93884	Candida boidinii	43%	95%
O94039	Candida albicans	50%	99%
P06834	Pichia angusta	42%	95%
P0CZ16	Rhodobacter capsulatus	45%	100%
P21725	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	49%	100%
P21726	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	49%	100%
P22976	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	46%	100%
P23254	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	51%	99%
P27302	Escherichia coli (strain K12)	48%	100%
P29277	Cereibacter sphaeroides	45%	100%
P29401	Homo sapiens	27%	100%
P33315	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	99%
P33570	Escherichia coli (strain K12)	47%	100%
P34736	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	49%	99%
P40142	Mus musculus	26%	100%
P43757	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	48%	100%
P45694	Bacillus subtilis (strain 168)	46%	100%
P46708	Mycobacterium leprae (strain TN)	41%	96%
P47312	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	31%	100%
P50137	Rattus norvegicus	26%	100%
P51010	Xanthobacter flavus	46%	100%
P51854	Homo sapiens	23%	100%
P56900	Sinorhizobium medicae (strain WSM419)	45%	97%
P57195	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	44%	100%
P57927	Pasteurella multocida (strain Pm70)	47%	100%
P57958	Pasteurella multocida (strain Pm70)	47%	100%
P58333	Rhizobium meliloti (strain 1021)	44%	97%
P59956	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	41%	96%
P66962	Staphylococcus aureus (strain Mu50 / ATCC 700699)	44%	100%
P66963	Staphylococcus aureus (strain MW2)	44%	100%
P75611	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	33%	100%
P99161	Staphylococcus aureus (strain N315)	44%	100%
P9WG24	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	41%	96%
P9WG25	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	41%	96%
Q12630	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	50%	99%
Q2NKZ4	Bos taurus	27%	100%
Q2NL26	Bos taurus	24%	100%
Q42675	Craterostigma plantagineum	48%	99%
Q42676	Craterostigma plantagineum	46%	100%
Q42677	Craterostigma plantagineum	48%	99%
Q43848	Solanum tuberosum	51%	91%
Q4QAC4	Leishmania major	87%	100%
Q556J0	Dictyostelium discoideum	41%	100%
Q5DZP0	Aliivibrio fischeri (strain ATCC 700601 / ES114)	46%	100%
Q5E7R1	Aliivibrio fischeri (strain ATCC 700601 / ES114)	47%	100%
Q5HG77	Staphylococcus aureus (strain COL)	44%	100%
Q5HPJ9	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	44%	100%
Q5R1W6	Pan troglodytes	27%	100%
Q5R4C1	Pongo abelii	26%	100%
Q5XAK5	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	46%	92%
Q60103	Xanthobacter flavus	48%	98%
Q60HC7	Macaca fascicularis	27%	100%
Q6AFD5	Leifsonia xyli subsp. xyli (strain CTCB07)	24%	100%
Q6B855	Bos taurus	27%	100%
Q6G9L6	Staphylococcus aureus (strain MSSA476)	44%	100%
Q6GH64	Staphylococcus aureus (strain MRSA252)	44%	100%
Q7MDD4	Vibrio vulnificus (strain YJ016)	46%	100%
Q7MHK7	Vibrio vulnificus (strain YJ016)	46%	100%
Q7SIC9	Zea mays	50%	99%
Q87GY4	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	47%	100%
Q87LK8	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	46%	100%
Q89AY2	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	43%	100%
Q8CPC7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	44%	100%
Q8D6H8	Vibrio vulnificus (strain CMCP6)	46%	100%
Q8DCA2	Vibrio vulnificus (strain CMCP6)	46%	100%
Q8KA26	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	44%	100%
Q8NZX4	Streptococcus pyogenes serotype M18 (strain MGAS8232)	46%	92%
Q8RWV0	Arabidopsis thaliana	51%	91%
Q8YRU9	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	50%	100%
Q99MX0	Mus musculus	23%	100%
Q9D4D4	Mus musculus	27%	100%
Q9H0I9	Homo sapiens	25%	100%
Q9KAD7	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	47%	100%
Q9KLW7	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	47%	100%
Q9KUP2	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	47%	100%
Q9URM2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	98%
V5BF33	Trypanosoma cruzi	69%	100%