PCIF1_WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphorylated CTD interacting factor 1 WW domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDR2_LEIBR

TriTrypDb:

LbrM.24.2080 , LBRM2903_240028500

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HDR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDR2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000993	RNA polymerase II complex binding	5	11
GO:0001098	basal transcription machinery binding	3	11
GO:0001099	basal RNA polymerase II transcription machinery binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008168	methyltransferase activity	4	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0008174	mRNA methyltransferase activity	5	11
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0019899	enzyme binding	3	11
GO:0043175	RNA polymerase core enzyme binding	5	11
GO:0070063	RNA polymerase binding	4	11
GO:0099122	RNA polymerase II C-terminal domain binding	6	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.602
CLV_NRD_NRD_1	113	115	PF00675	0.332
CLV_NRD_NRD_1	206	208	PF00675	0.485
CLV_NRD_NRD_1	238	240	PF00675	0.475
CLV_NRD_NRD_1	33	35	PF00675	0.361
CLV_NRD_NRD_1	54	56	PF00675	0.530
CLV_PCSK_FUR_1	204	208	PF00082	0.540
CLV_PCSK_KEX2_1	113	115	PF00082	0.332
CLV_PCSK_KEX2_1	179	181	PF00082	0.411
CLV_PCSK_KEX2_1	2	4	PF00082	0.573
CLV_PCSK_KEX2_1	206	208	PF00082	0.485
CLV_PCSK_KEX2_1	238	240	PF00082	0.475
CLV_PCSK_KEX2_1	33	35	PF00082	0.361
CLV_PCSK_KEX2_1	461	463	PF00082	0.367
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.406
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.573
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.422
CLV_PCSK_SKI1_1	173	177	PF00082	0.275
CLV_PCSK_SKI1_1	21	25	PF00082	0.307
CLV_PCSK_SKI1_1	291	295	PF00082	0.222
CLV_PCSK_SKI1_1	34	38	PF00082	0.345
CLV_PCSK_SKI1_1	402	406	PF00082	0.334
CLV_PCSK_SKI1_1	429	433	PF00082	0.386
CLV_PCSK_SKI1_1	461	465	PF00082	0.369
CLV_PCSK_SKI1_1	517	521	PF00082	0.582
CLV_PCSK_SKI1_1	571	575	PF00082	0.533
CLV_PCSK_SKI1_1	67	71	PF00082	0.333
DEG_APCC_DBOX_1	33	41	PF00400	0.403
DEG_APCC_DBOX_1	401	409	PF00400	0.328
DEG_COP1_1	575	583	PF00400	0.424
DEG_Nend_UBRbox_1	1	4	PF02207	0.574
DOC_CKS1_1	214	219	PF01111	0.580
DOC_CYCLIN_RxL_1	456	467	PF00134	0.328
DOC_MAPK_JIP1_4	402	408	PF00069	0.330
DOC_MAPK_MEF2A_6	243	250	PF00069	0.368
DOC_MAPK_MEF2A_6	402	410	PF00069	0.337
DOC_MAPK_MEF2A_6	565	572	PF00069	0.325
DOC_PP2B_LxvP_1	408	411	PF13499	0.373
DOC_PP2B_LxvP_1	447	450	PF13499	0.322
DOC_PP2B_LxvP_1	78	81	PF13499	0.365
DOC_USP7_MATH_1	129	133	PF00917	0.753
DOC_USP7_MATH_1	227	231	PF00917	0.483
DOC_USP7_MATH_1	304	308	PF00917	0.313
DOC_USP7_MATH_1	521	525	PF00917	0.472
DOC_USP7_MATH_1	573	577	PF00917	0.439
DOC_WW_Pin1_4	130	135	PF00397	0.497
DOC_WW_Pin1_4	193	198	PF00397	0.453
DOC_WW_Pin1_4	213	218	PF00397	0.316
DOC_WW_Pin1_4	330	335	PF00397	0.279
DOC_WW_Pin1_4	564	569	PF00397	0.496
DOC_WW_Pin1_4	581	586	PF00397	0.608
LIG_14-3-3_CanoR_1	291	296	PF00244	0.328
LIG_14-3-3_CanoR_1	429	438	PF00244	0.360
LIG_14-3-3_CanoR_1	88	98	PF00244	0.398
LIG_Actin_WH2_2	480	498	PF00022	0.420
LIG_Clathr_ClatBox_1	405	409	PF01394	0.325
LIG_FHA_1	196	202	PF00498	0.402
LIG_FHA_1	274	280	PF00498	0.517
LIG_FHA_1	292	298	PF00498	0.259
LIG_FHA_1	303	309	PF00498	0.279
LIG_FHA_1	405	411	PF00498	0.341
LIG_FHA_1	554	560	PF00498	0.338
LIG_FHA_1	90	96	PF00498	0.430
LIG_FHA_2	117	123	PF00498	0.415
LIG_FHA_2	141	147	PF00498	0.427
LIG_FHA_2	552	558	PF00498	0.359
LIG_LIR_Apic_2	500	506	PF02991	0.403
LIG_LIR_Apic_2	575	581	PF02991	0.550
LIG_LIR_Gen_1	249	260	PF02991	0.467
LIG_LIR_Gen_1	418	428	PF02991	0.326
LIG_LIR_Gen_1	444	451	PF02991	0.299
LIG_LIR_Gen_1	524	535	PF02991	0.344
LIG_LIR_Nem_3	374	380	PF02991	0.297
LIG_LIR_Nem_3	418	424	PF02991	0.321
LIG_LIR_Nem_3	444	448	PF02991	0.294
LIG_LIR_Nem_3	524	530	PF02991	0.347
LIG_LIR_Nem_3	536	542	PF02991	0.345
LIG_LIR_Nem_3	575	580	PF02991	0.549
LIG_NRBOX	415	421	PF00104	0.435
LIG_PCNA_yPIPBox_3	55	69	PF02747	0.353
LIG_Pex14_2	366	370	PF04695	0.279
LIG_Pex14_2	530	534	PF04695	0.302
LIG_REV1ctd_RIR_1	173	184	PF16727	0.257
LIG_SH2_CRK	338	342	PF00017	0.257
LIG_SH2_CRK	578	582	PF00017	0.443
LIG_SH2_NCK_1	578	582	PF00017	0.443
LIG_SH2_PTP2	445	448	PF00017	0.294
LIG_SH2_SRC	392	395	PF00017	0.307
LIG_SH2_STAP1	144	148	PF00017	0.376
LIG_SH2_STAP1	392	396	PF00017	0.445
LIG_SH2_STAP1	412	416	PF00017	0.217
LIG_SH2_STAT3	144	147	PF00017	0.383
LIG_SH2_STAT5	376	379	PF00017	0.279
LIG_SH2_STAT5	445	448	PF00017	0.298
LIG_SH2_STAT5	541	544	PF00017	0.334
LIG_SH2_STAT5	578	581	PF00017	0.462
LIG_SH3_3	228	234	PF00018	0.412
LIG_SH3_3	245	251	PF00018	0.373
LIG_SH3_3	338	344	PF00018	0.197
LIG_SH3_3	393	399	PF00018	0.526
LIG_SH3_3	580	586	PF00018	0.445
LIG_SH3_3	73	79	PF00018	0.439
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.381
LIG_SUMO_SIM_anti_2	444	450	PF11976	0.298
LIG_SUMO_SIM_par_1	402	407	PF11976	0.333
LIG_TYR_ITIM	443	448	PF00017	0.374
LIG_WRC_WIRS_1	574	579	PF05994	0.420
MOD_CDK_SPxxK_3	564	571	PF00069	0.480
MOD_CK1_1	153	159	PF00069	0.472
MOD_CK1_1	266	272	PF00069	0.510
MOD_CK1_1	379	385	PF00069	0.283
MOD_CK1_1	474	480	PF00069	0.600
MOD_CK1_1	576	582	PF00069	0.398
MOD_CK1_1	89	95	PF00069	0.547
MOD_CK2_1	116	122	PF00069	0.401
MOD_CK2_1	130	136	PF00069	0.644
MOD_CK2_1	140	146	PF00069	0.558
MOD_CK2_1	501	507	PF00069	0.453
MOD_CK2_1	551	557	PF00069	0.367
MOD_GlcNHglycan	107	110	PF01048	0.407
MOD_GlcNHglycan	279	282	PF01048	0.355
MOD_GlcNHglycan	367	370	PF01048	0.279
MOD_GlcNHglycan	381	384	PF01048	0.297
MOD_GlcNHglycan	429	432	PF01048	0.548
MOD_GlcNHglycan	45	48	PF01048	0.501
MOD_GlcNHglycan	477	480	PF01048	0.546
MOD_GlcNHglycan	523	526	PF01048	0.462
MOD_GSK3_1	2	9	PF00069	0.475
MOD_GSK3_1	273	280	PF00069	0.507
MOD_GSK3_1	471	478	PF00069	0.619
MOD_GSK3_1	497	504	PF00069	0.445
MOD_GSK3_1	517	524	PF00069	0.313
MOD_GSK3_1	581	588	PF00069	0.675
MOD_GSK3_1	86	93	PF00069	0.501
MOD_LATS_1	289	295	PF00433	0.197
MOD_N-GLC_1	156	161	PF02516	0.515
MOD_NEK2_1	116	121	PF00069	0.511
MOD_NEK2_1	463	468	PF00069	0.464
MOD_NEK2_1	473	478	PF00069	0.570
MOD_NEK2_2	573	578	PF00069	0.438
MOD_PIKK_1	195	201	PF00454	0.414
MOD_PIKK_1	68	74	PF00454	0.372
MOD_PIKK_1	86	92	PF00454	0.471
MOD_PKA_1	2	8	PF00069	0.695
MOD_PKA_2	2	8	PF00069	0.695
MOD_Plk_1	150	156	PF00069	0.364
MOD_Plk_1	227	233	PF00069	0.419
MOD_Plk_2-3	140	146	PF00069	0.577
MOD_Plk_4	274	280	PF00069	0.634
MOD_Plk_4	291	297	PF00069	0.337
MOD_Plk_4	573	579	PF00069	0.399
MOD_ProDKin_1	130	136	PF00069	0.497
MOD_ProDKin_1	193	199	PF00069	0.455
MOD_ProDKin_1	213	219	PF00069	0.307
MOD_ProDKin_1	330	336	PF00069	0.279
MOD_ProDKin_1	564	570	PF00069	0.482
MOD_ProDKin_1	581	587	PF00069	0.610
MOD_SUMO_for_1	457	460	PF00179	0.364
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.356
TRG_DiLeu_LyEn_5	400	405	PF01217	0.288
TRG_ENDOCYTIC_2	262	265	PF00928	0.375
TRG_ENDOCYTIC_2	325	328	PF00928	0.279
TRG_ENDOCYTIC_2	338	341	PF00928	0.279
TRG_ENDOCYTIC_2	445	448	PF00928	0.294
TRG_ENDOCYTIC_2	539	542	PF00928	0.329
TRG_ER_diArg_1	112	114	PF00400	0.324
TRG_ER_diArg_1	203	206	PF00400	0.515
TRG_ER_diArg_1	237	239	PF00400	0.445
TRG_ER_diArg_1	32	34	PF00400	0.346
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II31	Leptomonas seymouri	64%	98%
A0A1X0NXA7	Trypanosomatidae	46%	100%
A0A3Q8IBG9	Leishmania donovani	84%	100%
A0A422NWV1	Trypanosoma rangeli	48%	100%
A4I108	Leishmania infantum	84%	100%
C9ZWA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AX46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QAD0	Leishmania major	84%	100%
V5BAG8	Trypanosoma cruzi	48%	100%