Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDR1_LEIBR

TriTrypDb:

LbrM.24.2070 , LBRM2903_240028400

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.375
CLV_NRD_NRD_1	120	122	PF00675	0.486
CLV_NRD_NRD_1	314	316	PF00675	0.597
CLV_NRD_NRD_1	37	39	PF00675	0.520
CLV_NRD_NRD_1	79	81	PF00675	0.499
CLV_NRD_NRD_1	96	98	PF00675	0.562
CLV_PCSK_FUR_1	107	111	PF00082	0.444
CLV_PCSK_KEX2_1	107	109	PF00082	0.378
CLV_PCSK_KEX2_1	314	316	PF00082	0.597
CLV_PCSK_KEX2_1	36	38	PF00082	0.481
CLV_PCSK_KEX2_1	79	81	PF00082	0.456
CLV_PCSK_KEX2_1	96	98	PF00082	0.543
CLV_PCSK_SKI1_1	165	169	PF00082	0.642
CLV_PCSK_SKI1_1	194	198	PF00082	0.404
CLV_PCSK_SKI1_1	336	340	PF00082	0.532
CLV_PCSK_SKI1_1	79	83	PF00082	0.603
CLV_PCSK_SKI1_1	97	101	PF00082	0.454
DEG_SCF_FBW7_2	319	326	PF00400	0.452
DOC_MAPK_gen_1	96	104	PF00069	0.557
DOC_MAPK_MEF2A_6	297	304	PF00069	0.576
DOC_MAPK_MEF2A_6	97	106	PF00069	0.572
DOC_PP1_RVXF_1	5	11	PF00149	0.608
DOC_PP1_SILK_1	32	37	PF00149	0.377
DOC_USP7_MATH_1	206	210	PF00917	0.527
DOC_USP7_MATH_1	231	235	PF00917	0.537
DOC_WW_Pin1_4	169	174	PF00397	0.442
DOC_WW_Pin1_4	319	324	PF00397	0.494
LIG_14-3-3_CanoR_1	108	117	PF00244	0.416
LIG_14-3-3_CanoR_1	208	215	PF00244	0.533
LIG_14-3-3_CanoR_1	216	221	PF00244	0.442
LIG_14-3-3_CanoR_1	249	255	PF00244	0.570
LIG_14-3-3_CanoR_1	96	106	PF00244	0.519
LIG_FHA_1	320	326	PF00498	0.536
LIG_FHA_1	337	343	PF00498	0.379
LIG_FHA_1	99	105	PF00498	0.582
LIG_FHA_2	98	104	PF00498	0.526
LIG_LIR_Nem_3	51	57	PF02991	0.557
LIG_Pex14_1	175	179	PF04695	0.689
LIG_SH2_CRK	3	7	PF00017	0.532
LIG_SH2_GRB2like	16	19	PF00017	0.564
LIG_SH2_NCK_1	57	61	PF00017	0.421
LIG_SH2_STAP1	16	20	PF00017	0.556
LIG_SH2_STAT5	11	14	PF00017	0.492
LIG_SH2_STAT5	152	155	PF00017	0.495
LIG_SH2_STAT5	200	203	PF00017	0.557
LIG_SH2_STAT5	265	268	PF00017	0.463
LIG_SH3_1	160	166	PF00018	0.506
LIG_SH3_2	316	321	PF14604	0.609
LIG_SH3_3	160	166	PF00018	0.559
LIG_SH3_3	313	319	PF00018	0.648
LIG_SUMO_SIM_par_1	100	105	PF11976	0.374
LIG_TRAF2_1	42	45	PF00917	0.469
MOD_CK1_1	178	184	PF00069	0.598
MOD_CK1_1	272	278	PF00069	0.517
MOD_CK1_1	292	298	PF00069	0.375
MOD_CK2_1	206	212	PF00069	0.506
MOD_CK2_1	326	332	PF00069	0.505
MOD_CK2_1	97	103	PF00069	0.589
MOD_GlcNHglycan	129	132	PF01048	0.629
MOD_GlcNHglycan	208	211	PF01048	0.585
MOD_GlcNHglycan	250	253	PF01048	0.753
MOD_GSK3_1	233	240	PF00069	0.581
MOD_GSK3_1	272	279	PF00069	0.538
MOD_GSK3_1	289	296	PF00069	0.543
MOD_GSK3_1	98	105	PF00069	0.474
MOD_N-GLC_1	91	96	PF02516	0.412
MOD_NEK2_1	127	132	PF00069	0.685
MOD_NEK2_1	168	173	PF00069	0.659
MOD_NEK2_1	289	294	PF00069	0.660
MOD_NEK2_1	302	307	PF00069	0.564
MOD_PK_1	30	36	PF00069	0.557
MOD_PKA_1	109	115	PF00069	0.378
MOD_PKA_2	109	115	PF00069	0.473
MOD_PKA_2	248	254	PF00069	0.776
MOD_PKB_1	107	115	PF00069	0.572
MOD_Plk_1	102	108	PF00069	0.361
MOD_Plk_1	194	200	PF00069	0.393
MOD_Plk_2-3	326	332	PF00069	0.587
MOD_Plk_4	269	275	PF00069	0.507
MOD_Plk_4	30	36	PF00069	0.435
MOD_Plk_4	342	348	PF00069	0.660
MOD_ProDKin_1	169	175	PF00069	0.441
MOD_ProDKin_1	319	325	PF00069	0.490
MOD_SUMO_for_1	81	84	PF00179	0.482
TRG_ER_diArg_1	106	109	PF00400	0.393
TRG_ER_diArg_1	314	316	PF00400	0.599
TRG_ER_diArg_1	35	38	PF00400	0.412
TRG_ER_diArg_1	79	81	PF00400	0.521
TRG_ER_diArg_1	96	98	PF00400	0.442
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P5	Leptomonas seymouri	49%	100%
A0A3Q8ID13	Leishmania donovani	73%	100%
A0A422NWQ4	Trypanosoma rangeli	33%	100%
A4I107	Leishmania infantum	74%	99%
C9ZWA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AX45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%
Q4QAD1	Leishmania major	76%	100%
V5BJJ9	Trypanosoma cruzi	32%	100%