STOP axonemal protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

STOP axonemal protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDR0_LEIBR

TriTrypDb:

LbrM.24.2060 , LBRM2903_240028300

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HDR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDR0

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0034453	microtubule anchoring	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0008017	microtubule binding	5	3
GO:0008092	cytoskeletal protein binding	3	3
GO:0015631	tubulin binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.554
CLV_NRD_NRD_1	129	131	PF00675	0.647
CLV_NRD_NRD_1	58	60	PF00675	0.594
CLV_PCSK_FUR_1	127	131	PF00082	0.674
CLV_PCSK_FUR_1	56	60	PF00082	0.554
CLV_PCSK_KEX2_1	129	131	PF00082	0.648
CLV_PCSK_KEX2_1	58	60	PF00082	0.468
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.675
CLV_PCSK_PC7_1	54	60	PF00082	0.486
CLV_PCSK_SKI1_1	167	171	PF00082	0.644
CLV_Separin_Metazoa	151	155	PF03568	0.628
DEG_APCC_KENBOX_2	130	134	PF00400	0.433
DOC_MAPK_MEF2A_6	248	256	PF00069	0.651
DOC_MAPK_MEF2A_6	27	35	PF00069	0.578
DOC_USP7_MATH_1	92	96	PF00917	0.558
LIG_14-3-3_CanoR_1	59	65	PF00244	0.658
LIG_BRCT_BRCA1_1	177	181	PF00533	0.645
LIG_Dynein_DLC8_1	202	208	PF01221	0.456
LIG_EVH1_1	162	166	PF00568	0.621
LIG_EVH1_2	165	169	PF00568	0.571
LIG_FHA_1	206	212	PF00498	0.552
LIG_FHA_2	40	46	PF00498	0.530
LIG_FHA_2	75	81	PF00498	0.539
LIG_LIR_Apic_2	222	228	PF02991	0.539
LIG_LIR_Apic_2	255	260	PF02991	0.591
LIG_LIR_Nem_3	178	184	PF02991	0.643
LIG_Pex14_1	121	125	PF04695	0.673
LIG_SH2_CRK	225	229	PF00017	0.573
LIG_SH2_CRK	257	261	PF00017	0.578
LIG_SH2_NCK_1	257	261	PF00017	0.595
LIG_SH2_STAP1	187	191	PF00017	0.489
LIG_SH2_STAT5	187	190	PF00017	0.482
LIG_SH2_STAT5	47	50	PF00017	0.554
LIG_SH3_3	133	139	PF00018	0.633
LIG_SH3_3	160	166	PF00018	0.549
LIG_SH3_3	239	245	PF00018	0.603
LIG_TRAF2_1	148	151	PF00917	0.573
LIG_TRAF2_1	77	80	PF00917	0.536
MOD_CK1_1	6	12	PF00069	0.604
MOD_CK2_1	74	80	PF00069	0.473
MOD_GlcNHglycan	200	203	PF01048	0.684
MOD_GlcNHglycan	260	263	PF01048	0.601
MOD_GSK3_1	138	145	PF00069	0.602
MOD_GSK3_1	171	178	PF00069	0.656
MOD_N-GLC_1	185	190	PF02516	0.563
MOD_NEK2_1	108	113	PF00069	0.516
MOD_NEK2_1	175	180	PF00069	0.654
MOD_NEK2_1	198	203	PF00069	0.683
MOD_NEK2_1	217	222	PF00069	0.522
MOD_NEK2_1	74	79	PF00069	0.522
MOD_NEK2_2	60	65	PF00069	0.709
MOD_PIKK_1	203	209	PF00454	0.679
MOD_PKA_2	203	209	PF00069	0.503
MOD_PKA_2	60	66	PF00069	0.638
MOD_Plk_1	171	177	PF00069	0.573
MOD_Plk_1	39	45	PF00069	0.528
MOD_Plk_4	252	258	PF00069	0.569
MOD_Plk_4	60	66	PF00069	0.658
MOD_SUMO_for_1	67	70	PF00179	0.631
TRG_DiLeu_BaEn_1	80	85	PF01217	0.623
TRG_ER_diArg_1	56	59	PF00400	0.466
TRG_Pf-PMV_PEXEL_1	154	159	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS5	Leptomonas seymouri	82%	99%
A0A0S4J038	Bodo saltans	38%	100%
A0A0S4J0F3	Bodo saltans	27%	100%
A0A0S4JWV5	Bodo saltans	32%	98%
A0A1X0NVY6	Trypanosomatidae	61%	100%
A0A3R7MY93	Trypanosoma rangeli	60%	100%
A0A3S7WYJ9	Leishmania donovani	91%	100%
A4I106	Leishmania infantum	91%	100%
C9ZWA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AX44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QAD2	Leishmania major	92%	100%
V5BF29	Trypanosoma cruzi	62%	89%