Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP76

Species:

Leishmania braziliensis

UniProt:

A4HDQ9_LEIBR

TriTrypDb:

LbrM.24.2050 , LBRM2903_240028200

Length:

775

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0044612	nuclear pore linkers	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HDQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDQ9

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	1
GO:0006406	mRNA export from nucleus	6	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0046907	intracellular transport	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	589	593	PF00656	0.499
CLV_C14_Caspase3-7	609	613	PF00656	0.384
CLV_C14_Caspase3-7	740	744	PF00656	0.435
CLV_NRD_NRD_1	105	107	PF00675	0.328
CLV_NRD_NRD_1	115	117	PF00675	0.494
CLV_NRD_NRD_1	179	181	PF00675	0.531
CLV_NRD_NRD_1	242	244	PF00675	0.547
CLV_NRD_NRD_1	404	406	PF00675	0.601
CLV_NRD_NRD_1	44	46	PF00675	0.441
CLV_NRD_NRD_1	545	547	PF00675	0.468
CLV_NRD_NRD_1	563	565	PF00675	0.379
CLV_NRD_NRD_1	617	619	PF00675	0.455
CLV_NRD_NRD_1	673	675	PF00675	0.342
CLV_NRD_NRD_1	693	695	PF00675	0.611
CLV_NRD_NRD_1	704	706	PF00675	0.463
CLV_NRD_NRD_1	712	714	PF00675	0.327
CLV_NRD_NRD_1	748	750	PF00675	0.560
CLV_PCSK_FUR_1	177	181	PF00082	0.438
CLV_PCSK_KEX2_1	115	117	PF00082	0.494
CLV_PCSK_KEX2_1	179	181	PF00082	0.531
CLV_PCSK_KEX2_1	242	244	PF00082	0.555
CLV_PCSK_KEX2_1	544	546	PF00082	0.506
CLV_PCSK_KEX2_1	616	618	PF00082	0.471
CLV_PCSK_KEX2_1	673	675	PF00082	0.311
CLV_PCSK_KEX2_1	693	695	PF00082	0.549
CLV_PCSK_KEX2_1	704	706	PF00082	0.418
CLV_PCSK_KEX2_1	712	714	PF00082	0.323
CLV_PCSK_KEX2_1	748	750	PF00082	0.560
CLV_PCSK_SKI1_1	107	111	PF00082	0.424
CLV_PCSK_SKI1_1	179	183	PF00082	0.533
CLV_PCSK_SKI1_1	19	23	PF00082	0.493
CLV_PCSK_SKI1_1	213	217	PF00082	0.601
CLV_PCSK_SKI1_1	24	28	PF00082	0.358
CLV_PCSK_SKI1_1	260	264	PF00082	0.545
CLV_PCSK_SKI1_1	284	288	PF00082	0.506
CLV_PCSK_SKI1_1	336	340	PF00082	0.602
CLV_PCSK_SKI1_1	618	622	PF00082	0.396
CLV_PCSK_SKI1_1	630	634	PF00082	0.382
CLV_PCSK_SKI1_1	763	767	PF00082	0.430
DEG_APCC_DBOX_1	34	42	PF00400	0.426
DEG_COP1_1	600	608	PF00400	0.460
DEG_Nend_UBRbox_1	1	4	PF02207	0.441
DEG_SCF_FBW7_1	238	244	PF00400	0.545
DOC_CKS1_1	238	243	PF01111	0.548
DOC_MAPK_DCC_7	35	43	PF00069	0.338
DOC_MAPK_DCC_7	653	662	PF00069	0.413
DOC_MAPK_gen_1	115	123	PF00069	0.457
DOC_MAPK_gen_1	562	571	PF00069	0.566
DOC_MAPK_gen_1	616	625	PF00069	0.344
DOC_MAPK_gen_1	653	662	PF00069	0.413
DOC_MAPK_MEF2A_6	116	125	PF00069	0.450
DOC_MAPK_MEF2A_6	480	489	PF00069	0.600
DOC_MAPK_MEF2A_6	616	625	PF00069	0.447
DOC_MAPK_MEF2A_6	655	664	PF00069	0.385
DOC_PP1_RVXF_1	104	111	PF00149	0.433
DOC_PP2B_LxvP_1	133	136	PF13499	0.483
DOC_PP2B_LxvP_1	584	587	PF13499	0.417
DOC_USP7_MATH_1	203	207	PF00917	0.756
DOC_USP7_MATH_1	241	245	PF00917	0.644
DOC_USP7_MATH_1	292	296	PF00917	0.637
DOC_USP7_MATH_1	355	359	PF00917	0.433
DOC_USP7_MATH_1	410	414	PF00917	0.421
DOC_USP7_MATH_1	463	467	PF00917	0.455
DOC_USP7_MATH_1	51	55	PF00917	0.550
DOC_USP7_MATH_1	570	574	PF00917	0.409
DOC_USP7_MATH_1	606	610	PF00917	0.628
DOC_USP7_MATH_1	66	70	PF00917	0.616
DOC_USP7_MATH_1	88	92	PF00917	0.722
DOC_USP7_MATH_2	75	81	PF00917	0.546
DOC_WW_Pin1_4	237	242	PF00397	0.558
DOC_WW_Pin1_4	244	249	PF00397	0.537
DOC_WW_Pin1_4	297	302	PF00397	0.765
DOC_WW_Pin1_4	327	332	PF00397	0.846
DOC_WW_Pin1_4	577	582	PF00397	0.482
DOC_WW_Pin1_4	89	94	PF00397	0.561
DOC_WW_Pin1_4	99	104	PF00397	0.469
LIG_14-3-3_CanoR_1	179	184	PF00244	0.388
LIG_14-3-3_CanoR_1	205	214	PF00244	0.625
LIG_14-3-3_CanoR_1	242	248	PF00244	0.603
LIG_14-3-3_CanoR_1	395	404	PF00244	0.498
LIG_14-3-3_CanoR_1	484	490	PF00244	0.465
LIG_14-3-3_CanoR_1	500	504	PF00244	0.566
LIG_14-3-3_CanoR_1	546	555	PF00244	0.381
LIG_Actin_WH2_2	168	186	PF00022	0.549
LIG_BIR_III_2	575	579	PF00653	0.496
LIG_BRCT_BRCA1_1	28	32	PF00533	0.488
LIG_Clathr_ClatBox_1	441	445	PF01394	0.283
LIG_FHA_1	16	22	PF00498	0.473
LIG_FHA_1	209	215	PF00498	0.676
LIG_FHA_1	318	324	PF00498	0.545
LIG_FHA_1	340	346	PF00498	0.592
LIG_FHA_1	354	360	PF00498	0.469
LIG_FHA_1	446	452	PF00498	0.429
LIG_FHA_1	532	538	PF00498	0.506
LIG_FHA_1	649	655	PF00498	0.654
LIG_FHA_1	686	692	PF00498	0.408
LIG_FHA_2	160	166	PF00498	0.433
LIG_FHA_2	396	402	PF00498	0.561
LIG_FHA_2	738	744	PF00498	0.430
LIG_FHA_2	754	760	PF00498	0.455
LIG_GBD_Chelix_1	621	629	PF00786	0.430
LIG_GSK3_LRP6_1	331	336	PF00069	0.556
LIG_LIR_Apic_2	195	200	PF02991	0.428
LIG_LIR_Apic_2	550	555	PF02991	0.350
LIG_LIR_Gen_1	12	21	PF02991	0.421
LIG_LIR_Gen_1	141	152	PF02991	0.539
LIG_LIR_Nem_3	12	17	PF02991	0.399
LIG_LIR_Nem_3	141	147	PF02991	0.471
LIG_LIR_Nem_3	148	152	PF02991	0.485
LIG_LIR_Nem_3	167	173	PF02991	0.576
LIG_NRBOX	624	630	PF00104	0.324
LIG_PCNA_yPIPBox_3	653	665	PF02747	0.495
LIG_PCNA_yPIPBox_3	755	765	PF02747	0.485
LIG_Pex14_1	675	679	PF04695	0.339
LIG_Pex14_2	28	32	PF04695	0.484
LIG_Pex14_2	535	539	PF04695	0.416
LIG_PTAP_UEV_1	504	509	PF05743	0.420
LIG_PTB_Apo_2	8	15	PF02174	0.380
LIG_SH2_CRK	117	121	PF00017	0.266
LIG_SH2_CRK	149	153	PF00017	0.264
LIG_SH2_CRK	351	355	PF00017	0.457
LIG_SH2_NCK_1	197	201	PF00017	0.453
LIG_SH2_NCK_1	351	355	PF00017	0.457
LIG_SH2_SRC	197	200	PF00017	0.442
LIG_SH2_SRC	65	68	PF00017	0.583
LIG_SH2_STAP1	373	377	PF00017	0.434
LIG_SH2_STAT5	119	122	PF00017	0.372
LIG_SH2_STAT5	170	173	PF00017	0.596
LIG_SH3_3	170	176	PF00018	0.593
LIG_SH3_3	329	335	PF00018	0.843
LIG_SH3_3	479	485	PF00018	0.684
LIG_SH3_3	502	508	PF00018	0.560
LIG_SH3_3	575	581	PF00018	0.440
LIG_SH3_3	69	75	PF00018	0.537
LIG_SUMO_SIM_anti_2	122	127	PF11976	0.441
LIG_SUMO_SIM_anti_2	342	349	PF11976	0.564
LIG_SUMO_SIM_anti_2	600	607	PF11976	0.453
LIG_SUMO_SIM_anti_2	688	693	PF11976	0.316
LIG_SUMO_SIM_par_1	361	369	PF11976	0.380
LIG_SUMO_SIM_par_1	619	624	PF11976	0.487
LIG_SUMO_SIM_par_1	658	663	PF11976	0.442
LIG_TRAF2_1	398	401	PF00917	0.604
LIG_TRFH_1	351	355	PF08558	0.457
LIG_TYR_ITIM	147	152	PF00017	0.353
LIG_WW_3	32	36	PF00397	0.356
MOD_CDK_SPK_2	237	242	PF00069	0.651
MOD_CDK_SPK_2	297	302	PF00069	0.535
MOD_CDK_SPK_2	331	336	PF00069	0.582
MOD_CDK_SPxK_1	237	243	PF00069	0.638
MOD_CDK_SPxxK_3	99	106	PF00069	0.470
MOD_CK1_1	206	212	PF00069	0.597
MOD_CK1_1	226	232	PF00069	0.770
MOD_CK1_1	244	250	PF00069	0.567
MOD_CK1_1	285	291	PF00069	0.657
MOD_CK1_1	527	533	PF00069	0.342
MOD_CK1_1	591	597	PF00069	0.314
MOD_CK1_1	624	630	PF00069	0.382
MOD_CK1_1	645	651	PF00069	0.521
MOD_CK1_1	685	691	PF00069	0.525
MOD_CK2_1	395	401	PF00069	0.628
MOD_CK2_1	55	61	PF00069	0.466
MOD_CK2_1	753	759	PF00069	0.456
MOD_CK2_1	77	83	PF00069	0.621
MOD_CMANNOS	549	552	PF00535	0.407
MOD_Cter_Amidation	104	107	PF01082	0.298
MOD_GlcNHglycan	157	160	PF01048	0.471
MOD_GlcNHglycan	208	211	PF01048	0.527
MOD_GlcNHglycan	265	268	PF01048	0.682
MOD_GlcNHglycan	287	290	PF01048	0.631
MOD_GlcNHglycan	317	320	PF01048	0.710
MOD_GlcNHglycan	368	371	PF01048	0.393
MOD_GlcNHglycan	422	425	PF01048	0.481
MOD_GlcNHglycan	505	508	PF01048	0.639
MOD_GlcNHglycan	526	529	PF01048	0.483
MOD_GlcNHglycan	57	60	PF01048	0.599
MOD_GlcNHglycan	607	611	PF01048	0.421
MOD_GlcNHglycan	630	633	PF01048	0.439
MOD_GlcNHglycan	644	647	PF01048	0.621
MOD_GlcNHglycan	67	71	PF01048	0.617
MOD_GlcNHglycan	683	687	PF01048	0.507
MOD_GlcNHglycan	97	100	PF01048	0.428
MOD_GSK3_1	15	22	PF00069	0.389
MOD_GSK3_1	155	162	PF00069	0.456
MOD_GSK3_1	201	208	PF00069	0.762
MOD_GSK3_1	237	244	PF00069	0.626
MOD_GSK3_1	250	257	PF00069	0.627
MOD_GSK3_1	317	324	PF00069	0.745
MOD_GSK3_1	327	334	PF00069	0.641
MOD_GSK3_1	336	343	PF00069	0.706
MOD_GSK3_1	420	427	PF00069	0.503
MOD_GSK3_1	487	494	PF00069	0.461
MOD_GSK3_1	499	506	PF00069	0.490
MOD_GSK3_1	508	515	PF00069	0.476
MOD_GSK3_1	51	58	PF00069	0.442
MOD_GSK3_1	527	534	PF00069	0.296
MOD_GSK3_1	587	594	PF00069	0.485
MOD_GSK3_1	624	631	PF00069	0.341
MOD_GSK3_1	645	652	PF00069	0.539
MOD_GSK3_1	73	80	PF00069	0.626
MOD_GSK3_1	95	102	PF00069	0.449
MOD_LATS_1	282	288	PF00433	0.508
MOD_N-GLC_1	159	164	PF02516	0.267
MOD_N-GLC_1	485	490	PF02516	0.470
MOD_N-GLC_2	521	523	PF02516	0.444
MOD_NEK2_1	121	126	PF00069	0.292
MOD_NEK2_1	155	160	PF00069	0.298
MOD_NEK2_1	171	176	PF00069	0.412
MOD_NEK2_1	26	31	PF00069	0.382
MOD_NEK2_1	290	295	PF00069	0.614
MOD_NEK2_1	364	369	PF00069	0.432
MOD_NEK2_1	452	457	PF00069	0.366
MOD_NEK2_1	516	521	PF00069	0.476
MOD_NEK2_1	55	60	PF00069	0.413
MOD_NEK2_1	611	616	PF00069	0.634
MOD_NEK2_1	621	626	PF00069	0.455
MOD_NEK2_1	628	633	PF00069	0.381
MOD_NEK2_1	95	100	PF00069	0.431
MOD_NEK2_2	159	164	PF00069	0.430
MOD_PIKK_1	223	229	PF00454	0.767
MOD_PIKK_1	268	274	PF00454	0.536
MOD_PIKK_1	340	346	PF00454	0.609
MOD_PIKK_1	516	522	PF00454	0.482
MOD_PIKK_1	732	738	PF00454	0.383
MOD_PKA_1	179	185	PF00069	0.353
MOD_PKA_1	242	248	PF00069	0.603
MOD_PKA_2	179	185	PF00069	0.353
MOD_PKA_2	204	210	PF00069	0.656
MOD_PKA_2	241	247	PF00069	0.580
MOD_PKA_2	44	50	PF00069	0.562
MOD_PKA_2	499	505	PF00069	0.629
MOD_PKB_1	177	185	PF00069	0.369
MOD_Plk_1	121	127	PF00069	0.457
MOD_Plk_1	159	165	PF00069	0.435
MOD_Plk_1	166	172	PF00069	0.489
MOD_Plk_1	424	430	PF00069	0.411
MOD_Plk_1	485	491	PF00069	0.408
MOD_Plk_1	531	537	PF00069	0.350
MOD_Plk_1	591	597	PF00069	0.451
MOD_Plk_1	606	612	PF00069	0.400
MOD_Plk_2-3	321	327	PF00069	0.587
MOD_Plk_2-3	77	83	PF00069	0.540
MOD_Plk_4	159	165	PF00069	0.396
MOD_Plk_4	166	172	PF00069	0.526
MOD_Plk_4	531	537	PF00069	0.301
MOD_Plk_4	624	630	PF00069	0.375
MOD_Plk_4	737	743	PF00069	0.393
MOD_ProDKin_1	237	243	PF00069	0.560
MOD_ProDKin_1	244	250	PF00069	0.538
MOD_ProDKin_1	297	303	PF00069	0.765
MOD_ProDKin_1	327	333	PF00069	0.846
MOD_ProDKin_1	577	583	PF00069	0.484
MOD_ProDKin_1	89	95	PF00069	0.550
MOD_ProDKin_1	99	105	PF00069	0.465
MOD_SUMO_rev_2	221	226	PF00179	0.594
MOD_SUMO_rev_2	729	735	PF00179	0.350
TRG_DiLeu_BaEn_1	417	422	PF01217	0.463
TRG_ENDOCYTIC_2	117	120	PF00928	0.273
TRG_ENDOCYTIC_2	149	152	PF00928	0.342
TRG_ENDOCYTIC_2	170	173	PF00928	0.647
TRG_ER_diArg_1	114	116	PF00400	0.486
TRG_ER_diArg_1	176	179	PF00400	0.624
TRG_ER_diArg_1	241	243	PF00400	0.551
TRG_ER_diArg_1	473	476	PF00400	0.541
TRG_ER_diArg_1	544	546	PF00400	0.506
TRG_ER_diArg_1	616	618	PF00400	0.416
TRG_ER_diArg_1	673	675	PF00400	0.353
TRG_ER_diArg_1	692	694	PF00400	0.618
TRG_ER_diArg_1	712	715	PF00400	0.308
TRG_NLS_MonoExtN_4	42	49	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	693	697	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIR5	Leptomonas seymouri	46%	96%
A0A1X0NVW3	Trypanosomatidae	26%	100%
A0A3Q8ICZ9	Leishmania donovani	72%	100%
A0A3R7NQB0	Trypanosoma rangeli	29%	100%
A4I105	Leishmania infantum	72%	100%
E9AX43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QAD3	Leishmania major	71%	97%