Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDQ8_LEIBR

TriTrypDb:

LbrM.24.2040 , LBRM2903_240028100

Length:

862

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDQ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.606
CLV_MEL_PAP_1	848	854	PF00089	0.602
CLV_NRD_NRD_1	35	37	PF00675	0.467
CLV_NRD_NRD_1	397	399	PF00675	0.496
CLV_NRD_NRD_1	443	445	PF00675	0.580
CLV_NRD_NRD_1	462	464	PF00675	0.423
CLV_NRD_NRD_1	666	668	PF00675	0.569
CLV_NRD_NRD_1	69	71	PF00675	0.542
CLV_NRD_NRD_1	850	852	PF00675	0.606
CLV_PCSK_KEX2_1	34	36	PF00082	0.469
CLV_PCSK_KEX2_1	396	398	PF00082	0.503
CLV_PCSK_KEX2_1	443	445	PF00082	0.580
CLV_PCSK_KEX2_1	461	463	PF00082	0.435
CLV_PCSK_KEX2_1	680	682	PF00082	0.570
CLV_PCSK_KEX2_1	69	71	PF00082	0.542
CLV_PCSK_KEX2_1	850	852	PF00082	0.606
CLV_PCSK_PC1ET2_1	680	682	PF00082	0.570
CLV_PCSK_PC7_1	393	399	PF00082	0.500
CLV_PCSK_SKI1_1	372	376	PF00082	0.587
CLV_PCSK_SKI1_1	504	508	PF00082	0.448
CLV_PCSK_SKI1_1	536	540	PF00082	0.573
CLV_PCSK_SKI1_1	76	80	PF00082	0.382
DEG_APCC_DBOX_1	371	379	PF00400	0.583
DEG_APCC_DBOX_1	680	688	PF00400	0.578
DEG_SPOP_SBC_1	158	162	PF00917	0.487
DEG_SPOP_SBC_1	342	346	PF00917	0.552
DEG_SPOP_SBC_1	602	606	PF00917	0.552
DEG_SPOP_SBC_1	697	701	PF00917	0.579
DEG_SPOP_SBC_1	733	737	PF00917	0.575
DEG_SPOP_SBC_1	795	799	PF00917	0.637
DOC_CKS1_1	565	570	PF01111	0.554
DOC_CYCLIN_yCln2_LP_2	580	586	PF00134	0.639
DOC_CYCLIN_yCln2_LP_2	627	630	PF00134	0.551
DOC_MAPK_DCC_7	372	380	PF00069	0.579
DOC_MAPK_gen_1	34	42	PF00069	0.370
DOC_MAPK_gen_1	680	687	PF00069	0.576
DOC_MAPK_gen_1	74	82	PF00069	0.379
DOC_PP2B_LxvP_1	298	301	PF13499	0.542
DOC_PP2B_LxvP_1	578	581	PF13499	0.638
DOC_PP2B_LxvP_1	627	630	PF13499	0.526
DOC_USP7_MATH_1	193	197	PF00917	0.617
DOC_USP7_MATH_1	202	206	PF00917	0.536
DOC_USP7_MATH_1	23	27	PF00917	0.528
DOC_USP7_MATH_1	239	243	PF00917	0.705
DOC_USP7_MATH_1	265	269	PF00917	0.510
DOC_USP7_MATH_1	423	427	PF00917	0.502
DOC_USP7_MATH_1	431	435	PF00917	0.544
DOC_USP7_MATH_1	556	560	PF00917	0.657
DOC_USP7_MATH_1	569	573	PF00917	0.553
DOC_USP7_MATH_1	613	617	PF00917	0.700
DOC_USP7_MATH_1	619	623	PF00917	0.625
DOC_USP7_MATH_1	631	635	PF00917	0.512
DOC_USP7_MATH_1	783	787	PF00917	0.648
DOC_USP7_MATH_1	795	799	PF00917	0.702
DOC_USP7_MATH_1	803	807	PF00917	0.630
DOC_USP7_MATH_1	816	820	PF00917	0.501
DOC_WW_Pin1_4	209	214	PF00397	0.513
DOC_WW_Pin1_4	229	234	PF00397	0.547
DOC_WW_Pin1_4	244	249	PF00397	0.575
DOC_WW_Pin1_4	292	297	PF00397	0.644
DOC_WW_Pin1_4	318	323	PF00397	0.678
DOC_WW_Pin1_4	326	331	PF00397	0.639
DOC_WW_Pin1_4	373	378	PF00397	0.582
DOC_WW_Pin1_4	564	569	PF00397	0.694
DOC_WW_Pin1_4	598	603	PF00397	0.562
DOC_WW_Pin1_4	615	620	PF00397	0.522
DOC_WW_Pin1_4	646	651	PF00397	0.646
DOC_WW_Pin1_4	670	675	PF00397	0.614
DOC_WW_Pin1_4	691	696	PF00397	0.667
DOC_WW_Pin1_4	734	739	PF00397	0.721
DOC_WW_Pin1_4	790	795	PF00397	0.705
DOC_WW_Pin1_4	856	861	PF00397	0.518
LIG_14-3-3_CanoR_1	165	171	PF00244	0.436
LIG_14-3-3_CanoR_1	465	471	PF00244	0.439
LIG_14-3-3_CanoR_1	504	512	PF00244	0.564
LIG_14-3-3_CanoR_1	638	646	PF00244	0.564
LIG_14-3-3_CanoR_1	667	676	PF00244	0.571
LIG_14-3-3_CanoR_1	681	685	PF00244	0.541
LIG_14-3-3_CanoR_1	688	698	PF00244	0.556
LIG_14-3-3_CanoR_1	734	738	PF00244	0.663
LIG_14-3-3_CanoR_1	815	824	PF00244	0.559
LIG_Actin_WH2_2	358	374	PF00022	0.594
LIG_BIR_III_4	348	352	PF00653	0.653
LIG_BRCT_BRCA1_1	204	208	PF00533	0.639
LIG_BRCT_BRCA1_1	833	837	PF00533	0.608
LIG_deltaCOP1_diTrp_1	540	546	PF00928	0.537
LIG_EVH1_2	327	331	PF00568	0.558
LIG_FHA_1	11	17	PF00498	0.396
LIG_FHA_1	230	236	PF00498	0.548
LIG_FHA_1	254	260	PF00498	0.745
LIG_FHA_1	289	295	PF00498	0.540
LIG_FHA_1	374	380	PF00498	0.425
LIG_FHA_1	505	511	PF00498	0.479
LIG_FHA_1	630	636	PF00498	0.543
LIG_FHA_1	837	843	PF00498	0.578
LIG_FHA_2	23	29	PF00498	0.510
LIG_FHA_2	245	251	PF00498	0.579
LIG_FHA_2	311	317	PF00498	0.617
LIG_FHA_2	343	349	PF00498	0.758
LIG_FHA_2	535	541	PF00498	0.452
LIG_FHA_2	651	657	PF00498	0.651
LIG_FHA_2	698	704	PF00498	0.726
LIG_FHA_2	807	813	PF00498	0.621
LIG_GSK3_LRP6_1	326	332	PF00069	0.557
LIG_LIR_Apic_2	741	746	PF02991	0.685
LIG_LIR_Gen_1	205	213	PF02991	0.654
LIG_LIR_Gen_1	249	259	PF02991	0.585
LIG_LIR_Gen_1	474	483	PF02991	0.507
LIG_LIR_Gen_1	525	535	PF02991	0.578
LIG_LIR_Gen_1	832	841	PF02991	0.592
LIG_LIR_Gen_1	95	105	PF02991	0.518
LIG_LIR_Nem_3	205	211	PF02991	0.651
LIG_LIR_Nem_3	474	479	PF02991	0.509
LIG_LIR_Nem_3	525	531	PF02991	0.586
LIG_LIR_Nem_3	621	627	PF02991	0.540
LIG_LIR_Nem_3	781	785	PF02991	0.761
LIG_LIR_Nem_3	95	100	PF02991	0.514
LIG_MYND_1	582	586	PF01753	0.656
LIG_NRBOX	176	182	PF00104	0.563
LIG_PTB_Apo_2	180	187	PF02174	0.569
LIG_PTB_Phospho_1	180	186	PF10480	0.568
LIG_Rb_LxCxE_1	469	484	PF01857	0.482
LIG_SH2_CRK	528	532	PF00017	0.571
LIG_SH2_CRK	535	539	PF00017	0.503
LIG_SH2_CRK	624	628	PF00017	0.541
LIG_SH2_GRB2like	720	723	PF00017	0.527
LIG_SH2_NCK_1	709	713	PF00017	0.553
LIG_SH2_NCK_1	720	724	PF00017	0.499
LIG_SH2_SRC	720	723	PF00017	0.639
LIG_SH2_SRC	802	805	PF00017	0.561
LIG_SH2_STAP1	709	713	PF00017	0.553
LIG_SH2_STAP1	833	837	PF00017	0.608
LIG_SH2_STAT3	186	189	PF00017	0.586
LIG_SH2_STAT3	194	197	PF00017	0.540
LIG_SH2_STAT5	251	254	PF00017	0.562
LIG_SH2_STAT5	817	820	PF00017	0.695
LIG_SH3_3	233	239	PF00018	0.706
LIG_SH3_3	324	330	PF00018	0.681
LIG_SH3_3	565	571	PF00018	0.713
LIG_SH3_3	579	585	PF00018	0.578
LIG_SH3_3	592	598	PF00018	0.604
LIG_SH3_3	640	646	PF00018	0.563
LIG_SH3_3	726	732	PF00018	0.704
LIG_SH3_3	789	795	PF00018	0.700
LIG_SH3_3	810	816	PF00018	0.616
LIG_SUMO_SIM_anti_2	482	487	PF11976	0.517
LIG_SUMO_SIM_par_1	631	636	PF11976	0.546
LIG_SUMO_SIM_par_1	78	83	PF11976	0.626
LIG_SxIP_EBH_1	625	634	PF03271	0.536
LIG_TRAF2_1	50	53	PF00917	0.375
LIG_TYR_ITIM	526	531	PF00017	0.583
LIG_UBA3_1	207	216	PF00899	0.514
LIG_UBA3_1	378	383	PF00899	0.567
LIG_WW_2	582	585	PF00397	0.656
LIG_WW_3	731	735	PF00397	0.654
MOD_CDK_SPK_2	329	334	PF00069	0.552
MOD_CDK_SPxxK_3	209	216	PF00069	0.517
MOD_CDK_SPxxK_3	318	325	PF00069	0.657
MOD_CK1_1	159	165	PF00069	0.488
MOD_CK1_1	244	250	PF00069	0.639
MOD_CK1_1	26	32	PF00069	0.521
MOD_CK1_1	299	305	PF00069	0.630
MOD_CK1_1	329	335	PF00069	0.704
MOD_CK1_1	357	363	PF00069	0.677
MOD_CK1_1	370	376	PF00069	0.459
MOD_CK1_1	491	497	PF00069	0.558
MOD_CK1_1	508	514	PF00069	0.568
MOD_CK1_1	547	553	PF00069	0.667
MOD_CK1_1	576	582	PF00069	0.651
MOD_CK1_1	601	607	PF00069	0.594
MOD_CK1_1	618	624	PF00069	0.632
MOD_CK1_1	701	707	PF00069	0.613
MOD_CK1_1	751	757	PF00069	0.681
MOD_CK1_1	781	787	PF00069	0.688
MOD_CK1_1	806	812	PF00069	0.592
MOD_CK1_1	819	825	PF00069	0.631
MOD_CK2_1	133	139	PF00069	0.565
MOD_CK2_1	169	175	PF00069	0.448
MOD_CK2_1	22	28	PF00069	0.512
MOD_CK2_1	244	250	PF00069	0.595
MOD_CK2_1	261	267	PF00069	0.620
MOD_CK2_1	534	540	PF00069	0.448
MOD_CK2_1	697	703	PF00069	0.726
MOD_Cter_Amidation	678	681	PF01082	0.569
MOD_DYRK1A_RPxSP_1	734	738	PF00069	0.575
MOD_GlcNHglycan	102	106	PF01048	0.497
MOD_GlcNHglycan	166	169	PF01048	0.547
MOD_GlcNHglycan	171	174	PF01048	0.466
MOD_GlcNHglycan	204	207	PF01048	0.566
MOD_GlcNHglycan	243	246	PF01048	0.658
MOD_GlcNHglycan	262	266	PF01048	0.606
MOD_GlcNHglycan	278	281	PF01048	0.516
MOD_GlcNHglycan	298	301	PF01048	0.630
MOD_GlcNHglycan	359	362	PF01048	0.584
MOD_GlcNHglycan	507	510	PF01048	0.722
MOD_GlcNHglycan	546	549	PF01048	0.598
MOD_GlcNHglycan	595	598	PF01048	0.713
MOD_GlcNHglycan	670	673	PF01048	0.728
MOD_GlcNHglycan	700	703	PF01048	0.632
MOD_GlcNHglycan	729	732	PF01048	0.581
MOD_GlcNHglycan	761	764	PF01048	0.592
MOD_GlcNHglycan	785	788	PF01048	0.645
MOD_GlcNHglycan	805	808	PF01048	0.528
MOD_GlcNHglycan	852	855	PF01048	0.611
MOD_GlcNHglycan	87	92	PF01048	0.548
MOD_GSK3_1	22	29	PF00069	0.442
MOD_GSK3_1	239	246	PF00069	0.694
MOD_GSK3_1	249	256	PF00069	0.657
MOD_GSK3_1	261	268	PF00069	0.651
MOD_GSK3_1	272	279	PF00069	0.538
MOD_GSK3_1	288	295	PF00069	0.639
MOD_GSK3_1	337	344	PF00069	0.619
MOD_GSK3_1	350	357	PF00069	0.520
MOD_GSK3_1	504	511	PF00069	0.552
MOD_GSK3_1	569	576	PF00069	0.561
MOD_GSK3_1	598	605	PF00069	0.599
MOD_GSK3_1	615	622	PF00069	0.632
MOD_GSK3_1	629	636	PF00069	0.536
MOD_GSK3_1	646	653	PF00069	0.556
MOD_GSK3_1	668	675	PF00069	0.743
MOD_GSK3_1	697	704	PF00069	0.625
MOD_GSK3_1	734	741	PF00069	0.711
MOD_GSK3_1	781	788	PF00069	0.681
MOD_GSK3_1	790	797	PF00069	0.691
MOD_GSK3_1	802	809	PF00069	0.579
MOD_GSK3_1	832	839	PF00069	0.586
MOD_N-GLC_2	312	314	PF02516	0.566
MOD_NEK2_1	166	171	PF00069	0.430
MOD_NEK2_1	253	258	PF00069	0.701
MOD_NEK2_1	337	342	PF00069	0.698
MOD_NEK2_1	466	471	PF00069	0.595
MOD_NEK2_1	623	628	PF00069	0.665
MOD_NEK2_1	750	755	PF00069	0.630
MOD_NEK2_2	310	315	PF00069	0.563
MOD_NEK2_2	619	624	PF00069	0.537
MOD_PIKK_1	133	139	PF00454	0.414
MOD_PIKK_1	193	199	PF00454	0.471
MOD_PIKK_1	253	259	PF00454	0.552
MOD_PIKK_1	299	305	PF00454	0.653
MOD_PIKK_1	343	349	PF00454	0.650
MOD_PIKK_1	354	360	PF00454	0.573
MOD_PIKK_1	423	429	PF00454	0.568
MOD_PIKK_1	51	57	PF00454	0.416
MOD_PK_1	272	278	PF00069	0.499
MOD_PKA_1	680	686	PF00069	0.574
MOD_PKA_1	850	856	PF00069	0.616
MOD_PKA_2	164	170	PF00069	0.607
MOD_PKA_2	23	29	PF00069	0.528
MOD_PKA_2	488	494	PF00069	0.592
MOD_PKA_2	637	643	PF00069	0.566
MOD_PKA_2	680	686	PF00069	0.600
MOD_PKA_2	733	739	PF00069	0.657
MOD_PKA_2	850	856	PF00069	0.616
MOD_PKB_1	270	278	PF00069	0.512
MOD_Plk_1	128	134	PF00069	0.445
MOD_Plk_1	249	255	PF00069	0.560
MOD_Plk_1	266	272	PF00069	0.480
MOD_Plk_1	367	373	PF00069	0.570
MOD_Plk_1	401	407	PF00069	0.400
MOD_Plk_1	831	837	PF00069	0.614
MOD_Plk_4	249	255	PF00069	0.560
MOD_Plk_4	272	278	PF00069	0.551
MOD_Plk_4	619	625	PF00069	0.682
MOD_Plk_4	680	686	PF00069	0.718
MOD_Plk_4	738	744	PF00069	0.648
MOD_Plk_4	765	771	PF00069	0.559
MOD_Plk_4	832	838	PF00069	0.607
MOD_ProDKin_1	209	215	PF00069	0.515
MOD_ProDKin_1	229	235	PF00069	0.548
MOD_ProDKin_1	244	250	PF00069	0.577
MOD_ProDKin_1	292	298	PF00069	0.648
MOD_ProDKin_1	318	324	PF00069	0.679
MOD_ProDKin_1	326	332	PF00069	0.637
MOD_ProDKin_1	373	379	PF00069	0.579
MOD_ProDKin_1	564	570	PF00069	0.693
MOD_ProDKin_1	598	604	PF00069	0.563
MOD_ProDKin_1	615	621	PF00069	0.523
MOD_ProDKin_1	646	652	PF00069	0.649
MOD_ProDKin_1	670	676	PF00069	0.614
MOD_ProDKin_1	691	697	PF00069	0.665
MOD_ProDKin_1	734	740	PF00069	0.722
MOD_ProDKin_1	790	796	PF00069	0.707
MOD_ProDKin_1	856	862	PF00069	0.523
MOD_SUMO_for_1	5	8	PF00179	0.537
TRG_DiLeu_BaEn_1	474	479	PF01217	0.509
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.578
TRG_ENDOCYTIC_2	251	254	PF00928	0.590
TRG_ENDOCYTIC_2	410	413	PF00928	0.662
TRG_ENDOCYTIC_2	528	531	PF00928	0.579
TRG_ENDOCYTIC_2	535	538	PF00928	0.504
TRG_ENDOCYTIC_2	624	627	PF00928	0.542
TRG_ENDOCYTIC_2	833	836	PF00928	0.609
TRG_ER_diArg_1	107	110	PF00400	0.601
TRG_ER_diArg_1	163	166	PF00400	0.631
TRG_ER_diArg_1	33	36	PF00400	0.531
TRG_ER_diArg_1	396	398	PF00400	0.641
TRG_ER_diArg_1	443	445	PF00400	0.580
TRG_ER_diArg_1	460	463	PF00400	0.451
TRG_ER_diArg_1	850	852	PF00400	0.606
TRG_NES_CRM1_1	141	155	PF08389	0.523
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	551	555	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYM1	Leishmania donovani	68%	100%
A4I104	Leishmania infantum	68%	90%
E9AX42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QAD4	Leishmania major	66%	100%