Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDQ7_LEIBR

TriTrypDb:

LbrM.24.2030 , LBRM2903_240028000

Length:

793

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4

Expansion

Sequence features

A4HDQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDQ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.515
CLV_C14_Caspase3-7	294	298	PF00656	0.692
CLV_C14_Caspase3-7	36	40	PF00656	0.698
CLV_MEL_PAP_1	498	504	PF00089	0.617
CLV_NRD_NRD_1	182	184	PF00675	0.466
CLV_NRD_NRD_1	232	234	PF00675	0.489
CLV_NRD_NRD_1	500	502	PF00675	0.613
CLV_NRD_NRD_1	545	547	PF00675	0.620
CLV_NRD_NRD_1	588	590	PF00675	0.687
CLV_NRD_NRD_1	637	639	PF00675	0.699
CLV_NRD_NRD_1	700	702	PF00675	0.600
CLV_PCSK_KEX2_1	184	186	PF00082	0.466
CLV_PCSK_KEX2_1	500	502	PF00082	0.588
CLV_PCSK_KEX2_1	588	590	PF00082	0.685
CLV_PCSK_KEX2_1	637	639	PF00082	0.706
CLV_PCSK_KEX2_1	700	702	PF00082	0.600
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.561
CLV_PCSK_SKI1_1	251	255	PF00082	0.525
CLV_PCSK_SKI1_1	256	260	PF00082	0.482
CLV_PCSK_SKI1_1	327	331	PF00082	0.459
CLV_PCSK_SKI1_1	353	357	PF00082	0.551
CLV_PCSK_SKI1_1	59	63	PF00082	0.741
CLV_PCSK_SKI1_1	700	704	PF00082	0.461
CLV_PCSK_SKI1_1	708	712	PF00082	0.413
CLV_PCSK_SKI1_1	785	789	PF00082	0.636
DEG_Nend_UBRbox_1	1	4	PF02207	0.525
DEG_ODPH_VHL_1	696	709	PF01847	0.334
DEG_SPOP_SBC_1	645	649	PF00917	0.749
DOC_CDC14_PxL_1	62	70	PF14671	0.708
DOC_CDC14_PxL_1	90	98	PF14671	0.523
DOC_MAPK_gen_1	183	189	PF00069	0.477
DOC_MAPK_gen_1	233	239	PF00069	0.552
DOC_MAPK_gen_1	451	459	PF00069	0.572
DOC_MAPK_MEF2A_6	25	34	PF00069	0.568
DOC_MAPK_MEF2A_6	451	459	PF00069	0.548
DOC_PP1_RVXF_1	688	694	PF00149	0.389
DOC_PP2B_LxvP_1	341	344	PF13499	0.478
DOC_PP2B_LxvP_1	657	660	PF13499	0.665
DOC_PP4_FxxP_1	290	293	PF00568	0.537
DOC_USP7_MATH_1	194	198	PF00917	0.413
DOC_USP7_MATH_1	271	275	PF00917	0.704
DOC_USP7_MATH_1	347	351	PF00917	0.607
DOC_USP7_MATH_1	395	399	PF00917	0.754
DOC_USP7_MATH_1	626	630	PF00917	0.682
DOC_USP7_MATH_1	645	649	PF00917	0.736
DOC_USP7_MATH_1	660	664	PF00917	0.558
DOC_WW_Pin1_4	478	483	PF00397	0.656
LIG_14-3-3_CanoR_1	2	10	PF00244	0.483
LIG_14-3-3_CanoR_1	500	508	PF00244	0.642
LIG_14-3-3_CanoR_1	516	524	PF00244	0.444
LIG_14-3-3_CanoR_1	690	696	PF00244	0.523
LIG_14-3-3_CanoR_1	772	777	PF00244	0.285
LIG_Actin_WH2_2	707	725	PF00022	0.360
LIG_Actin_WH2_2	82	99	PF00022	0.463
LIG_APCC_ABBA_1	764	769	PF00400	0.540
LIG_BIR_III_2	213	217	PF00653	0.605
LIG_BRCT_BRCA1_1	319	323	PF00533	0.329
LIG_Clathr_ClatBox_1	209	213	PF01394	0.583
LIG_CtBP_PxDLS_1	216	220	PF00389	0.346
LIG_deltaCOP1_diTrp_1	758	767	PF00928	0.562
LIG_eIF4E_1	523	529	PF01652	0.370
LIG_FHA_1	120	126	PF00498	0.579
LIG_FHA_1	2	8	PF00498	0.554
LIG_FHA_1	364	370	PF00498	0.559
LIG_FHA_1	470	476	PF00498	0.679
LIG_FHA_1	519	525	PF00498	0.588
LIG_FHA_1	593	599	PF00498	0.594
LIG_FHA_2	138	144	PF00498	0.782
LIG_FHA_2	223	229	PF00498	0.357
LIG_FHA_2	34	40	PF00498	0.621
LIG_FHA_2	400	406	PF00498	0.562
LIG_FHA_2	479	485	PF00498	0.365
LIG_FHA_2	734	740	PF00498	0.540
LIG_FHA_2	751	757	PF00498	0.426
LIG_LIR_Gen_1	663	672	PF02991	0.621
LIG_LIR_Gen_1	758	767	PF02991	0.496
LIG_LIR_Nem_3	663	669	PF02991	0.579
LIG_LIR_Nem_3	748	752	PF02991	0.510
LIG_LIR_Nem_3	758	763	PF02991	0.509
LIG_LIR_Nem_3	769	773	PF02991	0.337
LIG_MYND_3	156	160	PF01753	0.576
LIG_MYND_3	203	207	PF01753	0.541
LIG_NRBOX	524	530	PF00104	0.442
LIG_Pex14_1	597	601	PF04695	0.579
LIG_SH2_CRK	491	495	PF00017	0.414
LIG_SH2_CRK	666	670	PF00017	0.582
LIG_SH2_PTP2	456	459	PF00017	0.599
LIG_SH2_SRC	728	731	PF00017	0.566
LIG_SH2_STAT5	379	382	PF00017	0.619
LIG_SH2_STAT5	456	459	PF00017	0.500
LIG_SH2_STAT5	523	526	PF00017	0.356
LIG_SH2_STAT5	601	604	PF00017	0.609
LIG_SH2_STAT5	728	731	PF00017	0.473
LIG_SH2_STAT5	752	755	PF00017	0.608
LIG_SH2_STAT5	80	83	PF00017	0.455
LIG_SH3_3	341	347	PF00018	0.687
LIG_SH3_3	48	54	PF00018	0.735
LIG_SH3_3	603	609	PF00018	0.759
LIG_SH3_3	735	741	PF00018	0.642
LIG_SUMO_SIM_anti_2	365	371	PF11976	0.554
LIG_SUMO_SIM_par_1	160	166	PF11976	0.522
LIG_SUMO_SIM_par_1	207	213	PF11976	0.572
LIG_TRAF2_1	683	686	PF00917	0.581
LIG_TYR_ITIM	408	413	PF00017	0.330
LIG_TYR_ITIM	489	494	PF00017	0.543
LIG_UBA3_1	178	184	PF00899	0.434
LIG_WRC_WIRS_1	292	297	PF05994	0.420
LIG_WW_2	344	347	PF00397	0.420
MOD_CK1_1	257	263	PF00069	0.687
MOD_CK1_1	394	400	PF00069	0.643
MOD_CK1_1	518	524	PF00069	0.580
MOD_CK1_1	563	569	PF00069	0.817
MOD_CK1_1	612	618	PF00069	0.674
MOD_CK1_1	731	737	PF00069	0.601
MOD_CK1_1	775	781	PF00069	0.321
MOD_CK2_1	137	143	PF00069	0.655
MOD_CK2_1	16	22	PF00069	0.606
MOD_CK2_1	222	228	PF00069	0.352
MOD_CK2_1	322	328	PF00069	0.602
MOD_CK2_1	645	651	PF00069	0.683
MOD_CK2_1	680	686	PF00069	0.679
MOD_CK2_1	750	756	PF00069	0.355
MOD_GlcNHglycan	117	120	PF01048	0.529
MOD_GlcNHglycan	143	146	PF01048	0.765
MOD_GlcNHglycan	173	176	PF01048	0.447
MOD_GlcNHglycan	195	199	PF01048	0.406
MOD_GlcNHglycan	256	259	PF01048	0.696
MOD_GlcNHglycan	271	274	PF01048	0.690
MOD_GlcNHglycan	349	352	PF01048	0.528
MOD_GlcNHglycan	393	396	PF01048	0.684
MOD_GlcNHglycan	4	7	PF01048	0.470
MOD_GlcNHglycan	460	465	PF01048	0.619
MOD_GlcNHglycan	648	651	PF01048	0.654
MOD_GSK3_1	115	122	PF00069	0.556
MOD_GSK3_1	134	141	PF00069	0.460
MOD_GSK3_1	265	272	PF00069	0.621
MOD_GSK3_1	291	298	PF00069	0.562
MOD_GSK3_1	317	324	PF00069	0.510
MOD_GSK3_1	391	398	PF00069	0.679
MOD_GSK3_1	469	476	PF00069	0.568
MOD_GSK3_1	502	509	PF00069	0.549
MOD_GSK3_1	550	557	PF00069	0.742
MOD_GSK3_1	560	567	PF00069	0.619
MOD_GSK3_1	597	604	PF00069	0.634
MOD_GSK3_1	611	618	PF00069	0.681
MOD_GSK3_1	646	653	PF00069	0.588
MOD_GSK3_1	680	687	PF00069	0.718
MOD_GSK3_1	72	79	PF00069	0.561
MOD_N-GLC_1	550	555	PF02516	0.497
MOD_N-GLC_1	564	569	PF02516	0.553
MOD_N-GLC_2	310	312	PF02516	0.613
MOD_N-GLC_2	67	69	PF02516	0.666
MOD_NEK2_1	1	6	PF00069	0.539
MOD_NEK2_1	317	322	PF00069	0.537
MOD_NEK2_1	336	341	PF00069	0.732
MOD_NEK2_1	434	439	PF00069	0.499
MOD_NEK2_1	502	507	PF00069	0.608
MOD_NEK2_1	611	616	PF00069	0.581
MOD_NEK2_1	74	79	PF00069	0.515
MOD_NEK2_2	337	342	PF00069	0.507
MOD_NEK2_2	626	631	PF00069	0.611
MOD_PIKK_1	297	303	PF00454	0.715
MOD_PIKK_1	327	333	PF00454	0.470
MOD_PIKK_1	435	441	PF00454	0.596
MOD_PIKK_1	680	686	PF00454	0.490
MOD_PIKK_1	74	80	PF00454	0.597
MOD_PKA_1	500	506	PF00069	0.641
MOD_PKA_2	1	7	PF00069	0.572
MOD_PKA_2	395	401	PF00069	0.464
MOD_PKA_2	473	479	PF00069	0.450
MOD_PKA_2	500	506	PF00069	0.631
MOD_PKA_2	515	521	PF00069	0.488
MOD_PKA_2	691	697	PF00069	0.521
MOD_Plk_1	337	343	PF00069	0.656
MOD_Plk_1	592	598	PF00069	0.453
MOD_Plk_1	650	656	PF00069	0.486
MOD_Plk_4	651	657	PF00069	0.474
MOD_Plk_4	745	751	PF00069	0.553
MOD_Plk_4	76	82	PF00069	0.560
MOD_ProDKin_1	478	484	PF00069	0.649
TRG_DiLeu_BaEn_4	130	136	PF01217	0.717
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.427
TRG_ENDOCYTIC_2	410	413	PF00928	0.558
TRG_ENDOCYTIC_2	456	459	PF00928	0.545
TRG_ENDOCYTIC_2	490	493	PF00928	0.404
TRG_ENDOCYTIC_2	666	669	PF00928	0.578
TRG_ER_diArg_1	182	185	PF00400	0.454
TRG_ER_diArg_1	500	502	PF00400	0.584
TRG_ER_diArg_1	587	589	PF00400	0.677
TRG_ER_diArg_1	636	638	PF00400	0.708
TRG_ER_diArg_1	689	692	PF00400	0.508
TRG_ER_diArg_1	699	701	PF00400	0.589
TRG_ER_diArg_1	716	719	PF00400	0.313
TRG_ER_diArg_1	771	774	PF00400	0.485
TRG_NES_CRM1_1	706	718	PF08389	0.425
TRG_Pf-PMV_PEXEL_1	453	458	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	701	706	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	785	790	PF00026	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1U0	Leptomonas seymouri	44%	100%
A0A1X0NVW0	Trypanosomatidae	24%	100%
A0A3S7WYK4	Leishmania donovani	78%	100%
A0A422NX08	Trypanosoma rangeli	25%	100%
A4I103	Leishmania infantum	78%	100%
C9ZWA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AX41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QAD5	Leishmania major	79%	99%
V5BAG5	Trypanosoma cruzi	25%	100%